微量元素与恶性淋巴瘤关系的研究
R733.1; 目的 探讨微量元素与恶性淋巴瘤发生、发展的关系.方法 采用原子吸收分光光度计对370例恶性淋巴瘤患者,100例健康成人进行血清微量元素的测定及分析.结果 恶性淋巴瘤患者组血清铜、铜/锌比值、锰含量高于对照组,而锌、铁、钙含量均低于对照组,差异显著(P＜0.05～P＜0.001).结果 还表明,不同类型何杰金氏病(HD)患者之间的被测元素变化较大,淋巴细胞消减型(LD)组血清铜和铜/锌比值高于混合细胞型(MC)和淋巴细胞为主型(LP),而锌低于混合细胞型(MC),差异显著(P＜0.05～P＜0.001).非何杰金氏病患者中,Ⅲ、Ⅳ期组血清铜含量和铜/锌比值高于Ⅰ、Ⅱ期患者组,差异...
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| Published in | 肿瘤防治研究 Vol. 27; no. 2; pp. 89 - 90 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
030013太原,山西省肿瘤研究所%山西省肿瘤医院血液内科
2000
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-8578 |
| DOI | 10.3971/j.issn.1000-8578.2000.02.004 |
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| Abstract | R733.1; 目的 探讨微量元素与恶性淋巴瘤发生、发展的关系.方法 采用原子吸收分光光度计对370例恶性淋巴瘤患者,100例健康成人进行血清微量元素的测定及分析.结果 恶性淋巴瘤患者组血清铜、铜/锌比值、锰含量高于对照组,而锌、铁、钙含量均低于对照组,差异显著(P＜0.05～P＜0.001).结果 还表明,不同类型何杰金氏病(HD)患者之间的被测元素变化较大,淋巴细胞消减型(LD)组血清铜和铜/锌比值高于混合细胞型(MC)和淋巴细胞为主型(LP),而锌低于混合细胞型(MC),差异显著(P＜0.05～P＜0.001).非何杰金氏病患者中,Ⅲ、Ⅳ期组血清铜含量和铜/锌比值高于Ⅰ、Ⅱ期患者组,差异显著(P＜0.001).结论 血清中铜、锌、锰、钙及铜/锌的测定对恶性淋巴瘤患者的病因调查、临床诊断、型态鉴别及其疗效观察可提供重要的依据.本研究资料的Logistic回归的多因素分析表明,铁元素和铜/锌比值相对危险度(OR)分别为0.4634和10.9919,偏回归系数(β)为-0.7691和2.3972,95%可信限(CI)分别为(-1.3432～-0.1949)和(1.6020～3.1923),提示,铁可能是恶性淋巴瘤的保护因素,而铜/锌比值可能是危险因素. |
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| AbstractList | R733.1; 目的 探讨微量元素与恶性淋巴瘤发生、发展的关系.方法 采用原子吸收分光光度计对370例恶性淋巴瘤患者,100例健康成人进行血清微量元素的测定及分析.结果 恶性淋巴瘤患者组血清铜、铜/锌比值、锰含量高于对照组,而锌、铁、钙含量均低于对照组,差异显著(P＜0.05～P＜0.001).结果 还表明,不同类型何杰金氏病(HD)患者之间的被测元素变化较大,淋巴细胞消减型(LD)组血清铜和铜/锌比值高于混合细胞型(MC)和淋巴细胞为主型(LP),而锌低于混合细胞型(MC),差异显著(P＜0.05～P＜0.001).非何杰金氏病患者中,Ⅲ、Ⅳ期组血清铜含量和铜/锌比值高于Ⅰ、Ⅱ期患者组,差异显著(P＜0.001).结论 血清中铜、锌、锰、钙及铜/锌的测定对恶性淋巴瘤患者的病因调查、临床诊断、型态鉴别及其疗效观察可提供重要的依据.本研究资料的Logistic回归的多因素分析表明,铁元素和铜/锌比值相对危险度(OR)分别为0.4634和10.9919,偏回归系数(β)为-0.7691和2.3972,95%可信限(CI)分别为(-1.3432～-0.1949)和(1.6020～3.1923),提示,铁可能是恶性淋巴瘤的保护因素,而铜/锌比值可能是危险因素. |
| Author | 郭润莲 郭晋纲 侯淑玲 赵先文 韩存芝 郑玉萍 荆洁线 |
| AuthorAffiliation | 030013太原,山西省肿瘤研究所%山西省肿瘤医院血液内科 |
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| Keywords | Logistic回归分析 微量元素 恶性淋巴瘤 |
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