Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study - Fortea, Juan; Vilaplana, Eduard; Carmona-Iragui, Maria; Benejam, Bessy; Videla, Laura; Barroeta, Isabel; Fernández, Susana; Altuna, Miren; Pegueroles, Jordi; Montal, Víctor; Valldeneu, Silvia; Giménez, Sandra; et al. (The Lancet (British edition), 2020)
Keywords: Abnormalities; Adult; Adults; Age; Alzheimer Disease; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - epidemiology; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Peptides - metabolism; Amyloidosis; Amyloidosis - diagnostic imaging; Amyloidosis - pathology; Apolipoprotein E; Apolipoproteins E; Apolipoproteins E - metabolism; Atrophy; Automation; Biomarkers; Biomarkers - blood; Caregivers; Carrier density; Case-Control Studies; Cerebrospinal fluid; Cognition; Cognitive ability; Cognitive Dysfunction; Cognitive Dysfunction - psychology; Cross-Sectional Studies; Dementia; Dementia disorders; Down Syndrome; Down Syndrome - complications; Down Syndrome - epidemiology; Down Syndrome - mortality; Down Syndrome - psychology; Down's syndrome; Fluorine isotopes; Fluorodeoxyglucose F18; Fluorodeoxyglucose F18 - administration & dosage; Hippocampus; Hospitals; Human health and pathology; Humans; Intellectual disabilities; Life Sciences; Magnetic Resonance Imaging; Magnetic Resonance Imaging - methods; Medical imaging; Medical research; Mental disorders; Metabolism; Middle Aged; Natural history; Neurobiology; Neurodegeneration; Neurodegenerative diseases; Neurofilament Proteins; Neurofilament Proteins - cerebrospinal fluid; Neurons and Cognition; Older people; Peptides; Plasma; Population; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Prevalence; Proteins; Psychiatrics and mental health; Spain; Spain - epidemiology; Tau protein; tau Proteins; tau Proteins - metabolism; Threonine; Tomography; Tracers; United Kingdom; United Kingdom - epidemiology; United Kingdom; Spain; United Kingdom--UK; United States--US