Pediatric idiopathic steroid-sensitive nephrotic syndrome: diagnosis and therapy —short version of the updated German best practice guideline (S2e) — AWMF register no. 166-001, 6/2020

Idiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The cours...

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Published inPediatric nephrology (Berlin, West) Vol. 36; no. 10; pp. 2971 - 2985
Main Authors Ehren, Rasmus, Benz, Marcus R., Brinkkötter, Paul T., Dötsch, Jörg, Eberl, Wolfgang R., Gellermann, Jutta, Hoyer, Peter F., Jordans, Isabelle, Kamrath, Clemens, Kemper, Markus J., Latta, Kay, Müller, Dominik, Oh, Jun, Tönshoff, Burkhard, Weber, Stefanie, Weber, Lutz T.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2021
Springer
Springer Nature B.V
Subjects
Care and treatment
Child
Children
Clinical practice guidelines
Diagnosis
Glucocorticoids
Glucocorticoids - therapeutic use
Guidelines
Humans
Kidney diseases
Medical diagnosis
Medicine
Medicine & Public Health
Nephrology
Nephrosis, Lipoid - drug therapy
Nephrotic syndrome
Nephrotic Syndrome - diagnosis
Nephrotic Syndrome - drug therapy
Nephrotic Syndrome - physiopathology
Pediatric research
Pediatrics
Practice guidelines (Medicine)
Recurrence
Steroids
Steroids - therapeutic use
Urology
Working groups
Germany
Guideline
Steroid-dependent nephrotic syndrome
Steroid-sensitive nephrotic syndrome
Treatment
Frequently relapsing nephrotic syndrome
Online AccessGet full text
ISSN0931-041X
1432-198X
1432-198X
DOI10.1007/s00467-021-05135-3

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Abstract Idiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The course of SSNS is often complicated by a high rate of relapses and the associated side effects of repeated glucocorticoid (steroid) therapy. The following recommendations for the treatment of SSNS are based on the comprehensive consideration of published evidence by a working group of the German Society for Pediatric Nephrology (GPN) based on the systematic Cochrane reviews on SSNS and the guidelines of the KDIGO working group (Kidney Disease - Improving Global Outcomes).
AbstractList Idiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The course of SSNS is often complicated by a high rate of relapses and the associated side effects of repeated glucocorticoid (steroid) therapy. The following recommendations for the treatment of SSNS are based on the comprehensive consideration of published evidence by a working group of the German Society for Pediatric Nephrology (GPN) based on the systematic Cochrane reviews on SSNS and the guidelines of the KDIGO working group (Kidney Disease - Improving Global Outcomes).Idiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The course of SSNS is often complicated by a high rate of relapses and the associated side effects of repeated glucocorticoid (steroid) therapy. The following recommendations for the treatment of SSNS are based on the comprehensive consideration of published evidence by a working group of the German Society for Pediatric Nephrology (GPN) based on the systematic Cochrane reviews on SSNS and the guidelines of the KDIGO working group (Kidney Disease - Improving Global Outcomes).
Idiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The course of SSNS is often complicated by a high rate of relapses and the associated side effects of repeated glucocorticoid (steroid) therapy. The following recommendations for the treatment of SSNS are based on the comprehensive consideration of published evidence by a working group of the German Society for Pediatric Nephrology (GPN) based on the systematic Cochrane reviews on SSNS and the guidelines of the KDIGO working group (Kidney Disease - Improving Global Outcomes).
Audience Academic
Author Tönshoff, Burkhard
Kemper, Markus J.
Kamrath, Clemens
Weber, Stefanie
Gellermann, Jutta
Benz, Marcus R.
Eberl, Wolfgang R.
Weber, Lutz T.
Oh, Jun
Ehren, Rasmus
Brinkkötter, Paul T.
Dötsch, Jörg
Latta, Kay
Jordans, Isabelle
Hoyer, Peter F.
Müller, Dominik
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  givenname: Markus J.
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  surname: Weber
  fullname: Weber, Lutz T.
  organization: Faculty of Medicine and University Hospital Cologne, Pediatric Nephrology, Children’s and Adolescents’ Hospital, University of Cologne
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34091756$$D View this record in MEDLINE/PubMed
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Issue 10
Keywords Guideline
Steroid-dependent nephrotic syndrome
Steroid-sensitive nephrotic syndrome
Treatment
Frequently relapsing nephrotic syndrome
Language English
License 2021. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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PublicationSubtitle Journal of the International Pediatric Nephrology Association
PublicationTitle Pediatric nephrology (Berlin, West)
PublicationTitleAbbrev Pediatr Nephrol
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PublicationYear 2021
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Snippet Idiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic...
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SubjectTerms Care and treatment
Child
Children
Clinical practice guidelines
Diagnosis
Glucocorticoids
Glucocorticoids - therapeutic use
Guidelines
Humans
Kidney diseases
Medical diagnosis
Medicine
Medicine & Public Health
Nephrology
Nephrosis, Lipoid - drug therapy
Nephrotic syndrome
Nephrotic Syndrome - diagnosis
Nephrotic Syndrome - drug therapy
Nephrotic Syndrome - physiopathology
Pediatric research
Pediatrics
Practice guidelines (Medicine)
Recurrence
Steroids
Steroids - therapeutic use
Urology
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Title Pediatric idiopathic steroid-sensitive nephrotic syndrome: diagnosis and therapy —short version of the updated German best practice guideline (S2e) — AWMF register no. 166-001, 6/2020
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