Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient - Alvarez, Jean-Claude; Moine, Pierre; Etting, Isabelle; Annane, Djillali; Larabi, Islam Amine (Clinical chemistry and laboratory medicine, 2020)
Keywords: Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - blood; Adenosine Monophosphate - pharmacokinetics; Alanine - analogs & derivatives; Alanine - blood; Alanine - pharmacokinetics; Antiviral Agents - blood; Antiviral Agents - pharmacokinetics; Antiviral drugs; Betacoronavirus; Calibration; Chromatography; Chromatography, Liquid - methods; Coronavirus Infections - blood; Coronaviruses; COVID-19; Drug Monitoring - methods; Drug Stability; Female; Furans - blood; Furans - pharmacokinetics; GS-441524; Half-life; Humans; Ionization; Ions; LC–MS/MS; Life Sciences; Limit of Detection; Liquid chromatography; LITAF protein; Male; Mass spectrometry; Mass spectroscopy; Metabolites; Middle Aged; Pandemics; Pneumonia, Viral - blood; Pyrroles - blood; Pyrroles - pharmacokinetics; Quadrupoles; remdesivir; Reproducibility of Results; SARS-CoV-2; Scientific imaging; Spectroscopy; Tandem Mass Spectrometry - methods; Triazines - blood; Triazines - pharmacokinetics; Zinc sulfate; GS-441524; Covid-19; remdesivir; LC–MS/MS