Assessment of functional diversities in patients with Asthma, COPD, Asthma-COPD overlap, and Cystic Fibrosis (CF)
The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise classification of obstructive lung diseases. From...
Saved in:
| Published in | PloS one Vol. 19; no. 2; p. e0292270 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
20.02.2024
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0292270 |
Cover
| Abstract | The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise classification of obstructive lung diseases. From the databases of 4 centers, a total of 756 lung function tests (194 healthy subjects, 175 with asthma, 71 with ACO, 78 with COPD and 238 with CF) were collected, and gradients among combinations of target parameters from spirometry (forced expiratory volume one second: FEV
1
; FEV
1
/forced vital capacity: FEV
1
/FVC; forced expiratory flow between 25–75% FVC: FEF
25-75
), and plethysmography (effective, resistive airway resistance: sR
eff
; aerodynamic work of breathing at rest: sWOB), separately for in- and expiration (sR
eff
IN
, sR
eff
EX
, sWOB
in
, sWOB
ex
) as well as static lung volumes (total lung capacity: TLC; functional residual capacity: FRC
pleth
; residual volume: RV), the control of breathing (mouth occlusion pressure: P
0.1
; mean inspiratory flow: V
T
/T
I
; the inspiratory to total time ratio: T
I
/T
tot
) and the inspiratory impedance (Z
in
pleth
= P
0.1
/V
T
/T
I
) were explored. Linear discriminant analyses (LDA) were applied to identify discriminant functions and classification rules using recursive partitioning decision trees. LDA showed a high classification accuracy (sensitivity and specificity > 90%) for healthy subjects, COPD and CF. The accuracy dropped for asthma (~70%) and even more for ACO (~60%). The decision tree revealed that P
0.1
, sR
tot
, and V
T
/T
I
differentiate most between healthy and asthma (68.9%), COPD (82.1%), and CF (60.6%). Moreover, using sWOB
ex
and Z
in
pleth
ACO can be discriminated from asthma and COPD (60%). Thus, the functional complexity of obstructive lung diseases can be understood, if specific spirometric and plethysmographic parameters are used. Moreover, the newly described parameters of airway dynamics and the central control of breathing including Z
in
pleth
may well serve as promising functional marker in the field of precision medicine. |
|---|---|
| AbstractList | The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise classification of obstructive lung diseases. From the databases of 4 centers, a total of 756 lung function tests (194 healthy subjects, 175 with asthma, 71 with ACO, 78 with COPD and 238 with CF) were collected, and gradients among combinations of target parameters from spirometry (forced expiratory volume one second: FEV
1
; FEV
1
/forced vital capacity: FEV
1
/FVC; forced expiratory flow between 25–75% FVC: FEF
25-75
), and plethysmography (effective, resistive airway resistance: sR
eff
; aerodynamic work of breathing at rest: sWOB), separately for in- and expiration (sR
eff
IN
, sR
eff
EX
, sWOB
in
, sWOB
ex
) as well as static lung volumes (total lung capacity: TLC; functional residual capacity: FRC
pleth
; residual volume: RV), the control of breathing (mouth occlusion pressure: P
0.1
; mean inspiratory flow: V
T
/T
I
; the inspiratory to total time ratio: T
I
/T
tot
) and the inspiratory impedance (Z
in
pleth
= P
0.1
/V
T
/T
I
) were explored. Linear discriminant analyses (LDA) were applied to identify discriminant functions and classification rules using recursive partitioning decision trees. LDA showed a high classification accuracy (sensitivity and specificity > 90%) for healthy subjects, COPD and CF. The accuracy dropped for asthma (~70%) and even more for ACO (~60%). The decision tree revealed that P
0.1
, sR
tot
, and V
T
/T
I
differentiate most between healthy and asthma (68.9%), COPD (82.1%), and CF (60.6%). Moreover, using sWOB
ex
and Z
in
pleth
ACO can be discriminated from asthma and COPD (60%). Thus, the functional complexity of obstructive lung diseases can be understood, if specific spirometric and plethysmographic parameters are used. Moreover, the newly described parameters of airway dynamics and the central control of breathing including Z
in
pleth
may well serve as promising functional marker in the field of precision medicine. The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise classification of obstructive lung diseases. From the databases of 4 centers, a total of 756 lung function tests (194 healthy subjects, 175 with asthma, 71 with ACO, 78 with COPD and 238 with CF) were collected, and gradients among combinations of target parameters from spirometry (forced expiratory volume one second: FEV1; FEV1/forced vital capacity: FEV1/FVC; forced expiratory flow between 25-75% FVC: FEF25-75), and plethysmography (effective, resistive airway resistance: sReff; aerodynamic work of breathing at rest: sWOB), separately for in- and expiration (sReffIN, sReffEX, sWOBin, sWOBex) as well as static lung volumes (total lung capacity: TLC; functional residual capacity: FRCpleth; residual volume: RV), the control of breathing (mouth occlusion pressure: P0.1; mean inspiratory flow: VT/TI; the inspiratory to total time ratio: TI/Ttot) and the inspiratory impedance (Zinpleth = P0.1/VT/TI) were explored. Linear discriminant analyses (LDA) were applied to identify discriminant functions and classification rules using recursive partitioning decision trees. LDA showed a high classification accuracy (sensitivity and specificity > 90%) for healthy subjects, COPD and CF. The accuracy dropped for asthma (~70%) and even more for ACO (~60%). The decision tree revealed that P0.1, sRtot, and VT/TI differentiate most between healthy and asthma (68.9%), COPD (82.1%), and CF (60.6%). Moreover, using sWOBex and Zinpleth ACO can be discriminated from asthma and COPD (60%). Thus, the functional complexity of obstructive lung diseases can be understood, if specific spirometric and plethysmographic parameters are used. Moreover, the newly described parameters of airway dynamics and the central control of breathing including Zinpleth may well serve as promising functional marker in the field of precision medicine. The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise classification of obstructive lung diseases. From the databases of 4 centers, a total of 756 lung function tests (194 healthy subjects, 175 with asthma, 71 with ACO, 78 with COPD and 238 with CF) were collected, and gradients among combinations of target parameters from spirometry (forced expiratory volume one second: FEV.sub.1 ; FEV.sub.1 /forced vital capacity: FEV.sub.1 /FVC; forced expiratory flow between 25-75% FVC: FEF.sub.25-75 ), and plethysmography (effective, resistive airway resistance: sR.sub.eff ; aerodynamic work of breathing at rest: sWOB), separately for in- and expiration (sR.sub.eff .sup.IN, sR.sub.eff .sup.EX, sWOB.sub.in, sWOB.sub.ex) as well as static lung volumes (total lung capacity: TLC; functional residual capacity: FRC.sub.pleth ; residual volume: RV), the control of breathing (mouth occlusion pressure: P.sub.0.1 ; mean inspiratory flow: V.sub.T /T.sub.I ; the inspiratory to total time ratio: T.sub.I /T.sub.tot) and the inspiratory impedance (Z.sub.in .sup.pleth = P.sub.0.1 /V.sub.T /T.sub.I) were explored. Linear discriminant analyses (LDA) were applied to identify discriminant functions and classification rules using recursive partitioning decision trees. LDA showed a high classification accuracy (sensitivity and specificity > 90%) for healthy subjects, COPD and CF. The accuracy dropped for asthma (~70%) and even more for ACO (~60%). The decision tree revealed that P.sub.0.1, sR.sub.tot, and V.sub.T /T.sub.I differentiate most between healthy and asthma (68.9%), COPD (82.1%), and CF (60.6%). Moreover, using sWOB.sub.ex and Z.sub.in .sup.pleth ACO can be discriminated from asthma and COPD (60%). Thus, the functional complexity of obstructive lung diseases can be understood, if specific spirometric and plethysmographic parameters are used. Moreover, the newly described parameters of airway dynamics and the central control of breathing including Z.sub.in .sup.pleth may well serve as promising functional marker in the field of precision medicine. The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise classification of obstructive lung diseases. From the databases of 4 centers, a total of 756 lung function tests (194 healthy subjects, 175 with asthma, 71 with ACO, 78 with COPD and 238 with CF) were collected, and gradients among combinations of target parameters from spirometry (forced expiratory volume one second: FEV1; FEV1/forced vital capacity: FEV1/FVC; forced expiratory flow between 25-75% FVC: FEF25-75), and plethysmography (effective, resistive airway resistance: sReff; aerodynamic work of breathing at rest: sWOB), separately for in- and expiration (sReffIN, sReffEX, sWOBin, sWOBex) as well as static lung volumes (total lung capacity: TLC; functional residual capacity: FRCpleth; residual volume: RV), the control of breathing (mouth occlusion pressure: P0.1; mean inspiratory flow: VT/TI; the inspiratory to total time ratio: TI/Ttot) and the inspiratory impedance (Zinpleth = P0.1/VT/TI) were explored. Linear discriminant analyses (LDA) were applied to identify discriminant functions and classification rules using recursive partitioning decision trees. LDA showed a high classification accuracy (sensitivity and specificity > 90%) for healthy subjects, COPD and CF. The accuracy dropped for asthma (~70%) and even more for ACO (~60%). The decision tree revealed that P0.1, sRtot, and VT/TI differentiate most between healthy and asthma (68.9%), COPD (82.1%), and CF (60.6%). Moreover, using sWOBex and Zinpleth ACO can be discriminated from asthma and COPD (60%). Thus, the functional complexity of obstructive lung diseases can be understood, if specific spirometric and plethysmographic parameters are used. Moreover, the newly described parameters of airway dynamics and the central control of breathing including Zinpleth may well serve as promising functional marker in the field of precision medicine.The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise classification of obstructive lung diseases. From the databases of 4 centers, a total of 756 lung function tests (194 healthy subjects, 175 with asthma, 71 with ACO, 78 with COPD and 238 with CF) were collected, and gradients among combinations of target parameters from spirometry (forced expiratory volume one second: FEV1; FEV1/forced vital capacity: FEV1/FVC; forced expiratory flow between 25-75% FVC: FEF25-75), and plethysmography (effective, resistive airway resistance: sReff; aerodynamic work of breathing at rest: sWOB), separately for in- and expiration (sReffIN, sReffEX, sWOBin, sWOBex) as well as static lung volumes (total lung capacity: TLC; functional residual capacity: FRCpleth; residual volume: RV), the control of breathing (mouth occlusion pressure: P0.1; mean inspiratory flow: VT/TI; the inspiratory to total time ratio: TI/Ttot) and the inspiratory impedance (Zinpleth = P0.1/VT/TI) were explored. Linear discriminant analyses (LDA) were applied to identify discriminant functions and classification rules using recursive partitioning decision trees. LDA showed a high classification accuracy (sensitivity and specificity > 90%) for healthy subjects, COPD and CF. The accuracy dropped for asthma (~70%) and even more for ACO (~60%). The decision tree revealed that P0.1, sRtot, and VT/TI differentiate most between healthy and asthma (68.9%), COPD (82.1%), and CF (60.6%). Moreover, using sWOBex and Zinpleth ACO can be discriminated from asthma and COPD (60%). Thus, the functional complexity of obstructive lung diseases can be understood, if specific spirometric and plethysmographic parameters are used. Moreover, the newly described parameters of airway dynamics and the central control of breathing including Zinpleth may well serve as promising functional marker in the field of precision medicine. |
| Audience | Academic |
| Author | Kraemer, Richard Baty, Florent Minder, Stefan Smith, Hans-Jürgen Gallati, Sabina Brutsche, Martin H. Matthys, Heinrich |
| AuthorAffiliation | 3 School of Biomedical and Precision Engineering (SBPE), University of Bern, Bern, Switzerland University of Western Ontario, CANADA 2 Department of Paediatrics, University of Bern, Bern, Switzerland 6 Hirslanden Precise, Genomic Medicine, Hirslanden Hospital Group, Zollikon/Zürich, Switzerland 1 Centre of Pulmonary Medicine, Hirslanden Hospital Group, Salem-Hospital, Bern, Switzerland 7 Department of Pneumology, University Hospital of Freiburg, Freiburg, Germany 5 Medical Development, Research in Respiratory Diagnostics, Berlin, Germany 4 Department of Pneumology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland |
| AuthorAffiliation_xml | – name: 7 Department of Pneumology, University Hospital of Freiburg, Freiburg, Germany – name: 6 Hirslanden Precise, Genomic Medicine, Hirslanden Hospital Group, Zollikon/Zürich, Switzerland – name: 4 Department of Pneumology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland – name: 2 Department of Paediatrics, University of Bern, Bern, Switzerland – name: 3 School of Biomedical and Precision Engineering (SBPE), University of Bern, Bern, Switzerland – name: University of Western Ontario, CANADA – name: 5 Medical Development, Research in Respiratory Diagnostics, Berlin, Germany – name: 1 Centre of Pulmonary Medicine, Hirslanden Hospital Group, Salem-Hospital, Bern, Switzerland |
| Author_xml | – sequence: 1 givenname: Richard orcidid: 0000-0002-1542-2420 surname: Kraemer fullname: Kraemer, Richard – sequence: 2 givenname: Florent orcidid: 0000-0002-1425-0428 surname: Baty fullname: Baty, Florent – sequence: 3 givenname: Hans-Jürgen surname: Smith fullname: Smith, Hans-Jürgen – sequence: 4 givenname: Stefan surname: Minder fullname: Minder, Stefan – sequence: 5 givenname: Sabina surname: Gallati fullname: Gallati, Sabina – sequence: 6 givenname: Martin H. surname: Brutsche fullname: Brutsche, Martin H. – sequence: 7 givenname: Heinrich surname: Matthys fullname: Matthys, Heinrich |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38377145$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkl1r2zAUhs3oWD-2fzCGYDBaSDLJsiTraoRs2QKFjK3sVqiynCjYkmvZ7frvd7xkJYZd1L6wdPy8r47OOefJiQ_eJslbgmeECvJxF_rW62rWQHiGU5mmAr9Izoik6ZSnmJ4crU-T8xh3GDOac_4qOaU5FYJk7Cy5m8doY6yt71AoUdl707kAvqhw97aNrnM2IudRo2Hlu4geXLdF89htaz1Bi_X3z5PDbjpsUABVpZsJ0r5Ai8fYOYOW7rYN0UV0uVhevU5elrqK9s3he5HcLL_cLL5Nr9dfV4v59dQwibuptCXjAttMm6wg8BhZClpiA3cosrIoJLcZ1yXmNCcsFUZKwrXAhqayYJheJKu9bRH0TjWtq3X7qIJ26m8gtBulW0iuskpkxFpNLAfrTDCuDU-1SFnBU8YxFuDF9l69b_Tjg66qJ0OC1dANdeiGGrqhDt0A3ae9rulva1sYqF-rq1Ey4z_ebdUm3INrLnJGCThcHhzacNfb2KnaRWOrSnsb-qjgIMkyLNmQ5Ps9utFwJ-fLAJZmwNVc5FCVNJMUqNl_KHgLWzsDyZcO4iPB1UgATGd_dxvdx6hWP388n13_GrMfjtit1VW3jaHqh-mLY_DdcRGfqvdvhgHI9oCBIYutLZ_XnD-OAgSZ |
| Cites_doi | 10.1183/13993003.01655-2017 10.1186/s12931-015-0252-0 10.1164/ajrccm.159.1.9712108 10.1183/09031936.00135110 10.1007/s10549-012-2201-7 10.1186/s12931-016-0470-0 10.1159/000490551 10.1164/rccm.202301-0106PP 10.1136/thx.2010.151332 10.1016/j.iac.2022.04.009 10.1016/S0140-6736(17)32136-0 10.1136/thoraxjnl-2014-205507 10.1016/S0022-3476(98)70344-0 10.1183/09041950.041s1693 10.1111/apm.12915 10.1016/j.rmed.2014.05.016 10.1016/j.resp.2005.05.017 10.1183/09031936.95.08030492 10.2147/COPD.S338359 10.1186/1465-9921-7-138 10.1155/2018/6567578 10.1183/09031936.05.00035205 10.1164/ajrccm.163.5.2101039 10.1164/ajrccm.157.5.9710042 10.2147/COPD.S330817 10.1136/thx.2010.142646 10.1164/rccm.202109-2064TR 10.1183/13993003.01660-2018 10.3109/15412555.2011.611200 10.3390/biomedicines9101437 10.1183/13993003.00651-2019 10.1016/j.jcf.2013.04.008 10.1164/rccm.202108-1819PP 10.3109/02770903.2011.555576 10.1164/rccm.201705-0973WS 10.1136/thx.2008.108027 10.1186/1465-9921-10-106 10.1007/s00134-018-5045-8 10.2147/COPD.S382761 10.1016/0034-5687(75)90059-6 10.1371/journal.pone.0062985 10.14814/phy2.15027 10.1586/ecp.13.2 10.1007/PL00013814 10.1159/000187717 10.1183/13993003.02460-2018 10.1183/13993003.01359-2015 10.1186/s12931-016-0484-7 10.1183/13993003.00010-2017 10.1164/rccm.200603-422OC 10.1136/bmj.j3772 10.2147/COPD.S175706 10.1164/rccm.200407-948OC 10.1164/ajrccm.154.6.8970362 10.3390/jpm13040677 10.1183/09031936.05.00034805 10.1080/15412555.2018.1443064 10.1016/j.alit.2018.01.002 10.2147/COPD.S319220 10.1038/sj.ejhg.5200338 10.1002/path.5364 |
| ContentType | Journal Article |
| Copyright | Copyright: © 2024 Kraemer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. COPYRIGHT 2024 Public Library of Science 2024 Kraemer et al 2024 Kraemer et al |
| Copyright_xml | – notice: Copyright: © 2024 Kraemer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. – notice: COPYRIGHT 2024 Public Library of Science – notice: 2024 Kraemer et al 2024 Kraemer et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1371/journal.pone.0292270 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | Functional diversities within patients with obstructive lung diseases |
| EISSN | 1932-6203 |
| ExternalDocumentID | oai_doaj_org_article_741eea1e65384756ac62a725d6256007 10.1371/journal.pone.0292270 PMC10878531 A783292493 38377145 10_1371_journal_pone_0292270 |
| Genre | Journal Article |
| GeographicLocations | Switzerland |
| GeographicLocations_xml | – name: Switzerland |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PUEGO PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ADRAZ ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7X8 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c590t-9ef5670e4ac4d1111c9f73f0c538d4fdd96e46af06381527c9916a70c329d503 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Fri Oct 03 12:51:35 EDT 2025 Sun Oct 26 03:50:38 EDT 2025 Tue Sep 30 17:10:46 EDT 2025 Fri Sep 05 10:18:20 EDT 2025 Mon Oct 20 22:59:16 EDT 2025 Mon Oct 20 17:14:33 EDT 2025 Thu Oct 16 16:24:36 EDT 2025 Thu Oct 16 16:26:45 EDT 2025 Thu May 22 21:24:35 EDT 2025 Wed Feb 19 02:06:04 EST 2025 Wed Oct 01 01:52:06 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | Copyright: © 2024 Kraemer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. cc-by |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c590t-9ef5670e4ac4d1111c9f73f0c538d4fdd96e46af06381527c9916a70c329d503 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. |
| ORCID | 0000-0002-1542-2420 0000-0002-1425-0428 |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292270&type=printable |
| PMID | 38377145 |
| PQID | 2929540957 |
| PQPubID | 23479 |
| PageCount | e0292270 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_741eea1e65384756ac62a725d6256007 unpaywall_primary_10_1371_journal_pone_0292270 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10878531 proquest_miscellaneous_2929540957 gale_infotracmisc_A783292493 gale_infotracacademiconefile_A783292493 gale_incontextgauss_ISR_A783292493 gale_incontextgauss_IOV_A783292493 gale_healthsolutions_A783292493 pubmed_primary_38377145 crossref_primary_10_1371_journal_pone_0292270 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-02-20 |
| PublicationDateYYYYMMDD | 2024-02-20 |
| PublicationDate_xml | – month: 02 year: 2024 text: 2024-02-20 day: 20 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2024 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | BJ Rosenstein (pone.0292270.ref044) 1998; 132 M Dreher (pone.0292270.ref056) 2009; 78 JM Leung (pone.0292270.ref040) 2017; 358 PG Gibson (pone.0292270.ref013) 2009; 64 A Agusti (pone.0292270.ref012) 2023 L Eltayara (pone.0292270.ref068) 1996; 154 M Adrish (pone.0292270.ref021) 2022; 42 JE Cotes (pone.0292270.ref047) 1993; 6 LC Bennett (pone.0292270.ref046) 2000; 159 R Kraemer (pone.0292270.ref058) 2021; 9 T Torresani (pone.0292270.ref059) 2013; 12 CA Brandsma (pone.0292270.ref007) 2020; 250 pone.0292270.ref036 R Kraemer (pone.0292270.ref033) 2022; 17 BR Celli (pone.0292270.ref038) 2021; 204 L Carrasco-Hernandez (pone.0292270.ref064) 2021; 9 S Liechti-Gallati (pone.0292270.ref045) 1999; 7 JL Lopez-Campos (pone.0292270.ref009) 2018; 15 EFM Wouters (pone.0292270.ref003) 2018; 27 S Yanagisawa (pone.0292270.ref020) 2018; 67 M Topalovic (pone.0292270.ref011) 2017; 18 JL Hankinson (pone.0292270.ref053) 1999; 159 A. Agusti (pone.0292270.ref025) 2014; 69 S Louie (pone.0292270.ref017) 2013; 6 S Verbanck (pone.0292270.ref028) 2006; 174 CC Reilly (pone.0292270.ref035) 2011; 66 V De Rose (pone.0292270.ref063) 2018; 2018 J Shi (pone.0292270.ref065) 2018; 2018 R Pellegrino (pone.0292270.ref048) 2005; 26 R Kraemer (pone.0292270.ref042) 2006; 7 C Brightling (pone.0292270.ref005) 2019; 54 J Cardoso (pone.0292270.ref008) 2021; 16 S Verbanck (pone.0292270.ref027) 2012; 135 J Stocks (pone.0292270.ref052) 1995; 8 W Yang (pone.0292270.ref037) 2021; 16 PH Quanjer (pone.0292270.ref061) 2011; 37 AR Alsayed (pone.0292270.ref022) 2023; 13 RA Pauwels (pone.0292270.ref060) 2001; 163 M Dransfield (pone.0292270.ref066) 2022; 205 AA Zeki (pone.0292270.ref014) 2011; 2011 M. Lopes-Pacheco (pone.0292270.ref010) 2019; 10 M Milanese (pone.0292270.ref019) 2014; 108 D Stolz (pone.0292270.ref051) 2018; 96 MR Miller (pone.0292270.ref049) 2005; 26 PG Woodruff (pone.0292270.ref041) 2017; 196 M Skov (pone.0292270.ref024) 2019; 127 PB Murphy (pone.0292270.ref030) 2011; 66 A Agusti (pone.0292270.ref002) 2017; 50 E Diaz-Guzman (pone.0292270.ref016) 2011; 8 R de Marco (pone.0292270.ref018) 2013; 8 S Verbanck (pone.0292270.ref029) 1998; 157 B Mahut (pone.0292270.ref031) 2012; 7 R Kraemer (pone.0292270.ref034) 2005; 171 A Agusti (pone.0292270.ref001) 2016; 47 JM Leung (pone.0292270.ref006) 2019; 53 P Kauppi (pone.0292270.ref015) 2011; 48 M Topalovic (pone.0292270.ref026) 2015; 16 I Telias (pone.0292270.ref055) 2018; 44 FM Franssen (pone.0292270.ref004) 2019; 14 S Stanojevic (pone.0292270.ref062) 2017; 50 M Goldman (pone.0292270.ref050) 2005; 31 R Kraemer (pone.0292270.ref043) 2009; 10 W Windisch (pone.0292270.ref057) 2006; 150 A Agusti (pone.0292270.ref023) 2017; 390 M Topalovic (pone.0292270.ref067) 2019; 53 R Kraemer (pone.0292270.ref039) 2016; 17 R Kraemer (pone.0292270.ref032) 2021; 16 WA Whitelaw (pone.0292270.ref054) 1975; 23 |
| References_xml | – volume: 50 issue: 4 year: 2017 ident: pone.0292270.ref002 article-title: Precision medicine in airway diseases: moving to clinical practice publication-title: Eur Respir J doi: 10.1183/13993003.01655-2017 – volume: 16 start-page: 881 year: 2015 ident: pone.0292270.ref026 article-title: Airways resistance and specific conductance for the diagnosis of obstructive airways diseases publication-title: Respir Res doi: 10.1186/s12931-015-0252-0 – volume: 159 start-page: 179 issue: 1 year: 1999 ident: pone.0292270.ref053 article-title: Spirometric reference values from a sample of the general U.S. population publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.159.1.9712108 – volume: 37 start-page: 720 issue: 3 year: 2011 ident: pone.0292270.ref061 article-title: The need to change the method for defining mild airway obstruction publication-title: Eur Respir J doi: 10.1183/09031936.00135110 – volume: 135 start-page: 857 issue: 3 year: 2012 ident: pone.0292270.ref027 article-title: Small airways function in breast cancer patients before and after radiotherapy publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-012-2201-7 – volume: 17 start-page: 1541 issue: 1 year: 2016 ident: pone.0292270.ref039 article-title: Diagnostic accuracy of methacholine challenge tests assessing airway hyperreactivity in asthmatic patients—a multifunctional approach publication-title: Respir Res doi: 10.1186/s12931-016-0470-0 – volume: 96 start-page: 382 issue: 4 year: 2018 ident: pone.0292270.ref051 article-title: Diagnosis, Prevention and Treatment of Stable COPD and Acute Exacerbations of COPD: The Swiss Recommendations 2018 publication-title: Respiration doi: 10.1159/000490551 – year: 2023 ident: pone.0292270.ref012 article-title: Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.202301-0106PP – volume: 10 start-page: 1 year: 2019 ident: pone.0292270.ref010 article-title: CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine publication-title: Front Pharmacol – volume: 66 start-page: 602 issue: 7 year: 2011 ident: pone.0292270.ref030 article-title: Neural respiratory drive as a physiological biomarker to monitor change during acute exacerbations of COPD publication-title: Thorax doi: 10.1136/thx.2010.151332 – volume: 42 start-page: 645 issue: 3 year: 2022 ident: pone.0292270.ref021 article-title: Phenotypes of Asthma-Chronic Obstructive Pulmonary Disease Overlap publication-title: Immunol Allergy Clin North Am doi: 10.1016/j.iac.2022.04.009 – volume: 390 start-page: 980 issue: 10098 year: 2017 ident: pone.0292270.ref023 article-title: What does endotyping mean for treatment in chronic obstructive pulmonary disease? publication-title: Lancet doi: 10.1016/S0140-6736(17)32136-0 – volume: 69 start-page: 857 issue: 9 year: 2014 ident: pone.0292270.ref025 article-title: The path to personalised medicine in COPD publication-title: Thorax doi: 10.1136/thoraxjnl-2014-205507 – volume: 132 start-page: 589 issue: 4 year: 1998 ident: pone.0292270.ref044 article-title: The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel publication-title: J Pediatr doi: 10.1016/S0022-3476(98)70344-0 – volume: 6 start-page: 41 issue: Suppl 16 year: 1993 ident: pone.0292270.ref047 article-title: Standardization of the measurement of transfer factor (diffusing capacity) publication-title: Eur Respir J doi: 10.1183/09041950.041s1693 – volume: 2018 start-page: 7280747 year: 2018 ident: pone.0292270.ref063 article-title: Airway Inflammatory/Immune Responses in COPD and Cystic Fibrosis publication-title: Mediators Inflamm – volume: 27 issue: 147 year: 2018 ident: pone.0292270.ref003 article-title: Personalised pulmonary rehabilitation in COPD publication-title: Eur Respir Rev – volume: 127 start-page: 352 issue: 5 year: 2019 ident: pone.0292270.ref024 article-title: Cystic fibrosis—an example of personalized and precision medicine publication-title: APMIS doi: 10.1111/apm.12915 – volume: 7 start-page: 165 year: 2012 ident: pone.0292270.ref031 article-title: Relationships between respiratory and airway resistances and activity-related dyspnea in patients with chronic obstructive pulmonary disease publication-title: Int J Chron Obstruct Pulmon Dis – volume: 108 start-page: 1091 issue: 8 year: 2014 ident: pone.0292270.ref019 article-title: Asthma control in elderly asthmatics. An Italian observational study publication-title: Respir Med doi: 10.1016/j.rmed.2014.05.016 – volume: 150 start-page: 251 issue: 2–3 year: 2006 ident: pone.0292270.ref057 article-title: Nocturnal non-invasive positive pressure ventilation: physiological effects on spontaneous breathing publication-title: Respir Physiol Neurobiol doi: 10.1016/j.resp.2005.05.017 – volume: 8 start-page: 492 issue: 3 year: 1995 ident: pone.0292270.ref052 article-title: Reference values for residual volume, functional residual capacity and total lung capacity. ATS Workshop on Lung Volume Measurements. Official Statement of The European Respiratory Society publication-title: Eur Respir J doi: 10.1183/09031936.95.08030492 – ident: pone.0292270.ref036 – volume: 16 start-page: 3217 year: 2021 ident: pone.0292270.ref037 article-title: Focus on Early COPD: Definition and Early Lung Development publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S338359 – volume: 7 start-page: 138 year: 2006 ident: pone.0292270.ref042 article-title: Progression of pulmonary hyperinflation and trapped gas associated with genetic and environmental factors in children with cystic fibrosis publication-title: Respir Res doi: 10.1186/1465-9921-7-138 – volume: 2018 start-page: 6567578 year: 2018 ident: pone.0292270.ref065 article-title: Cigarette Smoke-Induced Acquired Dysfunction of Cystic Fibrosis Transmembrane Conductance Regulator in the Pathogenesis of Chronic Obstructive Pulmonary Disease publication-title: Oxid Med Cell Longev doi: 10.1155/2018/6567578 – volume: 26 start-page: 948 issue: 5 year: 2005 ident: pone.0292270.ref048 article-title: Interpretative strategies for lung function tests publication-title: Eur Respir J doi: 10.1183/09031936.05.00035205 – volume: 163 start-page: 1256 issue: 5 year: 2001 ident: pone.0292270.ref060 article-title: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.163.5.2101039 – volume: 2011 start-page: 861926 year: 2011 ident: pone.0292270.ref014 article-title: The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly publication-title: J Allergy (Cairo) – volume: 157 start-page: 1573 issue: 5 Pt 1 year: 1998 ident: pone.0292270.ref029 article-title: Conductive and acinar lung-zone contributions to ventilation inhomogeneity in COPD publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.157.5.9710042 – volume: 16 start-page: 3167 year: 2021 ident: pone.0292270.ref008 article-title: Treatable Traits in COPD—A Proposed Approach publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S330817 – volume: 66 start-page: 240 issue: 3 year: 2011 ident: pone.0292270.ref035 article-title: Neural respiratory drive, pulmonary mechanics and breathlessness in patients with cystic fibrosis publication-title: Thorax doi: 10.1136/thx.2010.142646 – volume: 205 start-page: 631 issue: 6 year: 2022 ident: pone.0292270.ref066 article-title: Cystic Fibrosis Transmembrane Conductance Regulator: Roles in Chronic Obstructive Pulmonary Disease publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.202109-2064TR – volume: 53 start-page: 18016601 issue: 4 year: 2019 ident: pone.0292270.ref067 article-title: Artificial intelligence outperforms pulmonologists in the interpretation of pulmonary function tests publication-title: Eur Respir J doi: 10.1183/13993003.01660-2018 – volume: 8 start-page: 400 issue: 6 year: 2011 ident: pone.0292270.ref016 article-title: Asthma, chronic obstructive pulmonary disease, and mortality in the U.S. population publication-title: Copd doi: 10.3109/15412555.2011.611200 – volume: 9 issue: 10 year: 2021 ident: pone.0292270.ref064 article-title: Dysfunction in the Cystic Fibrosis Transmembrane Regulator in Chronic Obstructive Pulmonary Disease as a Potential Target for Personalised Medicine publication-title: Biomedicines doi: 10.3390/biomedicines9101437 – volume: 54 issue: 2 year: 2019 ident: pone.0292270.ref005 article-title: Airway inflammation in COPD: progress to precision medicine publication-title: Eur Respir J doi: 10.1183/13993003.00651-2019 – volume: 31 start-page: 15 year: 2005 ident: pone.0292270.ref050 article-title: Lung function testing: Whole-body plethysmography publication-title: Eur Respir Mon – volume: 12 start-page: 667 issue: 6 year: 2013 ident: pone.0292270.ref059 article-title: Newborn screening for cystic fibrosis in Switzerland—consequences after analysis of a 4 months pilot study publication-title: J Cyst Fibros doi: 10.1016/j.jcf.2013.04.008 – volume: 204 start-page: 1251 issue: 11 year: 2021 ident: pone.0292270.ref038 article-title: An Updated Definition and Severity Classification of Chronic Obstructive Pulmonary Disease Exacerbations: The Rome Proposal publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.202108-1819PP – volume: 48 start-page: 279 issue: 3 year: 2011 ident: pone.0292270.ref015 article-title: Overlap syndrome of asthma and COPD predicts low quality of life publication-title: J Asthma doi: 10.3109/02770903.2011.555576 – volume: 196 start-page: 375 issue: 3 year: 2017 ident: pone.0292270.ref041 article-title: American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201705-0973WS – volume: 64 start-page: 728 issue: 8 year: 2009 ident: pone.0292270.ref013 article-title: The overlap syndrome of asthma and COPD: what are its features and how important is it? publication-title: Thorax doi: 10.1136/thx.2008.108027 – volume: 10 start-page: 106 year: 2009 ident: pone.0292270.ref043 article-title: Long-term gas exchange characteristics as markers of deterioration in patients with cystic fibrosis publication-title: Respir Res doi: 10.1186/1465-9921-10-106 – volume: 44 start-page: 1532 issue: 9 year: 2018 ident: pone.0292270.ref055 article-title: The airway occlusion pressure (P(0.1)) to monitor respiratory drive during mechanical ventilation: increasing awareness of a not-so-new problem publication-title: Intensive Care Med doi: 10.1007/s00134-018-5045-8 – volume: 17 start-page: 2723 year: 2022 ident: pone.0292270.ref033 article-title: Functional Predictors Discriminating Asthma-COPD Overlap (ACO) from Chronic Obstructive Pulmonary Disease (COPD) publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S382761 – volume: 23 start-page: 181 issue: 2 year: 1975 ident: pone.0292270.ref054 article-title: Occlusion pressure as a measure of respiratory center output in conscious man publication-title: Respir Physiol doi: 10.1016/0034-5687(75)90059-6 – volume: 8 start-page: e62985 issue: 5 year: 2013 ident: pone.0292270.ref018 article-title: The coexistence of asthma and chronic obstructive pulmonary disease (COPD): prevalence and risk factors in young, middle-aged and elderly people from the general population publication-title: PLoS One doi: 10.1371/journal.pone.0062985 – volume: 9 start-page: 1 issue: 17 year: 2021 ident: pone.0292270.ref058 article-title: Normative reference equations of airway dynamics assessed by whole-body plethysmography during spontaneous breathing evaluated in infants, children, and adults publication-title: Physiol Rep doi: 10.14814/phy2.15027 – volume: 6 start-page: 197 issue: 2 year: 2013 ident: pone.0292270.ref017 article-title: The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations publication-title: Expert Rev Clin Pharmacol doi: 10.1586/ecp.13.2 – volume: 159 start-page: 99 issue: 1–2 year: 2000 ident: pone.0292270.ref046 article-title: Buccal cell DNA analysis in premature and term neonates: screening for mutations of the complete coding region for the cystic fibrosis transmembrane conductance regulator publication-title: Eur J Pediatr doi: 10.1007/PL00013814 – volume: 78 start-page: 154 issue: 2 year: 2009 ident: pone.0292270.ref056 article-title: Preserving oxygenation during walking in severe chronic obstructive pulmonary disease: noninvasive ventilation versus oxygen therapy publication-title: Respiration doi: 10.1159/000187717 – volume: 53 issue: 4 year: 2019 ident: pone.0292270.ref006 article-title: Introduction to precision medicine in COPD publication-title: Eur Respir J doi: 10.1183/13993003.02460-2018 – volume: 47 start-page: 410 issue: 2 year: 2016 ident: pone.0292270.ref001 article-title: Treatable traits: toward precision medicine of chronic airway diseases publication-title: Eur Respir J doi: 10.1183/13993003.01359-2015 – volume: 18 start-page: 9 issue: 1 year: 2017 ident: pone.0292270.ref011 article-title: Non-linear parameters of specific resistance loops to characterise obstructive airways diseases publication-title: Respir Res doi: 10.1186/s12931-016-0484-7 – volume: 50 start-page: 1 issue: 3 year: 2017 ident: pone.0292270.ref062 article-title: Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians publication-title: Eur Respir J doi: 10.1183/13993003.00010-2017 – volume: 174 start-page: 853 issue: 8 year: 2006 ident: pone.0292270.ref028 article-title: Small airway function improvement after smoking cessation in smokers without airway obstruction publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200603-422OC – volume: 358 start-page: j3772 year: 2017 ident: pone.0292270.ref040 article-title: Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets publication-title: BMJ doi: 10.1136/bmj.j3772 – volume: 14 start-page: 1465 year: 2019 ident: pone.0292270.ref004 article-title: Personalized medicine for patients with COPD: where are we? publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S175706 – volume: 171 start-page: 371 issue: 4 year: 2005 ident: pone.0292270.ref034 article-title: Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200407-948OC – volume: 154 start-page: 1726 issue: 6 Pt 1 year: 1996 ident: pone.0292270.ref068 article-title: Relationship between chronic dyspnea and expiratory flow limitation in patients with chronic obstructive pulmonary disease publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.154.6.8970362 – volume: 13 issue: 4 year: 2023 ident: pone.0292270.ref022 article-title: Asthma-COPD Overlap in Clinical Practice (ACO_CP 2023): Toward Precision Medicine publication-title: J Pers Med doi: 10.3390/jpm13040677 – volume: 26 start-page: 319 issue: 2 year: 2005 ident: pone.0292270.ref049 article-title: Standardisation of spirometry publication-title: Eur Respir J doi: 10.1183/09031936.05.00034805 – volume: 15 start-page: 108 issue: 2 year: 2018 ident: pone.0292270.ref009 article-title: Current Approaches for Phenotyping as a Target for Precision Medicine in COPD Management publication-title: Copd doi: 10.1080/15412555.2018.1443064 – volume: 67 start-page: 172 issue: 2 year: 2018 ident: pone.0292270.ref020 article-title: Definition and diagnosis of asthma-COPD overlap (ACO) publication-title: Allergol Int doi: 10.1016/j.alit.2018.01.002 – volume: 16 start-page: 2487 year: 2021 ident: pone.0292270.ref032 article-title: Bronchodilator Response in Patients with COPD, Asthma-COPD-Overlap (ACO) and Asthma, Evaluated by Plethysmographic and Spirometric z-Score Target Parameters publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S319220 – volume: 7 start-page: 590 issue: 5 year: 1999 ident: pone.0292270.ref045 article-title: Two buffer PAGE system-based SSCP/HD analysis: a general protocol for rapid and sensitive mutation screening in cystic fibrosis and any other human genetic disease publication-title: Eur J Hum Genet doi: 10.1038/sj.ejhg.5200338 – volume: 250 start-page: 624 issue: 5 year: 2020 ident: pone.0292270.ref007 article-title: Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine publication-title: J Pathol doi: 10.1002/path.5364 |
| SSID | ssj0053866 |
| Score | 2.4506018 |
| Snippet | The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the... |
| SourceID | doaj unpaywall pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database |
| StartPage | e0292270 |
| SubjectTerms | Analysis Asthma Asthma - diagnosis Biology and Life Sciences Care and treatment Cystic Fibrosis Development and progression Diagnosis Forced Expiratory Volume Humans Lung Lung diseases, Obstructive Medicine and Health Sciences Phenotype Physical Sciences Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary function tests Research and Analysis Methods Spirometry Vital Capacity |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELfQXuAFMT4zBhiEBJOazkkcO3kshWogwRAMtDfL8QerVJJCWqH999wlbtXAA3vgMfFJke_Dd-fc_Y6Q51Jz5wTWVPFUx9zwNK6qjMeFFVow73QpsMH5_Qdx8oW_O8_Pd0Z9YU1YDw_cM-4YPJ5zOnECLJPLXGgjUi3T3IrOWXd95KwoN8lUfwYDrRChUS6TyXGQy3jZ1G7M0jJNcTjxjiPq8Pr_PpV33NKfJZPX1_VSX_7Si8WOP5rdIjdDIEkn_Qb2yTVX3yb7wVRb-jLgSR_dIT8mW_RN2niKnqy_AKQ2FGVAtkznNQ0Yqy3Fy1k6aVcX3_WITk8_vh6FpxgfKFZ9LvRyRHVt6fQSkZ7pDNLupp3Dh6ezo7vkbPbmbHoSh0kLsclLtopL53MhmePacIuHqCm9zDwzwEjLvbWlcFxoj_ENzsE1GFVqyUyWljZn2T2yVwNrHxAqEp9VPiuYKzJuMgkBh_XG-jyXlUs9i0i84bpa9ngaqvupJiEP6TmnUEoqSCkir1A0W1pEw-5egI6ooCPqXzoSkScoWNW3lm5tWk0knGeYgGYRedZRICJGjSU33_S6bdXb069XIPr8aUD0IhD5BjTF6NDmAHtCpK0B5eGAEuzaDJafbtRQ4RIWw9WuWbcK1ksItMscNna_V8stf_DCQSY8j0gxUNgBA4cr9fyigxVPWCEheEsiMt7q9pVkdPA_ZPSQ3EghXuzQAtgh2Vv9XLtHEO-tqsedaf8GzjRRuA priority: 102 providerName: Directory of Open Access Journals – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Pb9MwFLZGd4ALMH4GBhiEgElN5jiO3RxLoRpIbBNs0zggy3FsVlHSQlKhceBvxy9xq2UIaRy4NfVLWn-2nz_b731B6KlQzBgOMVWMqpBpRsM8T1g4KLjixBqVcUhwfrfLdw7Z2-P0eA19WubCeATdGnE6q5qTfPgwK822R3Ib9Ira09MoTkS8vCOaO6OI0IxSQZ41ikOwM1ZDAtIltM5TR9V7aP1wd3_4sT1ppiGnJPHpdH97Ume6alT9__TdZyav84GVlxflXJ3-UNPpmVlrfA39Wta3DVb5Ei3qPNI_z0lB_jdArqOrnu_iYfuUDbRmyhtow3uUCr_wstdbN9G34UokFM8shgm33afEhY8dcYt6PCmxl4KtMOwh42FVn3xVfTza23_V91chXGAITp2qeR-rssCjUxCkxuNJ7nCeuB8ejbduoYPx64PRTuhfCBHqNCN1mBmbckEMU5oV4Ot1ZkViiXZeu2C2KDJuGFcWaBi8rlcD-VWC6IRmRUqS26hXOlDuIsxjm-Q2GRAzSJhOhONFhdWFTVORG2pJgMJls8t5K_shm7M_4ZZLLXIS8JUe3wC9hL6xsgXR7uYL12DSN5R05M0YFRvu_i4TKVeaUyVoWvCGd4oAPYKeJdsM2JXrkUPh3C6sk5MAPWksQLijhMigz2pRVfLN3tEFjD687xg990Z25rqqVj4bw9UJ-lPHcrNj6dyP7hQ_Xo4DCUUQs1ea2aKSrjxz64EsdRW7046LFT6wLyJilgZo0BkxHQC7JeXkpFE_j8lAOI4ZByhaDa4LtdG9f73hPrpCHYVtBAzIJurV3xfmgaOgdf7QO5LflquKTw priority: 102 providerName: Unpaywall |
| Title | Assessment of functional diversities in patients with Asthma, COPD, Asthma-COPD overlap, and Cystic Fibrosis (CF) |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38377145 https://www.proquest.com/docview/2929540957 https://pubmed.ncbi.nlm.nih.gov/PMC10878531 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292270&type=printable https://doaj.org/article/741eea1e65384756ac62a725d6256007 |
| UnpaywallVersion | publishedVersion |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: HH5 dateStart: 20060101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20060101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20061001 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: ABDBF dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVEBS databaseName: EBSCOhost Food Science Source customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: A8Z dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=fsr providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DIK dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: GX1 dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: RPM dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Proquest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8FG dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1932-6203 dateEnd: 20250930 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M48 dateStart: 20061201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELfG9gAviPEZGMUgJEBqKidx7OYBoa6sDKR11dim8hS5ib1VKklpWkH_e-4SN1r4kPoSKfG1Ss539u_s8-8IeS0V11pgThX3lcsT7ruTScDdbiqUYEarSOAB55OhOL7gX8bheIdsarZaBRb_DO2wntTFYtb59WP9ARz-fVm1QXqbH3XmeaY7zI98X0IQvwdzVYTFHE54va8A3l3uXiJqcYXPAnuY7n__0pisSk7_v0fuG1PXn2mVt1fZXK1_qtnsxpw1uEfuWrBJe5V17JMdnd0n-9adC_rWck6_e0BmvZqhk-aG4mxXLRLS1CZuQERNpxm1PKwFxQVc2iuW199Vm_ZPRx_b9s7FG4qZoTM1b1OVpbS_RjZoOoDQPC-mxUNyPjg67x-7thCDm4QRW7qRNqGQTHOV8BTH2CQyMjAsAX2m3KRpJDQXyiD8wTK5CYJOJVkS-FEasuAR2c1Aq08IFZ4JJiboMt0NeBJIwCOpSVIThnKifcMc4m4UHs8ruo243HOTEKZUSouxg2LbQQ45xF6pZZEsu3yQL65i63sxgCatlacFvC6XoVCJ8JX0w1SUeE865AX2aVydPK1dPu5JGO4wPg0c8qqUQMKMDDNyrtSqKOLPp5dbCH09awi9sUImByNJlD0FAd-ERFwNyYOGJLh90mh-ubHAGJswVy7T-aqIoT0CHB6F8GGPK4us9YPrEdLjoUO6DVttKLDZkk2vS9Zxj3UlYDvPIZ3arLfqo6fbKO8ZueMDXCzJAtgB2V0uVvo5wL3lpEVuybGEa7fv4XXwqUX2Do-Go7NWuYDSKj0cnl0MR71vvwGv5Vop |
| linkProvider | Scholars Portal |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Pb9MwFLZGd4ALMH4GBhiEgElN5jiO3RxLoRpIbBNs0zggy3FsVlHSQlKhceBvxy9xq2UIaRy4NfVLWn-2nz_b731B6KlQzBgOMVWMqpBpRsM8T1g4KLjixBqVcUhwfrfLdw7Z2-P0eA19WubCeATdGnE6q5qTfPgwK822R3Ib9Ira09MoTkS8vCOaO6OI0IxSQZ41ikOwM1ZDAtIltM5TR9V7aP1wd3_4sT1ppiGnJPHpdH97Ume6alT9__TdZyav84GVlxflXJ3-UNPpmVlrfA39Wta3DVb5Ei3qPNI_z0lB_jdArqOrnu_iYfuUDbRmyhtow3uUCr_wstdbN9G34UokFM8shgm33afEhY8dcYt6PCmxl4KtMOwh42FVn3xVfTza23_V91chXGAITp2qeR-rssCjUxCkxuNJ7nCeuB8ejbduoYPx64PRTuhfCBHqNCN1mBmbckEMU5oV4Ot1ZkViiXZeu2C2KDJuGFcWaBi8rlcD-VWC6IRmRUqS26hXOlDuIsxjm-Q2GRAzSJhOhONFhdWFTVORG2pJgMJls8t5K_shm7M_4ZZLLXIS8JUe3wC9hL6xsgXR7uYL12DSN5R05M0YFRvu_i4TKVeaUyVoWvCGd4oAPYKeJdsM2JXrkUPh3C6sk5MAPWksQLijhMigz2pRVfLN3tEFjD687xg990Z25rqqVj4bw9UJ-lPHcrNj6dyP7hQ_Xo4DCUUQs1ea2aKSrjxz64EsdRW7046LFT6wLyJilgZo0BkxHQC7JeXkpFE_j8lAOI4ZByhaDa4LtdG9f73hPrpCHYVtBAzIJurV3xfmgaOgdf7QO5LflquKTw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Assessment+of+functional+diversities+in+patients+with+Asthma%2C+COPD%2C+Asthma-COPD+overlap%2C+and+Cystic+Fibrosis&rft.jtitle=PloS+one&rft.au=Kraemer%2C+Richard&rft.au=Baty%2C+Florent&rft.au=Smith%2C+Hans-J%C3%BCrgen&rft.au=Minder%2C+Stefan&rft.date=2024-02-20&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=19&rft.issue=2&rft.spage=e0292270&rft_id=info:doi/10.1371%2Fjournal.pone.0292270&rft.externalDBID=IOV&rft.externalDocID=A783292493 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |