Immunological Effect of Active Hexose Correlated Compound (AHCC) in Healthy Volunteers: A Double-Blind, Placebo-Controlled Trial

• Published in: Nutrition and cancer Vol. 60; no. 5; pp. 643 - 651
• Main Authors: Terakawa, Naoyoshi, Matsui, Yoichi, Satoi, Sohei, Yanagimoto, Hiroaki, Takahashi, Kanji, Yamamoto, Tomohisa, Yamao, Jun, Takai, Soichiro, Kwon, A-Hon, Kamiyama, Yasuo
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.09.2008; Taylor& Francis
• Subjects: Biological and medical sciences; cytokines; Cytokines - immunology; dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; disease prevention; Double-Blind Method; Feeding. Feeding behavior; Female; Flow Cytometry; Flow Cytometry - methods; Fundamental and applied biological sciences. Psychology; health status; hexoses; Humans; immune response; immunity; immunologic factors; immunology; Japan; Killer Cells, Natural; Killer Cells, Natural - immunology; lipopolysaccharides; Male; mathematical models; metabolism; methods; Middle Aged; natural killer cells; Polysaccharides; Polysaccharides - immunology; randomized clinical trials; Reference Values; T-Lymphocytes; T-Lymphocytes - immunology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; volunteers; Japan; Human; Double blind study; Hexose; Cancerology; Volunteer
• ISSN: 0163-5581; 1532-7914; 1532-7914
• DOI: 10.1080/01635580801993280

The aim of this study was to evaluate the effects of active hexose correlated compound (AHCC) intake on immune responses by investigating the number and function of circulating dendritic cells (DCs) in healthy volunteers. Twenty-one healthy volunteers were randomized to receive placebo or AHCC at 3.0 g/day for 4 wk. The number of circulating cluster of differentiation (CD)11c+ DCs (DC1) and CD11c- DCs (DC2) were measured. Allogeneic mixed-leukocyte reaction (MLR) was performed. Natural killer (NK) cell activity and the proliferative response of T lymphocytes toward mitogen (phytohemagglutinin [PHA]) were measured. We also measured cytokine production stimulated by lipopolysaccharide [interleukin (IL)-2, IL-4, IL-6, IL-10, interferon gamma-γ, tumor necrosis factor-). The AHCC group (n = 10) after AHCC intake had a significantly higher number of total DCs compared to that at baseline and values from control subjects (n = 11). The number of DC1s in the AHCC group after intake was significantly higher than at baseline. DC2s in the AHCC group were significantly increased in comparison with controls. The MLR in the AHCC group was significantly increased compared to controls. No significant differences in PHA, NK cell activity, and cytokine production were found between groups. AHCC intake resulted in the increased number of DCs and function of DC1s, which have a role in specific immunity.