Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish...

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Published inScientific reports Vol. 11; no. 1; pp. 2366 - 9
Main Authors Lee, Juncheol, Kim, Bongyoung, Kim, Wonhee, Ahn, Chiwon, Choi, Hyun Young, Kim, Jae Guk, Kim, Jihoon, Shin, Hyungoo, Kang, Jun Goo, Moon, Shinje
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 27.01.2021
Nature Publishing Group
Nature Portfolio
Subjects
692/163
692/163/2743
692/308/174
Adipose tissue
Adult
Biomarkers - blood
Blood Glucose - metabolism
Body mass index
Endocrine System Diseases - epidemiology
Female
Homeostasis
Humanities and Social Sciences
Humans
Insulin
Insulin Resistance
Laboratory tests
Lipids
Lipids - blood
Male
Metabolic Diseases - epidemiology
Middle Aged
multidisciplinary
Population studies
Population Surveillance
Risk assessment
ROC Curve
Science
Science (multidisciplinary)
Triglycerides
United States - epidemiology
Young Adult
United States
United States > US
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-021-82053-2

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Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.
AbstractList This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.
This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999-2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999-2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.
Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.
ArticleNumber 2366
Author Kim, Jae Guk
Kim, Bongyoung
Ahn, Chiwon
Kim, Jihoon
Shin, Hyungoo
Kim, Wonhee
Choi, Hyun Young
Lee, Juncheol
Kang, Jun Goo
Moon, Shinje
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  organization: Department of Emergency Medicine, Hallym University
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  organization: Department of Emergency Medicine, College of Medicine, Chung-Ang University
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  surname: Moon
  fullname: Moon, Shinje
  email: sinjei1129@gmail.com
  organization: Department of Internal Medicine, Hallym University, Division of Endocrinology and Metabolism, Hallym University College of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33504930$$D View this record in MEDLINE/PubMed
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Snippet This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides...
Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP),...
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SubjectTerms 692/163
692/163/2743
692/308/174
Adipose tissue
Adult
Biomarkers - blood
Blood Glucose - metabolism
Body mass index
Endocrine System Diseases - epidemiology
Female
Homeostasis
Humanities and Social Sciences
Humans
Insulin
Insulin Resistance
Laboratory tests
Lipids
Lipids - blood
Male
Metabolic Diseases - epidemiology
Middle Aged
multidisciplinary
Population studies
Population Surveillance
Risk assessment
ROC Curve
Science
Science (multidisciplinary)
Triglycerides
United States - epidemiology
Young Adult
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Title Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
URI https://link.springer.com/article/10.1038/s41598-021-82053-2
https://www.ncbi.nlm.nih.gov/pubmed/33504930
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https://www.proquest.com/docview/2482657893
https://pubmed.ncbi.nlm.nih.gov/PMC7840900
https://doaj.org/article/e93c1e25fd2a4e9bbd371bb541cf9e0d
Volume 11
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