IL-17A enhances IL-13 activity by enhancing IL-13–induced signal transducer and activator of transcription 6 activation

Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in asthmatic patients remain unclear. We sought to gain mechanistic insight into how IL-17A can influence IL-13–driven responses. The effect of IL-...

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Published inJournal of allergy and clinical immunology Vol. 139; no. 2; pp. 462 - 471.e14
Main Authors Hall, Sara L., Baker, Theresa, Lajoie, Stephane, Richgels, Phoebe K., Yang, Yanfen, McAlees, Jaclyn W., van Lier, Adelaide, Wills-Karp, Marsha, Sivaprasad, Umasundari, Acciani, Thomas H., LeCras, Timothy D., Myers, Jocelyn Biagini, Kovacic, Melinda Butsch, Lewkowich, Ian P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2017
Elsevier Limited
Subjects
Airway management
Allergy and Immunology
Animals
Asthma
Asthma - chemically induced
Asthma - immunology
Cell Line
Cytokines
Cytokines - metabolism
Fibroblasts - immunology
Gene expression
Gene Expression Regulation
Human subjects
Humans
IL-13
IL-17A
Inflammation
Interleukin-13 - metabolism
Interleukin-13 Receptor alpha2 Subunit - genetics
Interleukin-17 - metabolism
Mice
Mice, Inbred BALB C
Mice, Knockout
Pathogenesis
Pathology
Pneumonia - chemically induced
Pneumonia - immunology
Proteins
Receptors, Interleukin-17 - genetics
signal transducer and activator of transcription 6
Signal Transduction
Smooth muscle
STAT6 Transcription Factor - genetics
STAT6 Transcription Factor - metabolism
Studies
Th2 Cells - immunology
IL-17A
signal transduction
pSTAT6
IL-13
AHR
BAL
NEC
Asthma
signal transducer and activator of transcription 6
AUC
IL-13R
PE
t1/2
cytokines
STAT6
WT
CLCA3
Phosphorylated STAT6
Bronchoalveolar lavage
Area under the curve
Half-life
Chloride channel, calcium activated 3
Wild-type
Airway hyperresponsiveness
IL-13 receptor
Phycoerythrin
Nasal epithelial cell
Online AccessGet full text
ISSN0091-6749
1085-8725
1097-6825
1097-6825
DOI10.1016/j.jaci.2016.04.037

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Abstract Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in asthmatic patients remain unclear. We sought to gain mechanistic insight into how IL-17A can influence IL-13–driven responses. The effect of IL-17A on IL-13–induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by using in vivo models of IL-13–induced lung pathology and in vitro culture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A, or both. Compared with mice given intratracheal IL-13 alone, those exposed to IL-13 and IL-17A had augmented airway hyperresponsiveness, mucus production, airway inflammation, and IL-13–induced gene expression. In vitro, IL-17A enhanced IL-13–induced gene expression in asthma-relevant murine and human cells. In contrast to the exacerbating influence of IL-17A on IL-13–induced responses, coexposure to IL-13 inhibited IL-17A–driven antimicrobial gene expression in vivo and in vitro. Mechanistically, in both primary human and murine cells, the IL-17A–driven increase in IL-13–induced gene expression was associated with enhanced IL-13–driven signal transducer and activator of transcription 6 activation. Our data suggest that IL-17A contributes to asthma pathophysiology by increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6. These data represent the first mechanistic explanation of how IL-17A can directly contribute to the pathogenesis of IL-13–driven pathology. [Display omitted]
AbstractList Background Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven pathology in asthmatic patients remain unclear. Objective We sought to gain mechanistic insight into how IL-17A can influence IL-13-driven responses. Methods The effect of IL-17A on IL-13-induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by using in vivo models of IL-13-induced lung pathology and in vitro culture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A, or both. Results Compared with mice given intratracheal IL-13 alone, those exposed to IL-13 and IL-17A had augmented airway hyperresponsiveness, mucus production, airway inflammation, and IL-13-induced gene expression. In vitro, IL-17A enhanced IL-13-induced gene expression in asthma-relevant murine and human cells. In contrast to the exacerbating influence of IL-17A on IL-13-induced responses, coexposure to IL-13 inhibited IL-17A-driven antimicrobial gene expression in vivo and in vitro. Mechanistically, in both primary human and murine cells, the IL-17A-driven increase in IL-13-induced gene expression was associated with enhanced IL-13-driven signal transducer and activator of transcription 6 activation. Conclusions Our data suggest that IL-17A contributes to asthma pathophysiology by increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6. These data represent the first mechanistic explanation of how IL-17A can directly contribute to the pathogenesis of IL-13-driven pathology.
Background Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in asthmatic patients remain unclear. Objective We sought to gain mechanistic insight into how IL-17A can influence IL-13–driven responses. Methods The effect of IL-17A on IL-13–induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by using in vivo models of IL-13–induced lung pathology and in vitro culture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A, or both. Results Compared with mice given intratracheal IL-13 alone, those exposed to IL-13 and IL-17A had augmented airway hyperresponsiveness, mucus production, airway inflammation, and IL-13–induced gene expression. In vitro , IL-17A enhanced IL-13–induced gene expression in asthma-relevant murine and human cells. In contrast to the exacerbating influence of IL-17A on IL-13–induced responses, coexposure to IL-13 inhibited IL-17A–driven antimicrobial gene expression in vivo and in vitro . Mechanistically, in both primary human and murine cells, the IL-17A–driven increase in IL-13–induced gene expression was associated with enhanced IL-13–driven signal transducer and activator of transcription 6 activation. Conclusions Our data suggest that IL-17A contributes to asthma pathophysiology by increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6. These data represent the first mechanistic explanation of how IL-17A can directly contribute to the pathogenesis of IL-13–driven pathology.
Background Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven pathology in asthmatic patients remain unclear. Objective We sought to gain mechanistic insight into how IL-17A can influence IL-13-driven responses. Methods The effect of IL-17A on IL-13-induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by usingin vivomodels of IL-13-induced lung pathology andin vitroculture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A, or both. Results Compared with mice given intratracheal IL-13 alone, those exposed to IL-13 and IL-17A had augmented airway hyperresponsiveness, mucus production, airway inflammation, and IL-13-induced gene expression.In vitro, IL-17A enhanced IL-13-induced gene expression in asthma-relevant murine and human cells. In contrast to the exacerbating influence of IL-17A on IL-13-induced responses, coexposure to IL-13 inhibited IL-17A-driven antimicrobial gene expressionin vivoandin vitro. Mechanistically, in both primary human and murine cells, the IL-17A-driven increase in IL-13-induced gene expression was associated with enhanced IL-13-driven signal transducer and activator of transcription 6 activation. Conclusions Our data suggest that IL-17A contributes to asthma pathophysiology by increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6. These data represent the first mechanistic explanation of how IL-17A can directly contribute to the pathogenesis of IL-13-driven pathology.
Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in asthmatic patients remain unclear. We sought to gain mechanistic insight into how IL-17A can influence IL-13–driven responses. The effect of IL-17A on IL-13–induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by using in vivo models of IL-13–induced lung pathology and in vitro culture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A, or both. Compared with mice given intratracheal IL-13 alone, those exposed to IL-13 and IL-17A had augmented airway hyperresponsiveness, mucus production, airway inflammation, and IL-13–induced gene expression. In vitro, IL-17A enhanced IL-13–induced gene expression in asthma-relevant murine and human cells. In contrast to the exacerbating influence of IL-17A on IL-13–induced responses, coexposure to IL-13 inhibited IL-17A–driven antimicrobial gene expression in vivo and in vitro. Mechanistically, in both primary human and murine cells, the IL-17A–driven increase in IL-13–induced gene expression was associated with enhanced IL-13–driven signal transducer and activator of transcription 6 activation. Our data suggest that IL-17A contributes to asthma pathophysiology by increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6. These data represent the first mechanistic explanation of how IL-17A can directly contribute to the pathogenesis of IL-13–driven pathology. [Display omitted]
Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven pathology in asthmatic patients remain unclear. We sought to gain mechanistic insight into how IL-17A can influence IL-13-driven responses. The effect of IL-17A on IL-13-induced airway hyperresponsiveness, gene expression, mucus hypersecretion, and airway inflammation was assessed by using in vivo models of IL-13-induced lung pathology and in vitro culture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A, or both. Compared with mice given intratracheal IL-13 alone, those exposed to IL-13 and IL-17A had augmented airway hyperresponsiveness, mucus production, airway inflammation, and IL-13-induced gene expression. In vitro, IL-17A enhanced IL-13-induced gene expression in asthma-relevant murine and human cells. In contrast to the exacerbating influence of IL-17A on IL-13-induced responses, coexposure to IL-13 inhibited IL-17A-driven antimicrobial gene expression in vivo and in vitro. Mechanistically, in both primary human and murine cells, the IL-17A-driven increase in IL-13-induced gene expression was associated with enhanced IL-13-driven signal transducer and activator of transcription 6 activation. Our data suggest that IL-17A contributes to asthma pathophysiology by increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transducer and activator of transcription 6. These data represent the first mechanistic explanation of how IL-17A can directly contribute to the pathogenesis of IL-13-driven pathology.
Author Lajoie, Stephane
Wills-Karp, Marsha
McAlees, Jaclyn W.
Richgels, Phoebe K.
Sivaprasad, Umasundari
LeCras, Timothy D.
Kovacic, Melinda Butsch
Lewkowich, Ian P.
van Lier, Adelaide
Baker, Theresa
Yang, Yanfen
Acciani, Thomas H.
Hall, Sara L.
Myers, Jocelyn Biagini
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  organization: Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Md
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  email: Ian.Lewkowich@cchmc.org
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/27417023$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1126/science.282.5397.2258
10.1164/rccm.200801-086OC
10.1074/jbc.M108109200
10.1016/j.jaci.2009.10.012
10.1164/rccm.201008-1383OC
10.1164/rccm.200904-0573OC
10.1074/jbc.M210196200
10.1371/journal.pone.0008578
10.1084/jem.20100023
10.1182/blood-2008-03-148726
10.1053/j.gastro.2010.09.047
10.1126/science.282.5397.2261
10.4049/jimmunol.179.6.4135
10.1126/scisignal.1164795
10.1074/jbc.273.51.33893
10.1016/j.jaci.2010.11.043
10.1164/rccm.200911-1775OC
10.1016/j.jaci.2015.02.026
10.1371/journal.pone.0003879
10.1084/jem.20101376
10.4049/jimmunol.1200506
10.1016/j.jaci.2008.04.016
10.1016/j.celrep.2014.01.012
10.1084/jem.20020906
10.1164/rccm.200903-0392OC
10.4049/jimmunol.182.3.1660
10.4049/jimmunol.1102216
10.1038/ncomms5732
10.1164/rccm.201212-2318OC
10.1053/rmed.2003.1507
10.1073/pnas.90.7.2584
10.4049/jimmunol.171.11.5901
10.1016/j.jaci.2013.11.042
10.1016/j.jaci.2004.06.023
10.1016/j.molimm.2004.09.004
10.1136/thoraxjnl-2012-202404
10.1126/scitranslmed.aab3142
10.1016/j.jaci.2004.10.032
10.4049/jimmunol.0803868
10.1189/jlb.0505244
10.4049/jimmunol.181.6.4089
10.1093/intimm/12.11.1499
10.1016/S0014-5793(99)01680-4
10.1016/j.jaci.2014.11.011
10.1006/bbrc.1998.8314
10.4049/jimmunol.167.8.4668
10.1016/j.jaci.2013.04.016
10.1073/pnas.96.19.10800
10.1164/rccm.201305-0874OC
10.1186/1465-9921-7-135
10.1067/mai.2001.117929
10.1038/nm734
10.1111/exd.12831
10.1016/j.gene.2005.04.004
10.1016/j.jaci.2014.05.038
10.1016/j.jaci.2009.02.024
10.1038/sj.onc.1206352
10.1084/jem.20020903
10.4049/jimmunol.0903323
10.1172/JCI5909
10.1006/jsre.1998.5503
10.1016/j.jaci.2015.01.014
10.1038/nm.2684
10.1001/jamadermatol.2013.8627
10.1038/ni.1926
10.4049/jimmunol.1303463
ContentType Journal Article
Copyright 2016 American Academy of Allergy, Asthma & Immunology
American Academy of Allergy, Asthma & Immunology
Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Copyright Elsevier Limited Feb 01, 2017
Copyright_xml – notice: 2016 American Academy of Allergy, Asthma & Immunology
– notice: American Academy of Allergy, Asthma & Immunology
– notice: Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
– notice: Copyright Elsevier Limited Feb 01, 2017
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ISSN 0091-6749
1085-8725
1097-6825
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Sun Sep 28 11:49:24 EDT 2025
Tue Oct 07 06:16:20 EDT 2025
Mon Jul 21 05:53:43 EDT 2025
Thu Oct 02 04:30:40 EDT 2025
Thu Apr 24 23:06:48 EDT 2025
Wed Apr 02 07:27:50 EDT 2025
Tue Oct 14 19:34:30 EDT 2025
IsDoiOpenAccess true
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Issue 2
Keywords IL-17A
signal transduction
pSTAT6
IL-13
AHR
BAL
NEC
Asthma
signal transducer and activator of transcription 6
AUC
IL-13R
PE
t1/2
cytokines
STAT6
WT
CLCA3
Phosphorylated STAT6
Bronchoalveolar lavage
Area under the curve
Half-life
Chloride channel, calcium activated 3
Wild-type
Airway hyperresponsiveness
IL-13 receptor
Phycoerythrin
Nasal epithelial cell
Language English
License Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
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PublicationTitle Journal of allergy and clinical immunology
PublicationTitleAlternate J Allergy Clin Immunol
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Elsevier Limited
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– name: Elsevier Limited
References Lewkowich, Lajoie, Clark, Herman, Sproles, Wills-Karp (bib48) 2008; 3
Woetmann, Brockdorff, Lovato, Nielsen, Leick, Rieneck (bib40) 2003; 278
Perkins, Yanase, Smulian, Gildea, Orekov, Potter (bib6) 2011; 208
Busse, Holgate, Kerwin, Chon, Feng, Lin (bib66) 2013; 188
Woodruff, Modrek, Choy, Jia, Abbas, Ellwanger (bib60) 2009; 180
McKinley, Alcorn, Peterson, Dupont, Kapadia, Logar (bib13) 2008; 181
Sahoo, Alekseev, Obertas, Nurieva (bib45) 2014; 5
Henness, Johnson, Ge, Armour, Hughes, Ammit (bib27) 2004; 114
Umeshita-Suyama, Sugimoto, Akaiwa, Arima, Yu, Wada (bib29) 2000; 12
Wery-Zennaro, Letourneur, David, Bertoglio, Pierre (bib30) 1999; 464
Wakashin, Hirose, Maezawa, Kagami, Suto, Watanabe (bib8) 2008; 178
Sozzani, Hasan, Seguelas, Caput, Ferrara, Pipy (bib31) 1998; 244
Wood, Whitters, Jacobson, Witek, Sypek, Kasaian (bib23) 2003; 197
Newcomb, Zhou, Moore, Goleniewska, Hershey, Kolls (bib64) 2009; 182
Wu, Bleecker, Moore, Busse, Castro, Chung (bib61) 2014; 133
Grunig, Warnock, Wakil, Venkayya, Brombacher, Rennick (bib1) 1998; 282
Newcomb, Boswell, Huckabee, Goleniewska, Dulek, Reiss (bib62) 2012; 188
Wills-Karp, Luyimbazi, Xu, Schofield, Neben, Karp (bib3) 1998; 282
Barczyk, Pierzchala, Sozanska (bib11) 2003; 97
Gray, Poljakovic, Kepka-Lenhart, Morris (bib35) 2005; 353
Chiaramonte, Mentink-Kane, Jacobson, Cheever, Whitters, Goad (bib21) 2003; 197
Besnard, Sabat, Dumoutier, Renauld, Willart, Lambrecht (bib51) 2011; 183
Huang, Wachi, Thai, Loukoianov, Tan, Forteza (bib47) 2008; 121
Allen, Vaze, Choi, Hailu, Tulbert, Cusack (bib53) 2014; 150
Kuperman, Huang, Koth, Chang, Dolganov, Zhu (bib5) 2002; 8
Wei, Sha, Bhattacharya, Abdel Fattah, Bonilla, Jyothula (bib44) 2014; 189
Chen, Sivaprasad, Gibson, Ericksen, Cunningham, Bass (bib24) 2013; 132
Dickensheets, Venkataraman, Schindler, Donnelly (bib37) 1999; 96
Persson, Kwon, Ramilowski, Silberberg, Soderhall, Orsmark-Pietras (bib59) 2015; 136
Zhu, Homer, Wang, Chen, Geba, Wang (bib4) 1999; 103
Moon, Parikh, Pritts, Fischer, Cottongim, Szabo (bib33) 1999; 82
Newcomb, Boswell, Reiss, Zhou, Goleniewska, Toki (bib50) 2013; 68
Guajardo, Schleifer, Daines, Ruddy, Aronow, Wills-Karp (bib20) 2005; 115
Walter, McIntire, Berry, McKenzie, Donaldson, DeKruyff (bib2) 2001; 167
Bullens, Truyen, Coteur, Dilissen, Hellings, Dupont (bib12) 2006; 7
Irvin, Zafar, Good, Rollins, Christianson, Gorska (bib16) 2014; 134
Wilson, Ramalingam, Rivollier, Shenderov, Mentink-Kane, Madala (bib65) 2011; 140
Wands, Roark, Aydintug, Jin, Hahn, Cook (bib52) 2005; 78
Qiao, Ying, Zhao, Liang, Guo, Shen (bib46) 2014; 6
Hebenstreit, Luft, Schmiedlechner, Duschl, Horejs-Hoeck (bib38) 2005; 42
Wang, Voo, Liu, Chen, Uygungil, Spoede (bib17) 2010; 207
Haque, Harbor, Tabrizi, Yi, Williams (bib42) 1998; 273
Kudo, Melton, Chen, Engler, Huang, Ren (bib9) 2012; 18
Molet, Hamid, Davoine, Nutku, Taha, Page (bib14) 2001; 108
Hebenstreit, Luft, Schmiedlechner, Regl, Frischauf, Aberger (bib39) 2003; 171
Al-Ramli, Prefontaine, Chouiali, Martin, Olivenstein, Lemiere (bib10) 2009; 123
Daines, Hershey (bib22) 2002; 277
Juan, Wilson, Wilde, Darlington (bib34) 1993; 90
Hinks, Zhou, Staples, Dimitrov, Manta, Petrossian (bib58) 2015; 136
Lu, Malumbres, Shields, Jiang, Sarosiek, Natkunam (bib41) 2008; 112
Lajoie, Lewkowich, Suzuki, Clark, Sproles, Dienger (bib7) 2010; 11
Hartupee, Liu, Novotny, Li, Hamilton (bib25) 2007; 179
Chen, Reich (bib32) 2010; 185
Tao, Jin, Xu, Liang, Yao, Zhang (bib43) 2014; 193
Newcomb, Boswell, Zhou, Huckabee, Goleniewska, Sevin (bib63) 2011; 127
Clausen, Slotved, Krogfelt, Andersen, Agner (bib54) 2016; 25
Hilty, Burke, Pedro, Cardenas, Bush, Bossley (bib55) 2010; 5
Wilson, Whitehead, Nakano, Free, Kolls, Cook (bib49) 2009; 180
Huang, Boushey (bib56) 2015; 135
Kinyanjui, Shan, Nakada, Qureshi, Fixman (bib18) 2013; 190
David, Bertoglio, Pierre (bib36) 2003; 22
Murdoch, Lloyd (bib19) 2010; 182
Hartupee, Liu, Novotny, Sun, Li, Hamilton (bib26) 2009; 182
Choy, Hart, Borthwick, Shikotra, Nagarkar, Siddiqui (bib57) 2015; 7
Cosmi, Maggi, Santarlasci, Capone, Cardilicchia, Frosali (bib15) 2010; 125
Heller, Qi, Junttila, Shirey, Vogel, Paul (bib28) 2008; 1
Walter (10.1016/j.jaci.2016.04.037_bib2) 2001; 167
Cosmi (10.1016/j.jaci.2016.04.037_bib15) 2010; 125
Daines (10.1016/j.jaci.2016.04.037_bib22) 2002; 277
Wang (10.1016/j.jaci.2016.04.037_bib17) 2010; 207
Busse (10.1016/j.jaci.2016.04.037_bib66) 2013; 188
Irvin (10.1016/j.jaci.2016.04.037_bib16) 2014; 134
Hilty (10.1016/j.jaci.2016.04.037_bib55) 2010; 5
Zhu (10.1016/j.jaci.2016.04.037_bib4) 1999; 103
Kinyanjui (10.1016/j.jaci.2016.04.037_bib18) 2013; 190
Qiao (10.1016/j.jaci.2016.04.037_bib46) 2014; 6
Besnard (10.1016/j.jaci.2016.04.037_bib51) 2011; 183
Woodruff (10.1016/j.jaci.2016.04.037_bib60) 2009; 180
Hartupee (10.1016/j.jaci.2016.04.037_bib25) 2007; 179
Newcomb (10.1016/j.jaci.2016.04.037_bib62) 2012; 188
Newcomb (10.1016/j.jaci.2016.04.037_bib63) 2011; 127
Wilson (10.1016/j.jaci.2016.04.037_bib49) 2009; 180
Newcomb (10.1016/j.jaci.2016.04.037_bib64) 2009; 182
Henness (10.1016/j.jaci.2016.04.037_bib27) 2004; 114
Hebenstreit (10.1016/j.jaci.2016.04.037_bib38) 2005; 42
Lajoie (10.1016/j.jaci.2016.04.037_bib7) 2010; 11
McKinley (10.1016/j.jaci.2016.04.037_bib13) 2008; 181
Chen (10.1016/j.jaci.2016.04.037_bib24) 2013; 132
Hartupee (10.1016/j.jaci.2016.04.037_bib26) 2009; 182
Murdoch (10.1016/j.jaci.2016.04.037_bib19) 2010; 182
Hebenstreit (10.1016/j.jaci.2016.04.037_bib39) 2003; 171
Heller (10.1016/j.jaci.2016.04.037_bib28) 2008; 1
Kuperman (10.1016/j.jaci.2016.04.037_bib5) 2002; 8
Perkins (10.1016/j.jaci.2016.04.037_bib6) 2011; 208
Lewkowich (10.1016/j.jaci.2016.04.037_bibE1) 2008; 3
Wood (10.1016/j.jaci.2016.04.037_bib23) 2003; 197
Huang (10.1016/j.jaci.2016.04.037_bib47) 2008; 121
Al-Ramli (10.1016/j.jaci.2016.04.037_bib10) 2009; 123
Woetmann (10.1016/j.jaci.2016.04.037_bib40) 2003; 278
Persson (10.1016/j.jaci.2016.04.037_bib59) 2015; 136
Clausen (10.1016/j.jaci.2016.04.037_bib54) 2016; 25
Wu (10.1016/j.jaci.2016.04.037_bib61) 2014; 133
Barczyk (10.1016/j.jaci.2016.04.037_bib11) 2003; 97
Guajardo (10.1016/j.jaci.2016.04.037_bib20) 2005; 115
Sozzani (10.1016/j.jaci.2016.04.037_bib31) 1998; 244
Gray (10.1016/j.jaci.2016.04.037_bib35) 2005; 353
Wilson (10.1016/j.jaci.2016.04.037_bib65) 2011; 140
Lewkowich (10.1016/j.jaci.2016.04.037_bib48) 2008; 3
Allen (10.1016/j.jaci.2016.04.037_bib53) 2014; 150
Grunig (10.1016/j.jaci.2016.04.037_bib1) 1998; 282
Wery-Zennaro (10.1016/j.jaci.2016.04.037_bib30) 1999; 464
Lu (10.1016/j.jaci.2016.04.037_bib41) 2008; 112
Sahoo (10.1016/j.jaci.2016.04.037_bib45) 2014; 5
Wills-Karp (10.1016/j.jaci.2016.04.037_bib3) 1998; 282
Hinks (10.1016/j.jaci.2016.04.037_bib58) 2015; 136
Chiaramonte (10.1016/j.jaci.2016.04.037_bib21) 2003; 197
Haque (10.1016/j.jaci.2016.04.037_bib42) 1998; 273
Wands (10.1016/j.jaci.2016.04.037_bib52) 2005; 78
Wei (10.1016/j.jaci.2016.04.037_bib44) 2014; 189
Chen (10.1016/j.jaci.2016.04.037_bib32) 2010; 185
Juan (10.1016/j.jaci.2016.04.037_bib34) 1993; 90
David (10.1016/j.jaci.2016.04.037_bib36) 2003; 22
Umeshita-Suyama (10.1016/j.jaci.2016.04.037_bib29) 2000; 12
Bullens (10.1016/j.jaci.2016.04.037_bib12) 2006; 7
Molet (10.1016/j.jaci.2016.04.037_bib14) 2001; 108
Newcomb (10.1016/j.jaci.2016.04.037_bib50) 2013; 68
Moon (10.1016/j.jaci.2016.04.037_bib33) 1999; 82
Choy (10.1016/j.jaci.2016.04.037_bib57) 2015; 7
Kudo (10.1016/j.jaci.2016.04.037_bib9) 2012; 18
Dickensheets (10.1016/j.jaci.2016.04.037_bib37) 1999; 96
Huang (10.1016/j.jaci.2016.04.037_bib56) 2015; 135
Tao (10.1016/j.jaci.2016.04.037_bib43) 2014; 193
Wakashin (10.1016/j.jaci.2016.04.037_bib8) 2008; 178
26290411 - Sci Transl Med. 2015 Aug 19;7(301):301ra129
21236478 - J Allergy Clin Immunol. 2011 Apr;127(4):1006-13.e1-4
19380778 - J Immunol. 2009 May 1;182(9):5317-21
19361847 - J Allergy Clin Immunol. 2009 May;123(5):1185-7
15696077 - J Allergy Clin Immunol. 2005 Feb;115(2):243-51
9856950 - Science. 1998 Dec 18;282(5397):2261-3
25145352 - Nat Commun. 2014 Aug 22;5:4732
19060952 - PLoS One. 2008;3(12):e3879
24452476 - JAMA Dermatol. 2014 Mar;150(3):260-5
11591797 - J Immunol. 2001 Oct 15;167(8):4668-75
24508458 - Cell Rep. 2014 Feb 27;6(4):709-23
19483109 - Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95
24589344 - J Allergy Clin Immunol. 2014 May;133(5):1280-8
20498360 - J Immunol. 2010 Jul 1;185(1):64-70
23509346 - J Immunol. 2013 Apr 15;190(8):3859-68
17083726 - Respir Res. 2006 Nov 03;7:135
15922518 - Gene. 2005 Jun 20;353(1):98-106
25567040 - J Allergy Clin Immunol. 2015 Jan;135(1):25-30
18716132 - Blood. 2008 Nov 15;112(10):4098-108
11058569 - Int Immunol. 2000 Nov;12 (11):1499-509
21464224 - J Exp Med. 2011 Apr 11;208(4):853-67
19661246 - Am J Respir Crit Care Med. 2009 Oct 15;180(8):720-30
20413629 - Am J Respir Crit Care Med. 2010 Aug 15;182(4):464-76
20109749 - J Allergy Clin Immunol. 2010 Jan;125(1):222-30.e1-4
12426308 - J Biol Chem. 2003 Jan 31;278(5):2787-91
22388091 - Nat Med. 2012 Mar 04;18(4):547-54
19109239 - Sci Signal. 2008 Dec 23;1(51):ra17
12814161 - Respir Med. 2003 Jun;97(6):726-33
17785852 - J Immunol. 2007 Sep 15;179(6):4135-41
23763980 - J Allergy Clin Immunol. 2013 Oct;132(4):951-8.e1-6
23422214 - Thorax. 2013 Aug;68(8):717-23
14634100 - J Immunol. 2003 Dec 1;171(11):5901-7
25863981 - J Allergy Clin Immunol. 2015 Sep;136(3):638-48
20951137 - Gastroenterology. 2011 Jan;140(1):254-64
11786536 - J Biol Chem. 2002 Mar 22;277(12):10387-93
21297073 - Am J Respir Crit Care Med. 2011 May 1;183(9):1153-63
20921287 - J Exp Med. 2010 Oct 25;207(11):2479-91
24200404 - Am J Respir Crit Care Med. 2013 Dec 1;188(11):1294-302
12642601 - J Exp Med. 2003 Mar 17;197(6):687-701
9856949 - Science. 1998 Dec 18;282(5397):2258-61
16204632 - J Leukoc Biol. 2005 Nov;78(5):1086-96
10611490 - FEBS Lett. 1999 Dec 24;464(1-2):91-6
8385337 - Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2584-8
25042748 - J Allergy Clin Immunol. 2014 Nov;134(5):1175-1186.e7
9535722 - Biochem Biophys Res Commun. 1998 Mar 27;244(3):665-70
20802484 - Nat Immunol. 2010 Oct;11(10):928-35
10079098 - J Clin Invest. 1999 Mar;103(6):779-88
10485906 - Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10800-5
11544464 - J Allergy Clin Immunol. 2001 Sep;108(3):430-8
25746968 - J Allergy Clin Immunol. 2015 Aug;136(2):323-33
20052417 - PLoS One. 2010 Jan 05;5(1):e8578
15480342 - J Allergy Clin Immunol. 2004 Oct;114(4):958-64
9852037 - J Biol Chem. 1998 Dec 18;273(51):33893-6
22210911 - J Immunol. 2012 Feb 1;188(3):1027-35
18768865 - J Immunol. 2008 Sep 15;181(6):4089-97
12642602 - J Exp Med. 2003 Mar 17;197(6):703-9
12776189 - Oncogene. 2003 May 29;22(22):3386-94
26269388 - Exp Dermatol. 2016 Jan;25(1):3-9
19155515 - J Immunol. 2009 Feb 1;182(3):1660-6
15589317 - Mol Immunol. 2005 Feb;42(3):295-303
10068525 - J Surg Res. 1999 Mar;82(1):48-55
18539194 - J Allergy Clin Immunol. 2008 Jun;121(6):1415-21, 1421.e1-3
24251647 - Am J Respir Crit Care Med. 2014 Jan 1;189(1):16-29
18787221 - Am J Respir Crit Care Med. 2008 Nov 15;178(10):1023-32
12091879 - Nat Med. 2002 Aug;8(8):885-9
25127857 - J Immunol. 2014 Sep 15;193(6):2801-11
References_xml – volume: 108
  start-page: 430
  year: 2001
  end-page: 438
  ident: bib14
  article-title: IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
  publication-title: J Allergy Clin Immunol
– volume: 181
  start-page: 4089
  year: 2008
  end-page: 4097
  ident: bib13
  article-title: TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
  publication-title: J Immunol
– volume: 96
  start-page: 10800
  year: 1999
  end-page: 10805
  ident: bib37
  article-title: Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression
  publication-title: Proc Natl Acad Sci U S A
– volume: 121
  start-page: 1415
  year: 2008
  end-page: 1421
  ident: bib47
  article-title: Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma
  publication-title: J Allergy Clin Immunol
– volume: 7
  start-page: 301ra129
  year: 2015
  ident: bib57
  article-title: TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
  publication-title: Sci Transl Med
– volume: 134
  start-page: 1175
  year: 2014
  end-page: 1186.e7
  ident: bib16
  article-title: Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
  publication-title: J Allergy Clin Immunol
– volume: 123
  start-page: 1185
  year: 2009
  end-page: 1187
  ident: bib10
  article-title: T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma
  publication-title: J Allergy Clin Immunol
– volume: 282
  start-page: 2258
  year: 1998
  end-page: 2261
  ident: bib3
  article-title: Interleukin-13: central mediator of allergic asthma
  publication-title: Science
– volume: 97
  start-page: 726
  year: 2003
  end-page: 733
  ident: bib11
  article-title: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
  publication-title: Respir Med
– volume: 273
  start-page: 33893
  year: 1998
  end-page: 33896
  ident: bib42
  article-title: Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction
  publication-title: J Biol Chem
– volume: 183
  start-page: 1153
  year: 2011
  end-page: 1163
  ident: bib51
  article-title: Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A
  publication-title: Am J Respir Crit Care Med
– volume: 180
  start-page: 388
  year: 2009
  end-page: 395
  ident: bib60
  article-title: T-helper type 2-driven inflammation defines major subphenotypes of asthma
  publication-title: Am J Respir Crit Care Med
– volume: 208
  start-page: 853
  year: 2011
  end-page: 867
  ident: bib6
  article-title: Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
  publication-title: J Exp Med
– volume: 182
  start-page: 5317
  year: 2009
  end-page: 5321
  ident: bib64
  article-title: A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
  publication-title: J Immunol
– volume: 5
  start-page: e8578
  year: 2010
  ident: bib55
  article-title: Disordered microbial communities in asthmatic airways
  publication-title: PLoS One
– volume: 112
  start-page: 4098
  year: 2008
  end-page: 4108
  ident: bib41
  article-title: PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
  publication-title: Blood
– volume: 3
  start-page: e3879
  year: 2008
  ident: bib48
  article-title: Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice
  publication-title: PLoS One
– volume: 90
  start-page: 2584
  year: 1993
  end-page: 2588
  ident: bib34
  article-title: Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3
  publication-title: Proc Natl Acad Sci U S A
– volume: 178
  start-page: 1023
  year: 2008
  end-page: 1032
  ident: bib8
  article-title: IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice
  publication-title: Am J Respir Crit Care Med
– volume: 185
  start-page: 64
  year: 2010
  end-page: 70
  ident: bib32
  article-title: Live cell imaging reveals continuous STAT6 nuclear trafficking
  publication-title: J Immunol
– volume: 171
  start-page: 5901
  year: 2003
  end-page: 5907
  ident: bib39
  article-title: IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site
  publication-title: J Immunol
– volume: 197
  start-page: 703
  year: 2003
  end-page: 709
  ident: bib23
  article-title: Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2
  publication-title: J Exp Med
– volume: 180
  start-page: 720
  year: 2009
  end-page: 730
  ident: bib49
  article-title: Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness
  publication-title: Am J Respir Crit Care Med
– volume: 244
  start-page: 665
  year: 1998
  end-page: 670
  ident: bib31
  article-title: IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production
  publication-title: Biochem Biophys Res Commun
– volume: 5
  start-page: 4732
  year: 2014
  ident: bib45
  article-title: Grail controls Th2 cell development by targeting STAT6 for degradation
  publication-title: Nat Commun
– volume: 7
  start-page: 135
  year: 2006
  ident: bib12
  article-title: IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
  publication-title: Respir Res
– volume: 193
  start-page: 2801
  year: 2014
  end-page: 2811
  ident: bib43
  article-title: Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis
  publication-title: J Immunol
– volume: 182
  start-page: 1660
  year: 2009
  end-page: 1666
  ident: bib26
  article-title: IL-17 signaling for mRNA stabilization does not require TNF receptor-associated factor 6
  publication-title: J Immunol
– volume: 1
  start-page: ra17
  year: 2008
  ident: bib28
  article-title: Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages
  publication-title: Sci Signal
– volume: 25
  start-page: 3
  year: 2016
  end-page: 9
  ident: bib54
  article-title: In vivo expression of antimicrobial peptides in atopic dermatitis
  publication-title: Exp Dermatol
– volume: 140
  start-page: 254
  year: 2011
  end-page: 264
  ident: bib65
  article-title: Colitis and intestinal inflammation in IL10-/- mice results from IL-13Ralpha2-mediated attenuation of IL-13 activity
  publication-title: Gastroenterology
– volume: 179
  start-page: 4135
  year: 2007
  end-page: 4141
  ident: bib25
  article-title: IL-17 enhances chemokine gene expression through mRNA stabilization
  publication-title: J Immunol
– volume: 18
  start-page: 547
  year: 2012
  end-page: 554
  ident: bib9
  article-title: IL-17A produced by alphabeta T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
  publication-title: Nat Med
– volume: 278
  start-page: 2787
  year: 2003
  end-page: 2791
  ident: bib40
  article-title: Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling
  publication-title: J Biol Chem
– volume: 68
  start-page: 717
  year: 2013
  end-page: 723
  ident: bib50
  article-title: IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation
  publication-title: Thorax
– volume: 136
  start-page: 323
  year: 2015
  end-page: 333
  ident: bib58
  article-title: Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms
  publication-title: J Allergy Clin Immunol
– volume: 277
  start-page: 10387
  year: 2002
  end-page: 10393
  ident: bib22
  article-title: A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma
  publication-title: J Biol Chem
– volume: 127
  start-page: 1006
  year: 2011
  end-page: 1013
  ident: bib63
  article-title: Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production
  publication-title: J Allergy Clin Immunol
– volume: 11
  start-page: 928
  year: 2010
  end-page: 935
  ident: bib7
  article-title: Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
  publication-title: Nat Immunol
– volume: 133
  start-page: 1280
  year: 2014
  end-page: 1288
  ident: bib61
  article-title: Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data
  publication-title: J Allergy Clin Immunol
– volume: 189
  start-page: 16
  year: 2014
  end-page: 29
  ident: bib44
  article-title: Regulation of IL-4 receptor signaling by STUB1 in lung inflammation
  publication-title: Am J Respir Crit Care Med
– volume: 353
  start-page: 98
  year: 2005
  end-page: 106
  ident: bib35
  article-title: Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta
  publication-title: Gene
– volume: 188
  start-page: 1027
  year: 2012
  end-page: 1035
  ident: bib62
  article-title: IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner
  publication-title: J Immunol
– volume: 188
  start-page: 1294
  year: 2013
  end-page: 1302
  ident: bib66
  article-title: Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
  publication-title: Am J Respir Crit Care Med
– volume: 6
  start-page: 709
  year: 2014
  end-page: 723
  ident: bib46
  article-title: E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation
  publication-title: Cell Rep
– volume: 82
  start-page: 48
  year: 1999
  end-page: 55
  ident: bib33
  article-title: Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha
  publication-title: J Surg Res
– volume: 125
  start-page: 222
  year: 2010
  end-page: 230
  ident: bib15
  article-title: Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4
  publication-title: J Allergy Clin Immunol
– volume: 464
  start-page: 91
  year: 1999
  end-page: 96
  ident: bib30
  article-title: Binding of IL-4 to the IL-13Ralpha(1)/IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation
  publication-title: FEBS Lett
– volume: 136
  start-page: 638
  year: 2015
  end-page: 648
  ident: bib59
  article-title: Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles
  publication-title: J Allergy Clin Immunol
– volume: 135
  start-page: 25
  year: 2015
  end-page: 30
  ident: bib56
  article-title: The microbiome in asthma
  publication-title: J Allergy Clin Immunol
– volume: 78
  start-page: 1086
  year: 2005
  end-page: 1096
  ident: bib52
  article-title: Distribution and leukocyte contacts of gammadelta T cells in the lung
  publication-title: J Leukoc Biol
– volume: 115
  start-page: 243
  year: 2005
  end-page: 251
  ident: bib20
  article-title: Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma
  publication-title: J Allergy Clin Immunol
– volume: 282
  start-page: 2261
  year: 1998
  end-page: 2263
  ident: bib1
  article-title: Requirement for IL-13 independently of IL-4 in experimental asthma
  publication-title: Science
– volume: 197
  start-page: 687
  year: 2003
  end-page: 701
  ident: bib21
  article-title: Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response
  publication-title: J Exp Med
– volume: 167
  start-page: 4668
  year: 2001
  end-page: 4675
  ident: bib2
  article-title: Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
  publication-title: J Immunol
– volume: 103
  start-page: 779
  year: 1999
  end-page: 788
  ident: bib4
  article-title: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
  publication-title: J Clin Invest
– volume: 22
  start-page: 3386
  year: 2003
  end-page: 3394
  ident: bib36
  article-title: Functional characterization of IL-13 receptor alpha2 gene promoter: a critical role of the transcription factor STAT6 for regulated expression
  publication-title: Oncogene
– volume: 190
  start-page: 3859
  year: 2013
  end-page: 3868
  ident: bib18
  article-title: Dose-dependent effects of IL-17 on IL-13-induced airway inflammatory responses and airway hyperresponsiveness
  publication-title: J Immunol
– volume: 150
  start-page: 260
  year: 2014
  end-page: 265
  ident: bib53
  article-title: The presence and impact of biofilm-producing staphylococci in atopic dermatitis
  publication-title: JAMA Dermatol
– volume: 207
  start-page: 2479
  year: 2010
  end-page: 2491
  ident: bib17
  article-title: A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
  publication-title: J Exp Med
– volume: 114
  start-page: 958
  year: 2004
  end-page: 964
  ident: bib27
  article-title: IL-17A augments TNF-alpha-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability
  publication-title: J Allergy Clin Immunol
– volume: 132
  start-page: 951
  year: 2013
  end-page: 958
  ident: bib24
  article-title: IL-13 receptor alpha2 contributes to development of experimental allergic asthma
  publication-title: J Allergy Clin Immunol
– volume: 42
  start-page: 295
  year: 2005
  end-page: 303
  ident: bib38
  article-title: SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells
  publication-title: Mol Immunol
– volume: 12
  start-page: 1499
  year: 2000
  end-page: 1509
  ident: bib29
  article-title: Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation
  publication-title: Int Immunol
– volume: 8
  start-page: 885
  year: 2002
  end-page: 889
  ident: bib5
  article-title: Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
  publication-title: Nat Med
– volume: 182
  start-page: 464
  year: 2010
  end-page: 476
  ident: bib19
  article-title: Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing γδ T cells
  publication-title: Am J Respir Crit Care Med
– volume: 282
  start-page: 2258
  year: 1998
  ident: 10.1016/j.jaci.2016.04.037_bib3
  article-title: Interleukin-13: central mediator of allergic asthma
  publication-title: Science
  doi: 10.1126/science.282.5397.2258
– volume: 178
  start-page: 1023
  year: 2008
  ident: 10.1016/j.jaci.2016.04.037_bib8
  article-title: IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200801-086OC
– volume: 277
  start-page: 10387
  year: 2002
  ident: 10.1016/j.jaci.2016.04.037_bib22
  article-title: A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M108109200
– volume: 125
  start-page: 222
  year: 2010
  ident: 10.1016/j.jaci.2016.04.037_bib15
  article-title: Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2009.10.012
– volume: 183
  start-page: 1153
  year: 2011
  ident: 10.1016/j.jaci.2016.04.037_bib51
  article-title: Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201008-1383OC
– volume: 180
  start-page: 720
  year: 2009
  ident: 10.1016/j.jaci.2016.04.037_bib49
  article-title: Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200904-0573OC
– volume: 278
  start-page: 2787
  year: 2003
  ident: 10.1016/j.jaci.2016.04.037_bib40
  article-title: Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M210196200
– volume: 5
  start-page: e8578
  year: 2010
  ident: 10.1016/j.jaci.2016.04.037_bib55
  article-title: Disordered microbial communities in asthmatic airways
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0008578
– volume: 208
  start-page: 853
  year: 2011
  ident: 10.1016/j.jaci.2016.04.037_bib6
  article-title: Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice
  publication-title: J Exp Med
  doi: 10.1084/jem.20100023
– volume: 112
  start-page: 4098
  year: 2008
  ident: 10.1016/j.jaci.2016.04.037_bib41
  article-title: PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
  publication-title: Blood
  doi: 10.1182/blood-2008-03-148726
– volume: 140
  start-page: 254
  year: 2011
  ident: 10.1016/j.jaci.2016.04.037_bib65
  article-title: Colitis and intestinal inflammation in IL10-/- mice results from IL-13Ralpha2-mediated attenuation of IL-13 activity
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.09.047
– volume: 282
  start-page: 2261
  year: 1998
  ident: 10.1016/j.jaci.2016.04.037_bib1
  article-title: Requirement for IL-13 independently of IL-4 in experimental asthma
  publication-title: Science
  doi: 10.1126/science.282.5397.2261
– volume: 179
  start-page: 4135
  year: 2007
  ident: 10.1016/j.jaci.2016.04.037_bib25
  article-title: IL-17 enhances chemokine gene expression through mRNA stabilization
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.6.4135
– volume: 1
  start-page: ra17
  year: 2008
  ident: 10.1016/j.jaci.2016.04.037_bib28
  article-title: Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages
  publication-title: Sci Signal
  doi: 10.1126/scisignal.1164795
– volume: 273
  start-page: 33893
  year: 1998
  ident: 10.1016/j.jaci.2016.04.037_bib42
  article-title: Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.51.33893
– volume: 127
  start-page: 1006
  year: 2011
  ident: 10.1016/j.jaci.2016.04.037_bib63
  article-title: Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2010.11.043
– volume: 182
  start-page: 464
  year: 2010
  ident: 10.1016/j.jaci.2016.04.037_bib19
  article-title: Resolution of allergic airway inflammation and airway hyperreactivity is mediated by IL-17-producing γδ T cells
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200911-1775OC
– volume: 136
  start-page: 638
  year: 2015
  ident: 10.1016/j.jaci.2016.04.037_bib59
  article-title: Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2015.02.026
– volume: 3
  start-page: e3879
  year: 2008
  ident: 10.1016/j.jaci.2016.04.037_bib48
  article-title: Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003879
– volume: 207
  start-page: 2479
  year: 2010
  ident: 10.1016/j.jaci.2016.04.037_bib17
  article-title: A novel subset of CD4(+) T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
  publication-title: J Exp Med
  doi: 10.1084/jem.20101376
– volume: 190
  start-page: 3859
  year: 2013
  ident: 10.1016/j.jaci.2016.04.037_bib18
  article-title: Dose-dependent effects of IL-17 on IL-13-induced airway inflammatory responses and airway hyperresponsiveness
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1200506
– volume: 121
  start-page: 1415
  year: 2008
  ident: 10.1016/j.jaci.2016.04.037_bib47
  article-title: Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2008.04.016
– volume: 6
  start-page: 709
  year: 2014
  ident: 10.1016/j.jaci.2016.04.037_bib46
  article-title: E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.01.012
– volume: 197
  start-page: 703
  year: 2003
  ident: 10.1016/j.jaci.2016.04.037_bib23
  article-title: Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2
  publication-title: J Exp Med
  doi: 10.1084/jem.20020906
– volume: 180
  start-page: 388
  year: 2009
  ident: 10.1016/j.jaci.2016.04.037_bib60
  article-title: T-helper type 2-driven inflammation defines major subphenotypes of asthma
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200903-0392OC
– volume: 182
  start-page: 1660
  year: 2009
  ident: 10.1016/j.jaci.2016.04.037_bib26
  article-title: IL-17 signaling for mRNA stabilization does not require TNF receptor-associated factor 6
  publication-title: J Immunol
  doi: 10.4049/jimmunol.182.3.1660
– volume: 188
  start-page: 1027
  year: 2012
  ident: 10.1016/j.jaci.2016.04.037_bib62
  article-title: IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent manner
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1102216
– volume: 5
  start-page: 4732
  year: 2014
  ident: 10.1016/j.jaci.2016.04.037_bib45
  article-title: Grail controls Th2 cell development by targeting STAT6 for degradation
  publication-title: Nat Commun
  doi: 10.1038/ncomms5732
– volume: 188
  start-page: 1294
  year: 2013
  ident: 10.1016/j.jaci.2016.04.037_bib66
  article-title: Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201212-2318OC
– volume: 97
  start-page: 726
  year: 2003
  ident: 10.1016/j.jaci.2016.04.037_bib11
  article-title: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
  publication-title: Respir Med
  doi: 10.1053/rmed.2003.1507
– volume: 90
  start-page: 2584
  year: 1993
  ident: 10.1016/j.jaci.2016.04.037_bib34
  article-title: Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.90.7.2584
– volume: 171
  start-page: 5901
  year: 2003
  ident: 10.1016/j.jaci.2016.04.037_bib39
  article-title: IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site
  publication-title: J Immunol
  doi: 10.4049/jimmunol.171.11.5901
– volume: 133
  start-page: 1280
  year: 2014
  ident: 10.1016/j.jaci.2016.04.037_bib61
  article-title: Unsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2013.11.042
– volume: 3
  start-page: e3879
  year: 2008
  ident: 10.1016/j.jaci.2016.04.037_bibE1
  article-title: Allergen uptake, activation, and IL-23 production by pulmonary myeloid DCs drives airway hyperresponsiveness in asthma-susceptible mice
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0003879
– volume: 114
  start-page: 958
  year: 2004
  ident: 10.1016/j.jaci.2016.04.037_bib27
  article-title: IL-17A augments TNF-alpha-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2004.06.023
– volume: 42
  start-page: 295
  year: 2005
  ident: 10.1016/j.jaci.2016.04.037_bib38
  article-title: SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3/CCL26 gene expression in HEK293 cells
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2004.09.004
– volume: 68
  start-page: 717
  year: 2013
  ident: 10.1016/j.jaci.2016.04.037_bib50
  article-title: IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammation
  publication-title: Thorax
  doi: 10.1136/thoraxjnl-2012-202404
– volume: 7
  start-page: 301ra129
  year: 2015
  ident: 10.1016/j.jaci.2016.04.037_bib57
  article-title: TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aab3142
– volume: 115
  start-page: 243
  year: 2005
  ident: 10.1016/j.jaci.2016.04.037_bib20
  article-title: Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2004.10.032
– volume: 182
  start-page: 5317
  year: 2009
  ident: 10.1016/j.jaci.2016.04.037_bib64
  article-title: A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0803868
– volume: 78
  start-page: 1086
  year: 2005
  ident: 10.1016/j.jaci.2016.04.037_bib52
  article-title: Distribution and leukocyte contacts of gammadelta T cells in the lung
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0505244
– volume: 181
  start-page: 4089
  year: 2008
  ident: 10.1016/j.jaci.2016.04.037_bib13
  article-title: TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice
  publication-title: J Immunol
  doi: 10.4049/jimmunol.181.6.4089
– volume: 12
  start-page: 1499
  year: 2000
  ident: 10.1016/j.jaci.2016.04.037_bib29
  article-title: Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation
  publication-title: Int Immunol
  doi: 10.1093/intimm/12.11.1499
– volume: 464
  start-page: 91
  year: 1999
  ident: 10.1016/j.jaci.2016.04.037_bib30
  article-title: Binding of IL-4 to the IL-13Ralpha(1)/IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(99)01680-4
– volume: 135
  start-page: 25
  year: 2015
  ident: 10.1016/j.jaci.2016.04.037_bib56
  article-title: The microbiome in asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2014.11.011
– volume: 244
  start-page: 665
  year: 1998
  ident: 10.1016/j.jaci.2016.04.037_bib31
  article-title: IL-13 induces tyrosine phosphorylation of phospholipase C gamma-1 following IRS-2 association in human monocytes: relationship with the inhibitory effect of IL-13 on ROI production
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.1998.8314
– volume: 167
  start-page: 4668
  year: 2001
  ident: 10.1016/j.jaci.2016.04.037_bib2
  article-title: Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
  publication-title: J Immunol
  doi: 10.4049/jimmunol.167.8.4668
– volume: 132
  start-page: 951
  year: 2013
  ident: 10.1016/j.jaci.2016.04.037_bib24
  article-title: IL-13 receptor alpha2 contributes to development of experimental allergic asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2013.04.016
– volume: 96
  start-page: 10800
  year: 1999
  ident: 10.1016/j.jaci.2016.04.037_bib37
  article-title: Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.96.19.10800
– volume: 189
  start-page: 16
  year: 2014
  ident: 10.1016/j.jaci.2016.04.037_bib44
  article-title: Regulation of IL-4 receptor signaling by STUB1 in lung inflammation
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201305-0874OC
– volume: 7
  start-page: 135
  year: 2006
  ident: 10.1016/j.jaci.2016.04.037_bib12
  article-title: IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?
  publication-title: Respir Res
  doi: 10.1186/1465-9921-7-135
– volume: 108
  start-page: 430
  year: 2001
  ident: 10.1016/j.jaci.2016.04.037_bib14
  article-title: IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/mai.2001.117929
– volume: 8
  start-page: 885
  year: 2002
  ident: 10.1016/j.jaci.2016.04.037_bib5
  article-title: Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
  publication-title: Nat Med
  doi: 10.1038/nm734
– volume: 25
  start-page: 3
  year: 2016
  ident: 10.1016/j.jaci.2016.04.037_bib54
  article-title: In vivo expression of antimicrobial peptides in atopic dermatitis
  publication-title: Exp Dermatol
  doi: 10.1111/exd.12831
– volume: 353
  start-page: 98
  year: 2005
  ident: 10.1016/j.jaci.2016.04.037_bib35
  article-title: Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta
  publication-title: Gene
  doi: 10.1016/j.gene.2005.04.004
– volume: 134
  start-page: 1175
  year: 2014
  ident: 10.1016/j.jaci.2016.04.037_bib16
  article-title: Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2014.05.038
– volume: 123
  start-page: 1185
  year: 2009
  ident: 10.1016/j.jaci.2016.04.037_bib10
  article-title: T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2009.02.024
– volume: 22
  start-page: 3386
  year: 2003
  ident: 10.1016/j.jaci.2016.04.037_bib36
  article-title: Functional characterization of IL-13 receptor alpha2 gene promoter: a critical role of the transcription factor STAT6 for regulated expression
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206352
– volume: 197
  start-page: 687
  year: 2003
  ident: 10.1016/j.jaci.2016.04.037_bib21
  article-title: Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response
  publication-title: J Exp Med
  doi: 10.1084/jem.20020903
– volume: 185
  start-page: 64
  year: 2010
  ident: 10.1016/j.jaci.2016.04.037_bib32
  article-title: Live cell imaging reveals continuous STAT6 nuclear trafficking
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0903323
– volume: 103
  start-page: 779
  year: 1999
  ident: 10.1016/j.jaci.2016.04.037_bib4
  article-title: Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
  publication-title: J Clin Invest
  doi: 10.1172/JCI5909
– volume: 82
  start-page: 48
  year: 1999
  ident: 10.1016/j.jaci.2016.04.037_bib33
  article-title: Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha
  publication-title: J Surg Res
  doi: 10.1006/jsre.1998.5503
– volume: 136
  start-page: 323
  year: 2015
  ident: 10.1016/j.jaci.2016.04.037_bib58
  article-title: Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2015.01.014
– volume: 18
  start-page: 547
  year: 2012
  ident: 10.1016/j.jaci.2016.04.037_bib9
  article-title: IL-17A produced by alphabeta T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
  publication-title: Nat Med
  doi: 10.1038/nm.2684
– volume: 150
  start-page: 260
  year: 2014
  ident: 10.1016/j.jaci.2016.04.037_bib53
  article-title: The presence and impact of biofilm-producing staphylococci in atopic dermatitis
  publication-title: JAMA Dermatol
  doi: 10.1001/jamadermatol.2013.8627
– volume: 11
  start-page: 928
  year: 2010
  ident: 10.1016/j.jaci.2016.04.037_bib7
  article-title: Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
  publication-title: Nat Immunol
  doi: 10.1038/ni.1926
– volume: 193
  start-page: 2801
  year: 2014
  ident: 10.1016/j.jaci.2016.04.037_bib43
  article-title: Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1303463
– reference: 21236478 - J Allergy Clin Immunol. 2011 Apr;127(4):1006-13.e1-4
– reference: 25567040 - J Allergy Clin Immunol. 2015 Jan;135(1):25-30
– reference: 23509346 - J Immunol. 2013 Apr 15;190(8):3859-68
– reference: 19109239 - Sci Signal. 2008 Dec 23;1(51):ra17
– reference: 11591797 - J Immunol. 2001 Oct 15;167(8):4668-75
– reference: 15922518 - Gene. 2005 Jun 20;353(1):98-106
– reference: 21464224 - J Exp Med. 2011 Apr 11;208(4):853-67
– reference: 19380778 - J Immunol. 2009 May 1;182(9):5317-21
– reference: 18716132 - Blood. 2008 Nov 15;112(10):4098-108
– reference: 11786536 - J Biol Chem. 2002 Mar 22;277(12):10387-93
– reference: 12426308 - J Biol Chem. 2003 Jan 31;278(5):2787-91
– reference: 8385337 - Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2584-8
– reference: 18768865 - J Immunol. 2008 Sep 15;181(6):4089-97
– reference: 20951137 - Gastroenterology. 2011 Jan;140(1):254-64
– reference: 14634100 - J Immunol. 2003 Dec 1;171(11):5901-7
– reference: 11058569 - Int Immunol. 2000 Nov;12 (11):1499-509
– reference: 10079098 - J Clin Invest. 1999 Mar;103(6):779-88
– reference: 20413629 - Am J Respir Crit Care Med. 2010 Aug 15;182(4):464-76
– reference: 25746968 - J Allergy Clin Immunol. 2015 Aug;136(2):323-33
– reference: 18787221 - Am J Respir Crit Care Med. 2008 Nov 15;178(10):1023-32
– reference: 20109749 - J Allergy Clin Immunol. 2010 Jan;125(1):222-30.e1-4
– reference: 12814161 - Respir Med. 2003 Jun;97(6):726-33
– reference: 24200404 - Am J Respir Crit Care Med. 2013 Dec 1;188(11):1294-302
– reference: 20498360 - J Immunol. 2010 Jul 1;185(1):64-70
– reference: 26290411 - Sci Transl Med. 2015 Aug 19;7(301):301ra129
– reference: 25042748 - J Allergy Clin Immunol. 2014 Nov;134(5):1175-1186.e7
– reference: 20802484 - Nat Immunol. 2010 Oct;11(10):928-35
– reference: 24251647 - Am J Respir Crit Care Med. 2014 Jan 1;189(1):16-29
– reference: 21297073 - Am J Respir Crit Care Med. 2011 May 1;183(9):1153-63
– reference: 19060952 - PLoS One. 2008;3(12):e3879
– reference: 16204632 - J Leukoc Biol. 2005 Nov;78(5):1086-96
– reference: 11544464 - J Allergy Clin Immunol. 2001 Sep;108(3):430-8
– reference: 22388091 - Nat Med. 2012 Mar 04;18(4):547-54
– reference: 19361847 - J Allergy Clin Immunol. 2009 May;123(5):1185-7
– reference: 10485906 - Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10800-5
– reference: 22210911 - J Immunol. 2012 Feb 1;188(3):1027-35
– reference: 19155515 - J Immunol. 2009 Feb 1;182(3):1660-6
– reference: 9535722 - Biochem Biophys Res Commun. 1998 Mar 27;244(3):665-70
– reference: 23422214 - Thorax. 2013 Aug;68(8):717-23
– reference: 25127857 - J Immunol. 2014 Sep 15;193(6):2801-11
– reference: 19661246 - Am J Respir Crit Care Med. 2009 Oct 15;180(8):720-30
– reference: 12642601 - J Exp Med. 2003 Mar 17;197(6):687-701
– reference: 15696077 - J Allergy Clin Immunol. 2005 Feb;115(2):243-51
– reference: 20052417 - PLoS One. 2010 Jan 05;5(1):e8578
– reference: 26269388 - Exp Dermatol. 2016 Jan;25(1):3-9
– reference: 23763980 - J Allergy Clin Immunol. 2013 Oct;132(4):951-8.e1-6
– reference: 17785852 - J Immunol. 2007 Sep 15;179(6):4135-41
– reference: 24589344 - J Allergy Clin Immunol. 2014 May;133(5):1280-8
– reference: 10611490 - FEBS Lett. 1999 Dec 24;464(1-2):91-6
– reference: 15480342 - J Allergy Clin Immunol. 2004 Oct;114(4):958-64
– reference: 24508458 - Cell Rep. 2014 Feb 27;6(4):709-23
– reference: 12091879 - Nat Med. 2002 Aug;8(8):885-9
– reference: 18539194 - J Allergy Clin Immunol. 2008 Jun;121(6):1415-21, 1421.e1-3
– reference: 25863981 - J Allergy Clin Immunol. 2015 Sep;136(3):638-48
– reference: 17083726 - Respir Res. 2006 Nov 03;7:135
– reference: 9856949 - Science. 1998 Dec 18;282(5397):2258-61
– reference: 12776189 - Oncogene. 2003 May 29;22(22):3386-94
– reference: 20921287 - J Exp Med. 2010 Oct 25;207(11):2479-91
– reference: 10068525 - J Surg Res. 1999 Mar;82(1):48-55
– reference: 15589317 - Mol Immunol. 2005 Feb;42(3):295-303
– reference: 9852037 - J Biol Chem. 1998 Dec 18;273(51):33893-6
– reference: 24452476 - JAMA Dermatol. 2014 Mar;150(3):260-5
– reference: 25145352 - Nat Commun. 2014 Aug 22;5:4732
– reference: 9856950 - Science. 1998 Dec 18;282(5397):2261-3
– reference: 12642602 - J Exp Med. 2003 Mar 17;197(6):703-9
– reference: 19483109 - Am J Respir Crit Care Med. 2009 Sep 1;180(5):388-95
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Snippet Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13–driven pathology in...
Background Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13–driven...
Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven pathology in...
Background Increased IL-17A production has been associated with more severe asthma; however, the mechanisms whereby IL-17A can contribute to IL-13-driven...
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StartPage 462
SubjectTerms Airway management
Allergy and Immunology
Animals
Asthma
Asthma - chemically induced
Asthma - immunology
Cell Line
Cytokines
Cytokines - metabolism
Fibroblasts - immunology
Gene expression
Gene Expression Regulation
Human subjects
Humans
IL-13
IL-17A
Inflammation
Interleukin-13 - metabolism
Interleukin-13 Receptor alpha2 Subunit - genetics
Interleukin-17 - metabolism
Mice
Mice, Inbred BALB C
Mice, Knockout
Pathogenesis
Pathology
Pneumonia - chemically induced
Pneumonia - immunology
Proteins
Receptors, Interleukin-17 - genetics
signal transducer and activator of transcription 6
Signal Transduction
Smooth muscle
STAT6 Transcription Factor - genetics
STAT6 Transcription Factor - metabolism
Studies
Th2 Cells - immunology
Title IL-17A enhances IL-13 activity by enhancing IL-13–induced signal transducer and activator of transcription 6 activation
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https://www.ncbi.nlm.nih.gov/pubmed/27417023
https://www.proquest.com/docview/1867911072
https://www.proquest.com/docview/1872837874
http://www.jacionline.org/article/S0091674916304304/pdf
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