Optimization of sepsis therapy based on patient-specific digital precision diagnostics using next generation sequencing (DigiSep-Trial)—study protocol for a randomized, controlled, interventional, open-label, multicenter trial - Brenner, Thorsten; Skarabis, Annabell; Stevens, Philip; Axnick, Jennifer; Haug, Peter; Grumaz, Silke; Bruckner, Thomas; Luntz, Steffen; Witzke, Oliver; Pletz, Mathias W.; Ruprecht, Thomas M.; Marschall, Ursula; et al. (Current controlled trials in cardiovascular medicine, 2021)
Keywords: Antibiotics; Bacteremia; Biomedicine; Blood culture; Care and treatment; Data collection; Desirability of Outcome Ranking/Response Adjusted for Duration of Antibiotic Risk (DOOR/RADAR) score; Diagnosis; Digital precision diagnostics; DNA sequencing; Health Sciences; Hospitals; Infections; Intensive care; Laboratories; Medicine; Medicine & Public Health; Methods; Molecular diagnostic techniques; Next generation sequencing; Nucleotide sequencing; Pathogens; Patients; Sepsis; Statistics for Life Sciences; Study Protocol; Germany; United States--US; Sepsis; Blood culture; Next generation sequencing; Digital precision diagnostics; Bacteremia; Desirability of Outcome Ranking/Response Adjusted for Duration of Antibiotic Risk (DOOR/RADAR) score