Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes
This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransfe...
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| Published in | International journal of hypertension Vol. 2022; pp. 1 - 8 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Hindawi
07.07.2022
John Wiley & Sons, Inc Wiley |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2090-0384 2090-0392 2090-0392 |
| DOI | 10.1155/2022/2760027 |
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| Abstract | This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0–2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r = 0.241, P<0.001) and Suita score (r = 0.291, P<0.001). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively, P<0.001), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively, P<0.001). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β = 0.241, P=0.004; β = 2.994, P<0.001; β = 0.139, P=0.001; and β = 0.265, P<0.001, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes. |
|---|---|
| AbstractList | This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0–2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r = 0.241,
P
<
0.001
) and Suita score (r = 0.291,
P
<
0.001
). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively,
P
<
0.001
), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively,
P
<
0.001
). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β = 0.241,
P
=
0.004
; β = 2.994,
P
<
0.001
; β = 0.139,
P
=
0.001
; and β = 0.265,
P
<
0.001
, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes. This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0–2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r = 0.241, P<0.001) and Suita score (r = 0.291, P<0.001). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively, P<0.001), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively, P<0.001). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β = 0.241, P=0.004; β = 2.994, P<0.001; β = 0.139, P=0.001; and β = 0.265, P<0.001, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes. This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0-2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r=0.241, P<0.001) and Suita score (r=0.291, P<0.001). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70±0.74 and 1.24±0.69, respectively, P<0.001), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24±0.74, 1.56±0.66, and 1.79±0.71, respectively, P<0.001). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β =0.241, P=0.004; β =2.994, P<0.001; β =0.139, P=0.001; and β =0.265, P<0.001, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes. This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0-2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r = 0.241, P < 0.001) and Suita score (r = 0.291, P < 0.001). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively, P < 0.001), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively, P < 0.001). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β = 0.241, P=0.004; β = 2.994, P < 0.001; β = 0.139, P=0.001; and β = 0.265, P < 0.001, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes.This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0-2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r = 0.241, P < 0.001) and Suita score (r = 0.291, P < 0.001). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively, P < 0.001), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively, P < 0.001). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β = 0.241, P=0.004; β = 2.994, P < 0.001; β = 0.139, P=0.001; and β = 0.265, P < 0.001, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes. This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0–2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT ( r = 0.241, P < 0.001) and Suita score ( r = 0.291, P < 0.001). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively, P < 0.001), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively, P < 0.001). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade ( β = 0.241, P =0.004; β = 2.994, P < 0.001; β = 0.139, P =0.001; and β = 0.265, P < 0.001, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes. |
| Audience | Academic |
| Author | Kameda, Wataru Ojima, Midori Ishihara, Hisamitsu Takakubo, Noe Ishizawa, Kenichi Nagasawa, Akiko Saigusa, Taro Watanabe, Kentaro Yamana, Midori Susa, Shinji |
| AuthorAffiliation | 1 Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan 2 Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan |
| AuthorAffiliation_xml | – name: 1 Division of Diabetes and Metabolic Diseases, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan – name: 2 Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan |
| Author_xml | – sequence: 1 givenname: Kentaro orcidid: 0000-0003-0770-6172 surname: Watanabe fullname: Watanabe, Kentaro organization: Division of Diabetes and Metabolic DiseasesDepartment of Internal MedicineNihon University School of MedicineTokyoJapannihon-u.ac.jp – sequence: 2 givenname: Noe surname: Takakubo fullname: Takakubo, Noe organization: Department of Neurology, Hematology, Metabolism, Endocrinology and DiabetologyYamagata University Faculty of MedicineYamagataJapanyamagata-u.ac.jp – sequence: 3 givenname: Taro surname: Saigusa fullname: Saigusa, Taro organization: Division of Diabetes and Metabolic DiseasesDepartment of Internal MedicineNihon University School of MedicineTokyoJapannihon-u.ac.jp – sequence: 4 givenname: Akiko surname: Nagasawa fullname: Nagasawa, Akiko organization: Division of Diabetes and Metabolic DiseasesDepartment of Internal MedicineNihon University School of MedicineTokyoJapannihon-u.ac.jp – sequence: 5 givenname: Midori surname: Yamana fullname: Yamana, Midori organization: Division of Diabetes and Metabolic DiseasesDepartment of Internal MedicineNihon University School of MedicineTokyoJapannihon-u.ac.jp – sequence: 6 givenname: Midori surname: Ojima fullname: Ojima, Midori organization: Division of Diabetes and Metabolic DiseasesDepartment of Internal MedicineNihon University School of MedicineTokyoJapannihon-u.ac.jp – sequence: 7 givenname: Wataru surname: Kameda fullname: Kameda, Wataru organization: Department of Neurology, Hematology, Metabolism, Endocrinology and DiabetologyYamagata University Faculty of MedicineYamagataJapanyamagata-u.ac.jp – sequence: 8 givenname: Shinji surname: Susa fullname: Susa, Shinji organization: Department of Neurology, Hematology, Metabolism, Endocrinology and DiabetologyYamagata University Faculty of MedicineYamagataJapanyamagata-u.ac.jp – sequence: 9 givenname: Kenichi orcidid: 0000-0003-4911-8889 surname: Ishizawa fullname: Ishizawa, Kenichi organization: Department of Neurology, Hematology, Metabolism, Endocrinology and DiabetologyYamagata University Faculty of MedicineYamagataJapanyamagata-u.ac.jp – sequence: 10 givenname: Hisamitsu orcidid: 0000-0001-8922-6660 surname: Ishihara fullname: Ishihara, Hisamitsu organization: Division of Diabetes and Metabolic DiseasesDepartment of Internal MedicineNihon University School of MedicineTokyoJapannihon-u.ac.jp |
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| CitedBy_id | crossref_primary_10_7143_jhep_50_595 crossref_primary_10_3390_jcm12185987 crossref_primary_10_1016_j_cjco_2025_01_005 crossref_primary_10_1210_clinem_dgae619 |
| Cites_doi | 10.2152/jmi.61.180 10.1016/j.atherosclerosis.2009.11.012 10.1016/j.cgh.2009.05.033 10.1002/hep.30223 10.1016/s0021-9150(03)00198-9 10.1210/jc.2007-2000 10.1272/jnms.80.410 10.1016/j.jhep.2012.11.014 10.1159/000103114 10.1016/j.atherosclerosis.2015.02.011 10.1111/apt.13405 10.1056/nejm199807233390404 10.1002/hep.23314 10.1038/s41440-019-0284-9 10.1111/j.1447-0594.2006.00329.x 10.1053/jhep.2003.50161 10.1016/j.bbrc.2006.09.039 10.1161/strokeaha.106.479642 10.2214/ajr.04.1216 10.1007/s00535-013-0911-1 10.1210/en.2011-2043 10.1053/j.ajkd.2008.12.034 10.1007/s00125-004-1334-6 10.1016/j.jhep.2016.05.013 10.1136/pgmj.2006.048371 10.1161/01.cir.34.4.553 10.1186/1471-230x-12-2 10.1186/s12944-015-0038-x 10.1111/j.1478-3231.2010.02375.x 10.1002/hep.27368 10.1016/j.gtc.2016.07.003 10.1038/s41467-017-02325-2 10.1042/cs20200446 10.1186/s13098-017-0231-3 10.1016/s0168-8227(03)00144-x 10.1097/mcg.0000000000001339 10.5551/jat.19356 10.3390/diagnostics11010098 10.2337/diabetes.54.12.3541 10.1053/jhep.2003.50316 10.1371/journal.pone.0174717 10.1002/hep.21327 10.1007/s00380-021-01948-2 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 Kentaro Watanabe et al. COPYRIGHT 2022 John Wiley & Sons, Inc. Copyright © 2022 Kentaro Watanabe et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2022 Kentaro Watanabe et al. 2022 |
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| Snippet | This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes.... |
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| SubjectTerms | Age Aspartate Atherosclerosis Biopsy Blood pressure Calcification Cardiovascular disease Carotid arteries Coronary heart disease Creatinine Cross-sectional studies Diabetes Ethics Fibrosis Hematology Hepatitis High density lipoprotein Hypertension Liver Medical research Medicine Medicine, Experimental Metabolism Mortality Regression analysis Reproducibility Risk factors Type 2 diabetes Ultrasonic imaging University faculty Uric acid Variables |
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| Title | Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes |
| URI | https://dx.doi.org/10.1155/2022/2760027 https://www.proquest.com/docview/2725126220 https://www.proquest.com/docview/2724585590 https://pubmed.ncbi.nlm.nih.gov/PMC9550504 https://doaj.org/article/031af71d859a42d48dfbbb8e8fae3a49 |
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