大肠重复癌微卫星不稳定性研究
R735.3; 目的探讨微卫星不稳定性(MSI)在大肠重复癌与单发大肠癌中的变化规律.方法 PCR-SSLP法对38例大肠重复癌患者的51例癌灶及对照35例单发大肠癌分别进行5个碱基序列位点MSI检测.结果大肠重复癌中复制错误(RER)阳性率为52.9%(27/51),对照组为17.1%(6/35), 两组差异有非常显著意义(χ2=11.25, P<0.01).大肠重复癌组中,RER阳性与低分化、近端大肠密切关联.RER阳性组与阴性组在年龄、性别、是否伴有转移、Dukes分期上未见异常.结论 MSI在大肠重复癌的发生上起着重要作用,MSI可作为预测大肠重复癌发生的有用标志,对MSI大肠癌...
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| Published in | 肿瘤防治研究 Vol. 30; no. 5; pp. 354 - 356 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | Chinese |
| Published |
150040,哈尔滨医科大学第三临床医学院腹外科
2003
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1000-8578 |
| DOI | 10.3971/j.issn.1000-8578.2003.05.004 |
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| Abstract | R735.3; 目的探讨微卫星不稳定性(MSI)在大肠重复癌与单发大肠癌中的变化规律.方法 PCR-SSLP法对38例大肠重复癌患者的51例癌灶及对照35例单发大肠癌分别进行5个碱基序列位点MSI检测.结果大肠重复癌中复制错误(RER)阳性率为52.9%(27/51),对照组为17.1%(6/35), 两组差异有非常显著意义(χ2=11.25, P<0.01).大肠重复癌组中,RER阳性与低分化、近端大肠密切关联.RER阳性组与阴性组在年龄、性别、是否伴有转移、Dukes分期上未见异常.结论 MSI在大肠重复癌的发生上起着重要作用,MSI可作为预测大肠重复癌发生的有用标志,对MSI大肠癌患者应警惕多重癌发生的可能性. |
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| AbstractList | R735.3; 目的探讨微卫星不稳定性(MSI)在大肠重复癌与单发大肠癌中的变化规律.方法 PCR-SSLP法对38例大肠重复癌患者的51例癌灶及对照35例单发大肠癌分别进行5个碱基序列位点MSI检测.结果大肠重复癌中复制错误(RER)阳性率为52.9%(27/51),对照组为17.1%(6/35), 两组差异有非常显著意义(χ2=11.25, P<0.01).大肠重复癌组中,RER阳性与低分化、近端大肠密切关联.RER阳性组与阴性组在年龄、性别、是否伴有转移、Dukes分期上未见异常.结论 MSI在大肠重复癌的发生上起着重要作用,MSI可作为预测大肠重复癌发生的有用标志,对MSI大肠癌患者应警惕多重癌发生的可能性. |
| Author | 赵家宏 任延律 于志伟 王宽 张岂凡 |
| AuthorAffiliation | 150040,哈尔滨医科大学第三临床医学院腹外科 |
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| Keywords | 结直肠肿瘤 重复癌 微卫星不稳定性 |
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| Title | 大肠重复癌微卫星不稳定性研究 |
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