Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100 micrograms given in a volume of 10 microliters caused intense pain lasting for a few minutes after injection and resulted in a narrow area of hyperalgesia to heat and a wide sur...
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| Published in | The Journal of physiology Vol. 448; no. 1; pp. 765 - 780 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
The Physiological Society
01.03.1992
Blackwell |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3751 1469-7793 |
| DOI | 10.1113/jphysiol.1992.sp019069 |
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| Abstract | 1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100
micrograms given in a volume of 10 microliters caused intense pain lasting for a few minutes after injection and resulted
in a narrow area of hyperalgesia to heat and a wide surrounding area of hyperalgesia to mechanical stimuli (stroking) lasting
for 1-2 h. 2. Nerve compression experiments with selective block of impulse conduction in myelinated (A) but not in unmyelinated
(C) fibres indicated that afferent signals in C fibres contributed to pain from capsaicin injection and to heat hyperalgesia,
whereas conduction in afferent A fibres was necessary for the perception of mechanical hyperalgesia. 3. Electrical intraneural
microstimulation normally eliciting non-painful tactile sensations was accompanied by pain when the sensation was projected
to skin areas within the region of mechanical hyperalgesia induced by capsaicin injection. 4. The threshold for pain evoked
by intraneural microstimulation was reversibly lowered and pain from suprathreshold stimulation was exaggerated during the
period of mechanical hyperalgesia, regardless of lidocaine anaesthesia of the cutaneous innervation territory of the stimulated
fibres. 5. The results indicate that hyperalgesia to stroking on a skin area surrounding a painful intradermal injection of
capsaicin is due to reversible changes in the central processing of mechanoreceptive input from myelinated fibres which normally
evoke non-painful tactile sensations. |
|---|---|
| AbstractList | 1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100 micrograms given in a volume of 10 microliters caused intense pain lasting for a few minutes after injection and resulted in a narrow area of hyperalgesia to heat and a wide surrounding area of hyperalgesia to mechanical stimuli (stroking) lasting for 1-2 h. 2. Nerve compression experiments with selective block of impulse conduction in myelinated (A) but not in unmyelinated (C) fibres indicated that afferent signals in C fibres contributed to pain from capsaicin injection and to heat hyperalgesia, whereas conduction in afferent A fibres was necessary for the perception of mechanical hyperalgesia. 3. Electrical intraneural microstimulation normally eliciting non-painful tactile sensations was accompanied by pain when the sensation was projected to skin areas within the region of mechanical hyperalgesia induced by capsaicin injection. 4. The threshold for pain evoked by intraneural microstimulation was reversibly lowered and pain from suprathreshold stimulation was exaggerated during the period of mechanical hyperalgesia, regardless of lidocaine anaesthesia of the cutaneous innervation territory of the stimulated fibres. 5. The results indicate that hyperalgesia to stroking on a skin area surrounding a painful intradermal injection of capsaicin is due to reversible changes in the central processing of mechanoreceptive input from myelinated fibres which normally evoke non-painful tactile sensations. 1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100 micrograms given in a volume of 10 microliters caused intense pain lasting for a few minutes after injection and resulted in a narrow area of hyperalgesia to heat and a wide surrounding area of hyperalgesia to mechanical stimuli (stroking) lasting for 1-2 h. 2. Nerve compression experiments with selective block of impulse conduction in myelinated (A) but not in unmyelinated (C) fibres indicated that afferent signals in C fibres contributed to pain from capsaicin injection and to heat hyperalgesia, whereas conduction in afferent A fibres was necessary for the perception of mechanical hyperalgesia. 3. Electrical intraneural microstimulation normally eliciting non-painful tactile sensations was accompanied by pain when the sensation was projected to skin areas within the region of mechanical hyperalgesia induced by capsaicin injection. 4. The threshold for pain evoked by intraneural microstimulation was reversibly lowered and pain from suprathreshold stimulation was exaggerated during the period of mechanical hyperalgesia, regardless of lidocaine anaesthesia of the cutaneous innervation territory of the stimulated fibres. 5. The results indicate that hyperalgesia to stroking on a skin area surrounding a painful intradermal injection of capsaicin is due to reversible changes in the central processing of mechanoreceptive input from myelinated fibres which normally evoke non-painful tactile sensations. 1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100 micrograms given in a volume of 10 microliters caused intense pain lasting for a few minutes after injection and resulted in a narrow area of hyperalgesia to heat and a wide surrounding area of hyperalgesia to mechanical stimuli (stroking) lasting for 1-2 h. 2. Nerve compression experiments with selective block of impulse conduction in myelinated (A) but not in unmyelinated (C) fibres indicated that afferent signals in C fibres contributed to pain from capsaicin injection and to heat hyperalgesia, whereas conduction in afferent A fibres was necessary for the perception of mechanical hyperalgesia. 3. Electrical intraneural microstimulation normally eliciting non-painful tactile sensations was accompanied by pain when the sensation was projected to skin areas within the region of mechanical hyperalgesia induced by capsaicin injection. 4. The threshold for pain evoked by intraneural microstimulation was reversibly lowered and pain from suprathreshold stimulation was exaggerated during the period of mechanical hyperalgesia, regardless of lidocaine anaesthesia of the cutaneous innervation territory of the stimulated fibres. 5. The results indicate that hyperalgesia to stroking on a skin area surrounding a painful intradermal injection of capsaicin is due to reversible changes in the central processing of mechanoreceptive input from myelinated fibres which normally evoke non-painful tactile sensations.1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100 micrograms given in a volume of 10 microliters caused intense pain lasting for a few minutes after injection and resulted in a narrow area of hyperalgesia to heat and a wide surrounding area of hyperalgesia to mechanical stimuli (stroking) lasting for 1-2 h. 2. Nerve compression experiments with selective block of impulse conduction in myelinated (A) but not in unmyelinated (C) fibres indicated that afferent signals in C fibres contributed to pain from capsaicin injection and to heat hyperalgesia, whereas conduction in afferent A fibres was necessary for the perception of mechanical hyperalgesia. 3. Electrical intraneural microstimulation normally eliciting non-painful tactile sensations was accompanied by pain when the sensation was projected to skin areas within the region of mechanical hyperalgesia induced by capsaicin injection. 4. The threshold for pain evoked by intraneural microstimulation was reversibly lowered and pain from suprathreshold stimulation was exaggerated during the period of mechanical hyperalgesia, regardless of lidocaine anaesthesia of the cutaneous innervation territory of the stimulated fibres. 5. The results indicate that hyperalgesia to stroking on a skin area surrounding a painful intradermal injection of capsaicin is due to reversible changes in the central processing of mechanoreceptive input from myelinated fibres which normally evoke non-painful tactile sensations. |
| Author | L E Lundberg R H LaMotte H E Torebjörk |
| AuthorAffiliation | Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden |
| AuthorAffiliation_xml | – name: Department of Clinical Neurophysiology, University Hospital, Uppsala, Sweden |
| Author_xml | – sequence: 1 givenname: H E surname: Torebjörk fullname: Torebjörk, H E – sequence: 2 givenname: L E surname: Lundberg fullname: Lundberg, L E – sequence: 3 givenname: R H surname: LaMotte fullname: LaMotte, R H |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5206497$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/1593489$$D View this record in MEDLINE/PubMed |
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| Snippet | 1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100
micrograms given in a volume of 10... 1. Capsaicin, the algesic substance in chilli peppers, was injected intradermally in healthy human subjects. A dose of 100 micrograms given in a volume of 10... |
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| SubjectTerms | Adult Biological and medical sciences Capsaicin - adverse effects Electric Stimulation Female Fundamental and applied biological sciences. Psychology Humans Hyperalgesia - chemically induced Hyperalgesia - physiopathology Male Mechanoreceptors - physiopathology Middle Aged Nerve Block Nerve Fibers, Myelinated - physiology Neural Conduction - drug effects Pain Measurement Sensory Thresholds - drug effects Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors Time Factors Vertebrates: nervous system and sense organs |
| Title | Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans |
| URI | http://jp.physoc.org/content/448/1/765.abstract https://onlinelibrary.wiley.com/doi/abs/10.1113%2Fjphysiol.1992.sp019069 https://www.ncbi.nlm.nih.gov/pubmed/1593489 https://www.proquest.com/docview/1753462084 https://www.proquest.com/docview/72959888 https://pubmed.ncbi.nlm.nih.gov/PMC1176227 |
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