格氏法合成7-氯-2-氧代庚酸

R914.5; 研究了合成西司他丁(一种肾脱氢二肽酶抑制剂)的中间体7-氯-2-氧代庚酸的新工艺.以1-溴-5-氯-戊烷为起始原料,制成单格氏试剂后与草酸二乙酯加成生成7-氯-2-氧代庚酸乙酯,酯水解制得7-氯-2-氧代庚酸.工艺总收率达46%,产品经质谱证实结构正确....

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Published in浙江大学学报（理学版） Vol. 33; no. 2; pp. 209 - 215
Main Authors 石晓华, 陈新志
Format Journal Article
LanguageChinese
Published 浙江大学,材化学院,浙江,杭州,310027 2006
Subjects
西司他丁
格氏法
7-氯-2-氧代庚酸
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ISSN1008-9497
DOI10.3321/j.issn:1008-9497.2006.02.021

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Abstract R914.5; 研究了合成西司他丁(一种肾脱氢二肽酶抑制剂)的中间体7-氯-2-氧代庚酸的新工艺.以1-溴-5-氯-戊烷为起始原料,制成单格氏试剂后与草酸二乙酯加成生成7-氯-2-氧代庚酸乙酯,酯水解制得7-氯-2-氧代庚酸.工艺总收率达46%,产品经质谱证实结构正确.
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Author 石晓华
陈新志
AuthorAffiliation 浙江大学,材化学院,浙江,杭州,310027
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SHI Xiao-hua
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格氏法
7-氯-2-氧代庚酸
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Snippet R914.5; 研究了合成西司他丁(一种肾脱氢二肽酶抑制剂)的中间体7-氯-2-氧代庚酸的新工艺.以1-溴-5-氯-戊烷为起始原料,制成单格氏试剂后与草酸二乙酯加成生成7-氯-2-氧代庚...
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Title 格氏法合成7-氯-2-氧代庚酸
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