Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance
CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced to...
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Published in | DRUG METABOLISM AND PHARMACOKINETICS Vol. 27; no. 1; pp. 55 - 67 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
2012
Japanese Society for the Study of Xenobiotics |
Subjects | |
Online Access | Get full text |
ISSN | 1347-4367 1880-0920 1880-0920 |
DOI | 10.2133/dmpk.DMPK-11-RV-121 |
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Abstract | CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions. |
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AbstractList | CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions.CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions. CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions. Summary: CYP2D6 has received intense attention since the beginning of the pharmacogenetic era in the 1970s. This is because of its involvement in the metabolism of more than 25% of the marketed drugs, the large geographical and inter-ethnic differences in the genetic polymorphism and possible drug-induced toxicity. Many interesting reviews have been published on CYP2D6 and this review aims to reinstate the importance of the genetic polymorphism of CYP2D6 in different populations as well as some clinical implications and important drug interactions. |
Author | Teh, Lay Kek Bertilsson, Leif |
Author_xml | – sequence: 1 givenname: Lay Kek surname: Teh fullname: Teh, Lay Kek email: tehlaykek@puncakalam.uitm.edu.my, tehlaykek@yahoo.com organization: Pharmacogenomics Centre (PROMISE), Faculty of Pharmacy, Universiti Teknologi MARA, Malaysia – sequence: 2 givenname: Leif surname: Bertilsson fullname: Bertilsson, Leif organization: Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University, Hospital-Huddinge, Karolinska Institutet, Stockholm, Sweden |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22185816$$D View this record in MEDLINE/PubMed http://kipublications.ki.se/Default.aspx?queryparsed=id:124156004$$DView record from Swedish Publication Index |
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49 Oscarson (10.2133/dmpk.DMPK-11-RV-121_bb0145) 1997; 52 Kramer (10.2133/dmpk.DMPK-11-RV-121_bb0335) 2009; 19 Lennard (10.2133/dmpk.DMPK-11-RV-121_bb0590) 1983; 34 Li (10.2133/dmpk.DMPK-11-RV-121_bb0715) 2011 Broly (10.2133/dmpk.DMPK-11-RV-121_bb0115) 1993; 3 Bradford (10.2133/dmpk.DMPK-11-RV-121_bb0455) 2002; 3 Scordo (10.2133/dmpk.DMPK-11-RV-121_bb0800) 2006; 53 Marez (10.2133/dmpk.DMPK-11-RV-121_bb0060) 1997; 7 Tateishi (10.2133/dmpk.DMPK-11-RV-121_bb0445) 1999; 65 Wuttke (10.2133/dmpk.DMPK-11-RV-121_bb0640) 2002; 72 Mitsunaga (10.2133/dmpk.DMPK-11-RV-121_bb0395) 2002; 505 Linder (10.2133/dmpk.DMPK-11-RV-121_bb0015) 1997; 43 Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0760) 1989; 1 Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0310) 2003; 73 Tamminga (10.2133/dmpk.DMPK-11-RV-121_bb0575) 2003; 59 Black (10.2133/dmpk.DMPK-11-RV-121_bb0535) 2011; 40 Marez (10.2133/dmpk.DMPK-11-RV-121_bb0240) 1995; 5 Brockmöller (10.2133/dmpk.DMPK-11-RV-121_bb0580) 2002; 72 Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0435) 1992; 51 Qin (10.2133/dmpk.DMPK-11-RV-121_bb0355) 2008; 92 Daly (10.2133/dmpk.DMPK-11-RV-121_bb0230) 1995; 95 Broly (10.2133/dmpk.DMPK-11-RV-121_bb0235) 1995; 96 Hamelin (10.2133/dmpk.DMPK-11-RV-121_bb0615) 2000; 67 Masimirembwa (10.2133/dmpk.DMPK-11-RV-121_bb0140) 1996; 42 Lim (10.2133/dmpk.DMPK-11-RV-121_bb0660) 2007; 25 Sachse (10.2133/dmpk.DMPK-11-RV-121_bb0385) 1998; 8 Fuselli (10.2133/dmpk.DMPK-11-RV-121_bb0200) 2004; 12 Evert (10.2133/dmpk.DMPK-11-RV-121_bb0225) 1994; 4 Toyama (10.2133/dmpk.DMPK-11-RV-121_bb0700) 2009; 39 Xu (10.2133/dmpk.DMPK-11-RV-121_bb0675) 2008; 19 Johansson (10.2133/dmpk.DMPK-11-RV-121_bb0125) 1994; 46 Contreras (10.2133/dmpk.DMPK-11-RV-121_bb0360) 2011; 12 Nakamura (10.2133/dmpk.DMPK-11-RV-121_bb0425) 1985; 38 Bernal (10.2133/dmpk.DMPK-11-RV-121_bb0490) 1999; 9 Kawanishi (10.2133/dmpk.DMPK-11-RV-121_bb0585) 2004; 59 Kagimoto (10.2133/dmpk.DMPK-11-RV-121_bb0175) 1990; 265 Bertilsson (10.2133/dmpk.DMPK-11-RV-121_bb0540) 1985; 7 Saxena (10.2133/dmpk.DMPK-11-RV-121_bb0220) 1994; 3 Li (10.2133/dmpk.DMPK-11-RV-121_bb0315) 2006; 34 Aubert (10.2133/dmpk.DMPK-11-RV-121_bb0705) 2009; 27 Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0095) 2010; 1 Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0405) 2011; 12 Wennerholm (10.2133/dmpk.DMPK-11-RV-121_bb0485) 2002; 71 Eichelbaum (10.2133/dmpk.DMPK-11-RV-121_bb0045) 1982; 31 Cai (10.2133/dmpk.DMPK-11-RV-121_bb0400) 2006; 6 Ismail (10.2133/dmpk.DMPK-11-RV-121_bb0495) 2003; 28 Schroth (10.2133/dmpk.DMPK-11-RV-121_bb0650) 2007; 25 Goryachkina (10.2133/dmpk.DMPK-11-RV-121_bb0595) 2008; 64 Johansson (10.2133/dmpk.DMPK-11-RV-121_bb0065) 1993; 90 Morita (10.2133/dmpk.DMPK-11-RV-121_bb0550) 2000; 20 Jornil (10.2133/dmpk.DMPK-11-RV-121_bb0525) 2011; 44 Daly (10.2133/dmpk.DMPK-11-RV-121_bb0255) 1996; 6 Pai (10.2133/dmpk.DMPK-11-RV-121_bb0785) 2004; 279 Kroemer (10.2133/dmpk.DMPK-11-RV-121_bb0010) 1995; 56 Marez (10.2133/dmpk.DMPK-11-RV-121_bb0245) 1996; 97 Wang (10.2133/dmpk.DMPK-11-RV-121_bb0480) 1993; 53 Gaedigk (10.2133/dmpk.DMPK-11-RV-121_bb0085) 2005; 77 Nelson (10.2133/dmpk.DMPK-11-RV-121_bb0050) 1996; 6 Allorge (10.2133/dmpk.DMPK-11-RV-121_bb0295) 2005; 59 Daly (10.2133/dmpk.DMPK-11-RV-121_bb0005) 1995; 73 Shimada (10.2133/dmpk.DMPK-11-RV-121_bb0195) 2001; 11 Kiyotani (10.2133/dmpk.DMPK-11-RV-121_bb0665) 2008; 99 |
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SubjectTerms | Biotransformation clinical implication CYP2D6 polymorphism Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Drug Interactions Genetic Predisposition to Disease Humans interethnic differences Pharmacogenetics - methods Pharmacokinetics Polymorphism, Genetic |
Title | Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance |
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