Differences in the individual curative effect of acupuncture for obese women with polycystic ovary syndrome based on metagenomic analysis: study protocol for a randomized controlled trial
Background Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been stud...
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| Published in | Current controlled trials in cardiovascular medicine Vol. 22; no. 1; pp. 454 - 11 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
15.07.2021
BioMed Central Ltd Springer Nature B.V BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1745-6215 1745-6215 |
| DOI | 10.1186/s13063-021-05426-y |
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| Abstract | Background
Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis.
Methods/design
This is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis.
Discussion
In this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture’s treatment effect.
Trial registration
Chinese Clinical Trial Registry
ChiCTR2000029882
. Registered on 16 February 2020 |
|---|---|
| AbstractList | BackgroundPolycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis.Methods/designThis is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis.DiscussionIn this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture’s treatment effect.Trial registrationChinese Clinical Trial Registry ChiCTR2000029882. Registered on 16 February 2020 Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis.BACKGROUNDPolycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis.This is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis.METHODS/DESIGNThis is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis.In this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture's treatment effect.DISCUSSIONIn this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture's treatment effect.Chinese Clinical Trial Registry ChiCTR2000029882 . Registered on 16 February 2020.TRIAL REGISTRATIONChinese Clinical Trial Registry ChiCTR2000029882 . Registered on 16 February 2020. Background Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis. Methods/design This is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis. Discussion In this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture’s treatment effect. Trial registration Chinese Clinical Trial Registry ChiCTR2000029882 . Registered on 16 February 2020 Background Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis. Methods/design This is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis. Discussion In this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture's treatment effect. Trial registration Chinese Clinical Trial Registry ChiCTR2000029882. Registered on 16 February 2020 Keywords: Acupuncture, Obesity, Polycystic ovary syndrome, Gut microbiota, Protocol Abstract Background Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis. Methods/design This is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis. Discussion In this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture’s treatment effect. Trial registration Chinese Clinical Trial Registry ChiCTR2000029882 . Registered on 16 February 2020 Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive treatment for PCOS. However, the add-on effect of acupuncture as an adjunctive treatment for obese women with PCOS has not been studied, and previous studies indicate that there are individual differences in the curative effect of acupuncture, while deeper research on the mechanism of differences in the individual curative effect of acupuncture for obese women with PCOS is still lacking. This trial aims to assess the add-on treatment efficacy of acupuncture for obese women with PCOS and to explore the role of the gut microbiome on the differences in the individual curative effect of acupuncture based on metagenomic analysis. This is an open-label, randomized, controlled trial. A total of 86 obese women with PCOS will be recruited. Subjects will be randomly assigned to a study group and a control group in a 1:1 ratio, with 43 subjects in each group (10 patients from each group who meet the study criteria will participate in the metagenomic analysis). An additional 10 subjects who meet the study criteria will be recruited to a healthy control group. The study group will receive acupuncture and clomiphene citrate treatment; the control group will only receive clomiphene citrate. Acupuncture treatment will be conducted three times a week from the fifth day of menstruation or withdrawal bleeding until the start of the next menstruation, for up to three menstrual cycles. The primary outcome will be LH/FSH. The secondary outcomes will comprise biometric features, hormone biomarkers, metabolic biomarkers, inflammatory biomarkers, Self-Rating Anxiety Scale, Self-Rating Depression Scale, and metagenomic analysis. The outcomes will be measured at baseline and post-intervention. Data will be analyzed using SPSS 19.0, and the gut microbiome will be analyzed using metagenomic analysis. In this study, we are evaluating the add-on effects of acupuncture and exploring the mechanism of the differences in the individual curative effect of acupuncture based on the gut microbiome, which may provide evidence to explain the different outcomes of different trials on acupuncture for PCOS and hopefully to provide a new aspect to study the mechanism of acupuncture's treatment effect. |
| ArticleNumber | 454 |
| Audience | Academic |
| Author | Wang, Xue Chen, Jiao Hong, Xiaojuan Zeng, Jiuzhi Fan, Huaying |
| Author_xml | – sequence: 1 givenname: Huaying surname: Fan fullname: Fan, Huaying organization: School of Acupuncture-Moxibustion and Tuina/The Third Affiliated Hospital, Chengdu University of Traditional Chinese Medicine – sequence: 2 givenname: Xiaojuan surname: Hong fullname: Hong, Xiaojuan organization: School of Acupuncture-Moxibustion and Tuina/The Third Affiliated Hospital, Chengdu University of Traditional Chinese Medicine – sequence: 3 givenname: Jiuzhi surname: Zeng fullname: Zeng, Jiuzhi organization: Department of Reproductive Medicine, Sichuan Women’s and Children’s Hospital – sequence: 4 givenname: Xue surname: Wang fullname: Wang, Xue organization: School of Acupuncture-Moxibustion and Tuina/The Third Affiliated Hospital, Chengdu University of Traditional Chinese Medicine – sequence: 5 givenname: Jiao surname: Chen fullname: Chen, Jiao email: chenjiao@cdutcm.edu.cn organization: School of Acupuncture-Moxibustion and Tuina/The Third Affiliated Hospital, Chengdu University of Traditional Chinese Medicine |
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| Cites_doi | 10.1038/372425a0 10.1080/01443615.2019.1697219 10.1038/nrendo.2018.24 10.1016/j.fertnstert.2008.09.018 10.1016/j.fertnstert.2003.10.004 10.1097/MED.0000000000000184 10.1038/srep45580 10.1186/s13059-016-1086-x 10.1210/jcem.84.11.6148 10.1038/nrmicro.2016.83 10.1093/qjmed/hct196 10.7326/0003-4819-158-3-201302050-00583 10.4103/0974-1208.106338 10.1136/bmj.c332 10.1530/JOE-19-0589 10.1097/GCO.0000000000000582 10.1016/j.chom.2017.04.010 10.1210/jcem.85.7.6682 10.1046/j.1365-2265.1999.00886.x 10.1097/HNP.0000000000000339 10.1016/j.fertnstert.2007.12.002 10.1111/jne.12131 10.1093/ajh/hpu251 10.1152/ajpendo.00495.2010 10.1111/j.1471-0528.2006.00973.x 10.1093/ajcn/77.2.379 10.1080/0167482X.2019.1666820 10.1016/j.pharmthera.2015.11.012 10.1016/j.fertnstert.2020.01.027 10.1080/07315724.2019.1657515 10.3889/oamjms.2018.379 10.1186/s12888-017-1489-6 10.1038/s41591-019-0509-0 10.1016/j.ejogrb.2005.03.010 10.1210/jc.2017-02153 10.1126/science.7624776 10.1210/jcem.83.9.5090 10.1038/nrdp.2016.57 10.1172/JCI200317490 10.1089/acm.2010.1610 10.1016/j.fertnstert.2010.02.054 10.1186/s12906-018-2358-7 10.1093/humrep/det262 10.1016/j.fertnstert.2018.01.038 10.1152/ajpendo.00039.2013 10.1126/science.1223813 10.2337/dc07-9921 10.1111/j.1365-2265.2007.02742.x 10.1016/S0015-0282(02)04554-5 10.1016/j.biopsych.2017.08.014 10.1111/j.1467-789X.2012.01053.x 10.1016/j.jams.2017.01.006 10.1128/mSystems.00017-19 10.1056/NEJMra041536 10.1093/humupd/dmq001 10.1002/14651858.CD007689.pub2 10.1097/CM9.0000000000000871 10.1093/humrep/der396 10.1530/EC-19-0522 10.1210/jc.2011-1126 10.1139/cjpp-2019-0413 10.1371/journal.pone.0168390 10.1007/s40618-020-01481-5 10.1210/jc.2003-032046 10.1186/s12859-018-2431-8 10.1001/jama.2017.7217 10.1016/j.fertnstert.2018.11.030 |
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| Keywords | Gut microbiota Obesity Polycystic ovary syndrome Acupuncture Protocol |
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| References_xml | – volume: 372 start-page: 425 issue: 6505 year: 1994 ident: 5426_CR55 publication-title: Nature. doi: 10.1038/372425a0 – ident: 5426_CR60 doi: 10.1080/01443615.2019.1697219 – volume: 14 start-page: 270 issue: 5 year: 2018 ident: 5426_CR1 publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2018.24 – volume: 92 start-page: 1966 issue: 6 year: 2009 ident: 5426_CR13 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2008.09.018 – ident: 5426_CR51 doi: 10.1016/j.fertnstert.2003.10.004 – volume: 22 start-page: 353 issue: 5 year: 2015 ident: 5426_CR58 publication-title: Curr Opin Endocrinol Diabetes Obes doi: 10.1097/MED.0000000000000184 – volume: 7 start-page: 45580 issue: 1 year: 2017 ident: 5426_CR46 publication-title: Sci Rep doi: 10.1038/srep45580 – volume: 17 start-page: 217 issue: 1 year: 2016 ident: 5426_CR72 publication-title: Genome Biol doi: 10.1186/s13059-016-1086-x – volume: 84 start-page: 4006 issue: 11 year: 1999 ident: 5426_CR4 publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.84.11.6148 – volume: 14 start-page: 508 issue: 8 year: 2016 ident: 5426_CR65 publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro.2016.83 – volume: 107 start-page: 341 issue: 5 year: 2014 ident: 5426_CR23 publication-title: QJM doi: 10.1093/qjmed/hct196 – volume: 158 start-page: 200 issue: 3 year: 2013 ident: 5426_CR50 publication-title: Ann Intern Med doi: 10.7326/0003-4819-158-3-201302050-00583 – volume: 5 start-page: 262 issue: 3 year: 2012 ident: 5426_CR18 publication-title: J Hum Reprod Sci doi: 10.4103/0974-1208.106338 – volume: 340 start-page: c332 year: 2010 ident: 5426_CR48 publication-title: BMJ (Clinical research ed) doi: 10.1136/bmj.c332 – volume: 27 start-page: 123 issue: 3 year: 2017 ident: 5426_CR59 publication-title: J Coll Physicians Surg Pak – volume: 245 start-page: 281 issue: 2 year: 2020 ident: 5426_CR61 publication-title: J Endocrinol doi: 10.1530/JOE-19-0589 – volume: 31 start-page: 428 issue: 6 year: 2019 ident: 5426_CR26 publication-title: Curr Opin Obstet Gynecol doi: 10.1097/GCO.0000000000000582 – volume: 21 start-page: 603 issue: 5 year: 2017 ident: 5426_CR47 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2017.04.010 – volume: 85 start-page: 2434 issue: 7 year: 2000 ident: 5426_CR2 publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.85.7.6682 – volume: 51 start-page: 779 issue: 6 year: 1999 ident: 5426_CR6 publication-title: Clin Endocrinol doi: 10.1046/j.1365-2265.1999.00886.x – volume: 33 start-page: 303 issue: 5 year: 2019 ident: 5426_CR21 publication-title: Holist Nurs Pract doi: 10.1097/HNP.0000000000000339 – volume: 91 start-page: 514 issue: 2 year: 2009 ident: 5426_CR20 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2007.12.002 – volume: 26 start-page: 58 issue: 2 year: 2014 ident: 5426_CR57 publication-title: J Neuroendocrinol doi: 10.1111/jne.12131 – volume: 28 start-page: 847 issue: 7 year: 2015 ident: 5426_CR67 publication-title: Am J Hypertens doi: 10.1093/ajh/hpu251 – volume: 32 start-page: 4457 issue: 10 year: 2017 ident: 5426_CR45 publication-title: Chin J Trad Chin Med – volume: 7 start-page: Cd007689 year: 2019 ident: 5426_CR70 publication-title: Cochrane Database Syst Rev – volume: 300 start-page: E37 issue: 1 year: 2011 ident: 5426_CR28 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00495.2010 – volume: 113 start-page: 1203 issue: 10 year: 2006 ident: 5426_CR16 publication-title: BJOG doi: 10.1111/j.1471-0528.2006.00973.x – volume: 77 start-page: 379 issue: 2 year: 2003 ident: 5426_CR52 publication-title: Am J Clin Nutr doi: 10.1093/ajcn/77.2.379 – volume: 41 start-page: 144 issue: 2 year: 2020 ident: 5426_CR69 publication-title: J Psychosom Obstet Gynaecol doi: 10.1080/0167482X.2019.1666820 – volume: 158 start-page: 52 year: 2016 ident: 5426_CR35 publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2015.11.012 – volume: 113 start-page: 1286 issue: 6 year: 2020 ident: 5426_CR44 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2020.01.027 – volume: 39 start-page: 371 issue: 4 year: 2020 ident: 5426_CR42 publication-title: J Am Coll Nutr doi: 10.1080/07315724.2019.1657515 – volume: 8 start-page: 324 year: 2017 ident: 5426_CR38 publication-title: Front Microbiol – volume: 6 start-page: 1685 issue: 9 year: 2018 ident: 5426_CR29 publication-title: Open Access Maced J Med Sci doi: 10.3889/oamjms.2018.379 – volume: 17 start-page: 329 issue: 1 year: 2017 ident: 5426_CR63 publication-title: BMC Psychiatry doi: 10.1186/s12888-017-1489-6 – volume: 25 start-page: 1225 issue: 8 year: 2019 ident: 5426_CR62 publication-title: Nat Med doi: 10.1038/s41591-019-0509-0 – volume: 122 start-page: 206 issue: 2 year: 2005 ident: 5426_CR11 publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/j.ejogrb.2005.03.010 – volume: 103 start-page: 1502 issue: 4 year: 2018 ident: 5426_CR41 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2017-02153 – volume: 269 start-page: 540 issue: 5223 year: 1995 ident: 5426_CR54 publication-title: Science. doi: 10.1126/science.7624776 – volume: 83 start-page: 3078 issue: 9 year: 1998 ident: 5426_CR5 publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.83.9.5090 – volume: 2 start-page: 16057 issue: 1 year: 2016 ident: 5426_CR8 publication-title: Nat Rev Dis Primers doi: 10.1038/nrdp.2016.57 – volume: 111 start-page: 1409 issue: 9 year: 2003 ident: 5426_CR56 publication-title: J Clin Invest doi: 10.1172/JCI200317490 – volume: 16 start-page: ST1 issue: 10 year: 2010 ident: 5426_CR49 publication-title: J Altern Complement Med doi: 10.1089/acm.2010.1610 – volume: 93 start-page: 2169 issue: 7 year: 2010 ident: 5426_CR22 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2010.02.054 – volume: 18 start-page: 298 issue: 1 year: 2018 ident: 5426_CR30 publication-title: BMC Complement Altern Med doi: 10.1186/s12906-018-2358-7 – volume: 28 start-page: 2562 issue: 9 year: 2013 ident: 5426_CR7 publication-title: Hum Reprod doi: 10.1093/humrep/det262 – volume: 109 start-page: 888 issue: 5 year: 2018 ident: 5426_CR17 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2018.01.038 – volume: 304 start-page: E934 issue: 9 year: 2013 ident: 5426_CR27 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00039.2013 – volume: 336 start-page: 1262 issue: 6086 year: 2012 ident: 5426_CR36 publication-title: Science. doi: 10.1126/science.1223813 – volume: 30 start-page: 1647 issue: 6 year: 2007 ident: 5426_CR53 publication-title: Diabetes Care doi: 10.2337/dc07-9921 – volume: 66 start-page: 373 issue: 3 year: 2007 ident: 5426_CR12 publication-title: Clin Endocrinol doi: 10.1111/j.1365-2265.2007.02742.x – volume: 79 start-page: 1 issue: 1 year: 2003 ident: 5426_CR10 publication-title: Fertil Steril doi: 10.1016/S0015-0282(02)04554-5 – volume: 83 start-page: 214 issue: 3 year: 2018 ident: 5426_CR34 publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2017.08.014 – volume: 14 start-page: 95 issue: 2 year: 2013 ident: 5426_CR68 publication-title: Obes Rev doi: 10.1111/j.1467-789X.2012.01053.x – volume: 10 start-page: 81 issue: 2 year: 2017 ident: 5426_CR24 publication-title: J Acupunct Meridian Stud doi: 10.1016/j.jams.2017.01.006 – ident: 5426_CR66 doi: 10.1128/mSystems.00017-19 – volume: 2018 start-page: 9250972 year: 2018 ident: 5426_CR64 publication-title: Depress Res Treat – volume: 352 start-page: 1223 issue: 12 year: 2005 ident: 5426_CR9 publication-title: N Engl J Med doi: 10.1056/NEJMra041536 – volume: 16 start-page: 347 issue: 4 year: 2010 ident: 5426_CR14 publication-title: Hum Reprod Update doi: 10.1093/humupd/dmq001 – ident: 5426_CR31 doi: 10.1002/14651858.CD007689.pub2 – volume: 133 start-page: 1844 issue: 15 year: 2020 ident: 5426_CR71 publication-title: Chin Med J doi: 10.1097/CM9.0000000000000871 – ident: 5426_CR15 doi: 10.1093/humrep/der396 – volume: 2019 start-page: 2326867 year: 2019 ident: 5426_CR25 publication-title: Evid Based Complement Alternat Med – volume: 9 start-page: 63 issue: 1 year: 2020 ident: 5426_CR39 publication-title: Endocr Connect doi: 10.1530/EC-19-0522 – volume: 96 start-page: 3143 issue: 10 year: 2011 ident: 5426_CR33 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-1126 – volume: 98 start-page: 803 issue: 11 year: 2020 ident: 5426_CR40 publication-title: Can J Physiol Pharmacol doi: 10.1139/cjpp-2019-0413 – volume: 12 start-page: e0168390 issue: 1 year: 2017 ident: 5426_CR37 publication-title: PLoS One doi: 10.1371/journal.pone.0168390 – ident: 5426_CR43 doi: 10.1007/s40618-020-01481-5 – volume: 89 start-page: 2745 issue: 6 year: 2004 ident: 5426_CR3 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2003-032046 – volume: 19 start-page: 399 issue: 1 year: 2018 ident: 5426_CR73 publication-title: BMC Bioinformatics doi: 10.1186/s12859-018-2431-8 – volume: 317 start-page: 2502 issue: 24 year: 2017 ident: 5426_CR32 publication-title: JAMA. doi: 10.1001/jama.2017.7217 – volume: 111 start-page: 571 issue: 3 year: 2019 ident: 5426_CR19 publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2018.11.030 |
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| Snippet | Background
Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate... Background Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate... Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate adjunctive... BackgroundPolycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an appropriate... Abstract Background Polycystic ovary syndrome is a common cause of infertility and shows a high incidence in women of reproductive age. Acupuncture is an... |
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| SubjectTerms | Acupuncture Biomedicine Body mass index Care and treatment Demographic aspects Diagnosis Gut microbiota Health Sciences Infertility Medicine Medicine & Public Health Obesity Polycystic ovary syndrome Protocol Statistics for Life Sciences Stein-Leventhal syndrome Study Protocol Testing Traditional Chinese medicine |
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| Title | Differences in the individual curative effect of acupuncture for obese women with polycystic ovary syndrome based on metagenomic analysis: study protocol for a randomized controlled trial |
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