Influence of Alcohol Consumption on the Development of Erosive Esophagitis in Both Sexes: A Longitudinal Study

The influence of changes in alcohol consumption on erosive esophagitis (EE) development in both sexes is unclear. This observational study investigated sex differences in the influence of alcohol consumption on EE development, and included 2582 patients without EE at baseline from 13,448 patients wh...

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Published inNutrients Vol. 14; no. 22; p. 4760
Main Authors Sogabe, Masahiro, Okahisa, Toshiya, Kagawa, Miwako, Ueda, Hiroyuki, Kagemoto, Kaizo, Tanaka, Hironori, Kida, Yoshifumi, Tomonari, Tetsu, Taniguchi, Tatsuya, Miyamoto, Hiroshi, Sato, Yasushi, Nakasono, Masahiko, Takayama, Tetsuji
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 10.11.2022
MDPI
Subjects
Age groups
Alcohol Drinking - adverse effects
Alcohol use
Body mass index
Cholesterol
Cohort Studies
Data collection
Development and progression
Drinking of alcoholic beverages
Endoscopy
Esophagitis
Esophagitis - epidemiology
Esophagitis - etiology
Esophagus
Female
Gastroesophageal reflux
Habits
Health aspects
Humans
Hypertension
Laboratories
Lifestyles
Longitudinal Studies
Male
Metabolic disorders
Peptic Ulcer
Physiological aspects
Risk factors
Sex factors in disease
Sexes
Sexual Behavior
Womens health
Japan
alcohol intake
development
erosive esophagitis
age
sex
Online AccessGet full text
ISSN2072-6643
2072-6643
DOI10.3390/nu14224760

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Abstract The influence of changes in alcohol consumption on erosive esophagitis (EE) development in both sexes is unclear. This observational study investigated sex differences in the influence of alcohol consumption on EE development, and included 2582 patients without EE at baseline from 13,448 patients who underwent >2 health check-ups over >1 year. The rates of non-drinkers who started drinking, and drinkers who abstained from drinking, who increased, and who decreased their weekly alcohol consumption were 7.2%, 9.7%, 14.7%, and 24.1% and 7.3%, 17.8%, 12.8%, and 39.0% in men and women, respectively. In the final cohort, 211/1405 (15.0%) men and 79/1177 (6.7%) women newly developed EE. The odds ratio (OR) for drinking in EE development was 1.252 (95% confidence interval (CI), 0.907–1.726) among men and 1.078 (95% CI, 0.666–1.747) among women. Among men aged <50 years, the OR for drinking ≥70 g/week in EE development was 2.825 (95% CI, 1.427–5.592), whereas among women, the OR for drinking ≥140 g/week in EE development was 3.248 (95% CI, 1.646–6.410). Among participants aged <50 years, the OR for daily drinking in EE development was 2.692 (95% CI, 1.298–5.586) among men and 4.030 (95% CI, 1.404–11.57) among women. The influence of alcohol consumption on EE development differed between the sexes. We recommend no alcohol consumption for individuals aged <50 years to avoid EE development. Daily drinkers should be assessed for EE development.
AbstractList The influence of changes in alcohol consumption on erosive esophagitis (EE) development in both sexes is unclear. This observational study investigated sex differences in the influence of alcohol consumption on EE development, and included 2582 patients without EE at baseline from 13,448 patients who underwent >2 health check-ups over >1 year. The rates of non-drinkers who started drinking, and drinkers who abstained from drinking, who increased, and who decreased their weekly alcohol consumption were 7.2%, 9.7%, 14.7%, and 24.1% and 7.3%, 17.8%, 12.8%, and 39.0% in men and women, respectively. In the final cohort, 211/1405 (15.0%) men and 79/1177 (6.7%) women newly developed EE. The odds ratio (OR) for drinking in EE development was 1.252 (95% confidence interval (CI), 0.907−1.726) among men and 1.078 (95% CI, 0.666−1.747) among women. Among men aged <50 years, the OR for drinking ≥70 g/week in EE development was 2.825 (95% CI, 1.427−5.592), whereas among women, the OR for drinking ≥140 g/week in EE development was 3.248 (95% CI, 1.646−6.410). Among participants aged <50 years, the OR for daily drinking in EE development was 2.692 (95% CI, 1.298−5.586) among men and 4.030 (95% CI, 1.404−11.57) among women. The influence of alcohol consumption on EE development differed between the sexes. We recommend no alcohol consumption for individuals aged <50 years to avoid EE development. Daily drinkers should be assessed for EE development.
The influence of changes in alcohol consumption on erosive esophagitis (EE) development in both sexes is unclear. This observational study investigated sex differences in the influence of alcohol consumption on EE development, and included 2582 patients without EE at baseline from 13,448 patients who underwent >2 health check-ups over >1 year. The rates of non-drinkers who started drinking, and drinkers who abstained from drinking, who increased, and who decreased their weekly alcohol consumption were 7.2%, 9.7%, 14.7%, and 24.1% and 7.3%, 17.8%, 12.8%, and 39.0% in men and women, respectively. In the final cohort, 211/1405 (15.0%) men and 79/1177 (6.7%) women newly developed EE. The odds ratio (OR) for drinking in EE development was 1.252 (95% confidence interval (CI), 0.907–1.726) among men and 1.078 (95% CI, 0.666–1.747) among women. Among men aged <50 years, the OR for drinking ≥70 g/week in EE development was 2.825 (95% CI, 1.427–5.592), whereas among women, the OR for drinking ≥140 g/week in EE development was 3.248 (95% CI, 1.646–6.410). Among participants aged <50 years, the OR for daily drinking in EE development was 2.692 (95% CI, 1.298–5.586) among men and 4.030 (95% CI, 1.404–11.57) among women. The influence of alcohol consumption on EE development differed between the sexes. We recommend no alcohol consumption for individuals aged <50 years to avoid EE development. Daily drinkers should be assessed for EE development.
The influence of changes in alcohol consumption on erosive esophagitis (EE) development in both sexes is unclear. This observational study investigated sex differences in the influence of alcohol consumption on EE development, and included 2582 patients without EE at baseline from 13,448 patients who underwent >2 health check-ups over >1 year. The rates of non-drinkers who started drinking, and drinkers who abstained from drinking, who increased, and who decreased their weekly alcohol consumption were 7.2%, 9.7%, 14.7%, and 24.1% and 7.3%, 17.8%, 12.8%, and 39.0% in men and women, respectively. In the final cohort, 211/1405 (15.0%) men and 79/1177 (6.7%) women newly developed EE. The odds ratio (OR) for drinking in EE development was 1.252 (95% confidence interval (CI), 0.907−1.726) among men and 1.078 (95% CI, 0.666−1.747) among women. Among men aged <50 years, the OR for drinking ≥70 g/week in EE development was 2.825 (95% CI, 1.427−5.592), whereas among women, the OR for drinking ≥140 g/week in EE development was 3.248 (95% CI, 1.646−6.410). Among participants aged <50 years, the OR for daily drinking in EE development was 2.692 (95% CI, 1.298−5.586) among men and 4.030 (95% CI, 1.404−11.57) among women. The influence of alcohol consumption on EE development differed between the sexes. We recommend no alcohol consumption for individuals aged <50 years to avoid EE development. Daily drinkers should be assessed for EE development.The influence of changes in alcohol consumption on erosive esophagitis (EE) development in both sexes is unclear. This observational study investigated sex differences in the influence of alcohol consumption on EE development, and included 2582 patients without EE at baseline from 13,448 patients who underwent >2 health check-ups over >1 year. The rates of non-drinkers who started drinking, and drinkers who abstained from drinking, who increased, and who decreased their weekly alcohol consumption were 7.2%, 9.7%, 14.7%, and 24.1% and 7.3%, 17.8%, 12.8%, and 39.0% in men and women, respectively. In the final cohort, 211/1405 (15.0%) men and 79/1177 (6.7%) women newly developed EE. The odds ratio (OR) for drinking in EE development was 1.252 (95% confidence interval (CI), 0.907−1.726) among men and 1.078 (95% CI, 0.666−1.747) among women. Among men aged <50 years, the OR for drinking ≥70 g/week in EE development was 2.825 (95% CI, 1.427−5.592), whereas among women, the OR for drinking ≥140 g/week in EE development was 3.248 (95% CI, 1.646−6.410). Among participants aged <50 years, the OR for daily drinking in EE development was 2.692 (95% CI, 1.298−5.586) among men and 4.030 (95% CI, 1.404−11.57) among women. The influence of alcohol consumption on EE development differed between the sexes. We recommend no alcohol consumption for individuals aged <50 years to avoid EE development. Daily drinkers should be assessed for EE development.
Audience Academic
Author Tanaka, Hironori
Miyamoto, Hiroshi
Sato, Yasushi
Nakasono, Masahiko
Kagawa, Miwako
Tomonari, Tetsu
Takayama, Tetsuji
Okahisa, Toshiya
Ueda, Hiroyuki
Sogabe, Masahiro
Kagemoto, Kaizo
Taniguchi, Tatsuya
Kida, Yoshifumi
AuthorAffiliation 1 Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan
4 Department of Internal Medicine, Tsurugi Municipal Handa Hospital, Tsurugi 779-4401, Japan
3 Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Shikokuchuo 779-0193, Japan
2 Health Service, Counseling and Accessibility Center, Tokushima University, Tokushima 770-8502, Japan
AuthorAffiliation_xml – name: 1 Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan
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– name: 4 Department of Internal Medicine, Tsurugi Municipal Handa Hospital, Tsurugi 779-4401, Japan
– name: 3 Department of Internal Medicine, Shikoku Central Hospital of the Mutual Aid Association of Public School Teachers, Shikokuchuo 779-0193, Japan
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Cites_doi 10.3390/biom10030400
10.1186/1471-230X-14-144
10.1111/apt.16585
10.1016/S0140-6736(20)31561-0
10.1016/S0889-8553(05)70035-2
10.1136/gutjnl-2017-314722
10.2307/2533568
10.3390/molecules23071684
10.1080/110241500750008565
10.1053/j.gastro.2008.12.005
10.1016/S0168-8278(01)00050-2
10.1007/s10620-013-2892-6
10.1007/s00535-017-1342-1
10.1111/j.1442-2050.2012.01417.x
10.3748/wjg.v19.i35.5883
10.1136/gut.2008.162305
10.5056/jnm20237
10.1053/j.gastro.2008.11.042
10.1093/jnci/89.17.1277
10.1016/0016-5085(78)90088-4
10.1161/circ.106.25.3143
10.1111/j.1572-0241.1999.987_j.x
10.1016/j.jhep.2020.03.039
10.1038/ajg.2011.326
10.3748/wjg.v22.i5.1800
10.1111/j.1572-0241.2003.07188.x
10.1136/gutjnl-2012-304269
10.1111/j.1523-5378.2007.00489.x
10.1111/j.1440-1746.2010.06534.x
10.5772/27178
10.1038/ajg.2014.206
10.1053/j.gastro.2008.12.052
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Keywords alcohol intake
development
erosive esophagitis
age
sex
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References Guy (ref_35) 2013; 9
Thrift (ref_31) 2014; 109
Kubo (ref_23) 2009; 136
Toki (ref_18) 2022; 28
Gammon (ref_25) 1997; 89
Goh (ref_3) 2011; 26
Anderson (ref_22) 2009; 136
Velanovich (ref_1) 2000; 166
Ronkainen (ref_5) 2011; 106
Pandeya (ref_26) 2009; 136
ref_34
Xie (ref_13) 2013; 25
Zamani (ref_12) 2021; 54
ref_15
Verne (ref_19) 1998; 27
Eslam (ref_10) 2020; 73
Sweet (ref_2) 2014; 63
Albert (ref_11) 1997; 53
Achem (ref_32) 2003; 98
Gyawali (ref_4) 2018; 67
ref_24
Lee (ref_16) 2009; 58
Lluch (ref_17) 1999; 94
Loke (ref_20) 2013; 19
Rajendra (ref_14) 2007; 12
Asanuma (ref_8) 2016; 22
Park (ref_33) 2014; 27
Lukkari (ref_6) 2001; 35
ref_28
Thrift (ref_30) 2014; 59
ref_27
ref_9
Barnes (ref_7) 2020; 396
Mayer (ref_21) 1978; 75
Souza (ref_29) 2017; 52
References_xml – ident: ref_27
  doi: 10.3390/biom10030400
– ident: ref_9
– ident: ref_24
  doi: 10.1186/1471-230X-14-144
– volume: 54
  start-page: 988
  year: 2021
  ident: ref_12
  article-title: Systematic review with meta-analysis: Association of Helicobacter pylori infection with gastro-oesophageal reflux and its complications
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/apt.16585
– volume: 396
  start-page: 565
  year: 2020
  ident: ref_7
  article-title: Sex and gender: Modifiers of health, disease, and medicine
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)31561-0
– volume: 27
  start-page: 861
  year: 1998
  ident: ref_19
  article-title: Diabetes and the gastrointestinal tract
  publication-title: Gastroenterol. Clin. N. Am.
  doi: 10.1016/S0889-8553(05)70035-2
– volume: 67
  start-page: 1351
  year: 2018
  ident: ref_4
  article-title: Modern diagnosis of GERD: The Lyon consensus
  publication-title: Gut
  doi: 10.1136/gutjnl-2017-314722
– volume: 53
  start-page: 1116
  year: 1997
  ident: ref_11
  article-title: A generalized estimating equation approach for modeling random length binary vector data
  publication-title: Biometrics
  doi: 10.2307/2533568
– ident: ref_28
  doi: 10.3390/molecules23071684
– volume: 166
  start-page: 516
  year: 2000
  ident: ref_1
  article-title: Quality of life and severity of symptoms in gastro-oesophageal reflux disease: A clinical review
  publication-title: Eur. J. Surg.
  doi: 10.1080/110241500750008565
– volume: 136
  start-page: 799
  year: 2009
  ident: ref_22
  article-title: The association between alcohol and reflux esophagitis, Barrett’s esophagus, and esophageal adenocarcinoma
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.12.005
– volume: 9
  start-page: 633
  year: 2013
  ident: ref_35
  article-title: Liver disease in women: The influence of gender on epidemiology, natural history, and patient outcomes
  publication-title: Gastroenterol. Hepatol.
– volume: 35
  start-page: 46
  year: 2001
  ident: ref_6
  article-title: The antiestrogen toremifene protects against alcoholic liver injury in female rats
  publication-title: J. Hepatol.
  doi: 10.1016/S0168-8278(01)00050-2
– volume: 59
  start-page: 108
  year: 2014
  ident: ref_30
  article-title: No significant effects of smoking or alcohol consumption on risk of Barrett’s esophagus
  publication-title: Dig. Dis. Sci.
  doi: 10.1007/s10620-013-2892-6
– volume: 52
  start-page: 767
  year: 2017
  ident: ref_29
  article-title: Reflux esophagitis and its role in the pathogenesis of Barrett’s metaplasia
  publication-title: J. Gastroenterol.
  doi: 10.1007/s00535-017-1342-1
– volume: 27
  start-page: 116
  year: 2014
  ident: ref_33
  article-title: Differences in the risk factors of reflux esophagitis according to age in Korea
  publication-title: Dis. Esophagus.
  doi: 10.1111/j.1442-2050.2012.01417.x
– volume: 19
  start-page: 5883
  year: 2013
  ident: ref_20
  article-title: Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v19.i35.5883
– volume: 58
  start-page: 174
  year: 2009
  ident: ref_16
  article-title: The effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease
  publication-title: Gut
  doi: 10.1136/gut.2008.162305
– volume: 28
  start-page: 86
  year: 2022
  ident: ref_18
  article-title: Predictive factors for future onset of reflux esophagitis: A longitudinal case-control study using health checkup records
  publication-title: J. Neurogastroenterol. Motil.
  doi: 10.5056/jnm20237
– volume: 136
  start-page: 806
  year: 2009
  ident: ref_23
  article-title: Alcohol types and sociodemographic characteristics as risk factors for Barrett’s esophagus
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.11.042
– volume: 89
  start-page: 1277
  year: 1997
  ident: ref_25
  article-title: Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/89.17.1277
– volume: 75
  start-page: 1133
  year: 1978
  ident: ref_21
  article-title: Effects of graded doses of alcohol upon esophageal motor function
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(78)90088-4
– ident: ref_15
  doi: 10.1161/circ.106.25.3143
– volume: 94
  start-page: 919
  year: 1999
  ident: ref_17
  article-title: Gastroesophageal reflux in diabetes mellitus
  publication-title: Am. J. Gastroenterol.
  doi: 10.1111/j.1572-0241.1999.987_j.x
– volume: 73
  start-page: 202
  year: 2020
  ident: ref_10
  article-title: A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2020.03.039
– volume: 106
  start-page: 1946
  year: 2011
  ident: ref_5
  article-title: Erosive esophagitis is a risk factor for Barrett’s esophagus: A community-based endoscopic follow-up study
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2011.326
– volume: 22
  start-page: 1800
  year: 2016
  ident: ref_8
  article-title: Gender difference in gastro-esophageal reflux diseases
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v22.i5.1800
– volume: 98
  start-page: 35
  year: 2003
  ident: ref_32
  article-title: Failure of esophageal peristalsis in older patients: Association with esophageal acid exposure
  publication-title: Am. J. Gastroenterol.
  doi: 10.1111/j.1572-0241.2003.07188.x
– volume: 63
  start-page: 871
  year: 2014
  ident: ref_2
  article-title: Update on the epidemiology of gastro-oesophageal reflux disease: A systematic review
  publication-title: Gut
  doi: 10.1136/gutjnl-2012-304269
– volume: 25
  start-page: 1195
  year: 2013
  ident: ref_13
  article-title: Meta-analysis: Eradication of Helicobacter pylori infection is associated with the development of endoscopic gastroesophageal reflux disease
  publication-title: Eur. J. Gastroenterol. Hepatol.
– volume: 12
  start-page: 177
  year: 2007
  ident: ref_14
  article-title: Helicobacter pylori, ethnicity, and the gastroesophageal reflux disease spectrum: A study from the East
  publication-title: Helicobacter
  doi: 10.1111/j.1523-5378.2007.00489.x
– volume: 26
  start-page: 2
  year: 2011
  ident: ref_3
  article-title: Gastroesophageal reflux disease in Asia: A historical perspective and present challenges
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2010.06534.x
– ident: ref_34
  doi: 10.5772/27178
– volume: 109
  start-page: 1586
  year: 2014
  ident: ref_31
  article-title: Alcohol and the risk of Barrett’s esophagus: A pooled analysis from the International BEACON Consortium
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2014.206
– volume: 136
  start-page: 1215
  year: 2009
  ident: ref_26
  article-title: Alcohol consumption and the risks of adenocarcinoma and squamous cell carcinoma of the esophagus
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.12.052
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SubjectTerms Age groups
Alcohol Drinking - adverse effects
Alcohol use
Body mass index
Cholesterol
Cohort Studies
Data collection
Development and progression
Drinking of alcoholic beverages
Endoscopy
Esophagitis
Esophagitis - epidemiology
Esophagitis - etiology
Esophagus
Female
Gastroesophageal reflux
Habits
Health aspects
Humans
Hypertension
Laboratories
Lifestyles
Longitudinal Studies
Male
Metabolic disorders
Peptic Ulcer
Physiological aspects
Risk factors
Sex factors in disease
Sexes
Sexual Behavior
Womens health
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Title Influence of Alcohol Consumption on the Development of Erosive Esophagitis in Both Sexes: A Longitudinal Study
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