Early strategy of scepter XC balloon angioplasty and simultaneous Nimodipine infusion for vasospasm following ruptured aneurysm

• Published in: BMC neurology Vol. 20; no. 1; pp. 1 - 8
• Main Authors: Chen, Chun-Ting, Chen, Ching-Chang, Wang, Alvin Yi-Chou, Wu, Yi-Ming, Chin, Shy-Chyi, Hsieh, Po-Chuan, Yeap, Mun-Chun, Hsu, Shih-Yuan, Lin, Ya-Jui
• Format: Journal Article
• Language: English
• Published: London BioMed Central 07.07.2020; BioMed Central Ltd; BMC
• Subjects: Aneurysm; Aneurysm rupture; Aneurysms; Angiography; Angioplasty; Balloon angioplasty; Balloon angioplasty; subarachnoid hemorrhage; Balloon catheters; Balloon treatment; Blood pressure; Cardiac patients; Cardiovascular system; Care and treatment; CAT scans; Catheters; Cerebral aneurysm; Cerebrovascular disease and stroke; Computed tomography; Consciousness; Embolization; Health aspects; Medical imaging; Medical treatment; Medicine; Medicine & Public Health; Morbidity; Mortality; Neurochemistry; Neurology; Neurosurgery; Nimodipine; Patients; Perfusion; Research Article; Scepter XC balloon; Stents; Stroke; Subarachnoid hemorrhage; Therapeutics; Thromboembolism; Vasoconstriction; Veins & arteries; United States > US; California; Cerebral aneurysm; Scepter XC balloon; Aneurysm rupture; Balloon angioplasty; subarachnoid hemorrhage
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-020-01856-4

Background Cerebral vasospasm still results in high morbidity and mortality rates in patients after aneurysmal subarachnoid hemorrhage (SAH). The aim of this study was to establish a protocol for the management of vasospasm and demonstrate our experience of angioplasty using the Scepter XC balloon catheter. Methods In this retrospective study, a computed tomography angiography and perfusion image was arranged if early symptoms occurred or on the 7th day following aneurysmal SAH. In patients with clear consciousness, balloon angioplasties were performed for symptomatic vasospasms, which were not improved within 6–12 h after maximal medical treatments. In unconscious patients, balloon angioplasties were performed for all patients with angiographic vasospasms. Results Fifty patients underwent Scepter XC balloon angioplasty among 396 consecutive patients who accepted endovascular or surgical treatments for ruptured aneurysms. All angioplasty procedures were successful without complications. 100% angiographic improvement and 94% clinical improvement were reached immediately after the angioplasties. A favorable functional outcome (modified Rankin Score of ≤2) could be achieved in 82% of patients. Even in patients with poor clinical grading (Hunt–Hess grade 4–5), a clinical improvement rate of 87.5% and favorable outcome rate was 70.8% could be achieved. Conclusion Balloon angioplasty with Scepter XC balloon catheter is safe and effective for post-SAH vasospasm. This device’s extra-compliant characteristics could considerably improve the quality of angioplasty procedures. For all patients, even those with poor neurological status, early treatment with combined protocol of nimodipine and angioplasty can have good clinical outcomes.