Bioequivalence, Food Effect, and Steady‐State Assessment of Dapagliflozin/Metformin Extended‐release Fixed‐dose Combination Tablets Relative to Single‐component Dapagliflozin and Metformin Extended‐release Tablets in Healthy Subjects - Chang, Ming; Liu, Xiaoni; Cui, Dapeng; Liang, Dan; LaCreta, Frank; Griffen, Steven C.; Lubin, Susan; Quamina‐Edghill, Donette; Boulton, David W. (Clinical therapeutics, 2015)
Keywords: Adult; Benzhydryl Compounds - administration & dosage; Benzhydryl Compounds - adverse effects; Benzhydryl Compounds - blood; Benzhydryl Compounds - therapeutic use; bioequivalence; Chemistry, Pharmaceutical; Cross-Over Studies; dapagliflozin; Delayed-Action Preparations; Diabetes; Drug Administration Schedule; Drug Combinations; Drug dosages; Fasting; Female; Food; Food-Drug Interactions - physiology; Glucose; Glucosides - administration & dosage; Glucosides - adverse effects; Glucosides - blood; Glucosides - therapeutic use; Healthy Volunteers; Humans; Hyperglycemia; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Hypoglycemic Agents - blood; Hypoglycemic Agents - therapeutic use; Internal Medicine; Laboratories; Male; Medical Education; Metformin - administration & dosage; Metformin - adverse effects; Metformin - blood; Metformin - therapeutic use; metformin XR; Middle Aged; pharmacokinetics; SGLT2 inhibitor; Studies; Tablets; Therapeutic Equivalency; type 2 diabetes mellitus; Womens health; Young Adult; pharmacokinetics; type 2 diabetes mellitus; metformin XR; SGLT2 inhibitor; dapagliflozin; bioequivalence