慢性中性粒细胞白血病合并多发性骨髓瘤二例报告并文献复习
目的探讨慢性中性粒细胞白血病（CNL）合并多发性骨髓瘤（MM）的诊断和治疗。方法总结2例CNL合并MM患者的临床特征、分子生物学特点，对其诊断、治疗进行回顾性分析。结果2例患者均符合CNL合并MM的诊断。例1随着MM达完全缓解，中性粒细胞计数恢复正常；MM复发后，中性粒细胞计数再次升高。例1行CSF3R、SETBP1基因突变检查显示，CSF3R外显子17突变阳性（P733T），外显子14突变阴性；SETBP1基因突变阴性。应用针对MM的方案治疗后，随着MM病情的控制，CNL亦可缓解。结论CNL合并MM临床罕见。CSF3R基因突变对于CNL的诊断具有重要意义。CNL合并MM伴CSF3R P733...
Saved in:
| Published in | 中华血液学杂志 Vol. 37; no. 8; pp. 688 - 691 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国医学科学院、北京协和医学院血液学研究所、血液病医院,天津,300020
2016
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-2727 |
| DOI | 10.3760/cma.j.issn.0253-2727.2016.08.011 |
Cover
| Abstract | 目的探讨慢性中性粒细胞白血病（CNL）合并多发性骨髓瘤（MM）的诊断和治疗。方法总结2例CNL合并MM患者的临床特征、分子生物学特点，对其诊断、治疗进行回顾性分析。结果2例患者均符合CNL合并MM的诊断。例1随着MM达完全缓解，中性粒细胞计数恢复正常；MM复发后，中性粒细胞计数再次升高。例1行CSF3R、SETBP1基因突变检查显示，CSF3R外显子17突变阳性（P733T），外显子14突变阴性；SETBP1基因突变阴性。应用针对MM的方案治疗后，随着MM病情的控制，CNL亦可缓解。结论CNL合并MM临床罕见。CSF3R基因突变对于CNL的诊断具有重要意义。CNL合并MM伴CSF3R P733T突变为国际首次报道。针对MM的方案可有效治疗CNL合并MM。 |
|---|---|
| AbstractList | 目的 探讨慢性中性粒细胞白血病(CNL)合并多发性骨髓瘤(MM)的诊断和治疗.方法 总结2例CNL合并MM患者的临床特征、分子生物学特点,对其诊断、治疗进行回顾性分析.结果 2例患者均符合CNL合并MM的诊断.例1随着MM达完全缓解,中性粒细胞计数恢复正常;MM复发后,中性粒细胞计数再次升高.例1行CSF3R、SETBP1基因突变检查显示,CSF3R外显子17突变阳性(P733T),外显子14突变阴性;SETBP1基因突变阴性.应用针对MM的方案治疗后,随着MM病情的控制,CNL亦可缓解.结论 CNL合并MM临床罕见.CSF3R基因突变对于CNL的诊断具有重要意义.CNL合并MM伴CSF3R P733T突变为国际首次报道.针对MM的方案可有效治疗CNL合并MM. 目的探讨慢性中性粒细胞白血病（CNL）合并多发性骨髓瘤（MM）的诊断和治疗。方法总结2例CNL合并MM患者的临床特征、分子生物学特点，对其诊断、治疗进行回顾性分析。结果2例患者均符合CNL合并MM的诊断。例1随着MM达完全缓解，中性粒细胞计数恢复正常；MM复发后，中性粒细胞计数再次升高。例1行CSF3R、SETBP1基因突变检查显示，CSF3R外显子17突变阳性（P733T），外显子14突变阴性；SETBP1基因突变阴性。应用针对MM的方案治疗后，随着MM病情的控制，CNL亦可缓解。结论CNL合并MM临床罕见。CSF3R基因突变对于CNL的诊断具有重要意义。CNL合并MM伴CSF3R P733T突变为国际首次报道。针对MM的方案可有效治疗CNL合并MM。 |
| Abstract_FL | Objective To explored the diagnosis and treatment of chronic neutrophilic leukemia (CNL) complicated with multiple myeloma (MM).Methods The clinical features and molecular biological characteristics of 2 patients with CNL complicated with MM were summarized,and the diagnosis and treatment of the patients were retrospectively reviewed.Results The diagnosis of CNL complicated with MM was established in 2 cases.Case 1 had CSF3R mutation(P733T),but CSF3R-exon 14 mutation and SETBP1 mutation were all negative.The neutrophil count returned to normal when MM was successfully treated in case 1.When the patient relapsed,neutrophil count increased again.Conclusion Coexistence of CNL and MM is rare.CSF3R is a very important molecular marker for CNL.To the best of our knowledge,it's the first time to report the coexistence of CNL and MM carried CSF3R mutation (P733T).Chemotherapy regimens for MM may be effective in the treatment of CNL complicated with MM. |
| Author | 姜波 齐军元 李庆华 徐燕 孙明媛 郑维维 陈芳 邱录贵 |
| AuthorAffiliation | 中国医学科学院、北京协和医学院血液学研究所、血液病医院,天津300020 |
| AuthorAffiliation_xml | – name: 中国医学科学院、北京协和医学院血液学研究所、血液病医院,天津,300020 |
| Author_xml | – sequence: 1 fullname: 姜波 齐军元 李庆华 徐燕 孙明媛 郑维维 陈芳 邱录贵 |
| BookMark | eNo9z8lKA0EQBuA-RDCJvoQH8TJjd08vM0cJbhAQIffQ05lsmIlmEBNPAXEhRjQKbgdRiSiKHjyIUfRpZknewpaIlyqo-qjiT4CYW3UdAKYQ1A3O4LSsCL2slzzP1SGmhoY55jqGiOnQ1CFCMRD_n4-ChOeVISRqT-JgOdy-DZv3_vuzqtHrcfS509-6ii6--jfN6Gw7ONoLem9B9zI47CgweHwYPJ1E513_o-1_74etu6DTUiA83Y3aL0H3wO9dj4GRvFjxnPG_ngSZudlMakFLL80vpmbSmqQm0gi1hMQ2otjiFuXEISY0ESGC5hmRpsMREsSAwqZMWlAim-QsaNg5yXMYMU6NJJgcnt0Qbl64hWy5ul5z1cPsZrHeqP-mh6bKruDEEMpi1S2slRRdrZUqotbIMmZxgglhxg8yFnxo |
| ContentType | Journal Article |
| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 2RA 92L CQIGP W91 ~WA 2B. 4A8 92I 93N PSX TCJ |
| DOI | 10.3760/cma.j.issn.0253-2727.2016.08.011 |
| DatabaseName | 维普_期刊 中文科技期刊数据库-CALIS站点 维普中文期刊数据库 中文科技期刊数据库-医药卫生 中文科技期刊数据库- 镜像站点 Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| DocumentTitleAlternate | Chronic neutrophilic leukemia complicated with multiple myeloma： two cases report and literature review |
| DocumentTitle_FL | Chronic neutrophilic leukemia complicated with multiple myeloma: two cases report and literature review |
| EndPage | 691 |
| ExternalDocumentID | zhxyx201608011 669742446 |
| GrantInformation_xml | – fundername: 国家自然科学基金(81500098)National Natural Science Foundation of China funderid: (81500098) |
| GroupedDBID | --- -05 2B. 2C~ 2RA 92F 92I 92L ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CIEJG CQIGP CW9 F5P OK1 RPM TCJ TGQ U1G U5O W91 ~WA 4A8 93N ABJNI PSX |
| ID | FETCH-LOGICAL-c581-459ac2b152979574e4808144a5f64c8e711a430ab56c90c1b4d903bdc7d216753 |
| ISSN | 0253-2727 |
| IngestDate | Thu May 29 04:00:17 EDT 2025 Wed Feb 14 10:16:02 EST 2024 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 8 |
| Keywords | 白血病,中性粒细胞,慢性 基因,CSF3R 多发性骨髓瘤 Gene,CSF3R Multiple myeloma Leukemia,neutrophilic,chronic |
| Language | Chinese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c581-459ac2b152979574e4808144a5f64c8e711a430ab56c90c1b4d903bdc7d216753 |
| Notes | Jiang Bo, Qi Junyuan, Li Qinghua, Xu Yan, Sun Mingyuan, Zheng Weiwei, Chen Fang, Qiu Lugui. （Institute of Hematology ＆ Blood Diseases Hospital, CAMS ＆ PUMC, Tianjin 300020, China） Multiple myeloma; Leukemia, neutrophilic, chronic; Gene, CSF3R 12-1090/R Objective To explored the diagnosis and treatment of chronic neutrophilic leukemia （CNL） complicated with multiple myeloma （MM）. Methods The clinical features and molecular biological characteristics of 2 patients with CNL complicated with MM were summarized, and the diagnosis and treatment of the patients were retrospectively reviewed. Results The diagnosis of CNL complicated with MM was established in 2 cases. Case 1 had CSF3R mutation（P733T）, but CSF3R-exon 14 mutation and SETBP1 mutation were all negative. The neutrophil count returned to normal when MM was successfully treated in case 1. When the patient relapsed, neutrophil count increased again. Conclusion Coexistence of CNL and MM is rare. CSF3R is a very important molecular marker for CNL. To the best of |
| PageCount | 4 |
| ParticipantIDs | wanfang_journals_zhxyx201608011 chongqing_primary_669742446 |
| PublicationCentury | 2000 |
| PublicationDate | 2016 |
| PublicationDateYYYYMMDD | 2016-01-01 |
| PublicationDate_xml | – year: 2016 text: 2016 |
| PublicationDecade | 2010 |
| PublicationTitle | 中华血液学杂志 |
| PublicationTitleAlternate | Chinese Journal of Hematology |
| PublicationTitle_FL | Chinese Journal of Hematology |
| PublicationYear | 2016 |
| Publisher | 中国医学科学院、北京协和医学院血液学研究所、血液病医院,天津,300020 |
| Publisher_xml | – name: 中国医学科学院、北京协和医学院血液学研究所、血液病医院,天津,300020 |
| SSID | ssj0042014 ssib051368330 ssib017477332 ssib001103535 ssib058574913 |
| Score | 2.0805275 |
| Snippet | ... 目的 探讨慢性中性粒细胞白血病(CNL)合并多发性骨髓瘤(MM)的诊断和治疗.方法 总结2例CNL合并MM患者的临床特征、分子生物学特点,对其诊断、治疗进行回顾性分析.结果... |
| SourceID | wanfang chongqing |
| SourceType | Aggregation Database Publisher |
| StartPage | 688 |
| SubjectTerms | CSF3R 中性粒细胞 基因 多发性骨髓瘤 慢性 白血病 |
| Title | 慢性中性粒细胞白血病合并多发性骨髓瘤二例报告并文献复习 |
| URI | http://lib.cqvip.com/qk/93752X/201608/669742446.html https://d.wanfangdata.com.cn/periodical/zhxyx201608011 |
| Volume | 37 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR1Na9RANJQK4kUUFWv96MEBL6lJZjIfxySbUgQFYYXelnzstghuq7ZQeypIVWpFq-DXQVQqiqIHD2IV_TX70f4L35tks2krVoUlPF7evM_ZeTNJ5o1hnI65Elj02bQa3DUZjI2mcnhqponbaMQ8TajAjcLnL_DxS-zchDsxMFgtfbU0NxuPJgu_3VfyP1EFHMQVd8n-Q2QLpoAAGOILV4gwXP8qxiTkRLrEczRgEU-QkBFfEq9SwgjiO0Q5GvCJ5CSURFKiQsQoRfwKYjwb6REjkGfoEmURKRHwgYYj4DGiPATkGFF2SYQinkc8qQGfKKr5SKRHfTwiAw2ERPq6FRBnImyE-yI4UXBX6wxNvDAXKiu6OTC3ypPpkrEu0siwZAhHhmA4cqgQL2MONBrjg_5FAtYkoG-gG1FwZ_-O9g44AgVAe18D8KN9koytVhUt5YUyZf5gutLeBeOy4z57j1qyPaD6b7HFHpDlZ4YFGLa-GUIra5cwCqOInYCi5dLOWymRe98LejqNac6OjsdOzgWfPzgRpFtEMQ30YiaVJi6k72xe6lW50J4sJ8hjDNyQnmHPcAKqX16XspTjUtMRWYGHXkrN6vjkQ4cs5UeeneGYT7V4dlDb9iyO32nBXy-5Eo1e1kJGCyH4LSbXNXfzFL21VvrC1PyNeSSBdRBu-N_jCM6dbc_wYMJL3f4iwbUpl7S_iIb1s2D63X02n2PATxeh6-mw1ziTK3l2NxWxYMvUdHPyKkxD9a7AZiNqTpYmsNUDxv585TniZcPIQWNgYeqQcbGz9Lqz-Lb19SNcu58fdr_f2rj5ovvsx8arxe6TpfaDO-31L-215-37q0Cw-f7d5odH3adrrW8rrZ93O8tv2qvLQNB5fLu78qm9dq-1_vKwUR0Lq8G4mZ-yYiautE3mqihxYpjGK6HA8jrDs3gYi9wGZ4msC9uOGLWi2OWJshI7ZqmyaJwmInVsLlx6xBhsTjfrR40RJXlkSZVEVMYsUTJSaWRLJazEEbGIkiFjuPBGbSYrplPjkCxwsy0fMk7l_qnlQ-z12tZ4HtuVYtjYh3D2iPS4MTh7ba5-AhYNs_FJ3Qd-AfqA0m4 |
| linkProvider | National Library of Medicine |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E6%85%A2%E6%80%A7%E4%B8%AD%E6%80%A7%E7%B2%92%E7%BB%86%E8%83%9E%E7%99%BD%E8%A1%80%E7%97%85%E5%90%88%E5%B9%B6%E5%A4%9A%E5%8F%91%E6%80%A7%E9%AA%A8%E9%AB%93%E7%98%A4%E4%BA%8C%E4%BE%8B%E6%8A%A5%E5%91%8A%E5%B9%B6%E6%96%87%E7%8C%AE%E5%A4%8D%E4%B9%A0&rft.jtitle=%E4%B8%AD%E5%8D%8E%E8%A1%80%E6%B6%B2%E5%AD%A6%E6%9D%82%E5%BF%97&rft.au=%E5%A7%9C%E6%B3%A2&rft.au=%E9%BD%90%E5%86%9B%E5%85%83&rft.au=%E6%9D%8E%E5%BA%86%E5%8D%8E&rft.au=%E5%BE%90%E7%87%95&rft.date=2016&rft.pub=%E4%B8%AD%E5%9B%BD%E5%8C%BB%E5%AD%A6%E7%A7%91%E5%AD%A6%E9%99%A2%E3%80%81%E5%8C%97%E4%BA%AC%E5%8D%8F%E5%92%8C%E5%8C%BB%E5%AD%A6%E9%99%A2%E8%A1%80%E6%B6%B2%E5%AD%A6%E7%A0%94%E7%A9%B6%E6%89%80%E3%80%81%E8%A1%80%E6%B6%B2%E7%97%85%E5%8C%BB%E9%99%A2%2C%E5%A4%A9%E6%B4%A5%2C300020&rft.issn=0253-2727&rft.volume=37&rft.issue=8&rft.spage=688&rft.epage=691&rft_id=info:doi/10.3760%2Fcma.j.issn.0253-2727.2016.08.011&rft.externalDocID=zhxyx201608011 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fimage.cqvip.com%2Fvip1000%2Fqk%2F93752X%2F93752X.jpg http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fzhxyx%2Fzhxyx.jpg |