Clinical study of Jianpi Qingchang decoction in the treatment of ulcerative colitis patients with spleen deficiency and dampness-heat syndrome accompanied by fatigue: Study protocol for a randomized controlled trial
Ulcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in Traditional Chinese Medicine (TCM). Jianpi Qingchang decoction (JPQC) is a combination formula specifically designed for the treatment of U...
Saved in:
| Published in | Contemporary clinical trials communications Vol. 42; p. 101409 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.12.2024
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2451-8654 2451-8654 |
| DOI | 10.1016/j.conctc.2024.101409 |
Cover
| Abstract | Ulcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in Traditional Chinese Medicine (TCM). Jianpi Qingchang decoction (JPQC) is a combination formula specifically designed for the treatment of UC. The primary objective of this study is to examine the clinical efficacy of JPQC in individuals diagnosed with UC who exhibit both spleen deficiency and dampness-heat syndrome, along with the presence of fatigue. The investigation will focus on assessing the impact of JPQC on the gut microbiota and metabolites in these patients, aiming to elucidate the regulatory mechanism that JPQC exerts on the gut microbiota and metabolites in the context of UC-related fatigue.
In this randomized clinical trial, 140 subjects diagnosed with UC will be recruited and randomized into two groups. They will receive either JPQC combined with mesalazine or mesalazine alone for 12 weeks. Follow-up visits will be conducted every four weeks, with a post-treatment visit scheduled at 6 months. The primary outcome measures include the Inflammatory bowel disease fatigue scale(IBD-F). Secondary efficacy indicators comprise the assessment of TCM syndrome and individual syndrome efficacy before and after treatment, Modified Mayo score, Simple clinical colitis activity index (SCCAI), as well as the Inflammatory Bowel Disease Questionnaire (IBDQ) for each group. The other outcomes are the Intestinal microbial diversity and non-targeted metabonomics, which will be measured at baseline and 12 weeks after randomization.
If effective, JPQC will provide substantial clinical evidence concerning the effectiveness and safety in the treatment of patients with UC experiencing spleen deficiency and dampness-heat syndrome accompanied by fatigue.
ChiCTR2300068348. |
|---|---|
| AbstractList | Ulcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in Traditional Chinese Medicine (TCM). Jianpi Qingchang decoction (JPQC) is a combination formula specifically designed for the treatment of UC. The primary objective of this study is to examine the clinical efficacy of JPQC in individuals diagnosed with UC who exhibit both spleen deficiency and dampness-heat syndrome, along with the presence of fatigue. The investigation will focus on assessing the impact of JPQC on the gut microbiota and metabolites in these patients, aiming to elucidate the regulatory mechanism that JPQC exerts on the gut microbiota and metabolites in the context of UC-related fatigue.
In this randomized clinical trial, 140 subjects diagnosed with UC will be recruited and randomized into two groups. They will receive either JPQC combined with mesalazine or mesalazine alone for 12 weeks. Follow-up visits will be conducted every four weeks, with a post-treatment visit scheduled at 6 months. The primary outcome measures include the Inflammatory bowel disease fatigue scale(IBD-F). Secondary efficacy indicators comprise the assessment of TCM syndrome and individual syndrome efficacy before and after treatment, Modified Mayo score, Simple clinical colitis activity index (SCCAI), as well as the Inflammatory Bowel Disease Questionnaire (IBDQ) for each group. The other outcomes are the Intestinal microbial diversity and non-targeted metabonomics, which will be measured at baseline and 12 weeks after randomization.
If effective, JPQC will provide substantial clinical evidence concerning the effectiveness and safety in the treatment of patients with UC experiencing spleen deficiency and dampness-heat syndrome accompanied by fatigue.
ChiCTR2300068348. Background: Ulcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under ''dysentery'' and ''intestinal bleeding'' in Traditional Chinese Medicine (TCM). Jianpi Qingchang decoction (JPQC) is a combination formula specifically designed for the treatment of UC. The primary objective of this study is to examine the clinical efficacy of JPQC in individuals diagnosed with UC who exhibit both spleen deficiency and dampness-heat syndrome, along with the presence of fatigue. The investigation will focus on assessing the impact of JPQC on the gut microbiota and metabolites in these patients, aiming to elucidate the regulatory mechanism that JPQC exerts on the gut microbiota and metabolites in the context of UC-related fatigue. Methods: In this randomized clinical trial, 140 subjects diagnosed with UC will be recruited and randomized into two groups. They will receive either JPQC combined with mesalazine or mesalazine alone for 12 weeks. Follow-up visits will be conducted every four weeks, with a post-treatment visit scheduled at 6 months. The primary outcome measures include the Inflammatory bowel disease fatigue scale(IBD-F). Secondary efficacy indicators comprise the assessment of TCM syndrome and individual syndrome efficacy before and after treatment, Modified Mayo score, Simple clinical colitis activity index (SCCAI), as well as the Inflammatory Bowel Disease Questionnaire (IBDQ) for each group. The other outcomes are the Intestinal microbial diversity and non-targeted metabonomics, which will be measured at baseline and 12 weeks after randomization. Discussion: If effective, JPQC will provide substantial clinical evidence concerning the effectiveness and safety in the treatment of patients with UC experiencing spleen deficiency and dampness-heat syndrome accompanied by fatigue. Trial registration: ChiCTR2300068348. Ulcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in Traditional Chinese Medicine (TCM). Jianpi Qingchang decoction (JPQC) is a combination formula specifically designed for the treatment of UC. The primary objective of this study is to examine the clinical efficacy of JPQC in individuals diagnosed with UC who exhibit both spleen deficiency and dampness-heat syndrome, along with the presence of fatigue. The investigation will focus on assessing the impact of JPQC on the gut microbiota and metabolites in these patients, aiming to elucidate the regulatory mechanism that JPQC exerts on the gut microbiota and metabolites in the context of UC-related fatigue.BackgroundUlcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in Traditional Chinese Medicine (TCM). Jianpi Qingchang decoction (JPQC) is a combination formula specifically designed for the treatment of UC. The primary objective of this study is to examine the clinical efficacy of JPQC in individuals diagnosed with UC who exhibit both spleen deficiency and dampness-heat syndrome, along with the presence of fatigue. The investigation will focus on assessing the impact of JPQC on the gut microbiota and metabolites in these patients, aiming to elucidate the regulatory mechanism that JPQC exerts on the gut microbiota and metabolites in the context of UC-related fatigue.In this randomized clinical trial, 140 subjects diagnosed with UC will be recruited and randomized into two groups. They will receive either JPQC combined with mesalazine or mesalazine alone for 12 weeks. Follow-up visits will be conducted every four weeks, with a post-treatment visit scheduled at 6 months. The primary outcome measures include the Inflammatory bowel disease fatigue scale(IBD-F). Secondary efficacy indicators comprise the assessment of TCM syndrome and individual syndrome efficacy before and after treatment, Modified Mayo score, Simple clinical colitis activity index (SCCAI), as well as the Inflammatory Bowel Disease Questionnaire (IBDQ) for each group. The other outcomes are the Intestinal microbial diversity and non-targeted metabonomics, which will be measured at baseline and 12 weeks after randomization.MethodsIn this randomized clinical trial, 140 subjects diagnosed with UC will be recruited and randomized into two groups. They will receive either JPQC combined with mesalazine or mesalazine alone for 12 weeks. Follow-up visits will be conducted every four weeks, with a post-treatment visit scheduled at 6 months. The primary outcome measures include the Inflammatory bowel disease fatigue scale(IBD-F). Secondary efficacy indicators comprise the assessment of TCM syndrome and individual syndrome efficacy before and after treatment, Modified Mayo score, Simple clinical colitis activity index (SCCAI), as well as the Inflammatory Bowel Disease Questionnaire (IBDQ) for each group. The other outcomes are the Intestinal microbial diversity and non-targeted metabonomics, which will be measured at baseline and 12 weeks after randomization.If effective, JPQC will provide substantial clinical evidence concerning the effectiveness and safety in the treatment of patients with UC experiencing spleen deficiency and dampness-heat syndrome accompanied by fatigue.DiscussionIf effective, JPQC will provide substantial clinical evidence concerning the effectiveness and safety in the treatment of patients with UC experiencing spleen deficiency and dampness-heat syndrome accompanied by fatigue.ChiCTR2300068348.Trial registrationChiCTR2300068348. AbstractBackgroundUlcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in Traditional Chinese Medicine (TCM). Jianpi Qingchang decoction (JPQC) is a combination formula specifically designed for the treatment of UC. The primary objective of this study is to examine the clinical efficacy of JPQC in individuals diagnosed with UC who exhibit both spleen deficiency and dampness-heat syndrome, along with the presence of fatigue. The investigation will focus on assessing the impact of JPQC on the gut microbiota and metabolites in these patients, aiming to elucidate the regulatory mechanism that JPQC exerts on the gut microbiota and metabolites in the context of UC-related fatigue. MethodsIn this randomized clinical trial, 140 subjects diagnosed with UC will be recruited and randomized into two groups. They will receive either JPQC combined with mesalazine or mesalazine alone for 12 weeks. Follow-up visits will be conducted every four weeks, with a post-treatment visit scheduled at 6 months. The primary outcome measures include the Inflammatory bowel disease fatigue scale(IBD-F). Secondary efficacy indicators comprise the assessment of TCM syndrome and individual syndrome efficacy before and after treatment, Modified Mayo score, Simple clinical colitis activity index (SCCAI), as well as the Inflammatory Bowel Disease Questionnaire (IBDQ) for each group. The other outcomes are the Intestinal microbial diversity and non-targeted metabonomics, which will be measured at baseline and 12 weeks after randomization. DiscussionIf effective, JPQC will provide substantial clinical evidence concerning the effectiveness and safety in the treatment of patients with UC experiencing spleen deficiency and dampness-heat syndrome accompanied by fatigue. Trial registrationChiCTR2300068348. |
| ArticleNumber | 101409 |
| Author | Zhang, Ya-Li Zheng, Lie Liu, Xiao-Yan Liu, Zi-Xuan Zhang, Wei-Bing Tan, Wei-wei Dai, Yan-Cheng |
| Author_xml | – sequence: 1 givenname: Zi-Xuan orcidid: 0009-0007-1980-5422 surname: Liu fullname: Liu, Zi-Xuan organization: Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China – sequence: 2 givenname: Xiao-Yan orcidid: 0000-0002-6605-7208 surname: Liu fullname: Liu, Xiao-Yan organization: Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China – sequence: 3 givenname: Wei-wei surname: Tan fullname: Tan, Wei-wei organization: Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China – sequence: 4 givenname: Wei-Bing surname: Zhang fullname: Zhang, Wei-Bing organization: Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China – sequence: 5 givenname: Ya-Li surname: Zhang fullname: Zhang, Ya-Li organization: Institute of Digestive Diseases, Long Hua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China – sequence: 6 givenname: Lie surname: Zheng fullname: Zheng, Lie email: liezhenglie@163.com organization: Department of Gastroenterology, Traditional Chinese Medicine Hospital of Shanxi Province, Xi'an, 710003, China – sequence: 7 givenname: Yan-Cheng surname: Dai fullname: Dai, Yan-Cheng email: daiyancheng2005@126.com organization: Department of Gastroenterology, Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200082, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39735170$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVk81u1DAQxyNUREvpGyDkI5ctcRwnWYRAqOKjqBJCBYmb5Ywnu14cO9hOq_CivA5OU6r2gICT7fHM72_Px8NszzqLWfaY5sc0p9Wz3TE4CxGOi7woZ1OZr-9lB0XJ6aqpeLl3a7-fHYWwy_MUx2pa8AfZPlvXjNM6P8h-nhhtNUhDQhzVRFxHPmhpB00-abuBrbQbohAcRO0s0ZbELZLoUcYebZzdRwPoZdQXSMAZHXUgQzqm20AuddySMBhEmyidhmSGiUiriJL9YDGE1TaxSJis8q5HIgFcP0irUZF2Il0ibUZ8Ts6vXjd4F11SIZ3zRBKfQK7XP5JvSkf0zpi0jV5L8yi730kT8Oh6Pcy-vH3z-eT96uzju9OT12cr4E0dV7JsOWtZ29QN6xpV5hWvm7LraAmKNS2i4h3Ly4Ir2chqzRm2RUcryiRtqo4DO8xOF65ycicGr3vpJ-GkFlcG5zdC-qjBoOC8lg0HCsBkqap1y4DDGlhXV6osc5lYfGGNdpDTpTTmBkhzMddd7MRSdzHXXSx1T3GvlrhhbHtUkFLvpbnzmLs3Vm_Fxl0ISquGNjVPhKfXBO--jxii6HUANEZadGMQjPKcsqouZrEnt8VuVH63VHIoFwfwLgSP3b9-4uUShqlaFxq9CFfdgkp7hJjSqf8XANet_Q0nDDs3eps6QVARCpGL83k-5vEoyjQZvPqaAC_-DPi7_i8JIyfB |
| Cites_doi | 10.1016/S0140-6736(23)00966-2 10.1038/s41575-018-0091-9 10.1111/apt.16145 10.1080/00365521.2021.1983640 10.1053/j.gastro.2021.08.060 10.1007/s12325-022-02364-2 10.1007/s11655-015-2118-1 10.1007/s40265-023-01888-3 10.1097/MIB.0000000000000314 10.1111/apt.16465 10.1097/MOG.0000000000000644 10.1016/j.clnesp.2017.10.004 10.1093/ibd/izad016 10.1093/ibd/izaa201 10.3390/foods10051030 10.1016/0016-5085(89)90905-0 10.1053/j.gastro.2022.08.050 10.1016/j.revmed.2023.05.007 10.1080/10408398.2021.1983768 10.3390/molecules27217377 10.1097/MD.0000000000006651 10.1186/s12916-022-02550-7 10.1053/j.gastro.2006.12.038 10.1136/gut.43.1.29 10.1016/j.cgh.2021.06.034 10.1186/s12876-022-02357-z |
| ContentType | Journal Article |
| Copyright | 2024 The Authors The Authors 2024 The Authors. Published by Elsevier Inc. 2024 The Authors. Published by Elsevier Inc. 2024 |
| Copyright_xml | – notice: 2024 The Authors – notice: The Authors – notice: 2024 The Authors. Published by Elsevier Inc. – notice: 2024 The Authors. Published by Elsevier Inc. 2024 |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1016/j.conctc.2024.101409 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2451-8654 |
| EndPage | 101409 |
| ExternalDocumentID | oai_doaj_org_article_557a85c1cc3a4d69b3c5c9c3f76d440a 10.1016/j.conctc.2024.101409 PMC11681875 39735170 10_1016_j_conctc_2024_101409 S245186542400156X 1_s2_0_S245186542400156X |
| Genre | Journal Article |
| GroupedDBID | .1- .FO 0R~ 1P~ 457 53G AAEDW AALRI AAXUO AAYWO ABMAC ACGFS ACVFH ADBBV ADCNI ADEZE ADVLN AEUPX AEVXI AEXQZ AFJKZ AFPUW AFRHN AFTJW AGHFR AIGII AITUG AJUYK AKBMS AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BCNDV EBS EJD FDB GROUPED_DOAJ HYE KQ8 M~E O9- OK1 ROL RPM SSZ Z5R 0SF 6I. AACTN AAFTH NCXOZ AAYXX CITATION NPM 7X8 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c587t-a4b53b3b8783f8d4065784ff14cd38beed5f30425da8a6953eb2f1613a186f5c3 |
| IEDL.DBID | DOA |
| ISSN | 2451-8654 |
| IngestDate | Wed Aug 27 01:31:09 EDT 2025 Tue Aug 19 09:00:38 EDT 2025 Tue Sep 30 17:06:41 EDT 2025 Fri Jul 11 16:02:49 EDT 2025 Sun Jan 05 01:57:19 EST 2025 Wed Oct 01 01:13:24 EDT 2025 Sat Jan 04 15:44:07 EST 2025 Tue Feb 25 19:58:24 EST 2025 Tue Aug 26 16:32:57 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Fatigue Spleen deficiency and dampness-heat syndrome Randomized controlled trial Ulcerative colitis Jianpi Qingchang decoction |
| Language | English |
| License | This is an open access article under the CC BY license. 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). cc-by-nc-nd |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c587t-a4b53b3b8783f8d4065784ff14cd38beed5f30425da8a6953eb2f1613a186f5c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work and share first authorship. |
| ORCID | 0009-0007-1980-5422 0000-0002-6605-7208 |
| OpenAccessLink | https://doaj.org/article/557a85c1cc3a4d69b3c5c9c3f76d440a |
| PMID | 39735170 |
| PQID | 3150136729 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_557a85c1cc3a4d69b3c5c9c3f76d440a unpaywall_primary_10_1016_j_conctc_2024_101409 pubmedcentral_primary_oai_pubmedcentral_nih_gov_11681875 proquest_miscellaneous_3150136729 pubmed_primary_39735170 crossref_primary_10_1016_j_conctc_2024_101409 elsevier_sciencedirect_doi_10_1016_j_conctc_2024_101409 elsevier_clinicalkeyesjournals_1_s2_0_S245186542400156X elsevier_clinicalkey_doi_10_1016_j_conctc_2024_101409 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2024-12-01 |
| PublicationDateYYYYMMDD | 2024-12-01 |
| PublicationDate_xml | – month: 12 year: 2024 text: 2024-12-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Contemporary clinical trials communications |
| PublicationTitleAlternate | Contemp Clin Trials Commun |
| PublicationYear | 2024 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Li, Sun, Wang, Yang, Sun, Qu, Wang, Yang (bib36) 2022; 42 Varbobitis, Kokkotis, Gizis, Perlepe, Laoudi, Bletsa, Bekiari, Koutsounas, Kounadis, Xourafas, Lagou, Kolios, Papakonstantinou, Bamias (bib19) 2021; 27 Li, Li, Xu, Liu, Pang, Liao, Li, Shi (bib26) 2023; 63 Yamashita (bib27) 2020; 13 Qazi (bib25) 2020; 36 Lu, Liu, Wang, Wang (bib35) 2021; 10 Xie, Jiang, Wli, Liu, Chen, Huang, Huang (bib17) 2020; 32 Tang (bib37) 2021 Gasche, Ahmad, Tulassay, Baumgart, Bokemeyer, Buning, Howaldt, Stallmach (bib34) 2015; 21 Chen, Zhang, Zhang, Chen, Tang, Qiao, Dai, Tang (bib12) 2022; 2022 Shen, Tang, Tang, Zhang, Liu, Ye, Wen, Wang, Lu (bib16) 2019; 34 Danese, Tran, D'Haens, Rubin, Aoyama, Zhou, Ilo, Yao, Sanchez Gonzalez, Panaccione (bib31) 2023; 29 Dai, Zheng, Zhang, Chen, Chen, Tang (bib13) 2017; 96 D'Haens, Sandborn, Feagan, Geboes, Hanauer, Irvine, Lemann, Marteau, Rutgeerts, Scholmerich, Sutherland (bib15) 2007; 132 Keefer, Bedell, Norton, Hart (bib4) 2022; 162 Gramont, Goutte, Feasson, Millet, Hupin, Cathebras (bib3) 2023; 44 Xu, Hu, Yang, Ji, Cheng, Zhu, Shen (bib6) 2022; 22 Skjellerudsveen, Skoie, Dalen, Grimstad, Omdal (bib30) 2023; 83 Mcging, Radford, Francis, Serres, Greenhaff, Moran (bib5) 2021; 54 Regueiro, Hunter, Lukanova, Shan, Wild, Knight, Bannikoppa, Naegeli (bib7) 2023; 40 Dai, Zhang, Wang, Guo, Yang, Ye, Tang (bib11) 2016; 22 Zhang, Sheng, Zheng, Ye (bib9) 2017; 32 Walmsley, Ayres, Pounder, Allan (bib22) 1998; 43 Luo, Wei, Song, Xu, Huang, Fan, Zhang, Han, Lin (bib28) 2022; 27 Scholten, Vermeulen, Dhonukshe-Rutten, Verhagen, Visscher, Olivier, Timmer, Witteman (bib33) 2018; 23 Hua, Lin, Li, Dai (bib18) 2022; 17 Le Berre, Honap, Peyrin-Biroulet (bib1) 2023; 402 Shi (bib10) 2022 Guyatt, Mitchell, Irvine, Singer, Williams, Goodacre, Tompkins (bib20) 1989; 96 Thomann, Wustenberg, Wirbel, Knoedler, Thomann, Zeller, Ebert, Lis, Reindl (bib29) 2022; 20 Bager, Hvas, Rud, Dahlerup (bib32) 2022; 57 Zhang, Dai, Dai (bib21) 2011; 19 D Silva, Fox, Nasser, Vallance, Quinn, Ronksley, Raman (bib23) 2022; 20 Pekow (bib2) 2022; 163 Schreiner, Rossel, Biedermann, Valko, Baumann, Greuter, Scharl, Vavricka, Pittet, Juillerat, Rogler, von Känel, Misselwitz (bib24) 2021; 53 Borren, van der Woude, Ananthakrishnan (bib8) 2019; 16 Zhang, Dai, Dai, Chen, Chen, Tang (bib14) 2018; 26 Varbobitis (10.1016/j.conctc.2024.101409_bib19) 2021; 27 Zhang (10.1016/j.conctc.2024.101409_bib21) 2011; 19 Xu (10.1016/j.conctc.2024.101409_bib6) 2022; 22 Dai (10.1016/j.conctc.2024.101409_bib11) 2016; 22 Shi (10.1016/j.conctc.2024.101409_bib10) 2022 Gramont (10.1016/j.conctc.2024.101409_bib3) 2023; 44 Skjellerudsveen (10.1016/j.conctc.2024.101409_bib30) 2023; 83 Danese (10.1016/j.conctc.2024.101409_bib31) 2023; 29 Keefer (10.1016/j.conctc.2024.101409_bib4) 2022; 162 Hua (10.1016/j.conctc.2024.101409_bib18) 2022; 17 Zhang (10.1016/j.conctc.2024.101409_bib9) 2017; 32 Tang (10.1016/j.conctc.2024.101409_bib37) 2021 Pekow (10.1016/j.conctc.2024.101409_bib2) 2022; 163 Bager (10.1016/j.conctc.2024.101409_bib32) 2022; 57 Walmsley (10.1016/j.conctc.2024.101409_bib22) 1998; 43 D'Haens (10.1016/j.conctc.2024.101409_bib15) 2007; 132 Yamashita (10.1016/j.conctc.2024.101409_bib27) 2020; 13 Schreiner (10.1016/j.conctc.2024.101409_bib24) 2021; 53 Regueiro (10.1016/j.conctc.2024.101409_bib7) 2023; 40 Luo (10.1016/j.conctc.2024.101409_bib28) 2022; 27 Qazi (10.1016/j.conctc.2024.101409_bib25) 2020; 36 Thomann (10.1016/j.conctc.2024.101409_bib29) 2022; 20 Gasche (10.1016/j.conctc.2024.101409_bib34) 2015; 21 Guyatt (10.1016/j.conctc.2024.101409_bib20) 1989; 96 Borren (10.1016/j.conctc.2024.101409_bib8) 2019; 16 Scholten (10.1016/j.conctc.2024.101409_bib33) 2018; 23 Shen (10.1016/j.conctc.2024.101409_bib16) 2019; 34 Li (10.1016/j.conctc.2024.101409_bib26) 2023; 63 Chen (10.1016/j.conctc.2024.101409_bib12) 2022; 2022 Dai (10.1016/j.conctc.2024.101409_bib13) 2017; 96 Lu (10.1016/j.conctc.2024.101409_bib35) 2021; 10 Le Berre (10.1016/j.conctc.2024.101409_bib1) 2023; 402 Li (10.1016/j.conctc.2024.101409_bib36) 2022; 42 Xie (10.1016/j.conctc.2024.101409_bib17) 2020; 32 Mcging (10.1016/j.conctc.2024.101409_bib5) 2021; 54 Zhang (10.1016/j.conctc.2024.101409_bib14) 2018; 26 D Silva (10.1016/j.conctc.2024.101409_bib23) 2022; 20 |
| References_xml | – volume: 17 start-page: 2057 year: 2022 end-page: 2061 ident: bib18 article-title: Effect of Jianpi Qingchang decoction on clinical Symptoms,Colon Lesions,and im-mune function of patients with ulcerative colitis publication-title: World Journal of Integrated Traditional and Western Medicine – volume: 83 start-page: 909 year: 2023 end-page: 921 ident: bib30 article-title: The effect of biological treatment on fatigue in inflammatory bowel disease: a systematic review and meta-analysis publication-title: Drugs – year: 2021 ident: bib37 article-title: Gut Microbiota and Metabolites Were Disturbed in Ulcerative Colitis and Partly Restored after Jianpi Qingchang Decoction Treatment – volume: 13 year: 2020 ident: bib27 article-title: Potential role of neuroactive tryptophan metabolites in central fatigue: establishment of the fatigue circuit publication-title: Int. J. Trypotophan Res. – volume: 402 start-page: 571 year: 2023 end-page: 584 ident: bib1 article-title: Ulcerative colitis publication-title: Lancet – volume: 20 start-page: 995 year: 2022 end-page: 1009 ident: bib23 article-title: Prevalence and risk factors for fatigue in adults with inflammatory bowel disease: a systematic review with meta-analysis publication-title: Clin. Gastroenterol. Hepatol. – volume: 27 start-page: 7377 year: 2022 ident: bib28 article-title: Interactions between gut microbiota and polyphenols: new insights into the treatment of fatigue publication-title: Molecules – volume: 23 start-page: 48 year: 2018 end-page: 53 ident: bib33 article-title: Surplus vitamin b12 use does not reduce fatigue in patients with irritable bowel syndrome or inflammatory bowel disease: a randomized double-blind placebo-controlled trial publication-title: Clin. Nutr. Espen – volume: 26 start-page: 929 year: 2018 end-page: 933 ident: bib14 article-title: Clinical assessment of Jianpi Qingchang formula in the treatment of ulcerative colitis patients with TCM type of spleen-deficiency and retention of damp-heat publication-title: Chin J Integr Trad West Med Dig. – year: 2022 ident: bib10 article-title: The Comparative Study on the Clinical Characteristics of Fatigue between Large Intestine Dampness-Heat Syndrome and Spleen Deficiency Dampness Syndrome in Patients with Ulcerative Colitis – volume: 44 start-page: 662 year: 2023 end-page: 669 ident: bib3 article-title: [Chronic fatigue: what investigations? And what for?] publication-title: Rev. Med. Interne – volume: 132 start-page: 763 year: 2007 end-page: 786 ident: bib15 article-title: A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis publication-title: Gastroenterology – volume: 19 start-page: 66 year: 2011 end-page: 68 ident: bib21 article-title: The digestive system disease professional committee of the Chinese association of integrated traditional Chinese and western medicine, Traditional Chinese Medicine Symptom Rating Scale for Gastrointestinal Diseases publication-title: Chin J Integr Trad West Med Dig – volume: 2022 year: 2022 ident: bib12 article-title: Jianpi Qingchang decoction ameliorates chronic colitis in piroxicam-induced IL-10 knockout mice by inhibiting endoplasmic reticulum stress publication-title: Evid Based Complement Alternat Med – volume: 10 start-page: 1030 year: 2021 ident: bib35 article-title: Recent advances in panax ginseng c.a. Meyer as a herb for anti-fatigue: an effects and mechanisms review publication-title: Foods – volume: 54 start-page: 368 year: 2021 end-page: 387 ident: bib5 article-title: Review article: the aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies publication-title: Aliment. Pharmacol. Ther. – volume: 34 start-page: 4155 year: 2019 end-page: 4160 ident: bib16 article-title: Variation between observers in describing mucosal appearances in proctocolitis publication-title: Br. Med. J. – volume: 36 start-page: 284 year: 2020 end-page: 294 ident: bib25 article-title: Fatigue in inflammatory bowel disease: a problematic ailment publication-title: Curr. Opin. Gastroenterol. – volume: 53 start-page: 138 year: 2021 end-page: 149 ident: bib24 article-title: Fatigue in inflammatory bowel disease and its impact on daily activities publication-title: Aliment. Pharmacol. Ther. – volume: 162 start-page: 1439 year: 2022 end-page: 1451 ident: bib4 article-title: How should pain, fatigue, and emotional wellness be incorporated into treatment goals for optimal management of inflammatory bowel disease? publication-title: Gastroenterology – volume: 20 start-page: 366 year: 2022 ident: bib29 article-title: Depression and fatigue in active IBD from a microbiome perspective-a bayesian approach to faecal metagenomics publication-title: BMC Med. – volume: 43 start-page: 29 year: 1998 end-page: 32 ident: bib22 article-title: A simple clinical colitis activity index publication-title: Gut – volume: 22 start-page: 811 year: 2016 end-page: 816 ident: bib11 article-title: Clinical presentation and treatment strategies for ulcerative colitis: a retrospective study of 247 inpatients publication-title: Chin. J. Integr. Med. – volume: 32 start-page: 767 year: 2020 end-page: 771 ident: bib17 article-title: Clinical study on treatment of left ulcerative colitis of spleen deficiency and damp-heat type by lichang decoction combined with ulcer ling publication-title: Clinical Journal of Traditional Chinese Medicine – volume: 16 start-page: 247 year: 2019 end-page: 259 ident: bib8 article-title: Fatigue in ibd: epidemiology, pathophysiology and management publication-title: Nat. Rev. Gastroenterol. Hepatol. – volume: 42 start-page: 956 year: 2022 end-page: 960 ident: bib36 article-title: [Mechanism of acupuncture and moxibustion in treatment of chronic fatigue syndrome from perspective of intestinal flora] publication-title: Zhongguo Zhen Jiu – volume: 63 start-page: 3065 year: 2023 end-page: 3080 ident: bib26 article-title: Gut microbiota as a potential target for developing anti-fatigue foods publication-title: Crit. Rev. Food Sci. Nutr. – volume: 22 start-page: 281 year: 2022 ident: bib6 article-title: Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study publication-title: BMC Gastroenterol. – volume: 32 start-page: 3585 year: 2017 end-page: 3589 ident: bib9 article-title: Consensus opinion of traditional Chinese medicine diagnosis and treatment experts on ulcerative colitis (2017) publication-title: China Journal of Traditional Chinese Medicine and Pharmacy – volume: 163 start-page: 1164 year: 2022 end-page: 1165 ident: bib2 article-title: Fatigue in inflammatory bowel disease: a common complaint with few answers publication-title: Gastroenterology – volume: 21 start-page: 579 year: 2015 end-page: 588 ident: bib34 article-title: Ferric maltol is effective in correcting iron deficiency anemia in patients with inflammatory bowel disease: results from a phase-3 clinical trial program publication-title: Inflamm. Bowel Dis. – volume: 40 start-page: 474 year: 2023 end-page: 488 ident: bib7 article-title: Burden of fatigue among patients with ulcerative colitis and crohn's disease: results from a global survey of patients and gastroenterologists publication-title: Adv. Ther. – volume: 57 start-page: 37 year: 2022 end-page: 43 ident: bib32 article-title: Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the tarif study publication-title: Scand. J. Gastroenterol. – volume: 29 start-page: 1723 year: 2023 end-page: 1729 ident: bib31 article-title: Upadacitinib induction and maintenance therapy improves abdominal pain, bowel urgency, and fatigue in patients with ulcerative colitis: a post hoc analysis of phase 3 data publication-title: Inflamm. Bowel Dis. – volume: 27 start-page: 826 year: 2021 end-page: 835 ident: bib19 article-title: The ibd-f patient self-assessment scale accurately depicts the level of fatigue and predicts a negative effect on the quality of life of patients with ibd in clinical remission publication-title: Inflamm. Bowel Dis. – volume: 96 year: 2017 ident: bib13 article-title: Effects of Jianpi Qingchang decoction on the quality of life of patients with ulcerative colitis: a randomized controlled trial publication-title: Medicine. (Baltimore) – volume: 96 start-page: 804 year: 1989 ident: bib20 article-title: A new measure of health status for clinical trials in inflammatory bowel disease publication-title: Gastroenterolog – volume: 402 start-page: 571 year: 2023 ident: 10.1016/j.conctc.2024.101409_bib1 article-title: Ulcerative colitis publication-title: Lancet doi: 10.1016/S0140-6736(23)00966-2 – volume: 17 start-page: 2057 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib18 article-title: Effect of Jianpi Qingchang decoction on clinical Symptoms,Colon Lesions,and im-mune function of patients with ulcerative colitis publication-title: World Journal of Integrated Traditional and Western Medicine – year: 2021 ident: 10.1016/j.conctc.2024.101409_bib37 – volume: 16 start-page: 247 year: 2019 ident: 10.1016/j.conctc.2024.101409_bib8 article-title: Fatigue in ibd: epidemiology, pathophysiology and management publication-title: Nat. Rev. Gastroenterol. Hepatol. doi: 10.1038/s41575-018-0091-9 – volume: 42 start-page: 956 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib36 article-title: [Mechanism of acupuncture and moxibustion in treatment of chronic fatigue syndrome from perspective of intestinal flora] publication-title: Zhongguo Zhen Jiu – volume: 53 start-page: 138 year: 2021 ident: 10.1016/j.conctc.2024.101409_bib24 article-title: Fatigue in inflammatory bowel disease and its impact on daily activities publication-title: Aliment. Pharmacol. Ther. doi: 10.1111/apt.16145 – volume: 19 start-page: 66 year: 2011 ident: 10.1016/j.conctc.2024.101409_bib21 article-title: The digestive system disease professional committee of the Chinese association of integrated traditional Chinese and western medicine, Traditional Chinese Medicine Symptom Rating Scale for Gastrointestinal Diseases publication-title: Chin J Integr Trad West Med Dig – volume: 57 start-page: 37 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib32 article-title: Long-term maintenance treatment with 300 mg thiamine for fatigue in patients with inflammatory bowel disease: results from an open-label extension of the tarif study publication-title: Scand. J. Gastroenterol. doi: 10.1080/00365521.2021.1983640 – volume: 162 start-page: 1439 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib4 article-title: How should pain, fatigue, and emotional wellness be incorporated into treatment goals for optimal management of inflammatory bowel disease? publication-title: Gastroenterology doi: 10.1053/j.gastro.2021.08.060 – volume: 40 start-page: 474 year: 2023 ident: 10.1016/j.conctc.2024.101409_bib7 article-title: Burden of fatigue among patients with ulcerative colitis and crohn's disease: results from a global survey of patients and gastroenterologists publication-title: Adv. Ther. doi: 10.1007/s12325-022-02364-2 – volume: 22 start-page: 811 year: 2016 ident: 10.1016/j.conctc.2024.101409_bib11 article-title: Clinical presentation and treatment strategies for ulcerative colitis: a retrospective study of 247 inpatients publication-title: Chin. J. Integr. Med. doi: 10.1007/s11655-015-2118-1 – volume: 34 start-page: 4155 year: 2019 ident: 10.1016/j.conctc.2024.101409_bib16 article-title: Variation between observers in describing mucosal appearances in proctocolitis publication-title: Br. Med. J. – volume: 83 start-page: 909 year: 2023 ident: 10.1016/j.conctc.2024.101409_bib30 article-title: The effect of biological treatment on fatigue in inflammatory bowel disease: a systematic review and meta-analysis publication-title: Drugs doi: 10.1007/s40265-023-01888-3 – volume: 21 start-page: 579 year: 2015 ident: 10.1016/j.conctc.2024.101409_bib34 article-title: Ferric maltol is effective in correcting iron deficiency anemia in patients with inflammatory bowel disease: results from a phase-3 clinical trial program publication-title: Inflamm. Bowel Dis. doi: 10.1097/MIB.0000000000000314 – volume: 54 start-page: 368 year: 2021 ident: 10.1016/j.conctc.2024.101409_bib5 article-title: Review article: the aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies publication-title: Aliment. Pharmacol. Ther. doi: 10.1111/apt.16465 – volume: 32 start-page: 3585 year: 2017 ident: 10.1016/j.conctc.2024.101409_bib9 article-title: Consensus opinion of traditional Chinese medicine diagnosis and treatment experts on ulcerative colitis (2017) publication-title: China Journal of Traditional Chinese Medicine and Pharmacy – volume: 2022 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib12 article-title: Jianpi Qingchang decoction ameliorates chronic colitis in piroxicam-induced IL-10 knockout mice by inhibiting endoplasmic reticulum stress publication-title: Evid Based Complement Alternat Med – volume: 36 start-page: 284 year: 2020 ident: 10.1016/j.conctc.2024.101409_bib25 article-title: Fatigue in inflammatory bowel disease: a problematic ailment publication-title: Curr. Opin. Gastroenterol. doi: 10.1097/MOG.0000000000000644 – volume: 23 start-page: 48 year: 2018 ident: 10.1016/j.conctc.2024.101409_bib33 article-title: Surplus vitamin b12 use does not reduce fatigue in patients with irritable bowel syndrome or inflammatory bowel disease: a randomized double-blind placebo-controlled trial publication-title: Clin. Nutr. Espen doi: 10.1016/j.clnesp.2017.10.004 – year: 2022 ident: 10.1016/j.conctc.2024.101409_bib10 – volume: 26 start-page: 929 year: 2018 ident: 10.1016/j.conctc.2024.101409_bib14 article-title: Clinical assessment of Jianpi Qingchang formula in the treatment of ulcerative colitis patients with TCM type of spleen-deficiency and retention of damp-heat publication-title: Chin J Integr Trad West Med Dig. – volume: 29 start-page: 1723 year: 2023 ident: 10.1016/j.conctc.2024.101409_bib31 article-title: Upadacitinib induction and maintenance therapy improves abdominal pain, bowel urgency, and fatigue in patients with ulcerative colitis: a post hoc analysis of phase 3 data publication-title: Inflamm. Bowel Dis. doi: 10.1093/ibd/izad016 – volume: 32 start-page: 767 year: 2020 ident: 10.1016/j.conctc.2024.101409_bib17 article-title: Clinical study on treatment of left ulcerative colitis of spleen deficiency and damp-heat type by lichang decoction combined with ulcer ling publication-title: Clinical Journal of Traditional Chinese Medicine – volume: 27 start-page: 826 year: 2021 ident: 10.1016/j.conctc.2024.101409_bib19 article-title: The ibd-f patient self-assessment scale accurately depicts the level of fatigue and predicts a negative effect on the quality of life of patients with ibd in clinical remission publication-title: Inflamm. Bowel Dis. doi: 10.1093/ibd/izaa201 – volume: 10 start-page: 1030 year: 2021 ident: 10.1016/j.conctc.2024.101409_bib35 article-title: Recent advances in panax ginseng c.a. Meyer as a herb for anti-fatigue: an effects and mechanisms review publication-title: Foods doi: 10.3390/foods10051030 – volume: 13 year: 2020 ident: 10.1016/j.conctc.2024.101409_bib27 article-title: Potential role of neuroactive tryptophan metabolites in central fatigue: establishment of the fatigue circuit publication-title: Int. J. Trypotophan Res. – volume: 96 start-page: 804 year: 1989 ident: 10.1016/j.conctc.2024.101409_bib20 article-title: A new measure of health status for clinical trials in inflammatory bowel disease publication-title: Gastroenterolog doi: 10.1016/0016-5085(89)90905-0 – volume: 163 start-page: 1164 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib2 article-title: Fatigue in inflammatory bowel disease: a common complaint with few answers publication-title: Gastroenterology doi: 10.1053/j.gastro.2022.08.050 – volume: 44 start-page: 662 year: 2023 ident: 10.1016/j.conctc.2024.101409_bib3 article-title: [Chronic fatigue: what investigations? And what for?] publication-title: Rev. Med. Interne doi: 10.1016/j.revmed.2023.05.007 – volume: 63 start-page: 3065 year: 2023 ident: 10.1016/j.conctc.2024.101409_bib26 article-title: Gut microbiota as a potential target for developing anti-fatigue foods publication-title: Crit. Rev. Food Sci. Nutr. doi: 10.1080/10408398.2021.1983768 – volume: 27 start-page: 7377 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib28 article-title: Interactions between gut microbiota and polyphenols: new insights into the treatment of fatigue publication-title: Molecules doi: 10.3390/molecules27217377 – volume: 96 year: 2017 ident: 10.1016/j.conctc.2024.101409_bib13 article-title: Effects of Jianpi Qingchang decoction on the quality of life of patients with ulcerative colitis: a randomized controlled trial publication-title: Medicine. (Baltimore) doi: 10.1097/MD.0000000000006651 – volume: 20 start-page: 366 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib29 article-title: Depression and fatigue in active IBD from a microbiome perspective-a bayesian approach to faecal metagenomics publication-title: BMC Med. doi: 10.1186/s12916-022-02550-7 – volume: 132 start-page: 763 year: 2007 ident: 10.1016/j.conctc.2024.101409_bib15 article-title: A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.12.038 – volume: 43 start-page: 29 year: 1998 ident: 10.1016/j.conctc.2024.101409_bib22 article-title: A simple clinical colitis activity index publication-title: Gut doi: 10.1136/gut.43.1.29 – volume: 20 start-page: 995 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib23 article-title: Prevalence and risk factors for fatigue in adults with inflammatory bowel disease: a systematic review with meta-analysis publication-title: Clin. Gastroenterol. Hepatol. doi: 10.1016/j.cgh.2021.06.034 – volume: 22 start-page: 281 year: 2022 ident: 10.1016/j.conctc.2024.101409_bib6 article-title: Prevalence and factors associated with fatigue in patients with ulcerative colitis in China: a cross-sectional study publication-title: BMC Gastroenterol. doi: 10.1186/s12876-022-02357-z |
| SSID | ssj0001637125 |
| Score | 2.283904 |
| Snippet | Ulcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in Traditional... AbstractBackgroundUlcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under "dysentery" and "intestinal bleeding" in... Background: Ulcerative colitis (UC) is a chronic non-specific inflammatory intestinal disease, categoried under ''dysentery'' and ''intestinal bleeding'' in... |
| SourceID | doaj unpaywall pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 101409 |
| SubjectTerms | Fatigue Jianpi Qingchang decoction Other Randomized controlled trial Spleen deficiency and dampness-heat syndrome Ulcerative colitis |
| SummonAdditionalLinks | – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFLamTgJeuF_KTQeJR1LV8SUObwMxTZM6gUal8mQ5jg2FLq1IK7T9Uf4Ox05SLQxEeWtTX5qc2-f4nM-EvJQyo55lLkGw4RPupE3ysXGJ8znKHJdyLJK4Tk7k0ZQfz8Rsj7zqamF6-_cxDwuXhTaSDaY8XOKhWm9fhu2kAdmfnrw_-BTOj-OCJkoK3lXH_aVrL_pEkv5eELoKMq_mSl7fVCtz_sMsFpcC0eEtMuluock_-TbarIuRvfiN3XHXe7xNbraIFA4aFbpD9lx1l1ybtHvu98jPljp0AZGKFpYejlGnVnP4gGEvFg5DiYvYWCAB8woQUsI2fz003yysawjGwcZ0uxpaOtcawntgqFchoQNHCXQWoRYUTFVCac5WwREnIV5AR60Axsa8-QqxMxTn4HGkzxv3Gk7jvwu8E0ucBRCMgwGMxOXybH6Bbduk_AV-jEeV3CfTw3cf3x4l7XEQiRUqWyeGF4IVrFCZYl6ViETQ23DvKbclUwUGe-HDyxlRGmVkLhhqmkdAywxV0gvLHpBBtazcIwKFyp2SJkvLlHLnVaGct5J6XlLjVFoMSdKpiV41rB-6S4f7qhtp6SAt3UhrSN4EXdq2DZzd8QKKWbcuQAuRGSUstZYZXsq8YFbY3DKfyZLzsRkS0Wmi7spi0ZHjQPN_TJ79qZ-rW29Ua6rrVI_1abCSYCQhbxjX7bPLPVvA1QCpHeZ80ZmKRn8UNplM5ZabWjM0-kADmGKbh43pbB8LYl8maDYeEtUzqt5z6_9Szb9EznNKJULLTAzJaGt_O4nm8f92eEJuhG9NytJTMlh_37hnCDzXxfPW3_wCdKKFKg priority: 102 providerName: Unpaywall |
| Title | Clinical study of Jianpi Qingchang decoction in the treatment of ulcerative colitis patients with spleen deficiency and dampness-heat syndrome accompanied by fatigue: Study protocol for a randomized controlled trial |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S245186542400156X https://www.clinicalkey.es/playcontent/1-s2.0-S245186542400156X https://dx.doi.org/10.1016/j.conctc.2024.101409 https://www.ncbi.nlm.nih.gov/pubmed/39735170 https://www.proquest.com/docview/3150136729 https://pubmed.ncbi.nlm.nih.gov/PMC11681875 https://doi.org/10.1016/j.conctc.2024.101409 https://doaj.org/article/557a85c1cc3a4d69b3c5c9c3f76d440a |
| UnpaywallVersion | publishedVersion |
| Volume | 42 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 2451-8654 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001637125 issn: 2451-8654 databaseCode: KQ8 dateStart: 20151030 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2451-8654 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001637125 issn: 2451-8654 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2451-8654 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001637125 issn: 2451-8654 databaseCode: M~E dateStart: 20150101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 2451-8654 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001637125 issn: 2451-8654 databaseCode: RPM dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bb9MwGLXQkIAXxJ1ymT4kXgN1fA1vAzFNkzaBRqXyZDm-QFGXVqQVGn-Uv8NnJ6laDWl74K1KHae1j7_v2Dk-JuS1lIpGpkKBZCMWPEhXVGMbihAr7HOcyrFs4npyKo8m_HgqpltHfSVNWGcP3DXcWyGU1cJR55jlXlY1c8JVjkUlPefjTI0wjW1NpvLqimQKU_ewVy4LunB-6bJrYcnTJZ40iFu5KFv276Sky5TzsnLy9rpZ2otfdj7fSkuH98jdnk_CQfc_7pMboXlAbp30b8wfkj-98eccspEsLCIcIyKWM_iMSStv-wWPU9C8vQFmDSAhhI36PBVfz13o7MHBZbFcC70ZawtpFRfaZZJjYC3JjCLt5ATbePD2fJnCaJGiPQzGCGBdVr03yHyhvoCINX1bh3dwln9dco1Y4FMAqTRYwDzqF-ez31i2l9TP8WM-aOQRmRx-_PLhqOgPcyic0GpVWF4LVrNaK82i9sgjMFbwGCl3nukaU7WIaWlFeKutrARDnESko8xSLaNw7DHZaxZNeEqg1lXQ0qrSl5SHqGsdopM0ck9t0GU9IsXQrWbZeXaYQcz2w3QwMAkGpoPBiLxPfb8pmxy38wXEoelxaK7C4YiIATlm2NSKYRgrml3xcPWv-0Lbx5LWUNOWZmzOSi6wKQRPql-cdU-37-zpUkeDrvHMVwO0DUaT9IrINmGxbg3DIZtM_Eos86SD-qZZkLkyQdV4RPTOINhpt91vmtn37FhOqURiqMSIvNmMl2t1zbP_0TXPyZ1UZSdCekH2Vj_X4SVSyVW9n6PGPrk5Of108PUv2XN6ag |
| linkProvider | Directory of Open Access Journals |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bb9MwFLamTgJeuF_KTQeJR1LV8SUObwMxTZM6gUal8mQ5jg2FLq1IK7T9Uf4Ox05SLQxEeWtTX5qc2-f4nM-EvJQyo55lLkGw4RPupE3ysXGJ8znKHJdyLJK4Tk7k0ZQfz8Rsj7zqamF6-_cxDwuXhTaSDaY8XOKhWm9fhu2kAdmfnrw_-BTOj-OCJkoK3lXH_aVrL_pEkv5eELoKMq_mSl7fVCtz_sMsFpcC0eEtMuluock_-TbarIuRvfiN3XHXe7xNbraIFA4aFbpD9lx1l1ybtHvu98jPljp0AZGKFpYejlGnVnP4gGEvFg5DiYvYWCAB8woQUsI2fz003yysawjGwcZ0uxpaOtcawntgqFchoQNHCXQWoRYUTFVCac5WwREnIV5AR60Axsa8-QqxMxTn4HGkzxv3Gk7jvwu8E0ucBRCMgwGMxOXybH6Bbduk_AV-jEeV3CfTw3cf3x4l7XEQiRUqWyeGF4IVrFCZYl6ViETQ23DvKbclUwUGe-HDyxlRGmVkLhhqmkdAywxV0gvLHpBBtazcIwKFyp2SJkvLlHLnVaGct5J6XlLjVFoMSdKpiV41rB-6S4f7qhtp6SAt3UhrSN4EXdq2DZzd8QKKWbcuQAuRGSUstZYZXsq8YFbY3DKfyZLzsRkS0Wmi7spi0ZHjQPN_TJ79qZ-rW29Ua6rrVI_1abCSYCQhbxjX7bPLPVvA1QCpHeZ80ZmKRn8UNplM5ZabWjM0-kADmGKbh43pbB8LYl8maDYeEtUzqt5z6_9Szb9EznNKJULLTAzJaGt_O4nm8f92eEJuhG9NytJTMlh_37hnCDzXxfPW3_wCdKKFKg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Clinical+study+of+Jianpi+Qingchang+decoction+in+the+treatment+of+ulcerative+colitis+patients+with+spleen+deficiency+and+dampness-heat+syndrome+accompanied+by+fatigue%3A+Study+protocol+for+a+randomized+controlled+trial&rft.jtitle=Contemporary+clinical+trials+communications&rft.au=Liu%2C+Zi-Xuan&rft.au=Liu%2C+Xiao-Yan&rft.au=Tan%2C+Wei-Wei&rft.au=Zhang%2C+Wei-Bing&rft.date=2024-12-01&rft.eissn=2451-8654&rft.volume=42&rft.spage=101409&rft_id=info:doi/10.1016%2Fj.conctc.2024.101409&rft_id=info%3Apmid%2F39735170&rft.externalDocID=39735170 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F24518654%2FS2451865424X00058%2Fcov150h.gif |