Orienting Fate: Spatial Regulation of Neurogenic Divisions

Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex has been sparse. A new study by Postiglione et al. in this issue of Neuron shows that mouse Inscuteable-mediated control of cleavage plane orientation regulates the ou...

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Published inNeuron (Cambridge, Mass.) Vol. 72; no. 2; pp. 191 - 193
Main Authors Wang, Xiaoqun, Lui, Jan H., Kriegstein, Arnold R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.10.2011
Elsevier Limited
Subjects
Animals
Cell cycle
Cell Cycle Proteins - metabolism
Cell division
Cell Lineage - physiology
Cell Polarity - physiology
Evolution
Insects
Neocortex - growth & development
Nervous system
Neurogenesis
Neurogenesis - physiology
Neurons
Neurons - metabolism
Rodents
Spindle Apparatus - metabolism
Stem cells
Studies
Symmetry
Online AccessGet full text
ISSN0896-6273
1097-4199
1097-4199
DOI10.1016/j.neuron.2011.10.003

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Summary:Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex has been sparse. A new study by Postiglione et al. in this issue of Neuron shows that mouse Inscuteable-mediated control of cleavage plane orientation regulates the output of neural progenitor cells.
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ISSN:0896-6273
1097-4199
1097-4199
DOI:10.1016/j.neuron.2011.10.003