Assessment of poly(methacrylic acid-co-N-vinyl pyrrolidone) as a carrier for the oral delivery of therapeutic proteins using Caco-2 and HT29-MTX cell lines - Carr, Daniel A.; Peppas, Nicholas A. (Journal of biomedical materials research. Part A, 2010)
Keywords: Administration, Oral; Algorithms; Assessments; Biological and medical sciences; Caco-2 Cells; Carriers; cell culture; Cell Survival - drug effects; Crosslinking; cytocompatibility; Drug Carriers; Drug Delivery Systems; Gastric Mucosa - metabolism; General pharmacology; Hormones. Endocrine system; HT29 Cells; Humans; Hydrogels; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - chemistry; Insulin; Insulin - administration & dosage; Insulin - chemistry; Intestinal Mucosa - metabolism; Kinetics; Materials Testing; Medical sciences; Methylmethacrylates - chemistry; Microparticles; Nanoparticles; oral delivery; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Povidone - chemistry; Proteins; Proteins - administration & dosage; Reproduction; Transport; Biological properties; Pancreatic hormone; Methacrylic acid polymer; Pharmaceutical technology; Control release polymer; Oral administration; Drug carrier; hydrogels; Insulin; Colloidal gel; Polyelectrolyte; Protein hormone; Pyrrolidone(vinyl) polymer; cell culture; Established cell line; oral delivery; Dosage form; cytocompatibility; Biocompatibility; Microparticle; Biomaterial; Hydrogel; Pharmacokinetics; Biomedical engineering