甲状腺乳头状癌中CA19-9、CA15-3和CA125的表达及意义

目的探讨糖类抗原19-9（CA19-9）、糖类抗原15-3（CA15-3）和糖类抗原125（CA125）在甲状腺乳头状癌（PTC）中的表达及临床意义。方法采用免疫组化MaxVision两步法检测80例PTC和80例甲状腺良性病变（BTL，包括34例结节性甲状腺肿、26例桥本甲状腺炎和20例滤泡性腺瘤）患者中CA19-9、CA15-3和CA125的表达状况，分析其表达与PTC患者临床病理特征的关系。结果80例PTC中CA19-9、CA15-3、CA125阳性表达率分别为85.0%、100.0%、43.8%，与BTL相比，差异具有统计学意义（P＜0.01）。CA19-9、CA15-3、CA125的...

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Bibliographic Details
Published in天津医药 Vol. 44; no. 12; pp. 1496 - 1499
Main Author 侯卫东;王俊宏;张志宇;李进;刘艳晓;丁红霞;禹远远;田勇;刘艳峰
Format Journal Article
LanguageChinese
Published 河南省平顶山市第一人民医院内分泌代谢科 邮编467000%中国人民解放军152医院病理科 2016
Subjects
甲状腺肿瘤;癌,乳头状;免疫组织化学;诊断,鉴别;敏感性与特异性;CA-19-9抗原;CA-15-3抗原;CA-125抗原
甲状腺肿瘤
CA-125抗原
carcinoma,papillary
免疫组织化学
诊断,鉴别
CA-125 antigen
sensitivity and specificity
CA-19-9 antigen
CA-15-3 antigen
敏感性与特异性
CA-15-3抗原
diagnosis,differential
CA-19-9抗原
immunohistochemistry
thyroid neoplasms
癌,乳头状
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ISSN0253-9896
DOI10.11958/20160511

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Summary:目的探讨糖类抗原19-9（CA19-9）、糖类抗原15-3（CA15-3）和糖类抗原125（CA125）在甲状腺乳头状癌（PTC）中的表达及临床意义。方法采用免疫组化MaxVision两步法检测80例PTC和80例甲状腺良性病变（BTL，包括34例结节性甲状腺肿、26例桥本甲状腺炎和20例滤泡性腺瘤）患者中CA19-9、CA15-3和CA125的表达状况，分析其表达与PTC患者临床病理特征的关系。结果80例PTC中CA19-9、CA15-3、CA125阳性表达率分别为85.0%、100.0%、43.8%，与BTL相比，差异具有统计学意义（P＜0.01）。CA19-9、CA15-3、CA125的表达与患者年龄、性别、瘤结节数目、直径、淋巴结转移及TNM分期无关（P＞0.05）。CA19-9、CA15-3、CA125诊断PTC的灵敏度分别为85.0%、100.0%、43.8%，特异度分别为91.3%、36.3%、91.3%。结论CA19-9、CA153、CA125的表达有助于PTC和BTL的鉴别诊断。
Bibliography:Objective To investigate the expressions of carbohydrate antigen 19-9(CA19-9), carbohydrate antigen 15-3(CA15- 3) and carbohydrate antigen 125(CA125) and their clinical significance in papillary thyroid carcinoma (PTC).Methods The expressions of CA19-9, CA15-3 and CA125 were detected by immunohistochemical MaxVision method in80 cases of PTC and 80 cases of benign thyroid lesions (BTL), including 34 cases of nodular goiter, 26 cases of Hashimoto'sthyroiditis and 20 cases of follicular adenoma. The relationship between expressions of CA19-9, CA15-3 and CA125 andthe clinical pathological characteristics were analyzed. Results The expression rates of CA19-9, CA15-3 and CA125 in80 cases of PTC were 85%, 100% and 43.8% respectively, compared with BTL, the difference was statistically significant(P < 0.01). There was no significant correlation between expressions of CA19-9, CA15-3 and CA125 and age, gender,number and diameter of tumor nodules, lymph node metastasis, and TNM staging (P > 0.05). The sensiti
ISSN:0253-9896
DOI:10.11958/20160511