SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function - Winkler, Emma S.; Bailey, Adam L.; Kafai, Natasha M.; Nair, Sharmila; McCune, Broc T.; Yu, Jinsheng; Fox, Julie M.; Chen, Rita E.; Earnest, James T.; Keeler, Shamus P.; Ritter, Jon H.; Kang, Liang-I; et al. (Nature immunology, 2020)
Keywords: 631/250/2499; 631/326/596/4130; ACE2; Angiotensin; Angiotensin converting enzyme; Angiotensin I; Angiotensin-Converting Enzyme 2; Animal models; Animals; Antiviral drugs; Betacoronavirus - immunology; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell activation; Chlorocebus aethiops; Coronavirus Infections - immunology; Coronavirus Infections - pathology; Coronaviruses; COVID-19; Cytokeratin; Development and progression; Disease Models, Animal; Female; Gene expression; Genetic aspects; Health aspects; Humans; Immune response; Immunity, Innate - immunology; Immunology; Infections; Infectious Diseases; Inflammation; Innate immunity; Inoculation; Interferon; Interferon Type I - immunology; Interferon-gamma - immunology; Keratin-18 - genetics; Leukocytes (neutrophilic); Leukocytes - immunology; Lung diseases; Lymphocyte Activation - immunology; Lymphocytes T; Male; Mice; Mice, Transgenic; Monocytes; Monocytes - immunology; Neutrophil Infiltration - immunology; Neutrophils - immunology; NF-kappa B - immunology; Pandemics; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - genetics; Phenotypes; Pneumonia - genetics; Pneumonia - pathology; Pneumonia - virology; Pneumonia, Viral - immunology; Pneumonia, Viral - pathology; Promoter Regions, Genetic - genetics; Respiratory function; Respiratory tract infections; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; T-Lymphocytes - immunology; Transgenic animals; Transgenic mice; Vero Cells; Viral infections; Virus Replication - immunology; United States