Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver

A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3′ untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1 , respectively, as the independent variants most strongly associated with chronic hepati...

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Published inGenes and immunity Vol. 12; no. 6; pp. 428 - 433
Main Authors O'Brien, T R, Kohaar, I, Pfeiffer, R M, Maeder, D, Yeager, M, Schadt, E E, Prokunina-Olsson, L
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.09.2011
Nature Publishing Group
Subjects
3' Untranslated Regions
631/208/199
631/208/457/649
631/250/21/324
692/699/1503/234/2513/1549
Alleles
Antigens
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Data processing
Epidemiology
Gene Expression
Genetic Predisposition to Disease
Genetics
Genome-Wide Association Study
Genomes
Genomics
Genotype
Genotype & phenotype
Hepatitis B
Hepatitis B virus
Hepatitis B virus - immunology
Hepatitis B, Chronic - genetics
Hepatitis B, Chronic - immunology
Histocompatibility antigen HLA
Histocompatibility antigens
HLA histocompatibility antigens
HLA-DP alpha-Chains - genetics
HLA-DP alpha-Chains - immunology
HLA-DP beta-Chains - genetics
HLA-DP beta-Chains - immunology
Human Genetics
Humans
Immunology
Leukocytes
Liver
Liver - immunology
Original
original-article
Physiological aspects
Polymorphism, Single Nucleotide
Risk factors
RNA, Messenger - biosynthesis
Single nucleotide polymorphisms
Single-nucleotide polymorphism
United States > US
chronic hepatitis B
genomics
genetics
HLA
gene expression
Online AccessGet full text
ISSN1466-4879
1476-5470
1476-5470
DOI10.1038/gene.2011.11

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Abstract A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3′ untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1 , respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1 . We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (∼650 000 SNPs) and gene expression (>39 000 transcripts) data from each sample. We used the Kruskal–Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression ( p =10 −48 ), and rs9277535 was strongly associated with HLA-DPB1 expression ( p =10 −15 ). Consistent with these gene expression associations, we observed AEI for both rs3077 ( p =3.0 × 10 −7 ; 17 samples) and rs9277535 ( p =0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1 , suggesting that expression of these genes is important in control of HBV.
AbstractList A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3 untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (~650 000 SNPs) and gene expression (>39000 transcripts) data from each sample. We used the Kruskal-Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p = [10.sup.-48]), and rs9277535 was strongly associated with HLA-DPB1 expression (p = 10-15). Consistent with these gene expression associations, we observed AEI for both rs3077 (p = 3.0 x [10.sup.-7]; 17 samples) and rs9277535 (p = 0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (~650 000 SNPs) and gene expression (>39 000 transcripts) data from each sample. We used the Kruskal-Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p=10(-48)), and rs9277535 was strongly associated with HLA-DPB1 expression (p=10(-15)). Consistent with these gene expression associations, we observed AEI for both rs3077 (p=3.0 × 10(-7); 17 samples) and rs9277535 (p=0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (~650000 SNPs) and gene expression (>39000 transcripts) data from each sample. We used the Kruskal-Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p=10(-48)), and rs9277535 was strongly associated with HLA-DPB1 expression (p=10(-15)). Consistent with these gene expression associations, we observed AEI for both rs3077 (p=3.0 × 10(-7); 17 samples) and rs9277535 (p=0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3′ untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (∼650 000 SNPs) and gene expression (>39 000 transcripts) data from each sample. We used the Kruskal–Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p=10−48), and rs9277535 was strongly associated with HLA-DPB1 expression (p=10−15). Consistent with these gene expression associations, we observed AEI for both rs3077 (p=3.0 × 10−7; 17 samples) and rs9277535 (p=0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype ( similar to 650 000 SNPs) and gene expression (>39 000 transcripts) data from each sample. We used the Kruskal-Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p=10 super(-48)), and rs9277535 was strongly associated with HLA-DPB1 expression (p=10 super(-15)). Consistent with these gene expression associations, we observed AEI for both rs3077 (p=3.0 10 super(-7); 17 samples) and rs9277535 (p=0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3 untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (~650 000 SNPs) and gene expression (>39000 transcripts) data from each sample. We used the Kruskal-Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p = [10.sup.-48]), and rs9277535 was strongly associated with HLA-DPB1 expression (p = 10-15). Consistent with these gene expression associations, we observed AEI for both rs3077 (p = 3.0 x [10.sup.-7]; 17 samples) and rs9277535 (p = 0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV. Genes and Immunity (2011) 12, 428-433; doi: 10.1038/gene.2011.11; published online 24 February 2011 Keywords: chronic hepatitis B; HLA; gene expression; genetics; genomics
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (~650 000 SNPs) and gene expression (>39 000 transcripts) data from each sample. We used the Kruskal-Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p=10(-48)), and rs9277535 was strongly associated with HLA-DPB1 expression (p=10(-15)). Consistent with these gene expression associations, we observed AEI for both rs3077 (p=3.0 × 10(-7); 17 samples) and rs9277535 (p=0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1. We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (~650 000 SNPs) and gene expression (>39 000 transcripts) data from each sample. We used the Kruskal-Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression (p=10(-48)), and rs9277535 was strongly associated with HLA-DPB1 expression (p=10(-15)). Consistent with these gene expression associations, we observed AEI for both rs3077 (p=3.0 × 10(-7); 17 samples) and rs9277535 (p=0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1, suggesting that expression of these genes is important in control of HBV.
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3′ untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1 , respectively, as the independent variants most strongly associated with chronic hepatitis B. We examined whether these SNPs are associated with mRNA expression of HLA-DPA1 and HLA-DPB1 . We identified gene expression-associated SNPs (eSNPs) in normal liver samples obtained from 651 individuals of European ancestry by integrating genotype (∼650 000 SNPs) and gene expression (>39 000 transcripts) data from each sample. We used the Kruskal–Wallis test to determine associations between gene expression and genotype. To confirm findings, we measured allelic expression imbalance (AEI) of complementary DNA compared with DNA in liver specimens from subjects who were heterozygous for rs3077 and rs9277535. On a genome-wide basis, rs3077 was the SNP most strongly associated with HLA-DPA1 expression ( p =10 −48 ), and rs9277535 was strongly associated with HLA-DPB1 expression ( p =10 −15 ). Consistent with these gene expression associations, we observed AEI for both rs3077 ( p =3.0 × 10 −7 ; 17 samples) and rs9277535 ( p =0.001; 17 samples). We conclude that the variants previously associated with chronic hepatitis B are also strongly associated with mRNA expression of HLA-DPA1 and HLA-DPB1 , suggesting that expression of these genes is important in control of HBV.
Audience Academic
Author Maeder, D
Schadt, E E
Prokunina-Olsson, L
O'Brien, T R
Pfeiffer, R M
Yeager, M
Kohaar, I
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21346778$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1371/journal.pgen.1000436
10.1056/NEJMoa073491
10.1056/NEJMoa0810440
10.1016/S0168-8278(10)60728-3
10.1038/sj.gene.6364283
10.1093/epirev/mxj009
10.1038/ng2109
10.1371/journal.pone.0000622
10.1038/ng.486
10.1038/44853
10.1126/science.1143767
10.1371/journal.pbio.0060107
10.1038/nature06758
10.1038/ng.348
10.1093/hmg/ddp321
10.1017/S1462399404007690
10.1074/mcp.M500279-MCP200
10.1038/nature08516
10.1038/nrg2537
10.1016/j.ajhg.2010.02.005
10.1097/FPC.0b013e3283050107
10.1371/journal.pgen.0010078
10.1038/nature04244
ContentType Journal Article
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Issue 6
Keywords chronic hepatitis B
genomics
genetics
HLA
gene expression
Language English
License http://www.springer.com/tdm
This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0
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References Cookson, Liang, Abecasis, Moffatt, Lathrop (CR9) 2009; 10
Johnson, Zhang, Papp, Pinsonneault, Lim, Saffen (CR10) 2008; 18
Fellay, Shianna, Ge, Colombo, Ledergerber, Weale (CR19) 2007; 317
Thomas, Apps, Qi, Gao, Male, O’HUigin (CR18) 2009; 41
Conrad, Pinto, Redon, Feuk, Gokcumen, Zhang (CR15) 2010; 464
Matsuura, Tanaka, Nishida, Hige, Asahina, Ito (CR3) 2010; 52
Dixon, Liang, Moffatt, Chen, Heath, Wong (CR5) 2007; 39
Prokunina-Olsson, Welch, Hansson, Adhikari, Scott, Usher (CR21) 2009; 18
Uhlen, Bjorling, Agaton, Szigyarto, Amini, Andersen (CR11) 2005; 4
Garred, Larsen, Seyfarth, Fujita, Madsen (CR12) 2006; 7
Hirschfield, Liu, Xu, Lu, Xie, Lu (CR16) 2009; 360
Emilsson, Thorleifsson, Zhang, Leonardson, Zink, Zhu (CR7) 2008; 452
Dennis, Paracchini, Scerri, Prokunina-Olsson, Knight, Wade-Martins (CR23) 2009; 5
Shepard, Simard, Finelli, Fiore, Bell (CR1) 2006; 28
Prokunina, Alarcon-Riquelme (CR13) 2004; 6
Plenge, Seielstad, Padyukov, Lee, Remmers, Ding (CR17) 2007; 357
(CR4) 1999; 401
Zhang, Cheng, Badner, Chen, Chen, Luo (CR14) 2010; 86
Cheung, Spielman, Ewens, Weber, Morley, Burdick (CR22) 2005; 437
Kamatani, Wattanapokayakit, Ochi, Kawaguchi, Takahashi, Hosono (CR2) 2009; 41
Alberts, Terpstra, Li, Breitling, Nap, Jansen (CR8) 2007; 2
Stranger, Forrest, Clark, Minichiello, Deutsch, Lyle (CR20) 2005; 1
Schadt, Molony, Chudin, Hao, Yang, Lum (CR6) 2008; 6
CW Shepard (BFgene201111_CR1) 2006; 28
K Matsuura (BFgene201111_CR3) 2010; 52
Y Kamatani (BFgene201111_CR2) 2009; 41
D Zhang (BFgene201111_CR14) 2010; 86
R Thomas (BFgene201111_CR18) 2009; 41
MHC sequencing consortium (BFgene201111_CR4) 1999; 401
EE Schadt (BFgene201111_CR6) 2008; 6
W Cookson (BFgene201111_CR9) 2009; 10
J Fellay (BFgene201111_CR19) 2007; 317
MY Dennis (BFgene201111_CR23) 2009; 5
DF Conrad (BFgene201111_CR15) 2010; 464
V Emilsson (BFgene201111_CR7) 2008; 452
BE Stranger (BFgene201111_CR20) 2005; 1
VG Cheung (BFgene201111_CR22) 2005; 437
AD Johnson (BFgene201111_CR10) 2008; 18
GM Hirschfield (BFgene201111_CR16) 2009; 360
L Prokunina (BFgene201111_CR13) 2004; 6
RM Plenge (BFgene201111_CR17) 2007; 357
M Uhlen (BFgene201111_CR11) 2005; 4
AL Dixon (BFgene201111_CR5) 2007; 39
R Alberts (BFgene201111_CR8) 2007; 2
P Garred (BFgene201111_CR12) 2006; 7
L Prokunina-Olsson (BFgene201111_CR21) 2009; 18
References_xml – volume: 5
  start-page: e1000436
  year: 2009
  ident: CR23
  article-title: A common variant associated with dyslexia reduces expression of the KIAA0319 gene
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1000436
– volume: 357
  start-page: 1199
  year: 2007
  end-page: 1209
  ident: CR17
  article-title: TRAF1-C5 as a risk locus for rheumatoid arthritis—a genomewide study
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa073491
– volume: 360
  start-page: 2544
  year: 2009
  end-page: 2555
  ident: CR16
  article-title: Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 Variants
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0810440
– volume: 52
  start-page: S282
  issue: Supplement 1
  year: 2010
  end-page: S283
  ident: CR3
  article-title: Genome-wide association study identifies genetic variants in the HLA-DP locus associated with chronic hepatitis B
  publication-title: J Hepatol
  doi: 10.1016/S0168-8278(10)60728-3
– volume: 7
  start-page: 85
  year: 2006
  end-page: 94
  ident: CR12
  article-title: Mannose-binding lectin and its genetic variants
  publication-title: Genes Immun
  doi: 10.1038/sj.gene.6364283
– volume: 28
  start-page: 112
  year: 2006
  end-page: 125
  ident: CR1
  article-title: Hepatitis B virus infection: epidemiology and vaccination
  publication-title: Epidemiol Rev
  doi: 10.1093/epirev/mxj009
– volume: 39
  start-page: 1202
  year: 2007
  end-page: 1207
  ident: CR5
  article-title: A genome-wide association study of global gene expression
  publication-title: Nat Genet
  doi: 10.1038/ng2109
– volume: 2
  start-page: e622
  year: 2007
  ident: CR8
  article-title: Sequence polymorphisms cause many false cis eQTLs
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000622
– volume: 41
  start-page: 1290
  year: 2009
  end-page: 1294
  ident: CR18
  article-title: HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C
  publication-title: Nat Genet
  doi: 10.1038/ng.486
– volume: 401
  start-page: 921
  year: 1999
  end-page: 923
  ident: CR4
  article-title: Complete sequence and gene map of a human major histocompatibility complex
  publication-title: Nature
  doi: 10.1038/44853
– volume: 317
  start-page: 944
  year: 2007
  end-page: 947
  ident: CR19
  article-title: A whole-genome association study of major determinants for host control of HIV-1
  publication-title: Science
  doi: 10.1126/science.1143767
– volume: 6
  start-page: e107
  year: 2008
  ident: CR6
  article-title: Mapping the genetic architecture of gene expression in human liver
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0060107
– volume: 452
  start-page: 423
  year: 2008
  end-page: 428
  ident: CR7
  article-title: Genetics of gene expression and its effect on disease
  publication-title: Nature
  doi: 10.1038/nature06758
– volume: 41
  start-page: 591
  year: 2009
  end-page: 595
  ident: CR2
  article-title: A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians
  publication-title: Nat Genet
  doi: 10.1038/ng.348
– volume: 18
  start-page: 3795
  year: 2009
  end-page: 3804
  ident: CR21
  article-title: Tissue-specific alternative splicing of TCF7L2
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddp321
– volume: 6
  start-page: 1
  year: 2004
  end-page: 15
  ident: CR13
  article-title: Regulatory SNPs in complex diseases: their identification and functional validation
  publication-title: Expert Rev Mol Med
  doi: 10.1017/S1462399404007690
– volume: 4
  start-page: 1920
  year: 2005
  end-page: 1932
  ident: CR11
  article-title: A human protein atlas for normal and cancer tissues based on antibody proteomics
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M500279-MCP200
– volume: 464
  start-page: 704
  year: 2010
  end-page: 712
  ident: CR15
  article-title: Origins and functional impact of copy number variation in the human genome
  publication-title: Nature
  doi: 10.1038/nature08516
– volume: 10
  start-page: 184
  year: 2009
  end-page: 194
  ident: CR9
  article-title: Mapping complex disease traits with global gene expression
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2537
– volume: 86
  start-page: 411
  year: 2010
  end-page: 419
  ident: CR14
  article-title: Genetic control of individual differences in gene-specific methylation in human brain
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2010.02.005
– volume: 18
  start-page: 781
  year: 2008
  end-page: 791
  ident: CR10
  article-title: Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues
  publication-title: Pharmacogenet Genomics
  doi: 10.1097/FPC.0b013e3283050107
– volume: 1
  start-page: e78
  year: 2005
  ident: CR20
  article-title: Genome-wide associations of gene expression variation in humans
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.0010078
– volume: 437
  start-page: 1365
  year: 2005
  end-page: 1369
  ident: CR22
  article-title: Mapping determinants of human gene expression by regional and genome-wide association
  publication-title: Nature
  doi: 10.1038/nature04244
– volume: 18
  start-page: 3795
  year: 2009
  ident: BFgene201111_CR21
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddp321
– volume: 1
  start-page: e78
  year: 2005
  ident: BFgene201111_CR20
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.0010078
– volume: 7
  start-page: 85
  year: 2006
  ident: BFgene201111_CR12
  publication-title: Genes Immun
  doi: 10.1038/sj.gene.6364283
– volume: 86
  start-page: 411
  year: 2010
  ident: BFgene201111_CR14
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2010.02.005
– volume: 2
  start-page: e622
  year: 2007
  ident: BFgene201111_CR8
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0000622
– volume: 28
  start-page: 112
  year: 2006
  ident: BFgene201111_CR1
  publication-title: Epidemiol Rev
  doi: 10.1093/epirev/mxj009
– volume: 41
  start-page: 1290
  year: 2009
  ident: BFgene201111_CR18
  publication-title: Nat Genet
  doi: 10.1038/ng.486
– volume: 401
  start-page: 921
  year: 1999
  ident: BFgene201111_CR4
  publication-title: Nature
  doi: 10.1038/44853
– volume: 317
  start-page: 944
  year: 2007
  ident: BFgene201111_CR19
  publication-title: Science
  doi: 10.1126/science.1143767
– volume: 357
  start-page: 1199
  year: 2007
  ident: BFgene201111_CR17
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa073491
– volume: 52
  start-page: S282
  issue: Supplement 1
  year: 2010
  ident: BFgene201111_CR3
  publication-title: J Hepatol
  doi: 10.1016/S0168-8278(10)60728-3
– volume: 39
  start-page: 1202
  year: 2007
  ident: BFgene201111_CR5
  publication-title: Nat Genet
  doi: 10.1038/ng2109
– volume: 6
  start-page: e107
  year: 2008
  ident: BFgene201111_CR6
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0060107
– volume: 10
  start-page: 184
  year: 2009
  ident: BFgene201111_CR9
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2537
– volume: 18
  start-page: 781
  year: 2008
  ident: BFgene201111_CR10
  publication-title: Pharmacogenet Genomics
  doi: 10.1097/FPC.0b013e3283050107
– volume: 464
  start-page: 704
  year: 2010
  ident: BFgene201111_CR15
  publication-title: Nature
  doi: 10.1038/nature08516
– volume: 5
  start-page: e1000436
  year: 2009
  ident: BFgene201111_CR23
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1000436
– volume: 41
  start-page: 591
  year: 2009
  ident: BFgene201111_CR2
  publication-title: Nat Genet
  doi: 10.1038/ng.348
– volume: 360
  start-page: 2544
  year: 2009
  ident: BFgene201111_CR16
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa0810440
– volume: 437
  start-page: 1365
  year: 2005
  ident: BFgene201111_CR22
  publication-title: Nature
  doi: 10.1038/nature04244
– volume: 4
  start-page: 1920
  year: 2005
  ident: BFgene201111_CR11
  publication-title: Mol Cell Proteomics
  doi: 10.1074/mcp.M500279-MCP200
– volume: 6
  start-page: 1
  year: 2004
  ident: BFgene201111_CR13
  publication-title: Expert Rev Mol Med
  doi: 10.1017/S1462399404007690
– volume: 452
  start-page: 423
  year: 2008
  ident: BFgene201111_CR7
  publication-title: Nature
  doi: 10.1038/nature06758
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Snippet A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3′ untranslated regions of human...
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human...
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3 untranslated regions of human leukocyte...
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Publisher
StartPage 428
SubjectTerms 3' Untranslated Regions
631/208/199
631/208/457/649
631/250/21/324
692/699/1503/234/2513/1549
Alleles
Antigens
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Data processing
Epidemiology
Gene Expression
Genetic Predisposition to Disease
Genetics
Genome-Wide Association Study
Genomes
Genomics
Genotype
Genotype & phenotype
Hepatitis B
Hepatitis B virus
Hepatitis B virus - immunology
Hepatitis B, Chronic - genetics
Hepatitis B, Chronic - immunology
Histocompatibility antigen HLA
Histocompatibility antigens
HLA histocompatibility antigens
HLA-DP alpha-Chains - genetics
HLA-DP alpha-Chains - immunology
HLA-DP beta-Chains - genetics
HLA-DP beta-Chains - immunology
Human Genetics
Humans
Immunology
Leukocytes
Liver
Liver - immunology
Original
original-article
Physiological aspects
Polymorphism, Single Nucleotide
Risk factors
RNA, Messenger - biosynthesis
Single nucleotide polymorphisms
Single-nucleotide polymorphism
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Title Risk alleles for chronic hepatitis B are associated with decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver
URI https://link.springer.com/article/10.1038/gene.2011.11
https://www.ncbi.nlm.nih.gov/pubmed/21346778
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https://www.proquest.com/docview/968168408
https://pubmed.ncbi.nlm.nih.gov/PMC3169805
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