International consensus for the treatment of autoimmune pancreatitis

The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all...

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Published in	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 17; no. 1; pp. 1 - 6
Main Authors	Okazaki, Kazuichi, Chari, Suresh T., Frulloni, Luca, Lerch, Markus M., Kamisawa, Terumi, Kawa, Shigeyuki, Kim, Myung-Hwan, Lévy, Philippe, Masamune, Atsushi, Webster, George, Shimosegawa, Tooru
Format	Journal Article
Language	English
Published	Switzerland Elsevier B.V 01.01.2017 Elsevier Limited
Subjects	Algorithms Anti-Inflammatory Agents - therapeutic use Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy Autoimmune pancreatitis Back pain Delphi Technique Endocrinology & Metabolism Experts Gastroenterology and Hepatology Health care policy Humans Immunomodulatory Immunosuppressive Agents - therapeutic use Induction Chemotherapy - methods International International Cooperation Maintenance Chemotherapy - methods Pancreatitis - diagnosis Pancreatitis - drug therapy Pancreatitis - immunology Recurrence Rituximab Steroid Steroids Studies Treatment Steroid Rituximab Treatment Immunomodulatory Autoimmune pancreatitis
Online Access	Get full text
ISSN	1424-3903 1424-3911 1424-3911
DOI	10.1016/j.pan.2016.12.003

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Abstract	The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP. By a modified Delphi approach, a panel of international experts has proposed an international consensus on the treatment of AIP after intense discussion and deliberation during an international consensus symposium of the International Association of Pancreatology (IAP) 2016. Individual statements for nine clinical questions with recommendation levels and the therapeutic strategy have been proposed. The recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide. These recommendations can be tailored according to the local expertise and context in the management of individual patients.
AbstractList	The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP.BACKGROUND AND AIMSThe International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP.By a modified Delphi approach, a panel of international experts has proposed an international consensus on the treatment of AIP after intense discussion and deliberation during an international consensus symposium of the International Association of Pancreatology (IAP) 2016.METHODSBy a modified Delphi approach, a panel of international experts has proposed an international consensus on the treatment of AIP after intense discussion and deliberation during an international consensus symposium of the International Association of Pancreatology (IAP) 2016.Individual statements for nine clinical questions with recommendation levels and the therapeutic strategy have been proposed.RESULTSIndividual statements for nine clinical questions with recommendation levels and the therapeutic strategy have been proposed.The recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide. These recommendations can be tailored according to the local expertise and context in the management of individual patients.CONCLUSIONThe recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide. These recommendations can be tailored according to the local expertise and context in the management of individual patients. Background and aims The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP. Methods By a modified Delphi approach, a panel of international experts has proposed an international consensus on the treatment of AIP after intense discussion and deliberation during an international consensus symposium of the International Association of Pancreatology (IAP) 2016. Results Individual statements for nine clinical questions with recommendation levels and the therapeutic strategy have been proposed. Conclusion The recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide. These recommendations can be tailored according to the local expertise and context in the management of individual patients. The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP. By a modified Delphi approach, a panel of international experts has proposed an international consensus on the treatment of AIP after intense discussion and deliberation during an international consensus symposium of the International Association of Pancreatology (IAP) 2016. Individual statements for nine clinical questions with recommendation levels and the therapeutic strategy have been proposed. The recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide. These recommendations can be tailored according to the local expertise and context in the management of individual patients. Abstract Background and aims The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to differentiate two types of AIP each other. By initial steroid treatment for induction of remission, remission can be successfully induced in almost all subjects with type 1 and type 2 AIP. As relapse rate in type 1 AIP is significantly higher than in type 2 AIP, there has been ongoing debate on how to treat effectively relapse of type 1 AIP. Methods By a modified Delphi approach, a panel of international experts has proposed an international consensus on the treatment of AIP after intense discussion and deliberation during an international consensus symposium of the International Association of Pancreatology (IAP) 2016. Results Individual statements for nine clinical questions with recommendation levels and the therapeutic strategy have been proposed. Conclusion The recommendations are based on the available evidence, and eastern and western experts' opinions to find standard treatment of AIP worldwide. These recommendations can be tailored according to the local expertise and context in the management of individual patients.
Author	Chari, Suresh T. Frulloni, Luca Kawa, Shigeyuki Masamune, Atsushi Shimosegawa, Tooru Okazaki, Kazuichi Kim, Myung-Hwan Kamisawa, Terumi Webster, George Lerch, Markus M. Lévy, Philippe
Author_xml	– sequence: 1 givenname: Kazuichi orcidid: 0000-0003-3424-3142 surname: Okazaki fullname: Okazaki, Kazuichi email: okazaki@hirakata.kmu.ac.jp organization: Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan – sequence: 2 givenname: Suresh T. surname: Chari fullname: Chari, Suresh T. email: chari.suresh@mayo.edu organization: Mayo Clinic College of Medicine, Rochester, MN 55905, USA – sequence: 3 givenname: Luca orcidid: 0000-0001-7417-2655 surname: Frulloni fullname: Frulloni, Luca organization: Department of Medicine, Pancreas Institute, University of Verona, Verona, Italy – sequence: 4 givenname: Markus M. surname: Lerch fullname: Lerch, Markus M. organization: Department of Medicine A, University Medicine Greifswald, Germany – sequence: 5 givenname: Terumi surname: Kamisawa fullname: Kamisawa, Terumi organization: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan – sequence: 6 givenname: Shigeyuki surname: Kawa fullname: Kawa, Shigeyuki organization: Center for Health, Safety, and Environmental Management, Shinshu University, Matsumoto, Japan – sequence: 7 givenname: Myung-Hwan surname: Kim fullname: Kim, Myung-Hwan organization: Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea – sequence: 8 givenname: Philippe surname: Lévy fullname: Lévy, Philippe organization: Service de Pancréatologie-Gastroentérologie, Pôle des Maladies de l'Appareil Digestif, Université Denis Diderot-Paris VII Hôpital Beaujon, APHP, Clichy, France – sequence: 9 givenname: Atsushi surname: Masamune fullname: Masamune, Atsushi organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan – sequence: 10 givenname: George surname: Webster fullname: Webster, George organization: Pancreaticobiliary Medicine Unit, University College London Hospitals, London, UK – sequence: 11 givenname: Tooru surname: Shimosegawa fullname: Shimosegawa, Tooru organization: Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
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Keywords	Steroid Rituximab Treatment Immunomodulatory Autoimmune pancreatitis
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Snippet	The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us first to... Abstract Background and aims The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and... Background and aims The International Consensus Diagnostic Criteria (ICDC) for AIP has proposed two distinctive type of AIP, type 1 and type 2, and enabled us...
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SubjectTerms	Algorithms Anti-Inflammatory Agents - therapeutic use Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy Autoimmune pancreatitis Back pain Delphi Technique Endocrinology & Metabolism Experts Gastroenterology and Hepatology Health care policy Humans Immunomodulatory Immunosuppressive Agents - therapeutic use Induction Chemotherapy - methods International International Cooperation Maintenance Chemotherapy - methods Pancreatitis - diagnosis Pancreatitis - drug therapy Pancreatitis - immunology Recurrence Rituximab Steroid Steroids Studies Treatment
Title	International consensus for the treatment of autoimmune pancreatitis
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