自体骨髓间充质干细胞对肝硬化患者门静脉高压血流动力学的影响
目的观察白体骨髓间充质干细胞对乙型肝炎肝硬化失代偿患者门静脉血流动力学的影响。方法将2011年02月-2012年01月收治的乙型肝炎肝硬化失代偿住院患者46例配对分为两组。治疗组23例，对照组23例。两组患者在性别、年龄、诊断、生化及影像学指标方面差异无统计学意义。所有患者在签定知情同意书后进行治疗。对照组仅给予抗病毒及护肝利尿支持等治疗。治疗组抽取自体骨髓200ml，体外分离纯化骨髓间充质干细胞在体外诱导培养后制成10ml细胞悬液，经肝动脉注入肝脏，分别在治疗后第8、12周观察患者的门静脉血流动力学指标的变化。组内比较采用配对t检验，组间比较采用成组t检验。结果经骨髓间充质干细胞治疗8周和1...
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| Published in | 临床肝胆病杂志 Vol. 29; no. 11; pp. 848 - 851 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
焦作市第三人民医院,肝病三科,河南,焦作,454172%焦作市人民医院,内科,河南,焦作,454100%焦作市第四人民医院,内科,河南,焦作,454100
2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1001-5256 |
| DOI | 10.3969/j.issn.1001-5256.2013.11.012 |
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| Abstract | 目的观察白体骨髓间充质干细胞对乙型肝炎肝硬化失代偿患者门静脉血流动力学的影响。方法将2011年02月-2012年01月收治的乙型肝炎肝硬化失代偿住院患者46例配对分为两组。治疗组23例，对照组23例。两组患者在性别、年龄、诊断、生化及影像学指标方面差异无统计学意义。所有患者在签定知情同意书后进行治疗。对照组仅给予抗病毒及护肝利尿支持等治疗。治疗组抽取自体骨髓200ml，体外分离纯化骨髓间充质干细胞在体外诱导培养后制成10ml细胞悬液，经肝动脉注入肝脏，分别在治疗后第8、12周观察患者的门静脉血流动力学指标的变化。组内比较采用配对t检验，组间比较采用成组t检验。结果经骨髓间充质干细胞治疗8周和12周，治疗组门静脉内径（DPV）和脾静脉内径（DSV）下降，DPV在8周和12周分别为（13．26±1．3l）和（12．83±1．38）mm，与治疗前比较，t值为2．290和3．421，P〈0．05和P〈0．01；DSV在8周和12周分别为（8．39±1．38）和（8．02±1．24）mm，与治疗前比较，t值为2．079和2．787，P〈0．05和P〈0．01。与同期对照组比较，DPV在8周和12周t值为2．382和2．602，P值均〈0．05；DSV在8周和12周t值为3．236和4．185，P值均〈0．01，差异均有统计学意义。门静脉最大血流速度（PVX）增快，8周和12周分别为（20．72±4．63）和（20．58±3．46）cm／s，与治疗前比较，t值为2．833和3．198，P值均〈0．01，差异有统计学意义。与同期对照组（17．12±4．78）和（17．20±3．87）cm／s比较，差异有统计学意义（t值为2．530和3．123，P〈0．05和P〈0．01）。结论自体骨髓间充质干细胞可以明显改善乙型肝炎肝硬化失代偿患者的门静脉血流动力学指标。 |
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| AbstractList | 目的观察白体骨髓间充质干细胞对乙型肝炎肝硬化失代偿患者门静脉血流动力学的影响。方法将2011年02月-2012年01月收治的乙型肝炎肝硬化失代偿住院患者46例配对分为两组。治疗组23例，对照组23例。两组患者在性别、年龄、诊断、生化及影像学指标方面差异无统计学意义。所有患者在签定知情同意书后进行治疗。对照组仅给予抗病毒及护肝利尿支持等治疗。治疗组抽取自体骨髓200ml，体外分离纯化骨髓间充质干细胞在体外诱导培养后制成10ml细胞悬液，经肝动脉注入肝脏，分别在治疗后第8、12周观察患者的门静脉血流动力学指标的变化。组内比较采用配对t检验，组间比较采用成组t检验。结果经骨髓间充质干细胞治疗8周和12周，治疗组门静脉内径（DPV）和脾静脉内径（DSV）下降，DPV在8周和12周分别为（13．26±1．3l）和（12．83±1．38）mm，与治疗前比较，t值为2．290和3．421，P〈0．05和P〈0．01；DSV在8周和12周分别为（8．39±1．38）和（8．02±1．24）mm，与治疗前比较，t值为2．079和2．787，P〈0．05和P〈0．01。与同期对照组比较，DPV在8周和12周t值为2．382和2．602，P值均〈0．05；DSV在8周和12周t值为3．236和4．185，P值均〈0．01，差异均有统计学意义。门静脉最大血流速度（PVX）增快，8周和12周分别为（20．72±4．63）和（20．58±3．46）cm／s，与治疗前比较，t值为2．833和3．198，P值均〈0．01，差异有统计学意义。与同期对照组（17．12±4．78）和（17．20±3．87）cm／s比较，差异有统计学意义（t值为2．530和3．123，P〈0．05和P〈0．01）。结论自体骨髓间充质干细胞可以明显改善乙型肝炎肝硬化失代偿患者的门静脉血流动力学指标。 R575.2; 目的 观察自体骨髓间充质干细胞对乙型肝炎肝硬化失代偿患者门静脉血流动力学的影响.方法 将2011年02月-2012年01月收治的乙型肝炎肝硬化失代偿住院患者46例配对分为两组.治疗组23例,对照组23例.两组患者在性别、年龄、诊断、生化及影像学指标方面差异无统计学意义.所有患者在签定知情同意书后进行治疗.对照组仅给予抗病毒及护肝利尿支持等治疗.治疗组抽取自体骨髓200 ml,体外分离纯化骨髓间充质干细胞在体外诱导培养后制成10 ml细胞悬液,经肝动脉注入肝脏,分别在治疗后第8、12周观察患者的门静脉血流动力学指标的变化.组内比较采用配对t检验,组间比较采用成组t检验.结果 经骨髓间充质干细胞治疗8周和12周,治疗组门静脉内径(DPV)和脾静脉内径(DSV)下降,DPV在8周和12周分别为(13.26±1.31)和(12.83±1.38)mm,与治疗前比较,t值为2.290和3.421,P＜0.05和P＜0.01;DSV在8周和12周分别为(8.39±1.38)和(8.02±1.24)mm,与治疗前比较,t值为2.079和2.787,P＜0.05和P＜0.01.与同期对照组比较,DPV在8周和12周t值为2.382和2.602,P值均＜0.05;DSV在8周和12周t值为3.236和4.185,P值均＜0.01,差异均有统计学意义.门静脉最大血流速度(PVX)增快,8周和12周分别为(20.72±4.63)和(20.58±3.46)cm/s,与治疗前比较,t值为2.833和3.198,P值均＜0.01,差异有统计学意义.与同期对照组(17.12±4.78)和(17.20±3.87)cm/s比较,差异有统计学意义(t值为2.530和3.123,P＜0.05和P＜0.01).结论 自体骨髓间充质干细胞可以明显改善乙型肝炎肝硬化失代偿患者的门静脉血流动力学指标. |
| Author | 尚建中 马龙飞 马宏伟 赵秋芳 赵林华 李晓飞 范燕峰 张素娥 |
| AuthorAffiliation | 焦作市第三人民医院肝病三科,河南焦作454172 焦作市人民医院内科,河南焦作454100 焦作市第四人民医院内科,河南焦作454100 |
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| Author_xml | – sequence: 1 fullname: 尚建中 马龙飞 马宏伟 赵秋芳 赵林华 李晓飞 范燕峰 张素娥 |
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| DocumentTitleAlternate | Effect of autologous bone marrow -derived mesenchymal stem cells on portal hemodynamics in patients with liver cirrhosis |
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| Keywords | 间质干细胞移植 肝硬化 高血压,门静脉 血流动力学 |
| Language | Chinese |
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| Notes | mesenchymal stem cells transplantation; hypertension, portal; liver cirrhosis; hemodynamics Objective To observe the effect of autologous bone marrow - derived mesenchymal stem ceils （BMMSCs） on the portal hemody- namics in patients with hepatitis B virus （HBV） -related decompensated cirrhosis. Methods Forty -six patients with HBV -related deeom- pensated cirrhosis, who were admitted to the hospital from February 2011 to January 2012, were divided into treatment group （n = 23） and control group （ n = 23 ）. There were no significant differences in sex, age, diagnosis, biochemical parameters, and imaging findings between the two groups. All patients provided informed consent prior to treatment. Both groups received antiviral, liver - protecting, and diuretic treatment. In addition, in the treatment group, bone marrow （200 ml） was drawn from each patient, BMMSCs were isolated, purified, anti cultured, and the cultured cells were processed into cell suspension （ 10 ml） ; the cell suspension was injected into the l |
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| PublicationTitle | 临床肝胆病杂志 |
| PublicationTitleAlternate | Chinese Journal of Clinical Hepatology |
| PublicationTitle_FL | JOURNAL OF CLINICAL HEPATOLOGY |
| PublicationYear | 2013 |
| Publisher | 焦作市第三人民医院,肝病三科,河南,焦作,454172%焦作市人民医院,内科,河南,焦作,454100%焦作市第四人民医院,内科,河南,焦作,454100 |
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| Snippet | 目的观察白体骨髓间充质干细胞对乙型肝炎肝硬化失代偿患者门静脉血流动力学的影响。方法将2011年02月-2012年01月收治的乙型肝炎肝硬化失代偿住院患者46例配对分为两组。治疗... R575.2; 目的 观察自体骨髓间充质干细胞对乙型肝炎肝硬化失代偿患者门静脉血流动力学的影响.方法 将2011年02月-2012年01月收治的乙型肝炎肝硬化失代偿住院患者46例配对分... |
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| SubjectTerms | 肝硬化 血流动力学 门静脉 间质干细胞移植 高血压 |
| Title | 自体骨髓间充质干细胞对肝硬化患者门静脉高压血流动力学的影响 |
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