Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation

The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we...

Full description

Saved in:
Bibliographic Details
Published inCommunications biology Vol. 6; no. 1; pp. 915 - 11
Main Authors Tanaka, Yumiko, Yamagishi, Mai, Motomura, Yasutaka, Kamatani, Takashi, Oguchi, Yusuke, Suzuki, Nobutake, Kiniwa, Tsuyoshi, Kabata, Hiroki, Irie, Misato, Tsunoda, Tatsuhiko, Miya, Fuyuki, Goda, Keisuke, Ohara, Osamu, Funatsu, Takashi, Fukunaga, Koichi, Moro, Kazuyo, Uemura, Sotaro, Shirasaki, Yoshitaka
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 06.09.2023
Nature Publishing Group
Nature Portfolio
Subjects
13/21
13/62
14/1
14/63
38/91
631/1647/245/2186
631/1647/664/1364
631/1647/664/2172
Biology
Biomedical and Life Sciences
Cell activation
Cells
Cytokines
Gene expression
Life Sciences
Lymphoid cells
Medicine
Science
Transcription activation
Transcriptomes
Online AccessGet full text
ISSN2399-3642
2399-3642
DOI10.1038/s42003-023-05297-w

Cover

Abstract The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we have developed the Time-Dependent Cell-State Selection (TDCSS) technique, which employs live-cell imaging of secretion activity to detect an index of the transition state, followed by the simultaneous recovery of indexed cells for subsequent transcriptome analysis. In this study, we used the TDCSS technique to investigate the transition state of group 2 innate lymphoid cells (ILC2s) activation, which is indexed by the onset of interleukin (IL)-13 secretion. The TDCSS approach allowed us to identify time-dependent genes, including transiently induced genes (TIGs). Our findings of IL4 and MIR155HG as TIGs have shown a regulatory function in ILC2s activation. Time-Dependent Cell-State Selection combines live cell imaging and single-cell RNA sequencing to characterize and analyse ILC2s during their activation, revealing a set of genes that are transitionally upregulated (TIGs) in ILC2s during this phase.
AbstractList The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we have developed the Time-Dependent Cell-State Selection (TDCSS) technique, which employs live-cell imaging of secretion activity to detect an index of the transition state, followed by the simultaneous recovery of indexed cells for subsequent transcriptome analysis. In this study, we used the TDCSS technique to investigate the transition state of group 2 innate lymphoid cells (ILC2s) activation, which is indexed by the onset of interleukin (IL)-13 secretion. The TDCSS approach allowed us to identify time-dependent genes, including transiently induced genes (TIGs). Our findings of IL4 and MIR155HG as TIGs have shown a regulatory function in ILC2s activation.
The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we have developed the Time-Dependent Cell-State Selection (TDCSS) technique, which employs live-cell imaging of secretion activity to detect an index of the transition state, followed by the simultaneous recovery of indexed cells for subsequent transcriptome analysis. In this study, we used the TDCSS technique to investigate the transition state of group 2 innate lymphoid cells (ILC2s) activation, which is indexed by the onset of interleukin (IL)-13 secretion. The TDCSS approach allowed us to identify time-dependent genes, including transiently induced genes (TIGs). Our findings of IL4 and MIR155HG as TIGs have shown a regulatory function in ILC2s activation. Time-Dependent Cell-State Selection combines live cell imaging and single-cell RNA sequencing to characterize and analyse ILC2s during their activation, revealing a set of genes that are transitionally upregulated (TIGs) in ILC2s during this phase.
The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we have developed the Time-Dependent Cell-State Selection (TDCSS) technique, which employs live-cell imaging of secretion activity to detect an index of the transition state, followed by the simultaneous recovery of indexed cells for subsequent transcriptome analysis. In this study, we used the TDCSS technique to investigate the transition state of group 2 innate lymphoid cells (ILC2s) activation, which is indexed by the onset of interleukin (IL)-13 secretion. The TDCSS approach allowed us to identify time-dependent genes, including transiently induced genes (TIGs). Our findings of IL4 and MIR155HG as TIGs have shown a regulatory function in ILC2s activation.Time-Dependent Cell-State Selection combines live cell imaging and single-cell RNA sequencing to characterize and analyse ILC2s during their activation, revealing a set of genes that are transitionally upregulated (TIGs) in ILC2s during this phase.
The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we have developed the Time-Dependent Cell-State Selection (TDCSS) technique, which employs live-cell imaging of secretion activity to detect an index of the transition state, followed by the simultaneous recovery of indexed cells for subsequent transcriptome analysis. In this study, we used the TDCSS technique to investigate the transition state of group 2 innate lymphoid cells (ILC2s) activation, which is indexed by the onset of interleukin (IL)-13 secretion. The TDCSS approach allowed us to identify time-dependent genes, including transiently induced genes (TIGs). Our findings of IL4 and MIR155HG as TIGs have shown a regulatory function in ILC2s activation.The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we have developed the Time-Dependent Cell-State Selection (TDCSS) technique, which employs live-cell imaging of secretion activity to detect an index of the transition state, followed by the simultaneous recovery of indexed cells for subsequent transcriptome analysis. In this study, we used the TDCSS technique to investigate the transition state of group 2 innate lymphoid cells (ILC2s) activation, which is indexed by the onset of interleukin (IL)-13 secretion. The TDCSS approach allowed us to identify time-dependent genes, including transiently induced genes (TIGs). Our findings of IL4 and MIR155HG as TIGs have shown a regulatory function in ILC2s activation.
Abstract The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during the transition state of activation renders the analysis of the transcriptome of this state technically challenging. To address this issue, we have developed the Time-Dependent Cell-State Selection (TDCSS) technique, which employs live-cell imaging of secretion activity to detect an index of the transition state, followed by the simultaneous recovery of indexed cells for subsequent transcriptome analysis. In this study, we used the TDCSS technique to investigate the transition state of group 2 innate lymphoid cells (ILC2s) activation, which is indexed by the onset of interleukin (IL)-13 secretion. The TDCSS approach allowed us to identify time-dependent genes, including transiently induced genes (TIGs). Our findings of IL4 and MIR155HG as TIGs have shown a regulatory function in ILC2s activation.
ArticleNumber 915
Author Oguchi, Yusuke
Tanaka, Yumiko
Kabata, Hiroki
Irie, Misato
Fukunaga, Koichi
Moro, Kazuyo
Goda, Keisuke
Shirasaki, Yoshitaka
Yamagishi, Mai
Ohara, Osamu
Uemura, Sotaro
Kamatani, Takashi
Suzuki, Nobutake
Miya, Fuyuki
Tsunoda, Tatsuhiko
Motomura, Yasutaka
Funatsu, Takashi
Kiniwa, Tsuyoshi
Author_xml – sequence: 1
  givenname: Yumiko
  surname: Tanaka
  fullname: Tanaka, Yumiko
  organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
– sequence: 2
  givenname: Mai
  orcidid: 0000-0002-4449-5899
  surname: Yamagishi
  fullname: Yamagishi, Mai
  organization: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Live Cell Diagnosis, Ltd
– sequence: 3
  givenname: Yasutaka
  surname: Motomura
  fullname: Motomura, Yasutaka
  organization: Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University
– sequence: 4
  givenname: Takashi
  surname: Kamatani
  fullname: Kamatani, Takashi
  organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Department of AI Technology Development, M&D Data Science Center, Tokyo Medical and Dental University, Division of Precision Cancer Medicine, Tokyo Medical and Dental University Hospital, Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
– sequence: 5
  givenname: Yusuke
  orcidid: 0000-0003-1962-4334
  surname: Oguchi
  fullname: Oguchi, Yusuke
  organization: PRESTO, JST, RIKEN Cluster for Pioneering Research
– sequence: 6
  givenname: Nobutake
  surname: Suzuki
  fullname: Suzuki, Nobutake
  organization: Graduate School of Pharmaceutical Sciences, The University of Tokyo
– sequence: 7
  givenname: Tsuyoshi
  surname: Kiniwa
  fullname: Kiniwa, Tsuyoshi
  organization: RIKEN Center for Integrative Medical Sciences
– sequence: 8
  givenname: Hiroki
  surname: Kabata
  fullname: Kabata, Hiroki
  organization: Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
– sequence: 9
  givenname: Misato
  surname: Irie
  fullname: Irie, Misato
  organization: Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
– sequence: 10
  givenname: Tatsuhiko
  orcidid: 0000-0002-5439-7918
  surname: Tsunoda
  fullname: Tsunoda, Tatsuhiko
  organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo, RIKEN Center for Integrative Medical Sciences, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
– sequence: 11
  givenname: Fuyuki
  orcidid: 0000-0001-6758-2015
  surname: Miya
  fullname: Miya, Fuyuki
  organization: Center for Medical Genetics, Keio University School of Medicine
– sequence: 12
  givenname: Keisuke
  orcidid: 0000-0001-6302-6038
  surname: Goda
  fullname: Goda, Keisuke
  organization: Department of Chemistry, Graduate School of Science, The University of Tokyo, Department of Bioengineering, University of California, Institute of Technological Sciences, Wuhan University
– sequence: 13
  givenname: Osamu
  orcidid: 0000-0002-3328-9571
  surname: Ohara
  fullname: Ohara, Osamu
  organization: Kazusa DNA Research Institute
– sequence: 14
  givenname: Takashi
  orcidid: 0000-0002-9656-8308
  surname: Funatsu
  fullname: Funatsu, Takashi
  organization: Graduate School of Pharmaceutical Sciences, The University of Tokyo
– sequence: 15
  givenname: Koichi
  surname: Fukunaga
  fullname: Fukunaga, Koichi
  organization: Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
– sequence: 16
  givenname: Kazuyo
  surname: Moro
  fullname: Moro, Kazuyo
  organization: Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, RIKEN Center for Integrative Medical Sciences
– sequence: 17
  givenname: Sotaro
  orcidid: 0000-0001-9701-1803
  surname: Uemura
  fullname: Uemura, Sotaro
  email: uemura@bs.s.u-tokyo.ac.jp
  organization: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
– sequence: 18
  givenname: Yoshitaka
  orcidid: 0000-0002-3808-1630
  surname: Shirasaki
  fullname: Shirasaki, Yoshitaka
  email: shirasaki@g.ecc.u-tokyo.ac.jp
  organization: Graduate School of Pharmaceutical Sciences, The University of Tokyo
BookMark eNp9Ustu1DAUtVARLUN_gFUkNmxS_EziFUIjoCONxKasLdu5CR5l7MH29PH3OJMKaBddWH7cc47v47xFZz54QOg9wVcEs-5T4hRjVmNalqCyre9eoQvKpKxZw-nZf-dzdJnSDmNMpJQN42_QOWublklKLxDcuD3UPRzA9-BzZWGa6pR1hirBBDa74Cs3h9zgIFU5ap9cuU4PFdwfIqQEfTWCL7EI43HS2fmx2mzXtNKFfatnhXfo9aCnBJeP-wr9_Pb1Zn1db39836y_bGsrOp7rfrAaA2sNAUO1aKDHRmorwA52kBwEtxJwx4wRQjaNNZZ0PcGDND0mAA1boc2i2we9U4fo9jo-qKCdOj2EOCods7MTKMOFZK0YrMGci47IFnPdiHaQ0ljciqL1edE6HM0eeltqjnp6Ivo04t0vNYZbRTDvykBIUfj4qBDD7yOkrPYuzQ3WHsIxKdo1tMxElIpW6MMz6C4coy-9mlFEEMqbGUUXlI0hpQjD32wIVrMr1OIKVVyhTq5Qd4XUPSNZl09TKVm76WUqW6ip_ONHiP-yeoH1B1Zfz6g
CitedBy_id crossref_primary_10_1016_j_isci_2024_109840
Cites_doi 10.1002/jcp.21094
10.1038/s41596-019-0253-4
10.1039/C0LC00114G
10.1016/j.stem.2010.03.015
10.1016/j.jacig.2022.07.007
10.1002/eji.201041295
10.1165/rcmb.2012-0304OC
10.1016/j.jaci.2014.06.024
10.1038/s41467-017-02294-6
10.1038/s41590-018-0201-4
10.1038/s41598-019-56847-4
10.1016/j.jaci.2015.03.043
10.1038/srep04736
10.1073/pnas.0902636106
10.1016/j.cels.2017.03.010
10.1182/blood.V97.1.221
10.1073/pnas.1213764109
10.3389/fimmu.2019.00755
10.1002/eji.200939381
10.1084/jem.20151750
10.1038/nprot.2015.047
10.1038/ni.3444
10.1016/j.jaci.2020.01.038
10.1038/s41598-018-37186-2
10.1038/s41467-018-07882-8
10.1093/bioinformatics/btu638
10.1038/nature09232
10.1038/s41423-020-0404-0
10.1016/j.immuni.2012.06.020
10.1172/jci.insight.131480
10.1038/nature08636
10.4049/jimmunol.1300974
10.4049/jimmunol.1401184
10.1038/ni.2536
10.1038/nature08900
10.1021/acschembio.8b00371
10.1038/icb.2015.104
10.1016/S1074-7613(02)00332-1
10.1038/s41467-018-05485-x
10.1016/j.celrep.2014.07.012
10.1002/eji.202049055
10.1021/ac069490p
10.1084/jem.20170051
10.1002/bies.20769
10.1016/B978-0-12-391856-7.00038-X
10.1038/ni.2104
10.1038/s41592-019-0686-2
10.1126/sciadv.aba9319
10.1038/nbt.2859
10.1126/science.aap8992
10.1016/j.isci.2020.101479
10.4049/jimmunol.1300379
10.1038/nature09145
10.1016/j.cell.2018.05.014
10.1038/ni.3309
10.1038/nature24029
10.1016/j.cell.2015.04.044
10.1016/j.jaci.2016.06.035
10.1182/bloodadvances.2016002352
10.1016/j.yexmp.2012.09.011
10.1093/nar/gku555
10.3389/fimmu.2018.02232
10.1084/jem.20130071
ContentType Journal Article
Copyright The Author(s) 2023
The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023. Springer Nature Limited.
Springer Nature Limited 2023
Copyright_xml – notice: The Author(s) 2023
– notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023. Springer Nature Limited.
– notice: Springer Nature Limited 2023
DBID C6C
AAYXX
CITATION
3V.
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.1038/s42003-023-05297-w
DatabaseName Springer Nature OA Free Journals (Freely Accessible)
CrossRef
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Journals
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central (New) (NC LIVE)
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
ProQuest Central Student
SciTech Premium Collection
Biological Sciences
Science Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Science Journals
ProQuest One Academic Eastern Edition
Biological Science Database
ProQuest SciTech Collection
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef

Publicly Available Content Database
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: http://www.proquest.com/pqcentral?accountid=15518
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Medicine
EISSN 2399-3642
EndPage 11
ExternalDocumentID oai_doaj_org_article_b459375fcb0445819704a657f99bc075
PMC10482971
10_1038_s42003_023_05297_w
GrantInformation_xml – fundername: MEXT | JST | Precursory Research for Embryonic Science and Technology (PRESTO)
  grantid: JPMJPR17H6
  funderid: https://doi.org/10.13039/501100009023
– fundername: MEXT | Japan Society for the Promotion of Science (JSPS)
  grantid: 20H04512; JPMJCR1412; Core-to-Core Program
  funderid: https://doi.org/10.13039/501100001691
– fundername: MEXT | JST | Core Research for Evolutional Science and Technology (CREST)
  grantid: JPMJCR18H1; JPMJCR1412
  funderid: https://doi.org/10.13039/501100003382
– fundername: Cabinet Office, Government of Japan
  grantid: ImPACT Program of the Council for Science, Technology, and Innovation; ImPACT Program of the Council for Science, Technology, and Innovation
  funderid: https://doi.org/10.13039/501100002770
– fundername: Japan Agency for Medical Research and Development (AMED)
  grantid: JP20hm0102082; JP16ek0410031
  funderid: https://doi.org/10.13039/100009619
– fundername: ;
  grantid: JPMJPR17H6
– fundername: ;
  grantid: 20H04512; JPMJCR1412; Core-to-Core Program
– fundername: ;
  grantid: JPMJCR18H1; JPMJCR1412
– fundername: ;
  grantid: ImPACT Program of the Council for Science, Technology, and Innovation; ImPACT Program of the Council for Science, Technology, and Innovation
– fundername: ;
  grantid: JP20hm0102082; JP16ek0410031
GroupedDBID 0R~
53G
88I
AAJSJ
ABDBF
ABUWG
ACGFS
ACSMW
ACUHS
ADBBV
AFKRA
AJTQC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
C6C
CCPQU
DWQXO
EBLON
EBS
GNUQQ
GROUPED_DOAJ
HCIFZ
HYE
M2P
M7P
M~E
NAO
O9-
OK1
PGMZT
PIMPY
RNT
RPM
SNYQT
AASML
AAYXX
CITATION
PHGZM
PHGZT
3V.
7XB
8FE
8FH
8FK
AARCD
LK8
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c584t-dfca0e37b1eb2a56ed0b9ac5ecfcf94e54c9e083bb55966cbc18d10f9bd01ee63
IEDL.DBID C6C
ISSN 2399-3642
IngestDate Wed Aug 27 01:30:37 EDT 2025
Thu Aug 21 18:36:30 EDT 2025
Fri Sep 05 12:14:58 EDT 2025
Wed Aug 13 03:50:07 EDT 2025
Tue Jul 01 03:01:50 EDT 2025
Thu Apr 24 23:12:25 EDT 2025
Fri Feb 21 02:38:38 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c584t-dfca0e37b1eb2a56ed0b9ac5ecfcf94e54c9e083bb55966cbc18d10f9bd01ee63
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-6758-2015
0000-0002-3328-9571
0000-0001-9701-1803
0000-0001-6302-6038
0000-0003-1962-4334
0000-0002-3808-1630
0000-0002-5439-7918
0000-0002-4449-5899
0000-0002-9656-8308
OpenAccessLink https://www.nature.com/articles/s42003-023-05297-w
PMID 37673922
PQID 2861512468
PQPubID 4669726
PageCount 11
ParticipantIDs doaj_primary_oai_doaj_org_article_b459375fcb0445819704a657f99bc075
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10482971
proquest_miscellaneous_2862199508
proquest_journals_2861512468
crossref_primary_10_1038_s42003_023_05297_w
crossref_citationtrail_10_1038_s42003_023_05297_w
springer_journals_10_1038_s42003_023_05297_w
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2023-09-06
PublicationDateYYYYMMDD 2023-09-06
PublicationDate_xml – month: 09
  year: 2023
  text: 2023-09-06
  day: 06
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Communications biology
PublicationTitleAbbrev Commun Biol
PublicationYear 2023
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Banerjee, Schambach, Dejong, Hammond, Reiner (CR47) 2010; 40
Clerk (CR3) 2007; 212
Schneider (CR31) 2018; 174
Wang (CR53) 2020; 6
Huang (CR43) 2012; 42
Mjösberg (CR21) 2011; 12
Johansson, Malmhäll, Ramos-Ramírez, Rådinger (CR26) 2017; 139
Virtanen (CR66) 2019; 17
Chyan, Raines (CR16) 2018; 13
Furusawa (CR36) 2013; 191
Turner (CR30) 2013; 210
Kim (CR61) 2013; 14
Knolle (CR27) 2018; 9
Bal (CR35) 2016; 17
Roediger (CR45) 2015; 136
Ohno (CR14) 2020; 23
Schwartz (CR25) 2017; 214
Lim (CR32) 2016; 213
Shirasaki (CR12) 2014; 4
Mitrophanov, Groisman (CR13) 2008; 30
Tang (CR1) 2010; 6
Di Carlo, Lee (CR7) 2006; 78
Ricardo-Gonzalez (CR29) 2018; 19
Anders, Pyl, Huber (CR62) 2015; 31
Moro (CR17) 2010; 463
Hoyler (CR23) 2012; 37
Jeknić, Kudo, Covert (CR6) 2019; 10
Klein (CR11) 2015; 161
Ye (CR42) 2016; 2016
Matsushita (CR28) 2020; 5
Neill (CR18) 2010; 464
Zhang (CR22) 2020; 18
Baba (CR33) 2022; 1
Vlad, Suciu-Foca (CR40) 2012; 93
Nishimura (CR54) 2019; 9
CR55
Fallon (CR34) 2002; 17
O’Connell, Chaudhuri, Rao, Baltimore (CR38) 2009; 106
Sporri, Kovanen, Sasaki, Yoshimura, Leonard (CR41) 2001; 97
Bartemes, Kephart, Fox, Kita (CR20) 2014; 134
Jurgens, Popović, Wolkers (CR56) 2021; 51
Wallrapp (CR24) 2017; 549
Tanna, Schmidt, Cherepkova, Okoniewski, Platt (CR50) 2020; 15
Spiller, Wood, Rand, White (CR5) 2010; 465
Liu (CR2) 2013; 8
Franciszkiewicz (CR59) 2014; 193
Best (CR4) 2013; 14
Petrova, Pesic, Pardali, Gaestel, Arthur (CR37) 2020; 10
Saliba, Westermann, Gorski, Vogel (CR10) 2014; 42
Moro (CR48) 2016; 17
Zhou (CR65) 2019; 10
Travers (CR58) 2018; 9
Park, Hur, Cho, Park, Suh (CR9) 2011; 11
Sandhu (CR44) 2012; 109
Tay (CR15) 2010; 466
Liu (CR49) 2020; 146
Lane (CR52) 2017; 4
Camelo (CR19) 2017; 1
CR63
Kouzaki, Tojima, Kita, Shimizu (CR57) 2013; 49
Moro, Ealey, Kabata, Koyasu (CR60) 2015; 10
Polonsky, Chain, Friedman (CR8) 2016; 94
Yamamoto (CR39) 2018; 9
Trapnell (CR64) 2014; 32
Mirchandani (CR46) 2014; 192
Tang, Liu (CR51) 2018; 360
AI Lim (5297_CR32) 2016; 213
JE Turner (5297_CR30) 2013; 210
C Schneider (5297_CR31) 2018; 174
W Tang (5297_CR51) 2018; 360
C Schwartz (5297_CR25) 2017; 214
R Baba (5297_CR33) 2022; 1
S Liu (5297_CR49) 2020; 146
W Chyan (5297_CR16) 2018; 13
T Hoyler (5297_CR23) 2012; 37
A Banerjee (5297_CR47) 2010; 40
KR Bartemes (5297_CR20) 2014; 134
5297_CR55
Y Zhou (5297_CR65) 2019; 10
H Kouzaki (5297_CR57) 2013; 49
SM Bal (5297_CR35) 2016; 17
SK Sandhu (5297_CR44) 2012; 109
CY Huang (5297_CR43) 2012; 42
K Moro (5297_CR48) 2016; 17
AS Mirchandani (5297_CR46) 2014; 192
S Anders (5297_CR62) 2015; 31
DG Spiller (5297_CR5) 2010; 465
A Clerk (5297_CR3) 2007; 212
DR Neill (5297_CR18) 2010; 464
L Zhang (5297_CR22) 2020; 18
K Moro (5297_CR60) 2015; 10
MD Knolle (5297_CR27) 2018; 9
S Ohno (5297_CR14) 2020; 23
5297_CR63
J Furusawa (5297_CR36) 2013; 191
JM Mjösberg (5297_CR21) 2011; 12
T Petrova (5297_CR37) 2020; 10
PG Fallon (5297_CR34) 2002; 17
J Ye (5297_CR42) 2016; 2016
M Polonsky (5297_CR8) 2016; 94
K Matsushita (5297_CR28) 2020; 5
A Camelo (5297_CR19) 2017; 1
AM Klein (5297_CR11) 2015; 161
K Franciszkiewicz (5297_CR59) 2014; 193
D Di Carlo (5297_CR7) 2006; 78
S Jeknić (5297_CR6) 2019; 10
T Liu (5297_CR2) 2013; 8
AY Mitrophanov (5297_CR13) 2008; 30
AP Jurgens (5297_CR56) 2021; 51
D Kim (5297_CR61) 2013; 14
K Johansson (5297_CR26) 2017; 139
RM O’Connell (5297_CR38) 2009; 106
JA Best (5297_CR4) 2013; 14
J Travers (5297_CR58) 2018; 9
AE Saliba (5297_CR10) 2014; 42
K Moro (5297_CR17) 2010; 463
W Wang (5297_CR53) 2020; 6
T Tanna (5297_CR50) 2020; 15
MC Park (5297_CR9) 2011; 11
C Trapnell (5297_CR64) 2014; 32
A Wallrapp (5297_CR24) 2017; 549
P Virtanen (5297_CR66) 2019; 17
T Yamamoto (5297_CR39) 2018; 9
Y Shirasaki (5297_CR12) 2014; 4
B Sporri (5297_CR41) 2001; 97
K Nishimura (5297_CR54) 2019; 9
F Tang (5297_CR1) 2010; 6
RR Ricardo-Gonzalez (5297_CR29) 2018; 19
G Vlad (5297_CR40) 2012; 93
B Roediger (5297_CR45) 2015; 136
K Lane (5297_CR52) 2017; 4
S Tay (5297_CR15) 2010; 466
References_xml – volume: 19
  start-page: 1093
  year: 2018
  end-page: 1099
  ident: CR29
  article-title: Tissue signals imprint ILC2 identity with anticipatory function
  publication-title: Nat. Immunol.
– volume: 9
  start-page: 1
  year: 2018
  end-page: 15
  ident: CR58
  article-title: Chromatin regulates IL-33 release and extracellular cytokine activity
  publication-title: Nat. Commun.
– volume: 6
  start-page: eaba9319
  year: 2020
  ident: CR53
  article-title: Live-cell imaging and analysis reveal cell phenotypic transition dynamics inherently missing in snapshot data
  publication-title: Sci. Adv.
– volume: 192
  start-page: 2442
  year: 2014
  end-page: 2448
  ident: CR46
  article-title: Type 2 innate lymphoid cells drive CD4 + Th2 cell responses
  publication-title: J. Immunol.
– volume: 9
  start-page: 1
  year: 2019
  end-page: 15
  ident: CR54
  article-title: Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells
  publication-title: Sci. Rep.
– volume: 11
  start-page: 79
  year: 2011
  end-page: 86
  ident: CR9
  article-title: High-throughput single-cell quantification using simple microwell-based cell docking and programmable time-course live-cell imaging
  publication-title: Lab Chip
– volume: 37
  start-page: 634
  year: 2012
  end-page: 648
  ident: CR23
  article-title: The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
  publication-title: Immunity
– volume: 360
  start-page: eaap899
  year: 2018
  ident: CR51
  article-title: Rewritable multi-event analog recording in bacterial and mammalian cells
  publication-title: Science (80-.)
– volume: 97
  start-page: 221
  year: 2001
  end-page: 226
  ident: CR41
  article-title: JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling
  publication-title: Blood
– volume: 210
  start-page: 2951
  year: 2013
  end-page: 2965
  ident: CR30
  article-title: IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
  publication-title: J. Exp. Med.
– volume: 136
  start-page: 1653
  year: 2015
  end-page: 1663.e7
  ident: CR45
  article-title: IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation
  publication-title: J. Allergy Clin. Immunol.
– volume: 6
  start-page: 468
  year: 2010
  end-page: 478
  ident: CR1
  article-title: Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-seq analysis
  publication-title: Cell Stem Cell
– volume: 212
  start-page: 311
  year: 2007
  end-page: 322
  ident: CR3
  article-title: Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses
  publication-title: J. Cell. Physiol.
– volume: 549
  start-page: 351
  year: 2017
  end-page: 356
  ident: CR24
  article-title: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation
  publication-title: Nat
– volume: 1
  start-page: 577
  year: 2017
  end-page: 589
  ident: CR19
  article-title: IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells
  publication-title: Blood Adv.
– volume: 51
  start-page: 2178
  year: 2021
  ident: CR56
  article-title: T cells at work: How post‐transcriptional mechanisms control T cell homeostasis and activation
  publication-title: Eur. J. Immunol.
– volume: 464
  start-page: 1367
  year: 2010
  end-page: 1370
  ident: CR18
  article-title: Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
  publication-title: Nature
– volume: 13
  start-page: 1810
  year: 2018
  end-page: 1823
  ident: CR16
  article-title: Enzyme-activated fluorogenic probes for live-cell and in vivo imaging
  publication-title: ACS Chem. Biol.
– volume: 463
  start-page: 540
  year: 2010
  end-page: 544
  ident: CR17
  article-title: Innate production of TH 2 cytokines by adipose tissue-associated c-Kit+ Sca-1+ lymphoid cells
  publication-title: Nature
– volume: 191
  start-page: 1818
  year: 2013
  end-page: 1826
  ident: CR36
  article-title: Critical role of p38 and GATA3 in natural helper cell function
  publication-title: J. Immunol.
– volume: 93
  start-page: 294
  year: 2012
  end-page: 301
  ident: CR40
  article-title: Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3
  publication-title: Exp. Mol. Pathol.
– volume: 10
  start-page: 1
  year: 2020
  end-page: 15
  ident: CR37
  article-title: p38 MAPK signalling regulates cytokine production in IL-33 stimulated Type 2 Innate Lymphoid cells
  publication-title: Sci. Rep.
– volume: 193
  start-page: 4952
  year: 2014
  end-page: 4961
  ident: CR59
  article-title: Synaptic release of CCL5 storage vesicles triggers CXCR4 surface expression promoting CTL migration in response to CXCL12
  publication-title: J. Immunol.
– volume: 10
  start-page: 755
  year: 2019
  ident: CR6
  article-title: Techniques for studying decoding of single cell dynamics
  publication-title: Front. Immunol.
– volume: 4
  start-page: 458
  year: 2017
  end-page: 469.e5
  ident: CR52
  article-title: Measuring signaling and RNA-Seq in the same cell links gene expression to dynamic patterns of NF-κB activation
  publication-title: Cell Syst.
– volume: 31
  start-page: 166
  year: 2015
  end-page: 169
  ident: CR62
  article-title: HTSeq-A Python framework to work with high-throughput sequencing data
  publication-title: Bioinformatics
– volume: 161
  start-page: 1187
  year: 2015
  end-page: 1201
  ident: CR11
  article-title: Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
  publication-title: Cell
– volume: 465
  start-page: 736
  year: 2010
  end-page: 745
  ident: CR5
  article-title: Measurement of single-cell dynamics
  publication-title: Nature
– volume: 106
  start-page: 7113
  year: 2009
  end-page: 7118
  ident: CR38
  article-title: Inositol phosphatase SHIP1 is a primary target of miR-155
  publication-title: Proc. Natl Acad. Sci. Usa.
– volume: 9
  start-page: 2232
  year: 2018
  ident: CR27
  article-title: MicroRNA-155 protects group 2 innate lymphoid cells from apoptosis to promote type-2 immunity
  publication-title: Front. Immunol.
– volume: 94
  start-page: 242
  year: 2016
  end-page: 249
  ident: CR8
  article-title: Clonal expansion under the microscope: studying lymphocyte activation and differentiation using live‐cell imaging
  publication-title: Immunol. Cell Biol.
– volume: 14
  year: 2013
  ident: CR61
  article-title: TopHat2: Accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
  publication-title: Genome Biol.
– volume: 146
  start-page: 390
  year: 2020
  end-page: 405
  ident: CR49
  article-title: Optimal identification of human conventional and nonconventional (CRTH2–IL7Rα–) ILC2s using additional surface markers
  publication-title: J. Allergy Clin. Immunol.
– volume: 49
  start-page: 741
  year: 2013
  end-page: 750
  ident: CR57
  article-title: Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells
  publication-title: Am. J. Respir. Cell Mol. Biol.
– volume: 2016
  start-page: 8060182
  year: 2016
  ident: CR42
  article-title: MiR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis
  publication-title: Mediat. Inflamm.
– volume: 32
  start-page: 381
  year: 2014
  end-page: 386
  ident: CR64
  article-title: The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
  publication-title: Nat. Biotechnol.
– volume: 139
  start-page: 1007
  year: 2017
  end-page: 1016.e9
  ident: CR26
  article-title: MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation
  publication-title: J. Allergy Clin. Immunol.
– volume: 30
  start-page: 542
  year: 2008
  end-page: 555
  ident: CR13
  article-title: Positive feedback in cellular control systems
  publication-title: BioEssays
– volume: 134
  start-page: 671
  year: 2014
  ident: CR20
  article-title: Enhanced innate type 2 immune response in peripheral blood from patients with asthma
  publication-title: J. Allergy Clin. Immunol.
– volume: 17
  start-page: 76
  year: 2016
  end-page: 86
  ident: CR48
  article-title: Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses
  publication-title: Nat. Immunol.
– volume: 213
  start-page: 569
  year: 2016
  end-page: 583
  ident: CR32
  article-title: IL-12 drives functional plasticity of human group 2 innate lymphoid cells
  publication-title: J. Exp. Med.
– volume: 17
  start-page: 261
  year: 2019
  end-page: 272
  ident: CR66
  article-title: SciPy 1.0-fundamental algorithms for scientific computing in python
  publication-title: Nat. Methods
– volume: 4
  year: 2014
  ident: CR12
  article-title: Real-time single-cell imaging of protein secretion
  publication-title: Sci. Rep.
– volume: 9
  start-page: 2
  year: 2018
  end-page: 11
  ident: CR39
  article-title: DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells
  publication-title: Nat. Commun.
– volume: 214
  start-page: 2507
  year: 2017
  end-page: 2521
  ident: CR25
  article-title: ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control
  publication-title: J. Exp. Med.
– volume: 10
  start-page: 1
  year: 2019
  end-page: 10
  ident: CR65
  article-title: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
  publication-title: Nat. Commun.
– volume: 42
  start-page: 476
  year: 2012
  end-page: 488
  ident: CR43
  article-title: DUSP4 deficiency enhances CD25 expression and CD4 + T-cell proliferation without impeding T-cell development
  publication-title: Eur. J. Immunol.
– ident: CR63
– volume: 42
  start-page: 8845
  year: 2014
  end-page: 8860
  ident: CR10
  article-title: Single-cell RNA-seq: Advances and future challenges
  publication-title: Nucleic Acids Res.
– volume: 12
  start-page: 1055
  year: 2011
  end-page: 1062
  ident: CR21
  article-title: Human IL-25-and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
  publication-title: Nat. Immunol.
– volume: 15
  start-page: 513
  year: 2020
  end-page: 539
  ident: CR50
  article-title: Recording transcriptional histories using Record-seq
  publication-title: Nat. Protoc.
– volume: 17
  start-page: 7
  year: 2002
  end-page: 17
  ident: CR34
  article-title: IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
  publication-title: Immunity
– volume: 174
  start-page: 271
  year: 2018
  end-page: 284.e14
  ident: CR31
  article-title: A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling
  publication-title: Cell
– volume: 40
  start-page: 225
  year: 2010
  end-page: 231
  ident: CR47
  article-title: Micro-RNA-155 inhibits IFN-γ signaling in CD4+ T cells
  publication-title: Eur. J. Immunol.
– volume: 8
  start-page: 974
  year: 2013
  end-page: 982
  ident: CR2
  article-title: Single-cell imaging of Caspase-1 dynamics reveals an all-or-none inflammasome signaling response
  publication-title: Cell Rep.
– volume: 1
  start-page: 299
  year: 2022
  end-page: 304
  ident: CR33
  article-title: Upregulation of IL-4 receptor signaling pathway in circulating ILC2s from asthma patients
  publication-title: J. Allergy Clin. Immunol. Glob.
– volume: 78
  start-page: 7918
  year: 2006
  end-page: 7925
  ident: CR7
  article-title: Dynamic single-cell analysis for quantitative biology
  publication-title: Anal. Chem.
– volume: 17
  start-page: 636
  year: 2016
  end-page: 645
  ident: CR35
  article-title: IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
  publication-title: Nat. Immunol.
– ident: CR55
– volume: 109
  start-page: 20047
  year: 2012
  end-page: 20052
  ident: CR44
  article-title: MiR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the Eμ-miR-155 transgenic mouse model
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 23
  start-page: 101479
  year: 2020
  ident: CR14
  article-title: Kinetic trans-omic analysis reveals key regulatory mechanisms for insulin-regulated glucose metabolism in adipocytes
  publication-title: iScience
– volume: 18
  start-page: 230
  year: 2020
  end-page: 242
  ident: CR22
  article-title: The transcription factor RelB restrains group 2 innate lymphoid cells and type 2 immune pathology in vivo
  publication-title: Cell. Mol. Immunol.
– volume: 5
  start-page: e131480
  year: 2020
  ident: CR28
  article-title: Regnase-1 degradation is crucial for IL-33– and IL-25–mediated ILC2 activation
  publication-title: JCI Insight
– volume: 466
  start-page: 267
  year: 2010
  end-page: 271
  ident: CR15
  article-title: Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing
  publication-title: Nature
– volume: 14
  start-page: 404
  year: 2013
  end-page: 412
  ident: CR4
  article-title: Transcriptional insights into the CD8 + T cell response to infection and memory T cell formation
  publication-title: Nat. Immunol.
– volume: 10
  start-page: 792
  year: 2015
  end-page: 806
  ident: CR60
  article-title: Isolation and analysis of group 2 innate lymphoid cells in mice
  publication-title: Nat. Protoc.
– volume: 212
  start-page: 311
  year: 2007
  ident: 5297_CR3
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.21094
– volume: 15
  start-page: 513
  year: 2020
  ident: 5297_CR50
  publication-title: Nat. Protoc.
  doi: 10.1038/s41596-019-0253-4
– volume: 11
  start-page: 79
  year: 2011
  ident: 5297_CR9
  publication-title: Lab Chip
  doi: 10.1039/C0LC00114G
– volume: 6
  start-page: 468
  year: 2010
  ident: 5297_CR1
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.03.015
– volume: 1
  start-page: 299
  year: 2022
  ident: 5297_CR33
  publication-title: J. Allergy Clin. Immunol. Glob.
  doi: 10.1016/j.jacig.2022.07.007
– volume: 42
  start-page: 476
  year: 2012
  ident: 5297_CR43
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201041295
– ident: 5297_CR63
– volume: 49
  start-page: 741
  year: 2013
  ident: 5297_CR57
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2012-0304OC
– volume: 134
  start-page: 671
  year: 2014
  ident: 5297_CR20
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2014.06.024
– volume: 9
  start-page: 2
  year: 2018
  ident: 5297_CR39
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-02294-6
– volume: 19
  start-page: 1093
  year: 2018
  ident: 5297_CR29
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-018-0201-4
– volume: 10
  start-page: 1
  year: 2020
  ident: 5297_CR37
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-019-56847-4
– volume: 136
  start-page: 1653
  year: 2015
  ident: 5297_CR45
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2015.03.043
– volume: 4
  year: 2014
  ident: 5297_CR12
  publication-title: Sci. Rep.
  doi: 10.1038/srep04736
– volume: 106
  start-page: 7113
  year: 2009
  ident: 5297_CR38
  publication-title: Proc. Natl Acad. Sci. Usa.
  doi: 10.1073/pnas.0902636106
– volume: 4
  start-page: 458
  year: 2017
  ident: 5297_CR52
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2017.03.010
– volume: 97
  start-page: 221
  year: 2001
  ident: 5297_CR41
  publication-title: Blood
  doi: 10.1182/blood.V97.1.221
– volume: 109
  start-page: 20047
  year: 2012
  ident: 5297_CR44
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1213764109
– volume: 10
  start-page: 755
  year: 2019
  ident: 5297_CR6
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2019.00755
– volume: 40
  start-page: 225
  year: 2010
  ident: 5297_CR47
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.200939381
– volume: 213
  start-page: 569
  year: 2016
  ident: 5297_CR32
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20151750
– volume: 10
  start-page: 792
  year: 2015
  ident: 5297_CR60
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2015.047
– volume: 17
  start-page: 636
  year: 2016
  ident: 5297_CR35
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3444
– volume: 146
  start-page: 390
  year: 2020
  ident: 5297_CR49
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2020.01.038
– volume: 9
  start-page: 1
  year: 2019
  ident: 5297_CR54
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-37186-2
– volume: 10
  start-page: 1
  year: 2019
  ident: 5297_CR65
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-07882-8
– volume: 31
  start-page: 166
  year: 2015
  ident: 5297_CR62
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu638
– volume: 465
  start-page: 736
  year: 2010
  ident: 5297_CR5
  publication-title: Nature
  doi: 10.1038/nature09232
– volume: 18
  start-page: 230
  year: 2020
  ident: 5297_CR22
  publication-title: Cell. Mol. Immunol.
  doi: 10.1038/s41423-020-0404-0
– volume: 37
  start-page: 634
  year: 2012
  ident: 5297_CR23
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.06.020
– volume: 5
  start-page: e131480
  year: 2020
  ident: 5297_CR28
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.131480
– volume: 463
  start-page: 540
  year: 2010
  ident: 5297_CR17
  publication-title: Nature
  doi: 10.1038/nature08636
– volume: 192
  start-page: 2442
  year: 2014
  ident: 5297_CR46
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1300974
– volume: 193
  start-page: 4952
  year: 2014
  ident: 5297_CR59
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1401184
– volume: 14
  start-page: 404
  year: 2013
  ident: 5297_CR4
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2536
– volume: 464
  start-page: 1367
  year: 2010
  ident: 5297_CR18
  publication-title: Nature
  doi: 10.1038/nature08900
– volume: 13
  start-page: 1810
  year: 2018
  ident: 5297_CR16
  publication-title: ACS Chem. Biol.
  doi: 10.1021/acschembio.8b00371
– volume: 94
  start-page: 242
  year: 2016
  ident: 5297_CR8
  publication-title: Immunol. Cell Biol.
  doi: 10.1038/icb.2015.104
– volume: 14
  year: 2013
  ident: 5297_CR61
  publication-title: Genome Biol.
– volume: 17
  start-page: 7
  year: 2002
  ident: 5297_CR34
  publication-title: Immunity
  doi: 10.1016/S1074-7613(02)00332-1
– volume: 9
  start-page: 1
  year: 2018
  ident: 5297_CR58
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05485-x
– volume: 8
  start-page: 974
  year: 2013
  ident: 5297_CR2
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.07.012
– volume: 51
  start-page: 2178
  year: 2021
  ident: 5297_CR56
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.202049055
– volume: 2016
  start-page: 8060182
  year: 2016
  ident: 5297_CR42
  publication-title: Mediat. Inflamm.
– volume: 78
  start-page: 7918
  year: 2006
  ident: 5297_CR7
  publication-title: Anal. Chem.
  doi: 10.1021/ac069490p
– volume: 214
  start-page: 2507
  year: 2017
  ident: 5297_CR25
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20170051
– volume: 30
  start-page: 542
  year: 2008
  ident: 5297_CR13
  publication-title: BioEssays
  doi: 10.1002/bies.20769
– ident: 5297_CR55
  doi: 10.1016/B978-0-12-391856-7.00038-X
– volume: 12
  start-page: 1055
  year: 2011
  ident: 5297_CR21
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2104
– volume: 17
  start-page: 261
  year: 2019
  ident: 5297_CR66
  publication-title: Nat. Methods
  doi: 10.1038/s41592-019-0686-2
– volume: 6
  start-page: eaba9319
  year: 2020
  ident: 5297_CR53
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aba9319
– volume: 32
  start-page: 381
  year: 2014
  ident: 5297_CR64
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2859
– volume: 360
  start-page: eaap899
  year: 2018
  ident: 5297_CR51
  publication-title: Science (80-.)
  doi: 10.1126/science.aap8992
– volume: 23
  start-page: 101479
  year: 2020
  ident: 5297_CR14
  publication-title: iScience
  doi: 10.1016/j.isci.2020.101479
– volume: 191
  start-page: 1818
  year: 2013
  ident: 5297_CR36
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1300379
– volume: 466
  start-page: 267
  year: 2010
  ident: 5297_CR15
  publication-title: Nature
  doi: 10.1038/nature09145
– volume: 174
  start-page: 271
  year: 2018
  ident: 5297_CR31
  publication-title: Cell
  doi: 10.1016/j.cell.2018.05.014
– volume: 17
  start-page: 76
  year: 2016
  ident: 5297_CR48
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3309
– volume: 549
  start-page: 351
  year: 2017
  ident: 5297_CR24
  publication-title: Nat
  doi: 10.1038/nature24029
– volume: 161
  start-page: 1187
  year: 2015
  ident: 5297_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2015.04.044
– volume: 139
  start-page: 1007
  year: 2017
  ident: 5297_CR26
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2016.06.035
– volume: 1
  start-page: 577
  year: 2017
  ident: 5297_CR19
  publication-title: Blood Adv.
  doi: 10.1182/bloodadvances.2016002352
– volume: 93
  start-page: 294
  year: 2012
  ident: 5297_CR40
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2012.09.011
– volume: 42
  start-page: 8845
  year: 2014
  ident: 5297_CR10
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gku555
– volume: 9
  start-page: 2232
  year: 2018
  ident: 5297_CR27
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02232
– volume: 210
  start-page: 2951
  year: 2013
  ident: 5297_CR30
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20130071
SSID ssj0001999634
Score 2.2487671
Snippet The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of cells during...
Abstract The decision of whether cells are activated or not is controlled through dynamic intracellular molecular networks. However, the low population of...
SourceID doaj
pubmedcentral
proquest
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 915
SubjectTerms 13/21
13/62
14/1
14/63
38/91
631/1647/245/2186
631/1647/664/1364
631/1647/664/2172
Biology
Biomedical and Life Sciences
Cell activation
Cells
Cytokines
Gene expression
Life Sciences
Lymphoid cells
Medicine
Science
Transcription activation
Transcriptomes
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NaxUxEA9SELyItYqrVSJ4s6HZbLJvc9RiqcX21EJvIR-zWihb6dvS9r93Jtn37BbUi7dlM8smmUlmJpnfDGMflImpVb0VoGIntMUnn4wVUfYyqWS1SgQUPjpuD0714Zk5u1fqi2LCSnrgMnG7QRvUoKaPQWptUH8tpPatWfTWhoj6jnZfaeU9ZyqfrpAd3-gJJSObbnepcxgWqihBl1sLcTPTRDlh_8zKfBgj-eCiNOuf_Wfs6WQ48k-lw5vsEQzP2eNSSvJuiwFhOcSqpO3I6UBeZLQQX-ZSNzj__DyV2CBY8pF0FGEhL-443OZoWEj8O-18_KrUp8du8K_f9hQn7EM5uX3BTve_nOwdiKmEgohoWYwi9dFLaBahRg_amxaSDNZHA7GPvdVgdLSAVlgI6Fm0bQyx7lItexuSrAHa5iXbGC4HeMV4ChGNo8bjPEbdSe9r5WWjY0oBAGpZsXo1nS5O-cWpzMWFy_fcTecKCxyywGUWuJuKfVx_87Nk1_gr9Wfi0pqSMmPnFygvbpIX9y95qdj2isduWq5Lpzoy7JRuu4q9XzfjQiNm-QEurzONIjy7RJpuJhuzDs1bhvMfOWU3Or2EYa4rtrMSo99___OIX_-PEb9hT1QWe0o3sc02xqtreIuW1Bje5UXzC5HmHBs
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central (New) (NC LIVE)
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9UwFD_MOxRfRKdi3ZQIvmlYmia9zYOIGxtT3EXEwd5CvroNRu-8t2Pbf29O2t5LB-6ttClNc05yfsn5-AF85NL5kteKBu4qKlS8Ml4q6ljNPPdKcI-Jwsez8uhE_DiVpxswG3JhMKxyWBPTQu3nDs_Id3mFtpeLsvp69ZciaxR6VwcKDdNTK_gvqcTYI9iMS7JkE9jcO5j9-r0-dUF8X4g-e4YV1e5SpPCsaLooOr2m9GZkoVIh_xH6vB87ec-BmuzS4XN41gNK8q3TgBewEZoteNxRTN5twZPj3nn-EgKme9CB9bYleGZPU0IRWSY2nCgicuG78KGwJC2aMUyXvLwj4TYFzAZPznBxJIuOwj72iHz_uc8Jpkd0h7uv4OTw4M_-Ee1ZFqiL4KOlvnaGhWJq87jJNrIMnlllnAyudrUSQQqnQgRq1sbNR1k66_LK56xW1rM8hLJ4DZNm3oQ3QLx1ET8VJg6pExUzJueGFcJ5b0MIOcsgH0ZWu74EOTJhXOrkCi8q3UlDR2noJA19k8Gn1TtXXQGOB1vvocBWLbF4droxX5zpfi5qK2QEZbJ2lgkhIySaMmFKOa2Vsi5CqAx2BnHrfkYv9Vr_MviwehznIgrLNGF-ndpwTHlnsU01UpNRh8ZPmovzVNU77osxzTnP4POgUeuv__-P3z7c2W14ypNuY62JHZi0i-vwLsKo1r7v58Y_W8cepw
  priority: 102
  providerName: ProQuest
Title Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation
URI https://link.springer.com/article/10.1038/s42003-023-05297-w
https://www.proquest.com/docview/2861512468
https://www.proquest.com/docview/2862199508
https://pubmed.ncbi.nlm.nih.gov/PMC10482971
https://doaj.org/article/b459375fcb0445819704a657f99bc075
Volume 6
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9UwFD_MDcEX8ROr8xLBNw2madI2j3eXjXnRIepgbyFfnYPRK_d2zP33nqTtHR0q-NTSnNA056T5JTm_cwDecul8yRtFA3c1FQrvjJeKOtYwz70S3Eei8OeT8vhULM_k2Q7wkQuTnPZTSMv0mx69wz5sRPKiwhmGxrOpil7fg726KmS06kW5uN1XiQi-EAM_hhX1H6pO5qAUqn-CL-96R945Ik0zz9EjeDhARjLvG_kYdkL7BO73SSRvnkKILA46JrPtSNyKp4knRDYpyQ32PLnwvVdQ2JAuzk6RBXl5Q8Kv5AcbPDmP_zyy7jPTYzPIx08LTiLrod-zfQanR4ffF8d0SJ5AHWKKjvrGGRaKyua4djayDJ5ZZZwMrnGNEkEKpwLiL2txTVGWzrq89jlrlPUsD6EsnsNuu2rDCyDeOoRFhcF-dKJmxuTcsEI4720IIWcZ5GN3ajdEFo8JLi51OuEuat2rQKMKdFKBvs7g3bbOzz6uxj-lD6KWtpIxJnZ6sFqf68FGtBUSsZZsnGVCSEQ6FROmlFWjlHWIjDLYH3Wsh4G60byOkI6Lss7gzbYYh1hUlmnD6irJ8MhkZyhTT2xj0qBpSXvxIwXrxuVuZC_nGbwfzej27X__4pf_J_4KHvBk4DGkxD7sduur8BrRUmdnsDefL78t8XpwePLl6ywNl1nae_gN3hwXNg
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NTny8IBggOgYYCZ7AmuM4afIwITY2taytENqkvXn-Spk0pVvbqfSf42_D5yStOom97S1KnC_f2Xf23e9-AB95YmzKi5w6bjIqcn-kbJJTwwpmuc0FtwgUHgzT7qn4cZacbcDfBguDaZXNnBgmajs2uEe-yzO0vVyk2dera4qsURhdbSg0VE2tYPdCibEa2HHsFnO_hJvu9b57eX_i_Ojw5KBLa5YBarzxnVFbGMVc3NGRX2SqJHWW6VyZxJnCFLlwiTC5846K1t75TlOjTZTZiBW5tixyLo39cx_ApsANlBZs7h8Of_5a7fLgeiIWNVqHxdnuVIR0MG8qKQbZOnS-ZhEDccCat3s7V_NWwDbYwaNn8LR2YMm3SuOew4Yrt-BhRWm52IJHgzpY_wIcwktow7I7IxgjoAHARKaBfcerBLmwVbqSm5IZmk2EZ14uiPsTEnSdJSOcjMnEjQLPWDkivf4BJwjHqDaTX8LpvfT3K2iV49K9BmK18f5arHyXGpExpSKuWCyMtdo5F7E2RE3PSlOXPEfmjUsZQu9xJitpSC8NGaQh5234vLznqir4cWfrfRTYsiUW6w4nxpORrMe-1CLxTmBSGM2ESLwL1mFCpUmnyHNtvMvWhp1G3LKeQaZype9t-LC87Mc-CkuVbnwT2nCE2DPfJltTk7UPWr9SXvwOVcT9Ohxh1VEbvjQatXr7__94--6PfQ-PuyeDvuz3hsdv4AkPeo51LnagNZvcuLfehZvpd_U4IXB-30PzHylQXrQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKEYgL4ikCBYzEDQyOY3vjIyysWigVByr1ZvkxKZWqbLWbqvTfM3aSrVIBErcoHiuOx_Z8tuebIeS1UCFq0RgGItRMGnxyURkWeMOjiEaKmIjC3w707qH8cqSOtogeuTDZaT-HtMzL9Ogd9n4tsxcVWhiW7qZm7OLdWWxukJs1msS06Zrr-dXZSkLxlRw4Mryq_1B9YodyuP4JxrzuIXntmjRbn8U9cneAjfRD39D7ZAvaB-RWn0jy8iGBxORgY0LbjqbjeJa5QnSdE91g79OT2HsGwZp2yUIlJuTpJYVf2RcWIj1O6x5d9dnpsRl0b38uaGI-9Oe2j8jh4vOP-S4bEiiwgLiiY7EJjkM18yXun53SELk3LigITWiMBCWDAcRg3uO-QuvgQ1nHkjfGR14C6Oox2W6XLTwhNPqA0Khy2I9B1ty5UjheyRCjB4CSF6Qcu9OGIbp4SnJxavMtd1XbXgUWVWCzCuxFQd5s6pz1sTX-Kf0xaWkjmeJi5xfL1bEdxon1UiHeUk3wXEqFaGfGpdNq1hjjA6KjguyMOrbDZF1bUSdYJ6SuC_JqU4zTLCnLtbA8zzIisdk5ytSTsTFp0LSkPfmZA3bjljcxmMuCvB2H0dXX__7HT_9P_CW5_f3Twu7vHXx9Ru6IPNZThIkdst2tzuE5gqfOv8gz5Tf6lBcT
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Time-dependent+cell-state+selection+identifies+transiently+expressed+genes+regulating+ILC2+activation&rft.jtitle=Communications+biology&rft.au=Tanaka%2C+Yumiko&rft.au=Yamagishi%2C+Mai&rft.au=Motomura%2C+Yasutaka&rft.au=Kamatani%2C+Takashi&rft.date=2023-09-06&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2399-3642&rft.volume=6&rft.issue=1&rft_id=info:doi/10.1038%2Fs42003-023-05297-w&rft.externalDocID=10_1038_s42003_023_05297_w
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2399-3642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2399-3642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2399-3642&client=summon