Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance

CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced to...

Full description

Saved in:
Bibliographic Details
Published inDRUG METABOLISM AND PHARMACOKINETICS Vol. 27; no. 1; pp. 55 - 67
Main Authors Teh, Lay Kek, Bertilsson, Leif
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 2012
Japanese Society for the Study of Xenobiotics
Subjects
Online AccessGet full text
ISSN1347-4367
1880-0920
1880-0920
DOI10.2133/dmpk.DMPK-11-RV-121

Cover

Abstract CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.
AbstractList CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.
CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.
Summary: CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.
Author Teh, Lay Kek
Bertilsson, Leif
Author_xml – sequence: 1
  givenname: Lay Kek
  surname: Teh
  fullname: Teh, Lay Kek
  email: tehlaykek@puncakalam.uitm.edu.my, tehlaykek@yahoo.com
  organization: Pharmacogenomics Centre (PROMISE), Faculty of Pharmacy, Universiti Teknologi MARA, Malaysia
– sequence: 2
  givenname: Leif
  surname: Bertilsson
  fullname: Bertilsson, Leif
  organization: Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University, Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22185816$$D View this record in MEDLINE/PubMed
http://kipublications.ki.se/Default.aspx?queryparsed=id:124156004$$DView record from Swedish Publication Index
BookMark eNp9UU1v1DAQjVAR_YBfgIRy40KKP9b5QOJQ7cKyohWrCipxGjnOmLpN7GA7IP49jrLlwKEHe8Yz7z2N551mR9ZZzLKXlJwzyvnbbhjvzzdX-88FpcX1TUEZfZKd0LomBWkYOUo5X1XFipfVcXYawh0hnIsVe5YdM0ZrUdPyJIP9rfSDVO4HWjcYFXKn8_X3PduU7_Ir16OaeunzLVqMqfsm39mIHuOtNSrfGK3TwyoMubRdvu5NKss-3w2j81GmxvPsqZZ9wBeHeJZ9-_jh6_pTcfllu1tfXBZK1CIWLaeas0atWqU6QishZJdS7CrsmNZt3TasQyZKxWT6RiM0RSlYpYVuK1FzfpYVi274jePUwujNIP0fcNLAoXSfMgSxIoSWCf96wY_e_ZwwRBhMUNj30qKbAjRMVLSpGpaQrw7IqR2w-6f8sMMEaBaA8i4EjxqUiTIaZ6OXpgdKYPYLZr9g9gsohesbSH4lLv-P-yD_OGu7sNI8876dTYtHuHOTt2nJoBwdMMoWGKEMCGEVoSnwdIRIV1nRsixZOc_-flHC5M0vgx6CMrOhnfGoInTOPDrJX3hIx-o
CitedBy_id crossref_primary_10_1186_s13034_018_0243_2
crossref_primary_10_1016_j_cbi_2017_01_003
crossref_primary_10_1515_dmpt_2018_0011
crossref_primary_10_1038_tpj_2015_76
crossref_primary_10_2217_pgs_13_203
crossref_primary_10_1124_dmd_117_079780
crossref_primary_10_17116_jnevro201811806290
crossref_primary_10_1007_s12032_016_0773_5
crossref_primary_10_1089_cap_2017_0071
crossref_primary_10_1371_journal_pone_0202534
crossref_primary_10_1016_j_pharep_2014_04_002
crossref_primary_10_1158_1078_0432_CCR_15_0296
crossref_primary_10_3389_fvets_2019_00022
crossref_primary_10_1159_000478047
crossref_primary_10_1002_jat_3741
crossref_primary_10_1016_j_tips_2013_02_001
crossref_primary_10_1089_gtmb_2012_0122
crossref_primary_10_1007_s12325_019_00982_x
crossref_primary_10_4103_ijp_IJP_530_17
crossref_primary_10_1089_gtmb_2014_0318
crossref_primary_10_1111_1556_4029_12358
crossref_primary_10_1021_acs_jmedchem_6b01451
crossref_primary_10_1016_j_dmpk_2019_07_003
crossref_primary_10_1016_j_microc_2016_10_018
crossref_primary_10_1002_cpt_1643
crossref_primary_10_1016_j_clinthera_2014_06_024
crossref_primary_10_2217_pgs_2016_0185
crossref_primary_10_1016_j_jmoldx_2015_06_007
crossref_primary_10_1111_apm_12893
crossref_primary_10_1007_s41470_019_00063_y
crossref_primary_10_1016_j_jpba_2013_02_027
crossref_primary_10_3390_medicina59122057
crossref_primary_10_1038_s41397_019_0104_2
crossref_primary_10_1016_j_jopan_2015_03_007
crossref_primary_10_1002_mgg3_751
crossref_primary_10_3109_00498254_2015_1072253
crossref_primary_10_1016_j_dmpk_2018_06_001
crossref_primary_10_1016_j_tiv_2017_05_009
crossref_primary_10_1002_hep_26414
crossref_primary_10_1007_s11912_020_0865_4
crossref_primary_10_1016_j_bcp_2017_05_018
crossref_primary_10_1186_s12967_021_02816_3
crossref_primary_10_1016_j_bpa_2020_05_008
crossref_primary_10_1093_emph_eot010
crossref_primary_10_1016_j_ejphar_2013_12_025
crossref_primary_10_1111_jcpt_12310
crossref_primary_10_1007_s12272_018_1099_y
crossref_primary_10_1016_j_arr_2022_101819
crossref_primary_10_1371_journal_pone_0110691
crossref_primary_10_1200_JCO_2013_54_7992
crossref_primary_10_1016_j_dmpk_2017_02_002
crossref_primary_10_1016_j_jep_2014_10_018
crossref_primary_10_1002_cpt_1818
crossref_primary_10_1093_pm_pny033
crossref_primary_10_1021_acs_jmedchem_5b00191
crossref_primary_10_1080_00498254_2016_1193262
crossref_primary_10_1007_s00702_018_1894_0
crossref_primary_10_2133_dmpk_DMPK_13_RV_032
crossref_primary_10_3748_wjg_v25_i23_2846
crossref_primary_10_1007_s00044_023_03053_7
crossref_primary_10_2174_1875692117666190416145331
crossref_primary_10_1007_s00280_017_3324_7
crossref_primary_10_3892_br_2018_1145
crossref_primary_10_1007_s00228_015_1855_6
crossref_primary_10_1021_acsmedchemlett_7b00381
crossref_primary_10_1007_s40142_012_0006_y
crossref_primary_10_1007_s00044_021_02799_2
crossref_primary_10_1111_jvp_13113
crossref_primary_10_1007_s00049_020_00302_8
crossref_primary_10_1016_j_psychres_2020_113336
crossref_primary_10_1016_j_ipha_2023_10_008
crossref_primary_10_1515_dmpt_2016_0035
crossref_primary_10_3390_ijms24087336
crossref_primary_10_2217_pgs_14_56
crossref_primary_10_1002_jcph_243
crossref_primary_10_1016_j_jcf_2024_06_006
crossref_primary_10_1002_dta_1863
crossref_primary_10_1515_amma_2017_0023
crossref_primary_10_1007_s13181_024_01018_9
crossref_primary_10_1517_17425255_2014_964204
crossref_primary_10_2133_dmpk_DMPK_13_NT_116
crossref_primary_10_1186_s12936_018_2271_z
crossref_primary_10_1089_gtmb_2016_0235
crossref_primary_10_1371_journal_pone_0160172
crossref_primary_10_2217_pgs_14_155
crossref_primary_10_1016_j_pharmthera_2017_02_036
crossref_primary_10_1210_endocr_bqad179
crossref_primary_10_1111_bcpt_12478
crossref_primary_10_3109_03602532_2014_996649
crossref_primary_10_1093_jbcr_iry053
crossref_primary_10_1007_s00213_023_06484_7
crossref_primary_10_2217_pgs_15_13
crossref_primary_10_1007_s00228_013_1573_x
crossref_primary_10_1002_jcph_993
crossref_primary_10_2217_pgs_15_148
crossref_primary_10_1016_j_bcp_2022_115006
crossref_primary_10_1586_14787210_2015_1091724
crossref_primary_10_1007_s40262_015_0299_6
crossref_primary_10_1007_s11684_013_0249_3
crossref_primary_10_1111_bcpt_12363
crossref_primary_10_1002_jcla_21754
crossref_primary_10_1089_cap_2015_0137
crossref_primary_10_1371_journal_pone_0152946
crossref_primary_10_1016_j_jpba_2023_115839
crossref_primary_10_5306_wjco_v5_i3_374
crossref_primary_10_1016_j_toxlet_2016_10_010
crossref_primary_10_1007_s00228_016_2048_7
crossref_primary_10_3109_09540261_2013_825581
crossref_primary_10_1097_FTD_0000000000000212
crossref_primary_10_1371_journal_pone_0155234
crossref_primary_10_2217_pgs_2019_0049
crossref_primary_10_1002_dta_1959
crossref_primary_10_1124_dmd_119_088526
crossref_primary_10_1016_j_cllc_2014_12_004
crossref_primary_10_1186_s12936_019_2841_8
crossref_primary_10_3389_fphar_2015_00312
crossref_primary_10_1007_s00228_022_03449_1
crossref_primary_10_1177_0004563216686377
crossref_primary_10_1176_appi_ajp_2016_16040402
crossref_primary_10_1016_j_foodchem_2016_09_026
crossref_primary_10_1111_jvp_12890
crossref_primary_10_12793_tcp_2014_22_2_52
crossref_primary_10_1542_peds_2019_2608
crossref_primary_10_1124_dmd_116_074567
crossref_primary_10_1002_slct_202204536
crossref_primary_10_1515_dmpt_2016_0024
crossref_primary_10_3389_fphar_2017_00239
crossref_primary_10_1007_s10238_023_01142_w
crossref_primary_10_1111_cts_12768
crossref_primary_10_1007_s40291_017_0311_y
crossref_primary_10_1097_FPC_0000000000000188
crossref_primary_10_1016_j_chc_2022_03_003
crossref_primary_10_1038_srep09257
crossref_primary_10_1097_FPC_0000000000000228
crossref_primary_10_1007_s00436_019_06210_3
crossref_primary_10_1016_j_gene_2022_146960
Cites_doi 10.1373/49.6.1008
10.1038/sj.clpt.6100125
10.1001/jama.2009.1420
10.1038/sj.tpj.6500378
10.1007/s10549-011-1777-7
10.2217/pgs.11.107
10.1093/annonc/mdn155
10.1016/j.clpt.2004.04.009
10.1097/00008571-200310000-00006
10.1016/S0140-6736(89)90094-9
10.1001/archpsyc.1981.01780310031002
10.1111/j.1469-1809.2010.00585.x
10.1186/1479-7364-3-2-169
10.1097/00008571-199512001-00014
10.1097/00008571-199812000-00010
10.1002/prot.20399
10.1124/jpet.102.039891
10.1093/clinchem/48.7.983
10.1016/j.ygeno.2008.05.004
10.1007/BF02281880
10.1097/00008571-200204000-00008
10.1038/clpt.2010.144
10.1038/clpt.2010.137
10.1067/mcp.2002.120239
10.1097/00008571-199606000-00012
10.1016/S0140-6736(00)99016-0
10.1038/sj.clpt.6100367
10.1016/j.clpt.2004.08.020
10.1136/bmj.c693
10.1016/S0026-895X(25)09721-4
10.1046/j.1365-2710.2001.00347.x
10.1046/j.1365-2125.2003.01805.x
10.1093/hmg/4.12.2251
10.1007/BF00225204
10.1016/S0009-9236(03)00067-5
10.1038/clpt.1983.242
10.2133/dmpk.19.313
10.1093/jjco/hyp076
10.1097/FPC.0b013e3283317b95
10.1007/BF00562059
10.1124/dmd.108.023242
10.2133/dmpk.20.294
10.1097/00007691-198512000-00021
10.2165/00003088-198207050-00001
10.1007/BF00197419
10.1124/dmd.111.040832
10.1007/s00228-003-0562-x
10.1007/s00228-003-0701-4
10.1038/sj.mp.4001494
10.1097/00008571-199610000-00008
10.1007/s002280100360
10.1016/S0009-9236(98)90040-6
10.1111/j.1365-2125.1990.tb03627.x
10.1080/004982598238886
10.1038/tpj.2009.31
10.1002/cncr.24111
10.1038/347773a0
10.1067/mcp.2002.127494
10.1097/FPC.0b013e3282f5106e
10.1124/dmd.106.009548
10.1097/00008571-199608000-00005
10.1016/j.ejps.2011.08.003
10.1111/j.1600-0447.1993.tb03325.x
10.1007/BF00201601
10.1124/dmd.108.022368
10.1016/S0090-9556(24)14915-X
10.3109/00498254.2011.603385
10.1016/S0027-5107(02)00122-7
10.1038/clpt.1993.44
10.1007/s00228-007-0445-7
10.1093/hmg/3.6.923
10.1097/00008571-199706000-00004
10.1186/gm280
10.1016/S0140-6736(77)91430-1
10.1007/BF00279968
10.1200/JCO.2007.12.2705
10.1016/0024-3205(95)00223-S
10.1097/00008571-199610000-00003
10.1016/S0022-3565(25)10669-1
10.1097/00004714-200004000-00005
10.1007/978-3-642-78680-8_10
10.1016/j.cccn.2004.04.020
10.1016/j.clpt.2004.10.014
10.1097/00008571-200103000-00005
10.1038/clpt.2009.216
10.1200/jco.2009.27.18s.cra508
10.1097/00008571-199704000-00009
10.1038/sj.ejhg.5201243
10.1097/00008571-199910000-00013
10.1111/j.1440-1681.1988.tb01032.x
10.1016/S0021-9258(17)44890-3
10.1007/s00228-010-0831-4
10.1200/JCO.2007.11.4850
10.1038/clpt.1992.38
10.1097/00004714-200004000-00019
10.2165/00003088-200241070-00001
10.1093/carcin/17.9.1923
10.1124/dmd.108.026096
10.1097/00008571-199906000-00015
10.1007/s00228-007-0404-3
10.1592/phco.31.7.630
10.1016/j.clpt.2006.08.008
10.1097/00008571-199804000-00010
10.1016/S0022-3565(25)20152-5
10.2217/pgs.11.8
10.1097/00008571-199802000-00003
10.2174/138920011795713706
10.2165/00002512-199202040-00008
10.1016/S0022-3565(25)22379-5
10.1016/S0009-9236(99)70077-9
10.1097/00008571-199110000-00005
10.1016/S0022-3565(25)38970-6
10.1097/00008571-199306000-00001
10.1038/clpt.1982.29
10.1289/ehp.9298107
10.1093/carcin/18.6.1203
10.1097/00008571-199708000-00010
10.1097/00008571-199810000-00008
10.1016/j.amjopharm.2011.09.006
10.1016/j.phrs.2005.10.005
10.1073/pnas.90.24.11825
10.2133/dmpk.18.269
10.1097/00008571-199510000-00006
10.1097/00008571-199410000-00005
10.1007/BF00195139
10.1124/dmd.107.015149
10.1016/0140-6736(93)92546-6
10.1046/j.1365-2710.2003.00490.x
10.1067/mcp.2000.106464
10.2165/00003088-199529030-00005
10.1111/j.1365-2125.2011.03905.x
10.1097/00008571-199310000-00005
10.1038/clpt.1985.194
10.1016/S0009-9236(96)90214-3
10.1093/clinchem/46.9.1411
10.1097/01.fpc.0000230112.96086.e0
10.1067/mcp.2002.127111
10.1097/00008571-199906000-00003
10.1067/mcp.2002.125783
10.1074/jbc.M402337200
10.1124/dmd.105.008292
10.1124/mol.52.6.1034
10.1097/00008571-199602000-00002
10.1093/clinchem/43.2.254
10.1046/j.1365-2125.1996.00489.x
10.1007/s10549-008-0272-2
10.1111/j.1349-7006.2008.00780.x
10.1097/00008571-200107000-00005
ContentType Journal Article
Copyright 2012 The Japanese Society for the Study of Xenobiotics
Copyright_xml – notice: 2012 The Japanese Society for the Study of Xenobiotics
CorporateAuthor Pharmacogenomics Centre (PROMISE
Universiti Teknologi MARA
Hospital-Huddinge
Karolinska Institutet
Faculty of Pharmacy
Division of Clinical Pharmacology
Department of Laboratory Medicine
Karolinska University
CorporateAuthor_xml – name: Hospital-Huddinge
– name: Karolinska Institutet
– name: Department of Laboratory Medicine
– name: Faculty of Pharmacy
– name: Division of Clinical Pharmacology
– name: Pharmacogenomics Centre (PROMISE
– name: Karolinska University
– name: Universiti Teknologi MARA
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ADTPV
AOWAS
DOI 10.2133/dmpk.DMPK-11-RV-121
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
SwePub
SwePub Articles
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE


Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1880-0920
EndPage 67
ExternalDocumentID oai_swepub_ki_se_540016
22185816
10_2133_dmpk_DMPK_11_RV_121
co1metab_2012_002701_003_0055_00671666266
S1347436715304626
Genre Journal Article
Review
GroupedDBID ---
--M
0R~
29G
2WC
4.4
457
53G
5GY
7-5
8P~
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AATCM
AAXUO
ABJNI
ABMAC
ABXDB
ABYKQ
ACDAQ
ACGFO
ACGFS
ACRLP
ADBBV
ADEZE
AEBSH
AEKER
AENEX
AFKWA
AFTJW
AFXIZ
AGHFR
AGUBO
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
AXJTR
BAWUL
BKOJK
BKOMP
BLXMC
CS3
DIK
DU5
E3Z
EBS
EFJIC
EFLBG
EJD
F5P
FDB
FEDTE
FIRID
FYGXN
GBLVA
GX1
HH5
HVGLF
HZ~
JMI
JSF
JSH
KOM
KQ8
M41
MOJWN
M~E
O9-
OAUVE
RJT
RNS
ROL
RZJ
SPCBC
SSP
SSZ
T5K
TKC
TR2
~G-
AAQFI
AATTM
AAXKI
AAYWO
ACVFH
ADCNI
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
BNPGV
OVT
SSH
AAYXX
ACLOT
CITATION
EFKBS
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ADTPV
AOWAS
ID FETCH-LOGICAL-c585t-b31f329c4bccd01755adbcced7ed2ffb8b92de256c2a00395f1ea527f5fb75833
IEDL.DBID AIKHN
ISSN 1347-4367
1880-0920
IngestDate Tue Sep 30 03:29:02 EDT 2025
Wed Oct 01 14:50:45 EDT 2025
Mon Jul 21 05:51:48 EDT 2025
Wed Oct 01 06:42:29 EDT 2025
Thu Apr 24 22:53:17 EDT 2025
Thu Jul 10 16:11:20 EDT 2025
Fri Feb 23 02:32:24 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords clinical implication
interethnic differences
CYP2D6 polymorphism
Language English
License http://www.elsevier.com/tdm/userlicense/1.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c585t-b31f329c4bccd01755adbcced7ed2ffb8b92de256c2a00395f1ea527f5fb75833
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
PMID 22185816
PQID 925719792
PQPubID 23479
PageCount 13
ParticipantIDs swepub_primary_oai_swepub_ki_se_540016
proquest_miscellaneous_925719792
pubmed_primary_22185816
crossref_citationtrail_10_2133_dmpk_DMPK_11_RV_121
crossref_primary_10_2133_dmpk_DMPK_11_RV_121
medicalonline_journals_co1metab_2012_002701_003_0055_00671666266
elsevier_sciencedirect_doi_10_2133_dmpk_DMPK_11_RV_121
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2012
PublicationDateYYYYMMDD 2012-01-01
PublicationDate_xml – year: 2012
  text: 2012
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle DRUG METABOLISM AND PHARMACOKINETICS
PublicationTitleAlternate Drug Metab Pharmacokinet
PublicationYear 2012
Publisher Elsevier Ltd
Japanese Society for the Study of Xenobiotics
Publisher_xml – name: Elsevier Ltd
– name: Japanese Society for the Study of Xenobiotics
References Halling, Petersen, Grandjean, Weihe, Brosen (bb0790) 2008; 18
Guo, Chen, Tan, Klaassen, Zhou (bb0620) 2011
Garcia-Barceló, Chow, Lam, Chiu, Wing, Waye (bb0390) 2000; 46
Yamazaki, Kiyotani, Tsubuko, Matsunaga, Fujieda, Saito, Miura, Kobayashi, Kamataki (bb0290) 2003; 18
Wang, Huang, Lai, Liu, Lai (bb0480) 1993; 53
Gaedigk, Bradford, Alander, Leeder (bb0205) 2006; 34
Marez, Legrand, Sabbagh, Lo-Guidice, Boone, Broly (bb0245) 1996; 97
Ebisawa, Hiratsuka, Sakuyama, Konno, Sasaki, Mizugaki (bb0105) 2005; 20
Mahgoub, Idle, Dring, Lancaster, Smith (bb0035) 1977; 2
Bertilsson, Aberg-Wistedt, Gustafsson, Nordin (bb0540) 1985; 7
Chida, Yokoi, Nemoto, Inaba, Kinoshita, Kamataki (bb0285) 1999; 9
Bertilsson (bb0775) 2010; 88
Sachse, Brockmäller, Bauer, Reum, Roots (bb0270) 1996; 6
Smith, Moss, Gough, Spurr, Wolf (bb0745) 1992; 98
Daly (bb0005) 1995; 73
Parker, Soberman (bb0600) 2011; 31
Goetz, Kamal, Ames (bb0750) 2008; 83
Mann, Miksys, Gaedigk, Kish, Mash, Tyndale (bb0795) 2011
Toyama, Yamashita, Sugiura, Kondo, Iwase, Fujii (bb0700) 2009; 39
Matsunaga, Yamazaki, Kiyotani, Iwano, Saruwatari, Nakagawa, Soyama, Ozawa, Sawada, Kashiyama, Kinoshita, Kamataki (bb0170) 2009; 37
Fuselli, Dupanloup, Frigato, Cruciani, Scozzari, Moral, Sistonen, Sajantila, Barbujani (bb0200) 2004; 12
Bertilsson, Dahl, Sjoqvist, Aberg-Wistedt, Humble, Johansson, Lundqvist, Ingelman-Sundberg (bb0545) 1993; 341
Contreras, Monge-Cazares, Alfaro-Ruiz, Hernandez-Morales, Miranda-Ortiz, Carrillo-Sanchez, Jimenez-Sanchez, Silva-Zolezzi (bb0360) 2011; 12
Ishiguro, Kubota, Sasaki, Iga (bb0135) 2004; 347
Broly, Marez, Lo Guidice, Sabbagh, Legrand, Boone, Meyer (bb0235) 1995; 96
Abduljalil, Frank, Gaedigk, Klaassen, Tomalik-Scharte, Jetter, Jaehde, Kirchheiner, Fuhr (bb0410) 2010; 88
Yokota, Tamura, Furuya, Kimura, Watanabe, Kanazawa, Kondo, Gonzalez (bb0120) 1993; 3
Worrall, Corrigan, High, Starr, Matthias, Wolf, Jones, Hand, Gilford, Farrell, Hoban, Fryer, Strange (bb0735) 1998; 8
Schillevoort, de Boer, van der Weide, Steijns, Roos, Jansen, Leufkens (bb0570) 2002; 12
Wright, Niehaus, Drögemöller, Koen, Gaedigk, Warnich (bb0350) 2010; 74
Kramer, Walker, O'Kane, Mrazek, Fisher, Dukek, Bruflat, Black (bb0335) 2009; 19
Kalow (bb0415) 1982; 7
Jornil, Jensen, Larsen, Linnet (bb0525) 2011; 44
Mikus, Bochner, Eichelbaum, Horak, Somogyi, Spector (bb0530) 1994; 268
Rau, Diepenbruck, Diepenbruck, Eschenhagen (bb0160) 2006; 80
Guthrie (bb0520) 1996
Steen, Molven, Aarskog, Gulbrandsen (bb0215) 1995; 4
Eichelbaum, Spannbrucker, Steinke, Dengler (bb0040) 1979; 16
Dahl (bb0565) 2002; 41
SØrensen, SØrensen, Miners, Somogyi, Grgurinovich, Birkett (bb0630) 2003; 55
Lee, Nam, Hee (bb0430) 1988; 15
Pelkonen, Breimer (bb0020) 1994; 110
Sachse, Brockmöller, Bauer, Roots (bb0080) 1997; 60
Masimirembwa, Persson, Bertilsson, Hasler, Ingelman-Sundberg (bb0140) 1996; 42
Kagimoto, Heim, Kagimoto, Zeugin, Meyer (bb0175) 1990; 265
Okishiro, Taguchi, Jin Kim, Shimazu, Tamaki, Noguchi (bb0695) 2009; 115
Lorizio, Rugo, Beattie, Tchu, Melese, Melisko, Wu, Lawrence, Nikoloff, Ziv (bb0685) 2011; 3
Chou, Yan, de Leon, Barnhill, Rogers, Cronin, Pho, Xiao, Ryder, Liu, Teiling, Wedlund (bb0560) 2000; 20
Gaedigk, Eklund, Pearce, Leeder, Alander, Phillips, Bradford, Kennedy (bb0320) 2007; 81
Johansson, Yue, Dahl, Heim, Säwe, Bertilsson, Meyer, Sjöqvist, Ingelman-Sundberg (bb0450) 1991; 40
Linder, Prough, Valdes (bb0015) 1997; 43
Bertilsson (bb0420) 1995; 29
Panserat, Mura, Gérard, Vincent-Viry, Galteau, Jacqz-Aigrain, Krishnamoorthy (bb0070) 1994; 94
Sakuyama, Sasaki, Ujiie, Obata, Mizugaki, Ishikawa, Hiratsuka (bb0075) 2008; 36
Soyama, Kubo, Miyajima, Saito, Shiseki, Komamura, Ueno, Kamakura, Kitakaze, Tomoike, Ozawa, Sawada (bb0100) 2004; 19
Kelly, Juurlink, Gomes, Duong-Hua, Pritchard, Austin, Paszat (bb0710) 2010; 340
Zhou, Yu, Lin, Wang, Yun, Hu, Wang (bb0345) 2009; 9
Kiyotani, Mushiroda, Sasa, Bando, Sumitomo, Hosono, Kubo, Nakamura, Zembutsu (bb0665) 2008; 99
Raimundo, Toscano, Klein, Fischer, Griese, Eichelbaum, Schwab, Zanger (bb0155) 2004; 76
Marez, Sabbagh, Legrand, Lo-Guidice, Boone, Broly (bb0240) 1995; 5
Zineh, Beitelshees, Gaedigk, Walker, Pauly, Eberst, Leeder, Phillips, Gelfand, Johnson (bb0645) 2004; 76
Klein, Tatzel, Raimundo, Saussele, Hustert, Pleiss, Eichelbaum, Zanger (bb0325) 2007; 35
Bertilsson, Lou, Du, Liu, Kuang, Liao, Wang, Reviriego, Iselius, Sjoqvist (bb0435) 1992; 51
Kawanishi, Lundgren, Agren, Bertilsson (bb0585) 2004; 59
Li, Pan, Porter, Jensen, Silber, Russo, Tine, Heim, Ring, Wedlund (bb0315) 2006; 34
Eichelbaum, Bertilsson, Säwe, Zekorn (bb0045) 1982; 31
Broly, Meyer (bb0115) 1993; 3
Shimada, Yamazaki, Mimura, Inui, Guengerich (bb0025) 1994; 270
Lim, Chen, Singh, Yap, Ng, Wong, Wong, Lee, Chowbay (bb0670) 2011; 71
Lou, Ying, Bertilsson, Sjoqvist (bb0460) 1987; 2
Xu, Sun, Yao, Shi, Wu, Ouyang, Li, Wang, Fan, Fan, Lin, He, Li, Xie (bb0675) 2008; 19
Evert, Griese, Eichelbaum (bb0225) 1994; 4
Bijl, van Schaik, Lammers, Hofman, Vulto, van Gelder, Stricker, Visser (bb0680) 2009; 118
Scordo, Dahl, Spina, Cordici, Arena (bb0800) 2006; 53
Kroemer, Eichelbaum (bb0010) 1995; 56
Gaedigk, Coetsee (bb0260) 2008; 64
Anwar, Abdel-Rahman, El-Zein, Mostafa, Au (bb0730) 1996; 17
Brockmöller, Kirchheiner, Schmider, Walter, Sachse, Müller-Oerlinghausen, Roots (bb0580) 2002; 72
Llerena, Edman, Cobaleda, Benitez, Schalling, Bertilsson (bb0765) 1993; 87
Matimba, Del-Favero, Van Broeckhoven, Masimirembwa (bb0340) 2009; 3
Beard (bb0605) 1992; 2
Pai, Kommaddi, Chinta, Mori, Boyd, Ravindranath (bb0785) 2004; 279
LØvlie, Daly, Idle, Steen (bb0380) 1997; 7
Kubota, Chida, Ishizaki (bb0505) 1996; 60
Zackrisson, Lindblom, Ahlner (bb0770) 2010; 88
Wang, Lai, Huang (bb0130) 1999; 27
Qin, Shen, Zhang, Xie, Shen, Chen, Tang, Xiong, Yang, Shi, Feng, He, Xing (bb0355) 2008; 92
Ismail, Teh, Amir, Alwi, Lopez (bb0495) 2003; 28
Ji, Pan, Marti-Jaun, Hänseler, Rentsch, Hersberger (bb0265) 2002; 48
Pelkonen, Maenpaa, Taavitsainen, Rautio, Raunio (bb0030) 1998; 28
Gaedigk, Bradford, Marcucci, Leeder (bb0305) 2002; 72
London, Daly, Leathart, Navidi, Carpenter, Idle (bb0740) 1997; 18
Oscarson, Hidestrand, Johansson, Ingelman-Sundberg (bb0145) 1997; 52
Wuttke, Rau, Heide, Bergmann, Bohm, Weil, Werner, Eschenhagen (bb0640) 2002; 72
Aklillu, Persson, Bertilsson, Johansson, Rodrigues, Ingelman-Sundberg (bb0370) 1996; 278
Allorge, Bréant, Harlow, Chowdry, Lo-Guidice, Chevalier, Cauffiez, Lhermitte, Blaney, Tucker, Broly, Ellis (bb0295) 2005; 59
Sachse, Brockmöller, Hildebrand, Müller, Roots (bb0385) 1998; 8
Bradford (bb0455) 2002; 3
Dalen, Dahl, Bernal Ruiz, Nordin, Bertilsson (bb0515) 1998; 63
Schroth, Goetz, Hamann, Fasching, Schmidt, Winter, Fritz, Simon, Suman, Ames, Safgren, Kuffel, Ulmer, Bolander, Strick, Beckmann, Koelbl, Weinshilboum, Ingle, Eichelbaum, Schwab, Brauch (bb0655) 2009; 302
Morita, Shimoda, Someya, Yoshimura, Kamijima, Kato (bb0550) 2000; 20
Gaedigk, Jaime, Bertino, Bérard, Pratt, Bradford, Leeder (bb0095) 2010; 1
Tamminga, Wemer, Oosterhuis, de Boer, Vranckx, Drenth, de Zeeuw, de Leij, Jonkman (bb0575) 2003; 59
Daly, Fairbrother, Andreassen, London, Idle, Steen (bb0255) 1996; 6
Johansson, Lundqvist, Bertilsson, Dahl, Sjöqvist, Ingelman-Sundberg (bb0065) 1993; 90
Marez-Allorge, Ellis, Lo Guidice, Tucker, Broly (bb0280) 1999; 9
Caporaso, DeBaun, Rothman (bb0725) 1995; 5
Gaedigk, Ndjountché, Leeder, Bradford (bb0085) 2005; 77
Gaedigk, Ryder, Bradford, Leeder (bb0090) 2003; 49
Teh, Ismail, Yusoff, Hussein, Isa, Rahman (bb0465) 2001; 26
Shimada, Tsumura, Yamazaki, Guengerich, Inoue (bb0195) 2001; 11
Kirchheiner, Nickchen, Bauer, Wong, Licinio, Roots, Brockmoller (bb0555) 2004; 9
Black, Walker, O'Kane, Harmandayan (bb0535) 2011; 40
Kiyotani, Mushiroda, Imamura, Tanigawara, Hosono, Kubo, Sasa, Nakamura, Zembutsu (bb0690) 2012; 131
Gough, Miles, Spurr, Moss, Gaedigk, Eichelbaum, Wolf (bb0180) 1990; 347
Li, Gödecke, Chen, Imai, Lankin, Farnsworth, Pauli, van Breemen, Nikolić (bb0715) 2011
Bernal, Sinues, Johansson, McLellan, Wennerholm, Dahl, Ingelman-Sundberg, Bertilsson (bb0490) 1999; 9
Toscano, Klein, Blievernicht, Schaeffeler, Saussele, Raimundo, Eichelbaum, Schwab, Zanger (bb0165) 2006; 16
Wennerholm, Johansson, Hidestrand, Bertilsson, Gustafsson, Ingelman-Sundberg (bb0150) 2001; 11
Leathart, London, Steward, Adams, Idle, Daly (bb0300) 1998; 8
Gaedigk, Ndjountché, Gaedigk, Leeder, Bradford (bb0310) 2003; 73
Gaedigk, Isidoro-García, Pearce, Sánchez, García-Solaesa, Lorenzo-Romo, Gonzalez-Tejera, Corey (bb0250) 2010; 66
Yokoi, Kosaka, Chida, Chiba, Nakamura, Ishizaki, Kinoshita, Sato, Gonzalez, Kamataki (bb0275) 1996; 6
Nebert (bb0755) 1997; 60
Agúndez, Ramirez, Hernandez, Llerena, Benítez (bb0190) 1997; 7
Thum, Borlak (bb0625) 2000; 355
Griese, Zanger, Brudermanns, Gaedigk, Mikus, Morike, Stuven, Eichelbaum (bb0375) 1998; 8
Bertilsson, Alm, De Las Canserras, Widen, Edman, Schalling (bb0760) 1989; 1
Nakamura, Goto, Ray, McAllister, Jacqz, Wilkinson, Branch (bb0425) 1985; 38
Cai, Nikoloff, Pan, de Leon, Fanti, Fairchild, Koch, Wedlund (bb0400) 2006; 6
Goryachkina, Burbello, Boldueva, Babak, Bergman, Bertilsson (bb0595) 2008; 64
Gaedigk, Hernandez, García-Solaesa, Sánchez, Isidoro-García (bb0405) 2011; 12
Dahl, Johansson, Bertilsson, Ingelman-Sundberg, Sjöqvist (bb0365) 1995; 274
Ismail, Teh (bb0500) 2001; 57
Kimura, Umeno, Skoda, Meyer, Gonzalez (bb0055) 1989; 45
Johansson, Oscarson, Yue, Bertilsson, Sjoqvist, Ingelman-Sundberg (bb0125) 1994; 46
Gaedigk, Blum, Gaedigk, Eichelbaum, Mayer (bb0210) 1991; 48
Tyndale, Aoyama, Broly, Matsunaga, Inaba, Kalow, Gelboin, Meyer, Gonzalez (bb0110) 1991; 1
Saxena, Shaw, Relling, Frame, Moir, Evans, Caporaso, Weiffenbach (bb0220) 1994; 3
Träskman, Äsberg, Bertilsson, Sjöstrand (bb0780) 1981; 38
Marez, Legrand, Sabbagh, Lo Guidice, Spire, Lafitte, Meyer, Broly (bb0060) 1997; 7
Barclay, Sawyers, Begg, Zhang, Roberts, Kennedy, Elliott (bb0635) 2003; 13
Daly, Leathart, London, Idle (bb0230) 1995; 95
Zakrzewski-Jakubiak, Doan, Lamoureux, Singh, Turgeon, Tannenbaum (bb0610) 2011
Aubert, Stanek, Yao, Teagarden, Subar, Epstein, Skaar, Desta, Flockhart (bb0705) 2009; 27
Nelson, Koymans, Kamataki, Stegeman, Feyere
Toscano (10.2133/dmpk.DMPK-11-RV-121_bb0165) 2006; 16
Eichelbaum (10.2133/dmpk.DMPK-11-RV-121_bb0040) 1979; 16
Dalen (10.2133/dmpk.DMPK-11-RV-121_bb0515) 1998; 63
Nebert (10.2133/dmpk.DMPK-11-RV-121_bb0755) 1997; 60
Klein (10.2133/dmpk.DMPK-11-RV-121_bb0325) 2007; 35
Mikus (10.2133/dmpk.DMPK-11-RV-121_bb0530) 1994; 268
Garcia-Barceló (10.2133/dmpk.DMPK-11-RV-121_bb0390) 2000; 46
Wright (10.2133/dmpk.DMPK-11-RV-121_bb0350) 2010; 74
Kubota (10.2133/dmpk.DMPK-11-RV-121_bb0505) 1996; 60
Caraci (10.2133/dmpk.DMPK-11-RV-121_bb0720) 2011; 12
Dahl (10.2133/dmpk.DMPK-11-RV-121_bb0565) 2002; 41
Roh (10.2133/dmpk.DMPK-11-RV-121_bb0440) 1996; 6
Guthrie (10.2133/dmpk.DMPK-11-RV-121_bb0520) 1996
Hanioka (10.2133/dmpk.DMPK-11-RV-121_bb0185) 1990; 47
Leathart (10.2133/dmpk.DMPK-11-RV-121_bb0300) 1998; 8
Zackrisson (10.2133/dmpk.DMPK-11-RV-121_bb0770) 2010; 88
Yu (10.2133/dmpk.DMPK-11-RV-121_bb0475) 2002; 303
Zakrzewski-Jakubiak (10.2133/dmpk.DMPK-11-RV-121_bb0610) 2011
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0320) 2007; 81
Thum (10.2133/dmpk.DMPK-11-RV-121_bb0625) 2000; 355
Lim (10.2133/dmpk.DMPK-11-RV-121_bb0670) 2011; 71
Raimundo (10.2133/dmpk.DMPK-11-RV-121_bb0155) 2004; 76
Johansson (10.2133/dmpk.DMPK-11-RV-121_bb0450) 1991; 40
Beard (10.2133/dmpk.DMPK-11-RV-121_bb0605) 1992; 2
Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0510) 1996; 5
Matsunaga (10.2133/dmpk.DMPK-11-RV-121_bb0170) 2009; 37
Kirchheiner (10.2133/dmpk.DMPK-11-RV-121_bb0555) 2004; 9
Schillevoort (10.2133/dmpk.DMPK-11-RV-121_bb0570) 2002; 12
Pelkonen (10.2133/dmpk.DMPK-11-RV-121_bb0020) 1994; 110
Halling (10.2133/dmpk.DMPK-11-RV-121_bb0790) 2008; 18
Ji (10.2133/dmpk.DMPK-11-RV-121_bb0265) 2002; 48
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0260) 2008; 64
Worrall (10.2133/dmpk.DMPK-11-RV-121_bb0735) 1998; 8
Chou (10.2133/dmpk.DMPK-11-RV-121_bb0560) 2000; 20
Barclay (10.2133/dmpk.DMPK-11-RV-121_bb0635) 2003; 13
Gough (10.2133/dmpk.DMPK-11-RV-121_bb0180) 1990; 347
Yokoi (10.2133/dmpk.DMPK-11-RV-121_bb0275) 1996; 6
Sachse (10.2133/dmpk.DMPK-11-RV-121_bb0270) 1996; 6
Kimura (10.2133/dmpk.DMPK-11-RV-121_bb0055) 1989; 45
Llerena (10.2133/dmpk.DMPK-11-RV-121_bb0765) 1993; 87
Lee (10.2133/dmpk.DMPK-11-RV-121_bb0430) 1988; 15
SØrensen (10.2133/dmpk.DMPK-11-RV-121_bb0630) 2003; 55
Agúndez (10.2133/dmpk.DMPK-11-RV-121_bb0190) 1997; 7
Lee (10.2133/dmpk.DMPK-11-RV-121_bb0330) 2009; 37
Sachse (10.2133/dmpk.DMPK-11-RV-121_bb0080) 1997; 60
Mann (10.2133/dmpk.DMPK-11-RV-121_bb0795) 2011
Wennerholm (10.2133/dmpk.DMPK-11-RV-121_bb0150) 2001; 11
Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0545) 1993; 341
Abduljalil (10.2133/dmpk.DMPK-11-RV-121_bb0410) 2010; 88
Kalow (10.2133/dmpk.DMPK-11-RV-121_bb0415) 1982; 7
Ishiguro (10.2133/dmpk.DMPK-11-RV-121_bb0135) 2004; 347
Kiyotani (10.2133/dmpk.DMPK-11-RV-121_bb0690) 2012; 131
Mahgoub (10.2133/dmpk.DMPK-11-RV-121_bb0035) 1977; 2
Anwar (10.2133/dmpk.DMPK-11-RV-121_bb0730) 1996; 17
Pelkonen (10.2133/dmpk.DMPK-11-RV-121_bb0030) 1998; 28
Lorizio (10.2133/dmpk.DMPK-11-RV-121_bb0685) 2011; 3
Schroth (10.2133/dmpk.DMPK-11-RV-121_bb0655) 2009; 302
LØvlie (10.2133/dmpk.DMPK-11-RV-121_bb0380) 1997; 7
Wang (10.2133/dmpk.DMPK-11-RV-121_bb0130) 1999; 27
Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0420) 1995; 29
Yokota (10.2133/dmpk.DMPK-11-RV-121_bb0120) 1993; 3
Träskman (10.2133/dmpk.DMPK-11-RV-121_bb0780) 1981; 38
Bijl (10.2133/dmpk.DMPK-11-RV-121_bb0680) 2009; 118
Griese (10.2133/dmpk.DMPK-11-RV-121_bb0375) 1998; 8
Lou (10.2133/dmpk.DMPK-11-RV-121_bb0460) 1987; 2
Okishiro (10.2133/dmpk.DMPK-11-RV-121_bb0695) 2009; 115
Teh (10.2133/dmpk.DMPK-11-RV-121_bb0465) 2001; 26
Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0775) 2010; 88
Soyama (10.2133/dmpk.DMPK-11-RV-121_bb0100) 2004; 19
Rau (10.2133/dmpk.DMPK-11-RV-121_bb0160) 2006; 80
Steen (10.2133/dmpk.DMPK-11-RV-121_bb0215) 1995; 4
Aklillu (10.2133/dmpk.DMPK-11-RV-121_bb0370) 1996; 278
London (10.2133/dmpk.DMPK-11-RV-121_bb0740) 1997; 18
Tyndale (10.2133/dmpk.DMPK-11-RV-121_bb0110) 1991; 1
Chida (10.2133/dmpk.DMPK-11-RV-121_bb0285) 1999; 9
Marez-Allorge (10.2133/dmpk.DMPK-11-RV-121_bb0280) 1999; 9
Kelly (10.2133/dmpk.DMPK-11-RV-121_bb0710) 2010; 340
Wanwimolruk (10.2133/dmpk.DMPK-11-RV-121_bb0470) 1990; 29
Ismail (10.2133/dmpk.DMPK-11-RV-121_bb0500) 2001; 57
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0205) 2006; 34
Panserat (10.2133/dmpk.DMPK-11-RV-121_bb0070) 1994; 94
Ebisawa (10.2133/dmpk.DMPK-11-RV-121_bb0105) 2005; 20
Dahl (10.2133/dmpk.DMPK-11-RV-121_bb0365) 1995; 274
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0250) 2010; 66
Caporaso (10.2133/dmpk.DMPK-11-RV-121_bb0725) 1995; 5
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0305) 2002; 72
Zineh (10.2133/dmpk.DMPK-11-RV-121_bb0645) 2004; 76
Goetz (10.2133/dmpk.DMPK-11-RV-121_bb0750) 2008; 83
Shimada (10.2133/dmpk.DMPK-11-RV-121_bb0025) 1994; 270
Sakuyama (10.2133/dmpk.DMPK-11-RV-121_bb0075) 2008; 36
Zhou (10.2133/dmpk.DMPK-11-RV-121_bb0345) 2009; 9
Yamazaki (10.2133/dmpk.DMPK-11-RV-121_bb0290) 2003; 18
Smith (10.2133/dmpk.DMPK-11-RV-121_bb0745) 1992; 98
Guo (10.2133/dmpk.DMPK-11-RV-121_bb0620) 2011
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0210) 1991; 48
Parker (10.2133/dmpk.DMPK-11-RV-121_bb0600) 2011; 31
Matimba (10.2133/dmpk.DMPK-11-RV-121_bb0340) 2009; 3
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0090) 2003; 49
Oscarson (10.2133/dmpk.DMPK-11-RV-121_bb0145) 1997; 52
Kramer (10.2133/dmpk.DMPK-11-RV-121_bb0335) 2009; 19
Lennard (10.2133/dmpk.DMPK-11-RV-121_bb0590) 1983; 34
Li (10.2133/dmpk.DMPK-11-RV-121_bb0715) 2011
Broly (10.2133/dmpk.DMPK-11-RV-121_bb0115) 1993; 3
Bradford (10.2133/dmpk.DMPK-11-RV-121_bb0455) 2002; 3
Scordo (10.2133/dmpk.DMPK-11-RV-121_bb0800) 2006; 53
Marez (10.2133/dmpk.DMPK-11-RV-121_bb0060) 1997; 7
Tateishi (10.2133/dmpk.DMPK-11-RV-121_bb0445) 1999; 65
Wuttke (10.2133/dmpk.DMPK-11-RV-121_bb0640) 2002; 72
Mitsunaga (10.2133/dmpk.DMPK-11-RV-121_bb0395) 2002; 505
Linder (10.2133/dmpk.DMPK-11-RV-121_bb0015) 1997; 43
Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0760) 1989; 1
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0310) 2003; 73
Tamminga (10.2133/dmpk.DMPK-11-RV-121_bb0575) 2003; 59
Black (10.2133/dmpk.DMPK-11-RV-121_bb0535) 2011; 40
Marez (10.2133/dmpk.DMPK-11-RV-121_bb0240) 1995; 5
Brockmöller (10.2133/dmpk.DMPK-11-RV-121_bb0580) 2002; 72
Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0435) 1992; 51
Qin (10.2133/dmpk.DMPK-11-RV-121_bb0355) 2008; 92
Daly (10.2133/dmpk.DMPK-11-RV-121_bb0230) 1995; 95
Broly (10.2133/dmpk.DMPK-11-RV-121_bb0235) 1995; 96
Hamelin (10.2133/dmpk.DMPK-11-RV-121_bb0615) 2000; 67
Masimirembwa (10.2133/dmpk.DMPK-11-RV-121_bb0140) 1996; 42
Lim (10.2133/dmpk.DMPK-11-RV-121_bb0660) 2007; 25
Sachse (10.2133/dmpk.DMPK-11-RV-121_bb0385) 1998; 8
Fuselli (10.2133/dmpk.DMPK-11-RV-121_bb0200) 2004; 12
Evert (10.2133/dmpk.DMPK-11-RV-121_bb0225) 1994; 4
Toyama (10.2133/dmpk.DMPK-11-RV-121_bb0700) 2009; 39
Xu (10.2133/dmpk.DMPK-11-RV-121_bb0675) 2008; 19
Johansson (10.2133/dmpk.DMPK-11-RV-121_bb0125) 1994; 46
Contreras (10.2133/dmpk.DMPK-11-RV-121_bb0360) 2011; 12
Nakamura (10.2133/dmpk.DMPK-11-RV-121_bb0425) 1985; 38
Bernal (10.2133/dmpk.DMPK-11-RV-121_bb0490) 1999; 9
Kawanishi (10.2133/dmpk.DMPK-11-RV-121_bb0585) 2004; 59
Kagimoto (10.2133/dmpk.DMPK-11-RV-121_bb0175) 1990; 265
Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0540) 1985; 7
Saxena (10.2133/dmpk.DMPK-11-RV-121_bb0220) 1994; 3
Li (10.2133/dmpk.DMPK-11-RV-121_bb0315) 2006; 34
Aubert (10.2133/dmpk.DMPK-11-RV-121_bb0705) 2009; 27
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0095) 2010; 1
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0405) 2011; 12
Wennerholm (10.2133/dmpk.DMPK-11-RV-121_bb0485) 2002; 71
Eichelbaum (10.2133/dmpk.DMPK-11-RV-121_bb0045) 1982; 31
Cai (10.2133/dmpk.DMPK-11-RV-121_bb0400) 2006; 6
Ismail (10.2133/dmpk.DMPK-11-RV-121_bb0495) 2003; 28
Schroth (10.2133/dmpk.DMPK-11-RV-121_bb0650) 2007; 25
Goryachkina (10.2133/dmpk.DMPK-11-RV-121_bb0595) 2008; 64
Johansson (10.2133/dmpk.DMPK-11-RV-121_bb0065) 1993; 90
Morita (10.2133/dmpk.DMPK-11-RV-121_bb0550) 2000; 20
Jornil (10.2133/dmpk.DMPK-11-RV-121_bb0525) 2011; 44
Daly (10.2133/dmpk.DMPK-11-RV-121_bb0255) 1996; 6
Pai (10.2133/dmpk.DMPK-11-RV-121_bb0785) 2004; 279
Kroemer (10.2133/dmpk.DMPK-11-RV-121_bb0010) 1995; 56
Marez (10.2133/dmpk.DMPK-11-RV-121_bb0245) 1996; 97
Wang (10.2133/dmpk.DMPK-11-RV-121_bb0480) 1993; 53
Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0085) 2005; 77
Nelson (10.2133/dmpk.DMPK-11-RV-121_bb0050) 1996; 6
Allorge (10.2133/dmpk.DMPK-11-RV-121_bb0295) 2005; 59
Daly (10.2133/dmpk.DMPK-11-RV-121_bb0005) 1995; 73
Shimada (10.2133/dmpk.DMPK-11-RV-121_bb0195) 2001; 11
Kiyotani (10.2133/dmpk.DMPK-11-RV-121_bb0665) 2008; 99
References_xml – volume: 36
  start-page: 2460
  year: 2008
  end-page: 2467
  ident: bb0075
  article-title: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47–51, 53-55, and 57)
  publication-title: Drug Metab. Dispos.
– volume: 17
  start-page: 1923
  year: 1996
  end-page: 1929
  ident: bb0730
  article-title: Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients
  publication-title: Carcinogenesis
– volume: 20
  start-page: 294
  year: 2005
  end-page: 299
  ident: bb0105
  article-title: Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals
  publication-title: Drug Metab. Pharmacokinet.
– volume: 87
  start-page: 23
  year: 1993
  end-page: 28
  ident: bb0765
  article-title: Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P 4502D6
  publication-title: Acta Psychiatr. Scand.
– volume: 12
  start-page: 570
  year: 2011
  end-page: 577
  ident: bb0720
  article-title: Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract
  publication-title: Curr. Drug Metab.
– volume: 1
  start-page: 555
  year: 1989
  ident: bb0760
  article-title: Debrisoquine hydroxylation polymorphism and personality [letter]
  publication-title: Lancet
– start-page: 172
  year: 1996
  end-page: 186
  ident: bb0520
  article-title: The mammoth steppe and the origin of mongoloids and their dispersal
  publication-title: Prehistoric Mongoloid Dispersals
– volume: 341
  start-page: 63
  year: 1993
  ident: bb0545
  article-title: Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine
  publication-title: Lancet
– volume: 279
  start-page: 27383
  year: 2004
  end-page: 27389
  ident: bb0785
  article-title: A frame shift mutation and alternate splicing in human brain generates a functional form of the pseudogene, cytochrome P4502D7 that demethylates codeine to morphine
  publication-title: J. Biol. Chem.
– volume: 6
  start-page: 269
  year: 1996
  end-page: 272
  ident: bb0270
  article-title: A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D6*15
  publication-title: Pharmacogenetics
– volume: 270
  start-page: 414
  year: 1994
  end-page: 423
  ident: bb0025
  article-title: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians
  publication-title: J. Pharmacol. Exp. Ther.
– volume: 5
  start-page: 200
  year: 1996
  end-page: 223
  ident: bb0510
  article-title: Polymorphic drug oxidation
  publication-title: Relevance to the treatment of psychiatric disorders. CNS Drugs
– year: 2011
  ident: bb0795
  article-title: The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients
  publication-title: Neurobiol. Aging
– volume: 12
  start-page: 235
  year: 2002
  end-page: 240
  ident: bb0570
  article-title: Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case–control study
  publication-title: Pharmacogenetics
– volume: 71
  start-page: 737
  year: 2011
  end-page: 750
  ident: bb0670
  article-title: Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients
  publication-title: Br. J. Clin. Pharmacol.
– volume: 302
  start-page: 1429
  year: 2009
  end-page: 1436
  ident: bb0655
  article-title: Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
  publication-title: JAMA
– volume: 76
  start-page: 128
  year: 2004
  end-page: 138
  ident: bb0155
  article-title: A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
  publication-title: Clin. Pharmacol. Ther.
– volume: 60
  start-page: 284
  year: 1997
  end-page: 295
  ident: bb0080
  article-title: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences
  publication-title: Am. J. Hum. Genet.
– volume: 29
  start-page: 192
  year: 1995
  end-page: 209
  ident: bb0420
  article-title: Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19
  publication-title: Clin. Pharmacokinet.
– volume: 303
  start-page: 1291
  year: 2002
  end-page: 1300
  ident: bb0475
  article-title: Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelicisoforms
  publication-title: J. Pharmacol. Exp. Ther.
– volume: 59
  start-page: 339
  year: 2005
  end-page: 346
  ident: bb0295
  article-title: Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution
  publication-title: Proteins
– volume: 26
  start-page: 205
  year: 2001
  end-page: 211
  ident: bb0465
  article-title: Heterogeneity of the CYP2D6 gene among Malays in Malaysia
  publication-title: J. Clin. Pharm. Ther.
– volume: 38
  start-page: 631
  year: 1981
  end-page: 636
  ident: bb0780
  article-title: Monoamine metabolites in CSF and suicidal behavior
  publication-title: Arch. Gen. Psychiatry
– volume: 74
  start-page: 340
  year: 2010
  end-page: 350
  ident: bb0350
  article-title: Elucidation of CYP2D6 genetic diversity in a unique African population: implications for the future application of pharmacogenetics in the Xhosa population
  publication-title: Ann. Hum. Genet.
– volume: 8
  start-page: 181
  year: 1998
  end-page: 185
  ident: bb0385
  article-title: Correctness of prediction of the CYP2D6 phenotype confirmed by genotyping 47 intermediate and poor metabolizers of debrisoquine
  publication-title: Pharmacogenetics
– volume: 16
  start-page: 183
  year: 1979
  end-page: 187
  ident: bb0040
  article-title: Defective N-oxidation of sparteine in man: a new pharmacogenetic defect
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 34
  start-page: 563
  year: 2006
  end-page: 569
  ident: bb0205
  article-title: CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status
  publication-title: Drug Metab. Dispos.
– volume: 72
  start-page: 76
  year: 2002
  end-page: 89
  ident: bb0305
  article-title: Unique CYP22006)D6 activity distribution and genotype-phenotype discordance in black Americans
  publication-title: Clin. Pharmacol. Ther.
– volume: 19
  start-page: 1423
  year: 2008
  end-page: 1429
  ident: bb0675
  article-title: Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment
  publication-title: Ann. Oncol.
– volume: 110
  start-page: 289
  year: 1994
  end-page: 332
  ident: bb0020
  article-title: Role of environmental factors in the pharmacokinetics of drugs: Considerations with respect to animal models, P-450 enzymes, and probe drugs
  publication-title: Handb. Exp. Pharmacol.
– volume: 46
  start-page: 1411
  year: 2000
  end-page: 1413
  ident: bb0390
  article-title: Occurrence of CYP2D6 gene duplication in Hong Kong Chinese
  publication-title: Clin. Chem.
– volume: 355
  start-page: 979
  year: 2000
  end-page: 983
  ident: bb0625
  article-title: Gene expression in distinct regions of the heart
  publication-title: Lancet
– volume: 88
  start-page: 354
  year: 2010
  end-page: 359
  ident: bb0770
  article-title: High Frequency of Occurrence of CYP2D6 Gene Duplication/Multiduplication Indicating Ultrarapid Metabolism Among Suicide Cases
  publication-title: Clin. Pharmacol. Ther.
– volume: 83
  start-page: 160
  year: 2008
  end-page: 166
  ident: bb0750
  article-title: Tamoxifen Pharmacogenomics: The Role of CYP2D6 as a Predictor of Drug Response
  publication-title: Clin. Pharmacol. Ther.
– volume: 73
  start-page: 575
  year: 2003
  end-page: 576
  ident: bb0310
  article-title: Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects
  publication-title: Clin. Pharmacol. Ther.
– volume: 5
  start-page: 305
  year: 1995
  end-page: 311
  ident: bb0240
  article-title: A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype
  publication-title: Pharmacogenetics
– volume: 35
  start-page: 1247
  year: 2007
  end-page: 1250
  ident: bb0325
  article-title: A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6
  publication-title: Drug Metab. Dispos.
– volume: 66
  start-page: 859
  year: 2010
  end-page: 864
  ident: bb0250
  article-title: Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 20
  start-page: 246
  year: 2000
  end-page: 251
  ident: bb0560
  article-title: Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness
  publication-title: J. Clin. Psychopharmacol.
– volume: 19
  start-page: 313
  year: 2004
  end-page: 319
  ident: bb0100
  article-title: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene
  publication-title: Drug Metab. Pharmacokinet.
– volume: 65
  start-page: 570
  year: 1999
  end-page: 575
  ident: bb0445
  article-title: Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese Population
  publication-title: Clin. Pharmacol. Ther.
– volume: 9
  start-page: 287
  year: 1999
  end-page: 293
  ident: bb0285
  article-title: A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype
  publication-title: Pharmacogenetics
– volume: 55
  start-page: 635
  year: 2003
  end-page: 638
  ident: bb0630
  article-title: Polymorphic hydroxylation of perhexiline in vitro
  publication-title: Br. J. Clin. Pharmacol.
– volume: 48
  start-page: 943
  year: 1991
  end-page: 950
  ident: bb0210
  article-title: Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metaboliser of the debrisoquine/sparteine polymorphism
  publication-title: Am. J. Hum. Genet.
– volume: 4
  start-page: 2251
  year: 1995
  end-page: 2257
  ident: bb0215
  article-title: Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene
  publication-title: Hum. Mol. Genet.
– volume: 4
  start-page: 271
  year: 1994
  end-page: 274
  ident: bb0225
  article-title: Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codon
  publication-title: Pharmacogenetics
– volume: 11
  start-page: 143
  year: 2001
  end-page: 156
  ident: bb0195
  article-title: Characterization of (+/—)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6
  publication-title: Pharmacogenetics
– volume: 27
  start-page: 385
  year: 1999
  end-page: 388
  ident: bb0130
  article-title: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese
  publication-title: Drug Metab. Dispos.
– volume: 340
  start-page: c693
  year: 2010
  ident: bb0710
  article-title: Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: A population based cohort study
  publication-title: BMJ
– volume: 8
  start-page: 433
  year: 1998
  end-page: 439
  ident: bb0735
  article-title: Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6
  publication-title: Pharmacogenetics
– volume: 28
  start-page: 279
  year: 2003
  end-page: 284
  ident: bb0495
  article-title: Genetic polymorphism of CYP2D6 in Chinese subjects in Malaysia
  publication-title: J. Clin. Pharm. Ther.
– volume: 12
  start-page: 1617
  year: 2011
  end-page: 1622
  ident: bb0405
  article-title: Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: esolution of AmpliChip CYP450 test no-calls
  publication-title: Pharmacogenomics
– volume: 2
  start-page: 356
  year: 1992
  end-page: 367
  ident: bb0605
  article-title: Adverse reactions as a cause of hospital admission in the aged
  publication-title: Drugs Aging
– volume: 7
  start-page: 337
  year: 1997
  end-page: 340
  ident: bb0190
  article-title: Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe
  publication-title: Pharmacogenetics
– volume: 39
  start-page: 651
  year: 2009
  end-page: 656
  ident: bb0700
  article-title: No Association Between CYP2D6*10 Genotype and Survival of Node-negative Japanese Breast Cancer Patients Receiving Adjuvant Tamoxifen Treatment
  publication-title: Jpn. J. Clin. Oncol.
– volume: 274
  start-page: 516
  year: 1995
  end-page: 520
  ident: bb0365
  article-title: Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
  publication-title: J. Pharmacol. Exp. Ther.
– volume: 67
  start-page: 466
  year: 2000
  end-page: 477
  ident: bb0615
  article-title: Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity
  publication-title: Clin. Pharmacol. Ther.
– volume: 71
  start-page: 77
  year: 2002
  end-page: 88
  ident: bb0485
  article-title: The African-specific CYP2D6*17 allele encodes an enzyme with changed substrate specificity
  publication-title: Clin. Pharmacol. Ther.
– volume: 2
  start-page: 852
  year: 1987
  end-page: 853
  ident: bb0460
  article-title: Low frequency of slow debrisoquine hydroxylation in a native Chinese population
  publication-title: Lancet
– volume: 11
  start-page: 417
  year: 2001
  end-page: 427
  ident: bb0150
  article-title: Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity
  publication-title: Pharmacogenetics
– volume: 47
  start-page: 994
  year: 1990
  end-page: 1001
  ident: bb0185
  article-title: The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934—A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site
  publication-title: Am. J. Hum. Genet.
– volume: 118
  start-page: 125
  year: 2009
  end-page: 130
  ident: bb0680
  article-title: The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users
  publication-title: Breast Cancer Res. Treat.
– volume: 6
  start-page: 343
  year: 2006
  end-page: 350
  ident: bb0400
  article-title: CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing
  publication-title: Pharmacogenomics J.
– volume: 72
  start-page: 429
  year: 2002
  end-page: 437
  ident: bb0640
  article-title: Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol-associated adverse effects
  publication-title: Clin. Pharmacol. Ther.
– volume: 6
  start-page: 441
  year: 1996
  end-page: 447
  ident: bb0440
  article-title: Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population
  publication-title: Pharmacogenetics
– volume: 278
  start-page: 441
  year: 1996
  end-page: 446
  ident: bb0370
  article-title: Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
  publication-title: J. Pharmacol. Exp. Ther.
– year: 2011
  ident: bb0715
  article-title: In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4
  publication-title: Xenobiotica
– volume: 44
  start-page: 265
  year: 2011
  end-page: 272
  ident: bb0525
  article-title: Risk assessment of accidental nortriptyline poisoning: The importance of cytochrome P450 for nortriptyline elimination investigated using a population-based pharmacokinetic simulator
  publication-title: Eur. J. Pharm. Sci.
– volume: 37
  start-page: 699
  year: 2009
  end-page: 701
  ident: bb0170
  article-title: Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese
  publication-title: Drug Metab. Dispos.
– volume: 37
  start-page: 1464
  year: 2009
  end-page: 1470
  ident: bb0330
  article-title: Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans
  publication-title: Drug Metab. Dispos.
– volume: 115
  start-page: 952
  year: 2009
  end-page: 961
  ident: bb0695
  article-title: Genetic polymorphisms of CYP2D6*10 and CYP2C19* 2,* 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen
  publication-title: Cancer
– volume: 3
  start-page: 256
  year: 1993
  end-page: 263
  ident: bb0120
  article-title: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism
  publication-title: Pharmacogenetics
– volume: 29
  start-page: 244
  year: 1990
  end-page: 247
  ident: bb0470
  article-title: Evidence for the polymorphic oxidation of debrisoquine in New Zealand Caucasians
  publication-title: Br. J. Clin. Pharmacol.
– volume: 92
  start-page: 152
  year: 2008
  end-page: 158
  ident: bb0355
  article-title: Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China
  publication-title: Genomics
– volume: 88
  start-page: 304
  year: 2010
  end-page: 305
  ident: bb0775
  article-title: CYP2D6, serotonin and suicide—a relationship?
  publication-title: Clin. Pharmacol. Ther.
– volume: 48
  start-page: 983
  year: 2002
  end-page: 988
  ident: bb0265
  article-title: Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14B allele in mainland Chinese
  publication-title: Clin. Chem.
– volume: 80
  start-page: 555
  year: 2006
  end-page: 558
  ident: bb0160
  article-title: The 2988G>A polymorphism affects splicing of a CYP2D6 minigene
  publication-title: Clin. Pharmacol. Ther.
– volume: 73
  start-page: 539
  year: 1995
  end-page: 553
  ident: bb0005
  article-title: Molecular basis of polymorphic drug metabolism
  publication-title: J. Mol. Med.
– volume: 40
  start-page: 111
  year: 2011
  end-page: 119
  ident: bb0535
  article-title: Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
  publication-title: Drug Metab. Dispos.
– volume: 7
  start-page: 478
  year: 1985
  end-page: 480
  ident: bb0540
  article-title: Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants
  publication-title: Ther. Drug Monit.
– volume: 131
  start-page: 137
  year: 2012
  end-page: 145
  ident: bb0690
  article-title: Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients
  publication-title: Breast Cancer Res. Treat.
– volume: 25
  start-page: 5187
  year: 2007
  end-page: 5193
  ident: bb0650
  article-title: Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
  publication-title: J. Clin. Oncol.
– volume: 3
  start-page: 923
  year: 1994
  end-page: 926
  ident: bb0220
  article-title: Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype
  publication-title: Hum. Mol. Genet.
– volume: 15
  start-page: 889
  year: 1988
  end-page: 891
  ident: bb0430
  article-title: Oxidation phenotyping in Chinese and Malay populations
  publication-title: Clin. Exp. Pharmacol. Physiol.
– volume: 42
  start-page: 713
  year: 1996
  end-page: 719
  ident: bb0140
  article-title: A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity
  publication-title: Br. J. Clin. Pharmacol.
– volume: 2
  start-page: 584
  year: 1977
  end-page: 586
  ident: bb0035
  article-title: Polymorphic hydroxylation of debrisoquine in man
  publication-title: Lancet
– volume: 16
  start-page: 755
  year: 2006
  end-page: 766
  ident: bb0165
  article-title: Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events
  publication-title: Pharmacogenet. Genomics
– volume: 9
  start-page: 442
  year: 2004
  end-page: 473
  ident: bb0555
  article-title: Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
  publication-title: Mol. Psychiatry
– volume: 6
  start-page: 1
  year: 1996
  end-page: 42
  ident: bb0050
  article-title: P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
  publication-title: Pharmacogenetics
– volume: 505
  start-page: 83
  year: 2002
  end-page: 85
  ident: bb0395
  article-title: Frequent occurrence of CYP2D6*10 duplication allele in a Japanese population
  publication-title: Mutat. Res.
– volume: 3
  start-page: 64
  year: 2011
  ident: bb0685
  article-title: Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment
  publication-title: Genome Med.
– volume: 98
  start-page: 107
  year: 1992
  end-page: 112
  ident: bb0745
  article-title: Molecular Genetic Analysis of the Cytochrome P450-Debrisoquine Hydroxylase Locus and Association with Cancer Susceptibility
  publication-title: Environ. Health Perspect.
– volume: 12
  start-page: 916
  year: 2004
  end-page: 924
  ident: bb0200
  article-title: Molecular diversity at the CYP2D6 locus in the Mediterranean region
  publication-title: Eur. J. Hum. Genet.
– volume: 7
  start-page: 149
  year: 1997
  end-page: 152
  ident: bb0380
  article-title: Characterization of the 16+9 kb and 30+9 kb CYP2D6 Xbal haplotypes
  publication-title: Pharmacogenetics
– volume: 97
  start-page: 668
  year: 1996
  end-page: 670
  ident: bb0245
  article-title: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine
  publication-title: Hum. Genet.
– volume: 25
  start-page: 3837
  year: 2007
  end-page: 3845
  ident: bb0660
  article-title: Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
  publication-title: J. Clin. Oncol.
– volume: 45
  start-page: 889
  year: 1989
  end-page: 904
  ident: bb0055
  article-title: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
  publication-title: Am. J. Hum. Genet.
– volume: 9
  start-page: 380
  year: 2009
  end-page: 394
  ident: bb0345
  article-title: Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese
  publication-title: Pharmacogenomics J.
– volume: 41
  start-page: 453
  year: 2002
  end-page: 470
  ident: bb0565
  article-title: Cytochrome P450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?
  publication-title: Clin. Pharmacokinet.
– volume: 31
  start-page: 630
  year: 2011
  end-page: 641
  ident: bb0600
  article-title: Effects of paroxetine on the pharmacokinetics and pharmacodynamics of immediate-release and extended-release metoprolol
  publication-title: Pharmacotherapy
– volume: 59
  start-page: 57
  year: 2003
  end-page: 64
  ident: bb0575
  article-title: Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 99
  start-page: 995
  year: 2008
  end-page: 999
  ident: bb0665
  article-title: Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy
  publication-title: Cancer Sci.
– volume: 56
  start-page: 2285
  year: 1995
  end-page: 2298
  ident: bb0010
  article-title: “It's the genes, stupid”. Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism
  publication-title: Life Sci.
– volume: 8
  start-page: 529
  year: 1998
  end-page: 541
  ident: bb0300
  article-title: CYP2D6 phenotypegenotype relationships in African-Americans and Caucasians in Los Angeles
  publication-title: Pharmacogenetics
– volume: 76
  start-page: 536
  year: 2004
  end-page: 544
  ident: bb0645
  article-title: Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension
  publication-title: Clin. Pharmacol. Ther.
– volume: 34
  start-page: 1411
  year: 2006
  end-page: 1416
  ident: bb0315
  article-title: New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes
  publication-title: Drug Metab. Dispos.
– volume: 13
  start-page: 627
  year: 2003
  end-page: 632
  ident: bb0635
  article-title: Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status
  publication-title: Pharmacogenetics
– volume: 49
  start-page: 1008
  year: 2003
  end-page: 1011
  ident: bb0090
  article-title: CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism
  publication-title: Clin. Chem.
– volume: 46
  start-page: 452
  year: 1994
  end-page: 459
  ident: bb0125
  article-title: Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
  publication-title: Mol. Pharmacol.
– volume: 18
  start-page: 269
  year: 2003
  end-page: 271
  ident: bb0290
  article-title: Two novel haplotypes of CYP2D6 gene in a Japanese population
  publication-title: Drug Metab. Pharmacokinet.
– volume: 9
  start-page: 657
  year: 1999
  end-page: 660
  ident: bb0490
  article-title: Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultra-rapid metabolism of debrisoquine
  publication-title: Pharmacogenetics
– volume: 5
  start-page: S129
  year: 1995
  end-page: S134
  ident: bb0725
  article-title: Lung cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association
  publication-title: Pharmacogenetics
– volume: 7
  start-page: 193
  year: 1997
  end-page: 202
  ident: bb0060
  article-title: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution
  publication-title: Pharmacogenetics
– volume: 34
  start-page: 732
  year: 1983
  end-page: 737
  ident: bb0590
  article-title: Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers
  publication-title: Clin. Pharmacol. Ther.
– volume: 90
  start-page: 11825
  year: 1993
  end-page: 11829
  ident: bb0065
  article-title: Inherited amplification of an active gene in the cytochrome P450 CYP2D-locus as a cause of ultrarapid metabolism of debrisoquine
  publication-title: Proc. Natl. Acad. Sci. USA
– volume: 52
  start-page: 1034
  year: 1997
  end-page: 1040
  ident: bb0145
  article-title: A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function
  publication-title: Mol. Pharmacol.
– volume: 9
  start-page: 393
  year: 1999
  end-page: 396
  ident: bb0280
  article-title: A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype
  publication-title: Pharmacogenetics
– volume: 20
  start-page: 141
  year: 2000
  end-page: 149
  ident: bb0550
  article-title: Steady state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: Impact of CYP2D6 genotype on the hydroxylation of nortriptyline
  publication-title: J. Clin. Psychopharmacol.
– volume: 18
  start-page: 1203
  year: 1997
  end-page: 1214
  ident: bb0740
  article-title: Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County
  publication-title: Carcinogenesis
– volume: 88
  start-page: 643
  year: 2010
  end-page: 651
  ident: bb0410
  article-title: Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan
  publication-title: Clin. Pharmacol. Ther.
– volume: 347
  start-page: 217
  year: 2004
  end-page: 221
  ident: bb0135
  article-title: A long PCR assay to distinguish CYP2D6*5 and a novel CYP2D6 mutant allele associated with an 11-kb EcoRI haplotype
  publication-title: Clin. Chim. Acta
– volume: 96
  start-page: 601
  year: 1995
  end-page: 603
  ident: bb0235
  article-title: A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency
  publication-title: Hum. Genet.
– volume: 18
  start-page: 209
  year: 2008
  end-page: 212
  ident: bb0790
  article-title: Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
  publication-title: Pharmacogenet. Genomics
– volume: 31
  start-page: 184
  year: 1982
  end-page: 186
  ident: bb0045
  article-title: Polymorphic oxidation of sparteine and debrisoquine
  publication-title: Related pharmacogenetic entities. Clin. Pharmacol. Ther.
– volume: 1
  start-page: 1
  year: 2010
  end-page: 9
  ident: bb0095
  article-title: Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants
  publication-title: Front. Pharmacol.
– volume: 38
  start-page: 402
  year: 1985
  end-page: 408
  ident: bb0425
  article-title: Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations
  publication-title: Clin. Pharmacol. Ther.
– volume: 59
  start-page: 803
  year: 2004
  end-page: 807
  ident: bb0585
  article-title: Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 19
  start-page: 813
  year: 2009
  end-page: 822
  ident: bb0335
  article-title: CYP2D6: novel genomic structures and alleles
  publication-title: Pharmacogenet. Genomics
– volume: 94
  start-page: 401
  year: 1994
  end-page: 406
  ident: bb0070
  article-title: DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers
  publication-title: Hum. Genet.
– volume: 7
  start-page: 373
  year: 1982
  end-page: 400
  ident: bb0415
  article-title: Ethnic differences in drug metabolism
  publication-title: Clin. Pharmacokinet.
– year: 2011
  ident: bb0620
  article-title: Repeated administration of berberine inhibits cytochromes P450 in humans
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 12
  start-page: 745
  year: 2011
  end-page: 756
  ident: bb0360
  article-title: Resequencing, haplotype construction and identification of novel variants of CYP2D6 in Mexican Mestizos
  publication-title: Pharmacogenomics
– volume: 347
  start-page: 773
  year: 1990
  end-page: 776
  ident: bb0180
  article-title: Identification of the primary gene defect at the cytochrome P450 CYP2D locus
  publication-title: Nature
– volume: 268
  start-page: 546
  year: 1994
  end-page: 551
  ident: bb0530
  article-title: Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism
  publication-title: J. Pharmacol. Exp. Ther.
– volume: 40
  start-page: 553
  year: 1991
  end-page: 556
  ident: bb0450
  article-title: Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 95
  start-page: 337
  year: 1995
  end-page: 341
  ident: bb0230
  article-title: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution
  publication-title: Hum. Genet.
– volume: 81
  start-page: 817
  year: 2007
  end-page: 820
  ident: bb0320
  article-title: Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype
  publication-title: Clin. Pharmacol. Ther.
– year: 2011
  ident: bb0610
  article-title: Detection and Prevention of Drug-Drug Interactions in the Hospitalized Elderly: Utility of New Cytochrome P450-Based Software
  publication-title: Am. J. Geriatr. Pharmacother
– volume: 3
  start-page: 123
  year: 1993
  end-page: 130
  ident: bb0115
  article-title: Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene
  publication-title: Pharmacogenetics
– volume: 6
  start-page: 319
  year: 1996
  end-page: 328
  ident: bb0255
  article-title: Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype
  publication-title: Pharmacogenetics
– volume: 57
  start-page: 617
  year: 2001
  end-page: 618
  ident: bb0500
  article-title: Genetic polymorphism of CYP2D6: Malaysian Indians have the highest frequency for CYP2D6*4 in Asia
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 265
  start-page: 17209
  year: 1990
  end-page: 17214
  ident: bb0175
  article-title: Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes
  publication-title: J. Biol. Chem.
– volume: 64
  start-page: 275
  year: 2008
  end-page: 282
  ident: bb0595
  article-title: Inhibition of metoprolol metabolism and potentiation of its effects by paraoxetine in routinely treated patients with acute myocardial infarcation (AMI)
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 53
  start-page: 162
  year: 2006
  end-page: 165
  ident: bb0800
  article-title: No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population
  publication-title: Pharmacol. Res.
– volume: 6
  start-page: 395
  year: 1996
  end-page: 401
  ident: bb0275
  article-title: A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype
  publication-title: Pharmacogenetics
– volume: 43
  start-page: 254
  year: 1997
  end-page: 266
  ident: bb0015
  article-title: Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency
  publication-title: Clin. Chem.
– volume: 3
  start-page: 229
  year: 2002
  end-page: 243
  ident: bb0455
  article-title: CYP2D6 allele frequency in European Caucasians, Asians
  publication-title: Africans and their descendants. Pharmacogenomics
– volume: 72
  start-page: 438
  year: 2002
  end-page: 452
  ident: bb0580
  article-title: The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment
  publication-title: Clin. Pharmacol. Ther.
– volume: 27
  year: 2009
  ident: bb0705
  article-title: Risk of breast cancer recurrence in women initiating tamoxifen with CYP2D6 inhibitors
  publication-title: J. Clin. Oncol.
– volume: 77
  start-page: 228
  year: 2005
  end-page: 230
  ident: bb0085
  article-title: Limited association of the 2988g > a single nucleotide polymorphism with CYP2D6*41 in black subjects
  publication-title: Clin. Pharmacol. Ther.
– volume: 60
  start-page: 661
  year: 1996
  end-page: 666
  ident: bb0505
  article-title: Genotyping of S-mephenytoin 4' hydroxylation in an extended Japanese population
  publication-title: Clin. Pharmacol. Ther.
– volume: 60
  start-page: 265
  year: 1997
  end-page: 271
  ident: bb0755
  article-title: Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?
  publication-title: Am. J. Hum. Genet.
– volume: 1
  start-page: 26
  year: 1991
  end-page: 32
  ident: bb0110
  article-title: Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype
  publication-title: Pharmacogenetics
– volume: 3
  start-page: 169
  year: 2009
  end-page: 190
  ident: bb0340
  article-title: Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects
  publication-title: Hum. Genomics
– volume: 64
  start-page: 465
  year: 2008
  end-page: 475
  ident: bb0260
  article-title: The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 28
  start-page: 1203
  year: 1998
  end-page: 1253
  ident: bb0030
  article-title: Inhibition and induction of human cytochrome P450 (CYP) enzymes
  publication-title: Xenobiotica
– volume: 8
  start-page: 15
  year: 1998
  end-page: 26
  ident: bb0375
  article-title: Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
  publication-title: Pharmacogenetics
– volume: 63
  start-page: 444
  year: 1998
  end-page: 452
  ident: bb0515
  article-title: 10-Hydroxylation of nortriptyline in Caucasians with 0, 1, 2, 3 and 13 functional CYP2D6 genes
  publication-title: Clin. Pharmacol. Ther.
– volume: 51
  start-page: 388
  year: 1992
  end-page: 397
  ident: bb0435
  article-title: Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
  publication-title: Clin. Pharmacol. Ther.
– volume: 53
  start-page: 410
  year: 1993
  end-page: 418
  ident: bb0480
  article-title: Molecular basis of genetic variation in debrisoquine hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6
  publication-title: Clin. Pharmacol. Ther.
– volume: 49
  start-page: 1008
  year: 2003
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0090
  article-title: CYP2D6 poor metabolizer status can be ruled out by a single genotyping assay for the -1584G promoter polymorphism
  publication-title: Clin. Chem.
  doi: 10.1373/49.6.1008
– volume: 81
  start-page: 817
  issue: 6
  year: 2007
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0320
  article-title: Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/sj.clpt.6100125
– volume: 302
  start-page: 1429
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0655
  article-title: Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
  publication-title: JAMA
  doi: 10.1001/jama.2009.1420
– volume: 6
  start-page: 343
  issue: 5
  year: 2006
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0400
  article-title: CYP2D6 genetic variation in healthy adults and psychiatric African-American subjects: implications for clinical practice and genetic testing
  publication-title: Pharmacogenomics J.
  doi: 10.1038/sj.tpj.6500378
– volume: 131
  start-page: 137
  year: 2012
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0690
  article-title: Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-011-1777-7
– volume: 12
  start-page: 1617
  issue: 11
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0405
  article-title: Detection and characterization of the CYP2D6*9x2 gene duplication in two Spanish populations: esolution of AmpliChip CYP450 test no-calls
  publication-title: Pharmacogenomics
  doi: 10.2217/pgs.11.107
– volume: 19
  start-page: 1423
  issue: 8
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0675
  article-title: Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdn155
– volume: 76
  start-page: 128
  issue: 2
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0155
  article-title: A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/j.clpt.2004.04.009
– volume: 13
  start-page: 627
  year: 2003
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0635
  article-title: Correlation of CYP2D6 genotype with perhexiline phenotypic metabolizer status
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-200310000-00006
– volume: 1
  start-page: 555
  issue: 8637
  year: 1989
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0760
  article-title: Debrisoquine hydroxylation polymorphism and personality [letter]
  publication-title: Lancet
  doi: 10.1016/S0140-6736(89)90094-9
– volume: 38
  start-page: 631
  year: 1981
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0780
  article-title: Monoamine metabolites in CSF and suicidal behavior
  publication-title: Arch. Gen. Psychiatry
  doi: 10.1001/archpsyc.1981.01780310031002
– volume: 74
  start-page: 340
  issue: 4
  year: 2010
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0350
  article-title: Elucidation of CYP2D6 genetic diversity in a unique African population: implications for the future application of pharmacogenetics in the Xhosa population
  publication-title: Ann. Hum. Genet.
  doi: 10.1111/j.1469-1809.2010.00585.x
– volume: 3
  start-page: 169
  issue: 2
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0340
  article-title: Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects
  publication-title: Hum. Genomics
  doi: 10.1186/1479-7364-3-2-169
– volume: 3
  start-page: 229
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0455
  article-title: CYP2D6 allele frequency in European Caucasians, Asians
  publication-title: Africans and their descendants. Pharmacogenomics
– volume: 5
  start-page: S129
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0725
  article-title: Lung cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed association
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199512001-00014
– volume: 48
  start-page: 943
  year: 1991
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0210
  article-title: Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metaboliser of the debrisoquine/sparteine polymorphism
  publication-title: Am. J. Hum. Genet.
– volume: 8
  start-page: 529
  issue: 6
  year: 1998
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0300
  article-title: CYP2D6 phenotypegenotype relationships in African-Americans and Caucasians in Los Angeles
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199812000-00010
– volume: 59
  start-page: 339
  issue: 2
  year: 2005
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0295
  article-title: Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution
  publication-title: Proteins
  doi: 10.1002/prot.20399
– volume: 303
  start-page: 1291
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0475
  article-title: Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelicisoforms
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.102.039891
– volume: 48
  start-page: 983
  issue: 7
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0265
  article-title: Single-step assays to analyze CYP2D6 gene polymorphisms in Asians: allele frequencies and a novel *14B allele in mainland Chinese
  publication-title: Clin. Chem.
  doi: 10.1093/clinchem/48.7.983
– volume: 92
  start-page: 152
  issue: 3
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0355
  article-title: Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2008.05.004
– volume: 97
  start-page: 668
  issue: 5
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0245
  article-title: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine
  publication-title: Hum. Genet.
  doi: 10.1007/BF02281880
– volume: 12
  start-page: 235
  issue: 3
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0570
  article-title: Antipsychotic-induced extrapyramidal syndromes and cytochrome P450 2D6 genotype: a case–control study
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-200204000-00008
– volume: 88
  start-page: 304
  year: 2010
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0775
  article-title: CYP2D6, serotonin and suicide—a relationship?
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.2010.144
– volume: 88
  start-page: 643
  issue: 5
  year: 2010
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0410
  article-title: Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.2010.137
– volume: 71
  start-page: 77
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0485
  article-title: The African-specific CYP2D6*17 allele encodes an enzyme with changed substrate specificity
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1067/mcp.2002.120239
– volume: 6
  start-page: 269
  issue: 3
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0270
  article-title: A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D6*15
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199606000-00012
– volume: 355
  start-page: 979
  year: 2000
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0625
  article-title: Gene expression in distinct regions of the heart
  publication-title: Lancet
  doi: 10.1016/S0140-6736(00)99016-0
– volume: 83
  start-page: 160
  issue: 1
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0750
  article-title: Tamoxifen Pharmacogenomics: The Role of CYP2D6 as a Predictor of Drug Response
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/sj.clpt.6100367
– volume: 76
  start-page: 536
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0645
  article-title: Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/j.clpt.2004.08.020
– volume: 340
  start-page: c693
  year: 2010
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0710
  article-title: Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: A population based cohort study
  publication-title: BMJ
  doi: 10.1136/bmj.c693
– volume: 46
  start-page: 452
  issue: 3
  year: 1994
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0125
  article-title: Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
  publication-title: Mol. Pharmacol.
  doi: 10.1016/S0026-895X(25)09721-4
– volume: 26
  start-page: 205
  year: 2001
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0465
  article-title: Heterogeneity of the CYP2D6 gene among Malays in Malaysia
  publication-title: J. Clin. Pharm. Ther.
  doi: 10.1046/j.1365-2710.2001.00347.x
– volume: 55
  start-page: 635
  year: 2003
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0630
  article-title: Polymorphic hydroxylation of perhexiline in vitro
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1046/j.1365-2125.2003.01805.x
– volume: 4
  start-page: 2251
  issue: 12
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0215
  article-title: Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/4.12.2251
– volume: 95
  start-page: 337
  issue: 3
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0230
  article-title: An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution
  publication-title: Hum. Genet.
  doi: 10.1007/BF00225204
– volume: 73
  start-page: 575
  issue: 6
  year: 2003
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0310
  article-title: Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/S0009-9236(03)00067-5
– volume: 34
  start-page: 732
  issue: 6
  year: 1983
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0590
  article-title: Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.1983.242
– volume: 19
  start-page: 313
  issue: 4
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0100
  article-title: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.2133/dmpk.19.313
– volume: 39
  start-page: 651
  issue: 10
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0700
  article-title: No Association Between CYP2D6*10 Genotype and Survival of Node-negative Japanese Breast Cancer Patients Receiving Adjuvant Tamoxifen Treatment
  publication-title: Jpn. J. Clin. Oncol.
  doi: 10.1093/jjco/hyp076
– volume: 19
  start-page: 813
  issue: 10
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0335
  article-title: CYP2D6: novel genomic structures and alleles
  publication-title: Pharmacogenet. Genomics
  doi: 10.1097/FPC.0b013e3283317b95
– volume: 16
  start-page: 183
  year: 1979
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0040
  article-title: Defective N-oxidation of sparteine in man: a new pharmacogenetic defect
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/BF00562059
– volume: 36
  start-page: 2460
  issue: 12
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0075
  article-title: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47–51, 53-55, and 57)
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.108.023242
– volume: 20
  start-page: 294
  issue: 4
  year: 2005
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0105
  article-title: Two novel single nucleotide polymorphisms (SNPs) of the CYP2D6 gene in Japanese individuals
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.2133/dmpk.20.294
– volume: 7
  start-page: 478
  year: 1985
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0540
  article-title: Extremely rapid hydroxylation of debrisoquine: a case report with implication for treatment with nortriptyline and other tricyclic antidepressants
  publication-title: Ther. Drug Monit.
  doi: 10.1097/00007691-198512000-00021
– volume: 7
  start-page: 373
  issue: 5
  year: 1982
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0415
  article-title: Ethnic differences in drug metabolism
  publication-title: Clin. Pharmacokinet.
  doi: 10.2165/00003088-198207050-00001
– volume: 96
  start-page: 601
  issue: 5
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0235
  article-title: A nonsense mutation in the cytochrome P450 CYP2D6 gene identified in a Caucasian with an enzyme deficiency
  publication-title: Hum. Genet.
  doi: 10.1007/BF00197419
– volume: 40
  start-page: 111
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0535
  article-title: Frequency of Undetected CYP2D6 Hybrid Genes in Clinical Samples: Impact on Phenotype Prediction
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.111.040832
– volume: 59
  start-page: 57
  issue: 1
  year: 2003
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0575
  article-title: Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-003-0562-x
– volume: 59
  start-page: 803
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0585
  article-title: Increased incidence of CYP2D6 gene duplication in patients with persistent mood disorders: ultrarapid metabolism of antidepressants as a cause of nonresponse. A pilot study
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-003-0701-4
– volume: 9
  start-page: 442
  issue: 5
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0555
  article-title: Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response
  publication-title: Mol. Psychiatry
  doi: 10.1038/sj.mp.4001494
– volume: 6
  start-page: 441
  issue: 5
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0440
  article-title: Debrisoquine and S-mephenytoin hydroxylation phenotypes and genotypes in a Korean population
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199610000-00008
– volume: 57
  start-page: 617
  year: 2001
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0500
  article-title: Genetic polymorphism of CYP2D6: Malaysian Indians have the highest frequency for CYP2D6*4 in Asia
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s002280100360
– volume: 47
  start-page: 994
  issue: 6
  year: 1990
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0185
  article-title: The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934—A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site
  publication-title: Am. J. Hum. Genet.
– volume: 63
  start-page: 444
  year: 1998
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0515
  article-title: 10-Hydroxylation of nortriptyline in Caucasians with 0, 1, 2, 3 and 13 functional CYP2D6 genes
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/S0009-9236(98)90040-6
– volume: 29
  start-page: 244
  issue: 2
  year: 1990
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0470
  article-title: Evidence for the polymorphic oxidation of debrisoquine in New Zealand Caucasians
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/j.1365-2125.1990.tb03627.x
– volume: 28
  start-page: 1203
  year: 1998
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0030
  article-title: Inhibition and induction of human cytochrome P450 (CYP) enzymes
  publication-title: Xenobiotica
  doi: 10.1080/004982598238886
– volume: 9
  start-page: 380
  issue: 6
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0345
  article-title: Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese
  publication-title: Pharmacogenomics J.
  doi: 10.1038/tpj.2009.31
– volume: 115
  start-page: 952
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0695
  article-title: Genetic polymorphisms of CYP2D6*10 and CYP2C19* 2,* 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen
  publication-title: Cancer
  doi: 10.1002/cncr.24111
– volume: 5
  start-page: 200
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0510
  article-title: Polymorphic drug oxidation
  publication-title: Relevance to the treatment of psychiatric disorders. CNS Drugs
– volume: 347
  start-page: 773
  issue: 6295
  year: 1990
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0180
  article-title: Identification of the primary gene defect at the cytochrome P450 CYP2D locus
  publication-title: Nature
  doi: 10.1038/347773a0
– volume: 72
  start-page: 438
  issue: 4
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0580
  article-title: The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1067/mcp.2002.127494
– volume: 60
  start-page: 265
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0755
  article-title: Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?
  publication-title: Am. J. Hum. Genet.
– volume: 18
  start-page: 209
  issue: 3
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0790
  article-title: Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
  publication-title: Pharmacogenet. Genomics
  doi: 10.1097/FPC.0b013e3282f5106e
– volume: 34
  start-page: 1411
  issue: 8
  year: 2006
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0315
  article-title: New cytochrome P450 2D6*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.106.009548
– volume: 45
  start-page: 889
  issue: 6
  year: 1989
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0055
  article-title: The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
  publication-title: Am. J. Hum. Genet.
– volume: 6
  start-page: 319
  issue: 4
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0255
  article-title: Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199608000-00005
– volume: 44
  start-page: 265
  issue: 3
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0525
  article-title: Risk assessment of accidental nortriptyline poisoning: The importance of cytochrome P450 for nortriptyline elimination investigated using a population-based pharmacokinetic simulator
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2011.08.003
– volume: 87
  start-page: 23
  year: 1993
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0765
  article-title: Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P 4502D6
  publication-title: Acta Psychiatr. Scand.
  doi: 10.1111/j.1600-0447.1993.tb03325.x
– volume: 94
  start-page: 401
  issue: 4
  year: 1994
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0070
  article-title: DNA haplotype-dependent differences in the amino acid sequence of debrisoquine 4-hydroxylase (CYP2D6): evidence for two major allozymes in extensive metabolisers
  publication-title: Hum. Genet.
  doi: 10.1007/BF00201601
– volume: 37
  start-page: 1464
  issue: 7
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0330
  article-title: Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.108.022368
– volume: 27
  start-page: 385
  issue: 3
  year: 1999
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0130
  article-title: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese
  publication-title: Drug Metab. Dispos.
  doi: 10.1016/S0090-9556(24)14915-X
– year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0715
  article-title: In vitro metabolic interactions between black cohosh (Cimicifuga racemosa) and tamoxifen via inhibition of cytochromes P450 2D6 and 3A4
  publication-title: Xenobiotica
  doi: 10.3109/00498254.2011.603385
– volume: 505
  start-page: 83
  issue: 1–2
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0395
  article-title: Frequent occurrence of CYP2D6*10 duplication allele in a Japanese population
  publication-title: Mutat. Res.
  doi: 10.1016/S0027-5107(02)00122-7
– volume: 53
  start-page: 410
  year: 1993
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0480
  article-title: Molecular basis of genetic variation in debrisoquine hydroxylation in Chinese subjects: polymorphism in RFLP and DNA sequence of CYP2D6
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.1993.44
– volume: 64
  start-page: 465
  issue: 5
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0260
  article-title: The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-007-0445-7
– volume: 3
  start-page: 923
  issue: 6
  year: 1994
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0220
  article-title: Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/3.6.923
– volume: 7
  start-page: 193
  issue: 3
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0060
  article-title: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199706000-00004
– volume: 3
  start-page: 64
  issue: 10
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0685
  article-title: Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatment
  publication-title: Genome Med.
  doi: 10.1186/gm280
– volume: 2
  start-page: 584
  year: 1977
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0035
  article-title: Polymorphic hydroxylation of debrisoquine in man
  publication-title: Lancet
  doi: 10.1016/S0140-6736(77)91430-1
– volume: 40
  start-page: 553
  issue: 6
  year: 1991
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0450
  article-title: Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/BF00279968
– volume: 25
  start-page: 5187
  issue: 33
  year: 2007
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0650
  article-title: Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2007.12.2705
– volume: 56
  start-page: 2285
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0010
  article-title: “It's the genes, stupid”. Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism
  publication-title: Life Sci.
  doi: 10.1016/0024-3205(95)00223-S
– volume: 6
  start-page: 395
  issue: 5
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0275
  article-title: A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199610000-00003
– volume: 274
  start-page: 516
  issue: 1
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0365
  article-title: Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1016/S0022-3565(25)10669-1
– volume: 20
  start-page: 141
  issue: 2
  year: 2000
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0550
  article-title: Steady state plasma levels of nortriptyline and its hydroxylated metabolites in Japanese patients: Impact of CYP2D6 genotype on the hydroxylation of nortriptyline
  publication-title: J. Clin. Psychopharmacol.
  doi: 10.1097/00004714-200004000-00005
– volume: 110
  start-page: 289
  year: 1994
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0020
  article-title: Role of environmental factors in the pharmacokinetics of drugs: Considerations with respect to animal models, P-450 enzymes, and probe drugs
  publication-title: Handb. Exp. Pharmacol.
  doi: 10.1007/978-3-642-78680-8_10
– volume: 347
  start-page: 217
  issue: 1–2
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0135
  article-title: A long PCR assay to distinguish CYP2D6*5 and a novel CYP2D6 mutant allele associated with an 11-kb EcoRI haplotype
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cccn.2004.04.020
– volume: 77
  start-page: 228
  issue: 3
  year: 2005
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0085
  article-title: Limited association of the 2988g > a single nucleotide polymorphism with CYP2D6*41 in black subjects
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/j.clpt.2004.10.014
– volume: 11
  start-page: 143
  issue: 2
  year: 2001
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0195
  article-title: Characterization of (+/—)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-200103000-00005
– volume: 88
  start-page: 354
  year: 2010
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0770
  article-title: High Frequency of Occurrence of CYP2D6 Gene Duplication/Multiduplication Indicating Ultrarapid Metabolism Among Suicide Cases
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.2009.216
– volume: 27
  issue: 18s
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0705
  article-title: Risk of breast cancer recurrence in women initiating tamoxifen with CYP2D6 inhibitors
  publication-title: J. Clin. Oncol.
  doi: 10.1200/jco.2009.27.18s.cra508
– volume: 7
  start-page: 149
  issue: 2
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0380
  article-title: Characterization of the 16+9 kb and 30+9 kb CYP2D6 Xbal haplotypes
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199704000-00009
– volume: 12
  start-page: 916
  issue: 11
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0200
  article-title: Molecular diversity at the CYP2D6 locus in the Mediterranean region
  publication-title: Eur. J. Hum. Genet.
  doi: 10.1038/sj.ejhg.5201243
– volume: 9
  start-page: 657
  issue: 5
  year: 1999
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0490
  article-title: Ten percent of North Spanish individuals carry duplicated or triplicated CYP2D6 genes associated with ultra-rapid metabolism of debrisoquine
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199910000-00013
– volume: 15
  start-page: 889
  issue: 11
  year: 1988
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0430
  article-title: Oxidation phenotyping in Chinese and Malay populations
  publication-title: Clin. Exp. Pharmacol. Physiol.
  doi: 10.1111/j.1440-1681.1988.tb01032.x
– volume: 265
  start-page: 17209
  issue: 28
  year: 1990
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0175
  article-title: Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)44890-3
– volume: 66
  start-page: 859
  issue: 9
  year: 2010
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0250
  article-title: Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-010-0831-4
– volume: 25
  start-page: 3837
  year: 2007
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0660
  article-title: Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast cancer
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2007.11.4850
– volume: 1
  start-page: 1
  issue: 121
  year: 2010
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0095
  article-title: Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants
  publication-title: Front. Pharmacol.
– volume: 51
  start-page: 388
  issue: 4
  year: 1992
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0435
  article-title: Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.1992.38
– volume: 20
  start-page: 246
  issue: 2
  year: 2000
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0560
  article-title: Extension of a pilot study: impact from the cytochrome P450 2D6 polymorphism on outcome and costs associated with severe mental illness
  publication-title: J. Clin. Psychopharmacol.
  doi: 10.1097/00004714-200004000-00019
– volume: 41
  start-page: 453
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0565
  article-title: Cytochrome P450 phenotyping/genotyping in patients receiving antipsychotics: useful aid to prescribing?
  publication-title: Clin. Pharmacokinet.
  doi: 10.2165/00003088-200241070-00001
– volume: 17
  start-page: 1923
  issue: 9
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0730
  article-title: Genetic polymorphism of GSTM1, CYP2E1 and CYP2D6 in Egyptian bladder cancer patients
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/17.9.1923
– volume: 37
  start-page: 699
  issue: 4
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0170
  article-title: Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.108.026096
– volume: 9
  start-page: 393
  issue: 3
  year: 1999
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0280
  article-title: A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199906000-00015
– volume: 64
  start-page: 275
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0595
  article-title: Inhibition of metoprolol metabolism and potentiation of its effects by paraoxetine in routinely treated patients with acute myocardial infarcation (AMI)
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-007-0404-3
– volume: 31
  start-page: 630
  issue: 7
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0600
  article-title: Effects of paroxetine on the pharmacokinetics and pharmacodynamics of immediate-release and extended-release metoprolol
  publication-title: Pharmacotherapy
  doi: 10.1592/phco.31.7.630
– volume: 80
  start-page: 555
  issue: 5
  year: 2006
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0160
  article-title: The 2988G>A polymorphism affects splicing of a CYP2D6 minigene
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/j.clpt.2006.08.008
– volume: 8
  start-page: 181
  issue: 2
  year: 1998
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0385
  article-title: Correctness of prediction of the CYP2D6 phenotype confirmed by genotyping 47 intermediate and poor metabolizers of debrisoquine
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199804000-00010
– volume: 278
  start-page: 441
  issue: 1
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0370
  article-title: Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1016/S0022-3565(25)20152-5
– volume: 12
  start-page: 745
  issue: 5
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0360
  article-title: Resequencing, haplotype construction and identification of novel variants of CYP2D6 in Mexican Mestizos
  publication-title: Pharmacogenomics
  doi: 10.2217/pgs.11.8
– volume: 8
  start-page: 15
  issue: 1
  year: 1998
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0375
  article-title: Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199802000-00003
– volume: 12
  start-page: 570
  issue: 6
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0720
  article-title: Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract
  publication-title: Curr. Drug Metab.
  doi: 10.2174/138920011795713706
– volume: 2
  start-page: 356
  issue: 4
  year: 1992
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0605
  article-title: Adverse reactions as a cause of hospital admission in the aged
  publication-title: Drugs Aging
  doi: 10.2165/00002512-199202040-00008
– volume: 270
  start-page: 414
  year: 1994
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0025
  article-title: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1016/S0022-3565(25)22379-5
– volume: 2
  start-page: 852
  issue: 8563
  year: 1987
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0460
  article-title: Low frequency of slow debrisoquine hydroxylation in a native Chinese population
  publication-title: Lancet
– volume: 65
  start-page: 570
  year: 1999
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0445
  article-title: Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese Population
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/S0009-9236(99)70077-9
– volume: 1
  start-page: 26
  issue: 1
  year: 1991
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0110
  article-title: Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199110000-00005
– volume: 268
  start-page: 546
  issue: 2
  year: 1994
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0530
  article-title: Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1016/S0022-3565(25)38970-6
– volume: 3
  start-page: 123
  issue: 3
  year: 1993
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0115
  article-title: Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199306000-00001
– volume: 31
  start-page: 184
  year: 1982
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0045
  article-title: Polymorphic oxidation of sparteine and debrisoquine
  publication-title: Related pharmacogenetic entities. Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.1982.29
– volume: 98
  start-page: 107
  year: 1992
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0745
  article-title: Molecular Genetic Analysis of the Cytochrome P450-Debrisoquine Hydroxylase Locus and Association with Cancer Susceptibility
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.9298107
– volume: 18
  start-page: 1203
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0740
  article-title: Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/18.6.1203
– volume: 7
  start-page: 337
  issue: 4
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0190
  article-title: Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199708000-00010
– volume: 8
  start-page: 433
  issue: 5
  year: 1998
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0735
  article-title: Susceptibility and outcome in oral cancer: preliminary data showing an association with polymorphism in cytochrome P450 CYP2D6
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199810000-00008
– year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0610
  article-title: Detection and Prevention of Drug-Drug Interactions in the Hospitalized Elderly: Utility of New Cytochrome P450-Based Software
  publication-title: Am. J. Geriatr. Pharmacother
  doi: 10.1016/j.amjopharm.2011.09.006
– volume: 53
  start-page: 162
  issue: 2
  year: 2006
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0800
  article-title: No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2005.10.005
– volume: 90
  start-page: 11825
  year: 1993
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0065
  article-title: Inherited amplification of an active gene in the cytochrome P450 CYP2D-locus as a cause of ultrarapid metabolism of debrisoquine
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.90.24.11825
– volume: 18
  start-page: 269
  issue: 4
  year: 2003
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0290
  article-title: Two novel haplotypes of CYP2D6 gene in a Japanese population
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.2133/dmpk.18.269
– volume: 5
  start-page: 305
  issue: 5
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0240
  article-title: A novel CYP2D6 allele with an abolished splice recognition site associated with the poor metabolizer phenotype
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199510000-00006
– volume: 4
  start-page: 271
  issue: 5
  year: 1994
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0225
  article-title: Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codon
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199410000-00005
– volume: 73
  start-page: 539
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0005
  article-title: Molecular basis of polymorphic drug metabolism
  publication-title: J. Mol. Med.
  doi: 10.1007/BF00195139
– volume: 35
  start-page: 1247
  issue: 8
  year: 2007
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0325
  article-title: A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.107.015149
– year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0620
  article-title: Repeated administration of berberine inhibits cytochromes P450 in humans
  publication-title: Eur. J. Clin. Pharmacol.
– volume: 60
  start-page: 284
  issue: 2
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0080
  article-title: Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences
  publication-title: Am. J. Hum. Genet.
– volume: 341
  start-page: 63
  issue: 8836
  year: 1993
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0545
  article-title: Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine
  publication-title: Lancet
  doi: 10.1016/0140-6736(93)92546-6
– volume: 28
  start-page: 279
  year: 2003
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0495
  article-title: Genetic polymorphism of CYP2D6 in Chinese subjects in Malaysia
  publication-title: J. Clin. Pharm. Ther.
  doi: 10.1046/j.1365-2710.2003.00490.x
– start-page: 172
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0520
  article-title: The mammoth steppe and the origin of mongoloids and their dispersal
– volume: 67
  start-page: 466
  issue: 5
  year: 2000
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0615
  article-title: Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 activity
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1067/mcp.2000.106464
– volume: 29
  start-page: 192
  issue: 3
  year: 1995
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0420
  article-title: Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19
  publication-title: Clin. Pharmacokinet.
  doi: 10.2165/00003088-199529030-00005
– volume: 71
  start-page: 737
  issue: 5
  year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0670
  article-title: Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1111/j.1365-2125.2011.03905.x
– volume: 3
  start-page: 256
  issue: 5
  year: 1993
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0120
  article-title: Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199310000-00005
– volume: 38
  start-page: 402
  issue: 4
  year: 1985
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0425
  article-title: Interethnic differences in genetic polymorphism of debrisoquine and mephenytoin hydroxylation between Japanese and Caucasian populations
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1038/clpt.1985.194
– volume: 60
  start-page: 661
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0505
  article-title: Genotyping of S-mephenytoin 4' hydroxylation in an extended Japanese population
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1016/S0009-9236(96)90214-3
– volume: 46
  start-page: 1411
  issue: 9
  year: 2000
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0390
  article-title: Occurrence of CYP2D6 gene duplication in Hong Kong Chinese
  publication-title: Clin. Chem.
  doi: 10.1093/clinchem/46.9.1411
– year: 2011
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0795
  article-title: The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients
  publication-title: Neurobiol. Aging
– volume: 16
  start-page: 755
  issue: 10
  year: 2006
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0165
  article-title: Impaired expression of CYP2D6 in intermediate metabolizers carrying the *41 allele caused by the intronic SNP 2988G>A: evidence for modulation of splicing events
  publication-title: Pharmacogenet. Genomics
  doi: 10.1097/01.fpc.0000230112.96086.e0
– volume: 72
  start-page: 429
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0640
  article-title: Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol-associated adverse effects
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1067/mcp.2002.127111
– volume: 9
  start-page: 287
  issue: 3
  year: 1999
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0285
  article-title: A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199906000-00003
– volume: 72
  start-page: 76
  issue: 1
  year: 2002
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0305
  article-title: Unique CYP22006)D6 activity distribution and genotype-phenotype discordance in black Americans
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1067/mcp.2002.125783
– volume: 279
  start-page: 27383
  year: 2004
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0785
  article-title: A frame shift mutation and alternate splicing in human brain generates a functional form of the pseudogene, cytochrome P4502D7 that demethylates codeine to morphine
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M402337200
– volume: 34
  start-page: 563
  issue: 4
  year: 2006
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0205
  article-title: CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status
  publication-title: Drug Metab. Dispos.
  doi: 10.1124/dmd.105.008292
– volume: 52
  start-page: 1034
  issue: 6
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0145
  article-title: A combination of mutations in the CYP2D6*17 (CYP2D6Z) allele causes alterations in enzyme function
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.52.6.1034
– volume: 6
  start-page: 1
  issue: 1
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0050
  article-title: P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-199602000-00002
– volume: 43
  start-page: 254
  year: 1997
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0015
  article-title: Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency
  publication-title: Clin. Chem.
  doi: 10.1093/clinchem/43.2.254
– volume: 42
  start-page: 713
  issue: 6
  year: 1996
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0140
  article-title: A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity
  publication-title: Br. J. Clin. Pharmacol.
  doi: 10.1046/j.1365-2125.1996.00489.x
– volume: 118
  start-page: 125
  issue: 1
  year: 2009
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0680
  article-title: The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users
  publication-title: Breast Cancer Res. Treat.
  doi: 10.1007/s10549-008-0272-2
– volume: 99
  start-page: 995
  year: 2008
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0665
  article-title: Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2008.00780.x
– volume: 11
  start-page: 417
  issue: 5
  year: 2001
  ident: 10.2133/dmpk.DMPK-11-RV-121_bb0150
  article-title: Characterization of the CYP2D6*29 allele commonly present in a black Tanzanian population causing reduced catalytic activity
  publication-title: Pharmacogenetics
  doi: 10.1097/00008571-200107000-00005
SSID ssj0033542
ssib002820371
Score 2.364042
SecondaryResourceType review_article
Snippet CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more...
Summary: CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the...
SourceID swepub
proquest
pubmed
crossref
medicalonline
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 55
SubjectTerms Biotransformation
clinical implication
CYP2D6 polymorphism
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Drug Interactions
Genetic Predisposition to Disease
Humans
interethnic differences
Pharmacogenetics - methods
Pharmacokinetics
Polymorphism, Genetic
Title Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance
URI https://dx.doi.org/10.2133/dmpk.DMPK-11-RV-121
http://mol.medicalonline.jp/en/journal/download?GoodsID=co1metab/2012/002701/003&name=0055-0067e
https://www.ncbi.nlm.nih.gov/pubmed/22185816
https://www.proquest.com/docview/925719792
http://kipublications.ki.se/Default.aspx?queryparsed=id:124156004
Volume 27
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVFSB
  databaseName: Free Full-Text Journals in Chemistry
  customDbUrl:
  eissn: 1880-0920
  dateEnd: 20141231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: HH5
  dateStart: 19860101
  isFulltext: true
  titleUrlDefault: http://abc-chemistry.org/
  providerName: ABC ChemistRy
– providerCode: PRVAFT
  databaseName: Open Access Digital Library
  customDbUrl:
  eissn: 1880-0920
  dateEnd: 20141231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: KQ8
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html
  providerName: Colorado Alliance of Research Libraries
– providerCode: PRVESC
  databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier)
  customDbUrl:
  eissn: 1880-0920
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: GBLVA
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
– providerCode: PRVESC
  databaseName: Elsevier ScienceDirect
  customDbUrl:
  eissn: 1880-0920
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: ACRLP
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
– providerCode: PRVESC
  databaseName: Elsevier SD Freedom Collection Journals [SCFCJ]
  customDbUrl:
  eissn: 1880-0920
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: AIKHN
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
– providerCode: PRVBFR
  databaseName: Free Medical Journals
  customDbUrl:
  eissn: 1880-0920
  dateEnd: 20141231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: DIK
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: http://www.freemedicaljournals.com
  providerName: Flying Publisher
– providerCode: PRVFQY
  databaseName: GFMER Free Medical Journals
  customDbUrl:
  eissn: 1880-0920
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: GX1
  dateStart: 0
  isFulltext: true
  titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php
  providerName: Geneva Foundation for Medical Education and Research
– providerCode: PRVLSH
  databaseName: Elsevier Journals
  customDbUrl:
  mediaType: online
  eissn: 1880-0920
  dateEnd: 99991231
  omitProxy: true
  ssIdentifier: ssj0033542
  issn: 1347-4367
  databaseCode: AKRWK
  dateStart: 20020101
  isFulltext: true
  providerName: Library Specific Holdings
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfGdkFCaHyuDJAPqKeGzk7iJJyYWqaOalNVtjFOluMPUW1JK5od9t_zXux0GoIdOCVx7CTO83v-vTjv9wj5wK0VukzjSGeFjZKMiyjXyqBArFUidla1f_meisl58vUyvdwioy4WBn-rDLbf2_TWWoeSYXibw9ViMfyGQZBJLDLQWYywFI_IDofZHjywncPj6eS0M8hxnLY5dLB-hA08-RAH72xoqtXVx_HJbIrhZfOLiHH2rwnqSeVXTjyDxd8A6R9so-0MdbRLngZoSQ_90z8jW7Z-Tvozz019O6Bnd6FW6wHt09kda_XtCyK7Q2RtraAKXTo6-jHjY_GJnnRJdCnSVPsLtN8SbfOzXmg6DmlWwOhQVRsa2Eav6XHV4ns48ZKcH305G02ikH0h0uBCNFEZMxfzQiel1gb0Nk2VgV1rMmu4c2VeFtxYQEyaK4zwTR0DufLMpa7MMJbrFdmul7XdI9QVJj8QTjMjXJIp9JqccczEeRbDbVSP8O6VSx2oyTFDxrUEFwXlJFFOEuUEHoucX0iQU48MNo1Wnpnj4eqik6W8N8AkzB0PN_x8T_IyKPla6iWrbKNKCSCKS3TwDxhyrUokNpOIA3BNFhBQj9BusEjQXlySUbVd3qxlARaTFVnBe-S1H0SbvnAAX2nOoHHfj6rNGWQED0VXsGcloG5A7m_-t4f75DH2wH9Yeku2m1839h1AraZ8H1QJt9P59-lvivgqEA
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LbxMxELZKegAJId6Epw8opyypvW9OVAlVQpooKmlVTpbXDxG1u4nI9tB_z8zam6oIeuC2D3t37fGMv1l7viHkIzcmUUUcBirNTRClPAkyJTUKxBiZhNbIZpfvPBmfRt_O4_M9MmxjYXBbpbf9zqY31tpfGfjeHGxWq8F3DIKMwiQFncUIy-Qe2Y9isMkdsn84mY7nrUEOw7jJoYPlA6zgyIc4eGcDXW4uPo1miymGl52cBYyzf01QD0u3cuIYLP4GSP9gG21mqKPH5JGHlvTQff0Tsmeqp6S3cNzU1326vAm12vZpjy5uWKuvnxHRniJrawlF6NrS4Y8FHyWf6axNokuRpto9oPmXaOqf1UrRkU-zAkaHykpTzzZ6SSdlg-_hxnNyevR1ORwHPvtCoMCFqIMiZDbkuYoKpTTobRxLDYdGp0Zza4usyLk2gJgUlxjhG1sGcuWpjW2RYizXC9Kp1pV5RajNdXaQWMV0YqNUotdktWU6zNIQXiO7hLddLpSnJscMGZcCXBSUk0A5CZQTeCzi5EyAnLqkv6u0ccwcdxdPWlmKWwNMwNxxd8UvtyQvvJJvhVqz0tSyEACiuEAH_4Ah16pAYjOBOADXZAEBdQltB4sA7cUlGVmZ9dVW5GAxWZ7mvEteukG0awsH8BVnDCr33Kja3UFGcH_pAo6MANQNyP31_7bwA7k_Xs6OxfFkPn1DHmBr3E-mt6RT_7oy7wB21cV7r1a_ATNWK1E
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pharmacogenomics+of+CYP2D6%3A+Molecular+Genetics%2C+Interethnic+Differences+and+Clinical+Importance&rft.jtitle=DRUG+METABOLISM+AND+PHARMACOKINETICS&rft.au=Lay+Kek+TEH&rft.au=Leif+BERTILSSON&rft.date=2012&rft.pub=Japanese+Society+for+the+Study+of+Xenobiotics&rft.issn=1347-4367&rft.volume=27&rft.issue=1&rft.spage=55&rft.epage=67&rft_id=info:doi/10.2133%2Fdmpk.DMPK-11-RV-121&rft.externalDocID=co1metab_2012_002701_003_0055_00671666266
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1347-4367&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1347-4367&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1347-4367&client=summon