p53、MDR基因在食管癌及癌旁组织中表达的分析

A735.1; 目的探讨食管癌和癌旁组织中p53、MDR基因的表达及其临床意义.方法采用免疫组化ABC法及逆转录酶-聚合酶链反应的方法,对50例食管癌和37例癌旁组织中p53、MDR基因的表达情况进行检测.结果 p53基因蛋白在食管癌中有显著表达为68%(34/50),癌旁组织中有表达为59%(22/37);其中在癌旁正常组织中占54%(13/24),在癌旁非典型增生中占69%(9/13).MDR基因在食管癌高、中、低分化中的表达水平有极显著意义,癌与正常组织有极显著意义.在不同年龄、性别、肿瘤大小上p53、MDR基因的表达无显著意义.结论 p53、MDR基因在食管癌中均呈高水平表达,癌旁组织...

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Published in肿瘤防治研究 Vol. 32; no. 8; pp. 460 - 462
Main Authors 杨廷桐, 李秀杰
Format Journal Article
LanguageChinese
Published 453003,河南新乡医学院病理学教研室 2005
Subjects
p53基因蛋白
MDR基因
逆转录-聚合酶链反应
癌旁组织
食管癌
Online AccessGet full text
ISSN1000-8578
DOI10.3971/j.issn.1000-8578.2005.08.002

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Abstract A735.1; 目的探讨食管癌和癌旁组织中p53、MDR基因的表达及其临床意义.方法采用免疫组化ABC法及逆转录酶-聚合酶链反应的方法,对50例食管癌和37例癌旁组织中p53、MDR基因的表达情况进行检测.结果 p53基因蛋白在食管癌中有显著表达为68%(34/50),癌旁组织中有表达为59%(22/37);其中在癌旁正常组织中占54%(13/24),在癌旁非典型增生中占69%(9/13).MDR基因在食管癌高、中、低分化中的表达水平有极显著意义,癌与正常组织有极显著意义.在不同年龄、性别、肿瘤大小上p53、MDR基因的表达无显著意义.结论 p53、MDR基因在食管癌中均呈高水平表达,癌旁组织中MDR有表达,p53基因突变早于组织形态学改变.
AbstractList A735.1; 目的探讨食管癌和癌旁组织中p53、MDR基因的表达及其临床意义.方法采用免疫组化ABC法及逆转录酶-聚合酶链反应的方法,对50例食管癌和37例癌旁组织中p53、MDR基因的表达情况进行检测.结果 p53基因蛋白在食管癌中有显著表达为68%(34/50),癌旁组织中有表达为59%(22/37);其中在癌旁正常组织中占54%(13/24),在癌旁非典型增生中占69%(9/13).MDR基因在食管癌高、中、低分化中的表达水平有极显著意义,癌与正常组织有极显著意义.在不同年龄、性别、肿瘤大小上p53、MDR基因的表达无显著意义.结论 p53、MDR基因在食管癌中均呈高水平表达,癌旁组织中MDR有表达,p53基因突变早于组织形态学改变.
Author 李秀杰
杨廷桐
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YANG Ting-tong
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MDR基因
逆转录-聚合酶链反应
癌旁组织
食管癌
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