Administration of a Toll-Like Receptor 9 Agonist Decreases the Proviral Reservoir in Virologically Suppressed HIV-Infected Patients - Winckelmann, Anni A.; Munk-Petersen, Lærke V.; Rasmussen, Thomas A.; Melchjorsen, Jesper; Hjelholt, Thomas J.; Montefiori, David; Østergaard, Lars; Søgaard, Ole S.; Tolstrup, Martin (PloS one, 2013)
Keywords: Acquired immune deficiency syndrome; Adult; Adults; AIDS; Antibodies; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Biology; CD4 antigen; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - virology; CD8 antigen; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - virology; Cell Compartmentation - drug effects; CpG islands; Degranulation; Deoxyribonucleic acid; Disease Reservoirs - virology; DNA; HIV; HIV Antibodies - biosynthesis; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; Human immunodeficiency virus; Humans; Immune system; Immunity; Immunity - drug effects; Immunization; Immunologic Memory - drug effects; In vivo methods and tests; Inflammation; Latency; Latent infection; Load distribution; Lymphocytes; Lymphocytes T; Macrophage inflammatory protein; Macrophages; Medicine; Middle Aged; Oligodeoxyribonucleotides - administration & dosage; Oligodeoxyribonucleotides - pharmacology; Oligodeoxyribonucleotides - therapeutic use; Patients; Phenotype; Proteins; Proviruses - drug effects; Randomization; Species Specificity; Stress concentration; T cell receptors; TLR9 protein; Toll-Like Receptor 9 - agonists; Toll-Like Receptor 9 - metabolism; Toll-like receptors; Vaccines; Viral Load - drug effects; Denmark; Aarhus Denmark