顺铂水针剂与粉针剂联合化疗方案治疗肺癌的随机临床研究
目的 比较顺铂水针剂与粉针剂治疗肺癌的疗效和毒性。方法 小细胞肺癌(SCLC)67例。给予EP方案，非小细胞肺癌(NSCLC)156例，给予NP方案化疗。患者被随机纳入顺铂水剂组和粉剂组，两组间同类型肺癌所用药物种类、剂量一致。结果 SCLC水剂组与粉剂组的有效率分别为84.8％与82.4％(P>0.05)，NSCLC分别为31.6％与29.9％(P>0.05)。水剂组与粉剂组毒性反应主要为胃肠道反应和骨髓抑制，其中急性恶心呕吐发生率分别为72.3％与65.8％(P<0.05)，迟发性恶心呕吐分别为60.7％与53.2％(P<0.05)；两组间血液毒性及肾毒性无显著性差...
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| Published in | Zhongguo fei ai za zhi Vol. 7; no. 3; pp. 243 - 246 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
610041,成都,四川大学华西医院肿瘤中心化疗科
2004
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 1009-3419 1999-6187 |
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| Abstract | 目的 比较顺铂水针剂与粉针剂治疗肺癌的疗效和毒性。方法 小细胞肺癌(SCLC)67例。给予EP方案，非小细胞肺癌(NSCLC)156例，给予NP方案化疗。患者被随机纳入顺铂水剂组和粉剂组，两组间同类型肺癌所用药物种类、剂量一致。结果 SCLC水剂组与粉剂组的有效率分别为84.8％与82.4％(P>0.05)，NSCLC分别为31.6％与29.9％(P>0.05)。水剂组与粉剂组毒性反应主要为胃肠道反应和骨髓抑制，其中急性恶心呕吐发生率分别为72.3％与65.8％(P<0.05)，迟发性恶心呕吐分别为60.7％与53.2％(P<0.05)；两组间血液毒性及肾毒性无显著性差异。SCLC水剂组与粉剂组平均住院费用分别为12468.73元与9278．66元(P<0.05)，NSCLC分别为17253.64元与14881.72元(P<0.05)。结论 顺铂水针剂虽使用方便，但疗效较粉针剂无明显提高，且胃肠反应更重，治疗费用更高，临床上应酌情选用。 |
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| AbstractList | 目的 比较顺铂水针剂与粉针剂治疗肺癌的疗效和毒性。方法 小细胞肺癌(SCLC)67例。给予EP方案，非小细胞肺癌(NSCLC)156例，给予NP方案化疗。患者被随机纳入顺铂水剂组和粉剂组，两组间同类型肺癌所用药物种类、剂量一致。结果 SCLC水剂组与粉剂组的有效率分别为84.8％与82.4％(P>0.05)，NSCLC分别为31.6％与29.9％(P>0.05)。水剂组与粉剂组毒性反应主要为胃肠道反应和骨髓抑制，其中急性恶心呕吐发生率分别为72.3％与65.8％(P<0.05)，迟发性恶心呕吐分别为60.7％与53.2％(P<0.05)；两组间血液毒性及肾毒性无显著性差异。SCLC水剂组与粉剂组平均住院费用分别为12468.73元与9278．66元(P<0.05)，NSCLC分别为17253.64元与14881.72元(P<0.05)。结论 顺铂水针剂虽使用方便，但疗效较粉针剂无明显提高，且胃肠反应更重，治疗费用更高，临床上应酌情选用。 R734.2%R730.53; 目的比较顺铂水针剂与粉针剂治疗肺癌的疗效和毒性.方法小细胞肺癌(SCLC)67例,给予EP方案,非小细胞肺癌(NSCLC)156例,给予NP方案化疗.患者被随机纳入顺铂水剂组和粉剂组,两组间同类型肺癌所用药物种类、剂量一致.结果SCLC水剂组与粉剂组的有效率分别为84.8%与82.4%(P＞0.05),NSCLC分别为31.6%与29.9%(P＞0.05).水剂组与粉剂组毒性反应主要为胃肠道反应和骨髓抑制,其中急性恶心呕吐发生率分别为72.3%与65.8%(P＜0.05),迟发性恶心呕吐分别为60.7%与53.2%(P＜0.05);两组间血液毒性及肾毒性无显著性差异.SCLC水剂组与粉剂组平均住院费用分别为12 468.73元与9 278.66元(P＜0.05),NSCLC分别为17 253.64元与14881.72元(P＜0.05).结论顺铂水针剂虽使用方便,但疗效较粉针剂无明显提高,且胃肠反应更重,治疗费用更高,临床上应酌情选用. |
| Author | 任莉 鄢希 勾红峰 邱萌 李潞 朱江 |
| AuthorAffiliation | 四川大学华西医院肿瘤中心化疗科，成都610041 |
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| Snippet | 目的 比较顺铂水针剂与粉针剂治疗肺癌的疗效和毒性。方法 小细胞肺癌(SCLC)67例。给予EP方案，非小细胞肺癌(NSCLC)156例，给予NP方案化疗。患者被随机纳入顺铂水剂组和粉剂... R734.2%R730.53; 目的比较顺铂水针剂与粉针剂治疗肺癌的疗效和毒性.方法小细胞肺癌(SCLC)67例,给予EP方案,非小细胞肺癌(NSCLC)156例,给予NP方案化疗.患者被随机纳入顺铂水... |
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| SubjectTerms | 小细胞肺癌／药物疗法 非小细胞肺癌／药物疗法 顺铂／治疗应用 |
| Title | 顺铂水针剂与粉针剂联合化疗方案治疗肺癌的随机临床研究 |
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