Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% neve...
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| Published in | Nature communications Vol. 14; no. 1; pp. 3043 - 17 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
26.05.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2041-1723 2041-1723 |
| DOI | 10.1038/s41467-023-38196-z |
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| Abstract | Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (
n
= 115) identified novel candidate genes, including
FADS1
at 11q12 and
ELF5
at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P
interaction
= 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.
Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians. |
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| AbstractList | Abstract Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians. Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset ( n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians. Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset ( n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P interaction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications. |
| ArticleNumber | 3043 |
| Author | Ohe, Yuichiro Hu, Zhibin Kobayashi, Masashi Liu, Jie Song, Bao Song, Lei Li, Jihua Li, Xuelian Liu, Jia Vermeulen, Roel C. H. Chang, I-Shou Kweon, Sun-Seog Horinouchi, Hidehito Kunitoh, Hideo Wang, Junwen Park, Jae Yong Patel, Harsh Goto, Koichi Wyatt, Kathleen Xu, Jun Song, Minsun Wakai, Kenji Yamaji, Taiki Wang, Zhaoming Berndt, Sonja I. Hsiao, Chin-Fu Christiani, David C. Burdett, Laurie Spitz, Margaret R. Choi, Jiyeon He, Qincheng Shen, Hongbing Breeze, Charles Wu, Chen Tanaka, Kazumi Honda, Takayuki Jin, Li Guo, Huan Nakayama, Haruhiko Lin, Hsien-Chih Sawada, Norie Wang, Chih-Liang Johansson, Mattias Chen, Chien-Jen Le Marchand, Loic Landi, Maria Teresa Park, In Kyu Choi, Yi Young Hamamoto, Ryuji Machiela, Mitchell J. Su, Jian Oh, In-Jae Iwasaki, Motoki Dai, Juncheng Ohtaki, Yoichi Wichmann, H-Erich Su, Wu-Chou Wong, Jason Y. Y. Aldrich, Melinda C. Liu, Li Liu, Jianjun Taylor, Fiona Shi, Jianxin Lan, Qing Shin, Min-Ho Chanock, Stephen J. Chung, Lap Ping Albanes, Demetrius Sihoe, Alan Dart Loon Jiang, Shih Sheng Guan, Peng Park, Kyong Hwa Kohno, Takash |
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| Cites_doi | 10.1093/aje/kwaa234 10.1038/nature06885 10.1038/ng.3404 10.1111/1759-7714.13328 10.1016/j.envint.2020.105975 10.1158/1940-6207.CAPR-11-0212 10.1016/j.metabol.2009.10.022 10.1093/hmg/ddv494 10.1186/s13059-021-02560-3 10.1093/nar/gkv1340 10.1158/1055-9965.EPI-19-1221 10.1038/ng.273 10.1038/ng.2351 10.1016/j.xgen.2021.100084 10.1016/j.ajhg.2016.10.003 10.1016/S2213-2600(19)30144-4 10.1093/hmg/dds382 10.1038/s41467-020-20885-8 10.1126/science.aaq1327 10.1200/JCO.2013.50.6105 10.1038/s41588-018-0164-2 10.1038/ng.3506 10.1093/hmg/dds334 10.1038/ng.2213 10.1158/0008-5472.CAN-14-0459 10.1074/jbc.M111.303669 10.1038/ng.3002 10.1093/bioinformatics/btw018 10.1038/ng.875 10.1038/s41588-018-0081-4 10.1038/s41588-019-0569-6 10.1164/rccm.201602-0300OC 10.1038/ng.2456 10.1038/sj.bjc.6602769 10.1016/j.molcel.2014.12.024 10.1038/ng.2353 10.1101/gad.1614608 10.1016/j.ydbio.2009.02.032 10.1002/ijc.29393 10.1038/s41467-020-16483-3 10.1002/ijc.27477 10.1016/j.je.2016.12.005 10.1001/jama.2016.6255 10.1038/ncb2607 10.1203/PDR.0b013e3180a03232 10.1038/ncomms12451 10.1038/ng.3406 10.5334/aogh.2419 10.1073/pnas.96.8.4240 10.1093/hmg/ddv252 10.1038/ng.667 10.2217/lmt.13.72 10.1038/ng.3423 10.1101/gr.209759.116 10.1038/ng.109 10.1158/2159-8290.CD-20-1165 10.1038/s41588-018-0193-x 10.1111/1759-7714.12916 10.1038/s41419-020-2457-5 10.1016/j.ajhg.2016.05.001 10.3322/caac.21492 10.1093/carcin/bgu076 10.1038/ng.3892 10.1016/j.ajhg.2009.09.012 10.1016/j.jtho.2019.04.008 10.1101/gr.2122004 10.1101/gr.137323.112 10.1016/j.cell.2012.03.030 10.1001/jamaoncol.2016.5945 10.1001/jamaoncol.2016.1025 10.2353/ajpath.2010.091075 10.1016/j.jtho.2016.05.021 10.1158/0008-5472.CAN-12-1160 10.1126/scitranslmed.aaf7837 10.1093/nar/gkw1186 10.1038/s41588-018-0099-7 10.1371/journal.pgen.1001051 10.1016/j.molcel.2009.08.009 10.2188/jea.JE20150257 10.1093/carcin/bgx113 10.1158/0008-5472.CAN-09-0081 10.1038/s41467-019-08831-9 10.1002/ijc.30702 10.1093/acprof:oso/9780195149616.001.0001 10.1002/cam4.1557 |
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| References | Seow (CR13) 2017; 26 Wu (CR23) 2009; 69 Sin (CR47) 2013; 31 Cao, Chen (CR4) 2019; 10 Nagai (CR30) 2017; 27 Miyake (CR53) 2009; 36 Hu (CR10) 2011; 43 Shiraishi (CR76) 2016; 7 Kinoshita, Ito, Nakayama (CR5) 2016; 26 Tan (CR43) 2020; 11 Bosse (CR82) 2012; 72 CR78 Angelidis (CR65) 2019; 10 Amos (CR19) 2008; 40 Verbanck, Chen, Neale, Do (CR86) 2018; 50 Zhao (CR41) 2020; 11 Vannier, Pavicic-Kaltenbrunner, Petalcorin, Ding, Boulton (CR51) 2012; 149 Zhang, Qi, Park, Chatterjee (CR26) 2018; 50 Katki, Kovalchik, Berg, Cheung, Chaturvedi (CR74) 2016; 315 Beane (CR83) 2011; 4 Dai (CR24) 2019; 7 CR8 Hsiung (CR12) 2010; 6 Boyle (CR33) 2012; 22 Chien (CR75) 2020; 29 Landi (CR6) 2021; 190 Moon (CR49) 2015; 47 Foley (CR38) 2021; 12 Bray (CR1) 2018; 68 Chen (CR72) 2020; 52 Finucane (CR80) 2015; 47 Chakrabarti (CR68) 2012; 14 Sarek, Vannier, Panier, Petrini, Boulton (CR52) 2015; 57 Sisti, Boffetta (CR7) 2012; 131 Glaser, Heinrich, Koletzko (CR40) 2010; 59 Hormozdiari (CR37) 2016; 99 Landi (CR18) 2009; 85 Choi, Chakrabarti, Escamilla-Hernandez, Sinha (CR67) 2009; 329 McKay (CR16) 2017; 49 (CR60) 2016; 99 Benner (CR32) 2016; 32 Emilsson (CR69) 2018; 361 Cheng (CR2) 2016; 11 Cantley, Neel (CR46) 1999; 96 Pan (CR39) 2017; 45 Margaret (CR54) 2022; 2 Oakes (CR42) 2008; 22 Zhang (CR63) 2020; 11 Barta, Powell, Wisnivesky (CR3) 2019; 85 Hamvas (CR70) 2007; 62 Mangino (CR87) 2012; 21 Blechter (CR71) 2021; 147 Shiraishi (CR15) 2012; 44 Telomeres Mendelian Randomization (CR57) 2017; 3 Lehner, Sanderson (CR48) 2004; 14 Amodio (CR45) 2010; 177 Li (CR62) 2018; 39 Dong (CR77) 2012; 44 Cheng (CR44) 2014; 3 Yang (CR79) 2012; 44 Moyerbrailean (CR81) 2016; 26 Finucane (CR36) 2018; 50 Chang (CR84) 2017; 195 Seow (CR59) 2014; 74 Gusev (CR85) 2016; 48 Bulik-Sullivan (CR27) 2015; 47 Plantier (CR66) 2012; 287 Dong (CR28) 2017; 141 Zhang (CR58) 2015; 24 Hung (CR22) 2008; 452 Matakidou, Eisen, Houlston (CR29) 2005; 93 Miki (CR14) 2010; 42 CR25 Wang (CR17) 2014; 46 Timofeeva (CR31) 2012; 21 Breeze (CR35) 2022; 23 Verbanck, Chen, Neale, Do (CR55) 2018; 50 Wang (CR11) 2016; 25 Ward, Kellis (CR34) 2016; 44 Zhang (CR61) 2014; 35 Wang (CR20) 2008; 40 Stanley (CR50) 2016; 8 Lan (CR9) 2012; 44 Maas (CR64) 2016; 2 Carrot-Zhang (CR73) 2021; 11 Machiela (CR56) 2015; 137 Hung (CR21) 2019; 14 DD Sin (38196_CR47) 2013; 31 A Matakidou (38196_CR29) 2005; 93 R Zhang (38196_CR61) 2014; 35 D Miki (38196_CR14) 2010; 42 FL Kinoshita (38196_CR5) 2016; 26 B Lehner (38196_CR48) 2004; 14 YS Choi (38196_CR67) 2009; 329 DH Moon (38196_CR49) 2015; 47 Q Lan (38196_CR9) 2012; 44 JD McKay (38196_CR16) 2017; 49 SE Stanley (38196_CR50) 2016; 8 J Sisti (38196_CR7) 2012; 131 G Sarek (38196_CR52) 2015; 57 38196_CR25 H Cheng (38196_CR44) 2014; 3 CE Breeze (38196_CR35) 2022; 23 JB Vannier (38196_CR51) 2012; 149 LC Cantley (38196_CR46) 1999; 96 J Yang (38196_CR79) 2012; 44 P Maas (38196_CR64) 2016; 2 B Blechter (38196_CR71) 2021; 147 HK Finucane (38196_CR80) 2015; 47 J Dong (38196_CR77) 2012; 44 CA Hsiung (38196_CR12) 2010; 6 F Bray (38196_CR1) 2018; 68 JA Barta (38196_CR3) 2019; 85 38196_CR8 J Chen (38196_CR72) 2020; 52 AT Margaret (38196_CR54) 2022; 2 B Bulik-Sullivan (38196_CR27) 2015; 47 N Amodio (38196_CR45) 2010; 177 A Gusev (38196_CR85) 2016; 48 Y Zhang (38196_CR26) 2018; 50 Y Li (38196_CR62) 2018; 39 IS Chang (38196_CR84) 2017; 195 J Beane (38196_CR83) 2011; 4 G Pan (38196_CR39) 2017; 45 R Chakrabarti (38196_CR68) 2012; 14 SR Oakes (38196_CR42) 2008; 22 TY Cheng (38196_CR2) 2016; 11 L Plantier (38196_CR66) 2012; 287 Y Miyake (38196_CR53) 2009; 36 K Shiraishi (38196_CR15) 2012; 44 J Dai (38196_CR24) 2019; 7 C Zhang (38196_CR58) 2015; 24 R Zhao (38196_CR41) 2020; 11 J Carrot-Zhang (38196_CR73) 2021; 11 Y Wang (38196_CR17) 2014; 46 RJ Hung (38196_CR21) 2019; 14 LH Chien (38196_CR75) 2020; 29 V Emilsson (38196_CR69) 2018; 361 M Cao (38196_CR4) 2019; 10 J Dong (38196_CR28) 2017; 141 AC Tan (38196_CR43) 2020; 11 GA Moyerbrailean (38196_CR81) 2016; 26 Z Wang (38196_CR11) 2016; 25 I Angelidis (38196_CR65) 2019; 10 WJ Seow (38196_CR13) 2017; 26 MN Timofeeva (38196_CR31) 2012; 21 C Benner (38196_CR32) 2016; 32 MT Landi (38196_CR18) 2009; 85 M Verbanck (38196_CR55) 2018; 50 Z Hu (38196_CR10) 2011; 43 Y Wang (38196_CR20) 2008; 40 Brown BC, Asian Genetic Epidemiology Network Type 2 Diabetes C, Ye CJ, Price AL, Zaitlen N. (38196_CR60) 2016; 99 C Wu (38196_CR23) 2009; 69 K Shiraishi (38196_CR76) 2016; 7 C Glaser (38196_CR40) 2010; 59 Y Bosse (38196_CR82) 2012; 72 C Telomeres Mendelian Randomization (38196_CR57) 2017; 3 YD Zhang (38196_CR63) 2020; 11 A Nagai (38196_CR30) 2017; 27 MJ Machiela (38196_CR56) 2015; 137 RJ Hung (38196_CR22) 2008; 452 M Mangino (38196_CR87) 2012; 21 AP Boyle (38196_CR33) 2012; 22 HA Katki (38196_CR74) 2016; 315 M Verbanck (38196_CR86) 2018; 50 MT Landi (38196_CR6) 2021; 190 38196_CR78 F Hormozdiari (38196_CR37) 2016; 99 A Hamvas (38196_CR70) 2007; 62 CI Amos (38196_CR19) 2008; 40 HK Finucane (38196_CR36) 2018; 50 CN Foley (38196_CR38) 2021; 12 WJ Seow (38196_CR59) 2014; 74 LD Ward (38196_CR34) 2016; 44 |
| References_xml | – volume: 190 start-page: 962 year: 2021 end-page: 976 ident: CR6 article-title: Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwaa234 – volume: 452 start-page: 633 year: 2008 end-page: 637 ident: CR22 article-title: A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 publication-title: Nature doi: 10.1038/nature06885 – volume: 47 start-page: 1228 year: 2015 end-page: 1235 ident: CR80 article-title: Partitioning heritability by functional annotation using genome-wide association summary statistics publication-title: Nat. Genet. doi: 10.1038/ng.3404 – volume: 11 start-page: 511 year: 2020 end-page: 518 ident: CR43 article-title: Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC) publication-title: Thorac. Cancer doi: 10.1111/1759-7714.13328 – volume: 147 start-page: 105975 year: 2021 ident: CR71 article-title: Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia publication-title: Environ. Int doi: 10.1016/j.envint.2020.105975 – volume: 4 start-page: 803 year: 2011 end-page: 817 ident: CR83 article-title: Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq publication-title: Cancer Prev. Res. (Philos.) doi: 10.1158/1940-6207.CAPR-11-0212 – volume: 59 start-page: 993 year: 2010 end-page: 999 ident: CR40 article-title: Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism publication-title: Metabolism doi: 10.1016/j.metabol.2009.10.022 – volume: 25 start-page: 620 year: 2016 end-page: 629 ident: CR11 article-title: Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddv494 – volume: 23 year: 2022 ident: CR35 article-title: Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associations publication-title: Genome Biol. doi: 10.1186/s13059-021-02560-3 – volume: 44 start-page: D877 year: 2016 end-page: D881 ident: CR34 article-title: HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1340 – volume: 29 start-page: 452 year: 2020 end-page: 459 ident: CR75 article-title: Predicting Lung Cancer Occurrence in Never-Smoking Females in Asia: TNSF-SQ, a Prediction Model publication-title: Cancer Epidemiol. Biomark. Prev. doi: 10.1158/1055-9965.EPI-19-1221 – volume: 40 start-page: 1407 year: 2008 end-page: 1409 ident: CR20 article-title: Common 5p15.33 and 6p21.33 variants influence lung cancer risk publication-title: Nat. Genet. doi: 10.1038/ng.273 – volume: 44 start-page: 895 year: 2012 end-page: 899 ident: CR77 article-title: Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population publication-title: Nat. Genet. doi: 10.1038/ng.2351 – volume: 2 start-page: 100084 year: 2022 ident: CR54 article-title: Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMed publication-title: Cell Genom. doi: 10.1016/j.xgen.2021.100084 – volume: 99 start-page: 1245 year: 2016 end-page: 1260 ident: CR37 article-title: Colocalization of GWAS and eQTL Signals Detects Target Genes publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2016.10.003 – volume: 7 start-page: 881 year: 2019 end-page: 891 ident: CR24 article-title: Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations publication-title: Lancet Respir. Med. doi: 10.1016/S2213-2600(19)30144-4 – volume: 21 start-page: 5385 year: 2012 end-page: 5394 ident: CR87 article-title: Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds382 – volume: 12 year: 2021 ident: CR38 article-title: A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits publication-title: Nat. Commun. doi: 10.1038/s41467-020-20885-8 – volume: 361 start-page: 769 year: 2018 end-page: 773 ident: CR69 article-title: Co-regulatory networks of human serum proteins link genetics to disease publication-title: Science doi: 10.1126/science.aaq1327 – ident: CR8 – volume: 31 start-page: 4536 year: 2013 end-page: 4543 ident: CR47 article-title: Pro-surfactant protein B as a biomarker for lung cancer prediction publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2013.50.6105 – volume: 50 start-page: 1196 year: 2018 ident: CR55 article-title: Publisher Correction: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases publication-title: Nat. Genet. doi: 10.1038/s41588-018-0164-2 – volume: 48 start-page: 245 year: 2016 end-page: 252 ident: CR85 article-title: Integrative approaches for large-scale transcriptome-wide association studies publication-title: Nat. Genet. doi: 10.1038/ng.3506 – ident: CR25 – volume: 21 start-page: 4980 year: 2012 end-page: 4995 ident: CR31 article-title: Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds334 – volume: 44 start-page: 369 year: 2012 end-page: 375 ident: CR79 article-title: Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits publication-title: Nat. Genet. doi: 10.1038/ng.2213 – volume: 74 start-page: 4090 year: 2014 end-page: 4098 ident: CR59 article-title: Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0459 – volume: 287 start-page: 10099 year: 2012 end-page: 10114 ident: CR66 article-title: Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.303669 – volume: 46 start-page: 736 year: 2014 end-page: 741 ident: CR17 article-title: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer publication-title: Nat. Genet. doi: 10.1038/ng.3002 – volume: 32 start-page: 1493 year: 2016 end-page: 1501 ident: CR32 article-title: FINEMAP: efficient variable selection using summary data from genome-wide association studies publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw018 – volume: 43 start-page: 792 year: 2011 end-page: 796 ident: CR10 article-title: A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese publication-title: Nat. Genet. doi: 10.1038/ng.875 – volume: 50 start-page: 621 year: 2018 end-page: 629 ident: CR36 article-title: Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types publication-title: Nat. Genet. doi: 10.1038/s41588-018-0081-4 – volume: 52 start-page: 177 year: 2020 end-page: 186 ident: CR72 article-title: Genomic landscape of lung adenocarcinoma in East Asians publication-title: Nat. Genet. doi: 10.1038/s41588-019-0569-6 – volume: 195 start-page: 663 year: 2017 end-page: 673 ident: CR84 article-title: Genetic Modifiers of Progression-Free Survival in Never-Smoking Lung Adenocarcinoma Patients Treated with First-Line Tyrosine Kinase Inhibitors publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201602-0300OC – volume: 44 start-page: 1330 year: 2012 end-page: 1335 ident: CR9 article-title: Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia publication-title: Nat. Genet. doi: 10.1038/ng.2456 – volume: 93 start-page: 825 year: 2005 end-page: 833 ident: CR29 article-title: Systematic review of the relationship between family history and lung cancer risk publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602769 – volume: 57 start-page: 622 year: 2015 end-page: 635 ident: CR52 article-title: TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.12.024 – volume: 44 start-page: 900 year: 2012 end-page: 903 ident: CR15 article-title: A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population publication-title: Nat. Genet. doi: 10.1038/ng.2353 – volume: 22 start-page: 581 year: 2008 end-page: 586 ident: CR42 article-title: The Ets transcription factor Elf5 specifies mammary alveolar cell fate publication-title: Genes Dev. doi: 10.1101/gad.1614608 – volume: 329 start-page: 227 year: 2009 end-page: 241 ident: CR67 article-title: Elf5 conditional knockout mice reveal its role as a master regulator in mammary alveolar development: failure of Stat5 activation and functional differentiation in the absence of Elf5 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2009.02.032 – volume: 137 start-page: 311 year: 2015 end-page: 319 ident: CR56 article-title: Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia publication-title: Int J. Cancer doi: 10.1002/ijc.29393 – ident: CR78 – volume: 11 year: 2020 ident: CR63 article-title: Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers publication-title: Nat. Commun. doi: 10.1038/s41467-020-16483-3 – volume: 131 start-page: 265 year: 2012 end-page: 275 ident: CR7 article-title: What proportion of lung cancer in never-smokers can be attributed to known risk factors? publication-title: Int J. Cancer doi: 10.1002/ijc.27477 – volume: 27 start-page: S2 year: 2017 end-page: S8 ident: CR30 article-title: Overview of the BioBank Japan Project: Study design and profile publication-title: J. Epidemiol. doi: 10.1016/j.je.2016.12.005 – volume: 315 start-page: 2300 year: 2016 end-page: 2311 ident: CR74 article-title: Development and Validation of Risk Models to Select Ever-Smokers for CT Lung Cancer Screening publication-title: JAMA doi: 10.1001/jama.2016.6255 – volume: 14 start-page: 1212 year: 2012 end-page: 1222 ident: CR68 article-title: Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2607 – volume: 62 start-page: 170 year: 2007 end-page: 175 ident: CR70 article-title: Comprehensive genetic variant discovery in the surfactant protein B gene publication-title: Pediatr. Res. doi: 10.1203/PDR.0b013e3180a03232 – volume: 7 year: 2016 ident: CR76 article-title: Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma publication-title: Nat. Commun. doi: 10.1038/ncomms12451 – volume: 47 start-page: 1236 year: 2015 end-page: 1241 ident: CR27 article-title: An atlas of genetic correlations across human diseases and traits publication-title: Nat. Genet. doi: 10.1038/ng.3406 – volume: 85 start-page: 8 year: 2019 ident: CR3 article-title: Global Epidemiology of Lung Cancer publication-title: Ann. Glob. Health doi: 10.5334/aogh.2419 – volume: 96 start-page: 4240 year: 1999 end-page: 4245 ident: CR46 article-title: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway publication-title: Proc. Natl Acad. Sci. U. S. A doi: 10.1073/pnas.96.8.4240 – volume: 24 start-page: 5356 year: 2015 end-page: 5366 ident: CR58 article-title: Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddv252 – volume: 42 start-page: 893 year: 2010 end-page: 896 ident: CR14 article-title: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations publication-title: Nat. Genet. doi: 10.1038/ng.667 – volume: 3 start-page: 67 year: 2014 end-page: 75 ident: CR44 article-title: Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment publication-title: Lung Cancer Manag. doi: 10.2217/lmt.13.72 – volume: 47 start-page: 1482 year: 2015 end-page: 1488 ident: CR49 article-title: Poly(A)-specific ribonuclease (PARN) mediates 3’-end maturation of the telomerase RNA component publication-title: Nat. Genet. doi: 10.1038/ng.3423 – volume: 26 start-page: 1627 year: 2016 end-page: 1638 ident: CR81 article-title: High-throughput allele-specific expression across 250 environmental conditions publication-title: Genome Res. doi: 10.1101/gr.209759.116 – volume: 40 start-page: 616 year: 2008 end-page: 622 ident: CR19 article-title: Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 publication-title: Nat. Genet. doi: 10.1038/ng.109 – volume: 11 start-page: 591 year: 2021 end-page: 598 ident: CR73 article-title: Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations publication-title: Cancer Disco. doi: 10.1158/2159-8290.CD-20-1165 – volume: 50 start-page: 1318 year: 2018 end-page: 1326 ident: CR26 article-title: Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits publication-title: Nat. Genet. doi: 10.1038/s41588-018-0193-x – volume: 10 start-page: 3 year: 2019 end-page: 7 ident: CR4 article-title: Epidemiology of lung cancer in China publication-title: Thorac. Cancer doi: 10.1111/1759-7714.12916 – volume: 11 year: 2020 ident: CR41 article-title: FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling publication-title: Cell Death Dis. doi: 10.1038/s41419-020-2457-5 – volume: 99 start-page: 76 year: 2016 end-page: 88 ident: CR60 article-title: Transethnic Genetic-Correlation Estimates from Summary Statistics publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2016.05.001 – volume: 68 start-page: 394 year: 2018 end-page: 424 ident: CR1 article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21492 – volume: 35 start-page: 1528 year: 2014 end-page: 1535 ident: CR61 article-title: A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility publication-title: Carcinogenesis doi: 10.1093/carcin/bgu076 – volume: 49 start-page: 1126 year: 2017 end-page: 1132 ident: CR16 article-title: Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes publication-title: Nat. Genet. doi: 10.1038/ng.3892 – volume: 26 start-page: 454 year: 2017 end-page: 465 ident: CR13 article-title: Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations publication-title: Hum. Mol. Genet. – volume: 85 start-page: 679 year: 2009 end-page: 691 ident: CR18 article-title: A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.09.012 – volume: 14 start-page: 1360 year: 2019 end-page: 1369 ident: CR21 article-title: Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region publication-title: J. Thorac. Oncol. doi: 10.1016/j.jtho.2019.04.008 – volume: 14 start-page: 1315 year: 2004 end-page: 1323 ident: CR48 article-title: A protein interaction framework for human mRNA degradation publication-title: Genome Res. doi: 10.1101/gr.2122004 – volume: 22 start-page: 1790 year: 2012 end-page: 1797 ident: CR33 article-title: Annotation of functional variation in personal genomes using RegulomeDB publication-title: Genome Res. doi: 10.1101/gr.137323.112 – volume: 149 start-page: 795 year: 2012 end-page: 806 ident: CR51 article-title: RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity publication-title: Cell doi: 10.1016/j.cell.2012.03.030 – volume: 3 start-page: 636 year: 2017 end-page: 651 ident: CR57 article-title: Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.5945 – volume: 2 start-page: 1295 year: 2016 end-page: 1302 ident: CR64 article-title: Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.1025 – volume: 177 start-page: 2622 year: 2010 end-page: 2634 ident: CR45 article-title: Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2010.091075 – volume: 11 start-page: 1653 year: 2016 end-page: 1671 ident: CR2 article-title: The International Epidemiology of Lung Cancer: Latest Trends, Disparities, and Tumor Characteristics publication-title: J. Thorac. Oncol. doi: 10.1016/j.jtho.2016.05.021 – volume: 72 start-page: 3753 year: 2012 end-page: 3763 ident: CR82 article-title: Molecular signature of smoking in human lung tissues publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-1160 – volume: 8 start-page: 351ra107 year: 2016 ident: CR50 article-title: Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaf7837 – volume: 45 start-page: 2408 year: 2017 end-page: 2422 ident: CR39 article-title: PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw1186 – volume: 50 start-page: 693 year: 2018 end-page: 698 ident: CR86 article-title: Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases publication-title: Nat. Genet. doi: 10.1038/s41588-018-0099-7 – volume: 6 start-page: e1001051 year: 2010 ident: CR12 article-title: The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001051 – volume: 36 start-page: 193 year: 2009 end-page: 206 ident: CR53 article-title: RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.08.009 – volume: 26 start-page: 579 year: 2016 end-page: 586 ident: CR5 article-title: Trends in Lung Cancer Incidence Rates by Histological Type in 1975-2008: A Population-Based Study in Osaka, Japan publication-title: J. Epidemiol. doi: 10.2188/jea.JE20150257 – volume: 39 start-page: 336 year: 2018 end-page: 346 ident: CR62 article-title: Genome-wide interaction study of smoking behavior and non-small cell lung cancer risk in Caucasian population publication-title: Carcinogenesis doi: 10.1093/carcin/bgx113 – volume: 69 start-page: 5065 year: 2009 end-page: 5072 ident: CR23 article-title: Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-0081 – volume: 10 year: 2019 ident: CR65 article-title: An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics publication-title: Nat. Commun. doi: 10.1038/s41467-019-08831-9 – volume: 141 start-page: 447 year: 2017 end-page: 456 ident: CR28 article-title: Fine mapping of chromosome 5p15.33 identifies novel lung cancer susceptibility loci in Han Chinese publication-title: Int J. Cancer doi: 10.1002/ijc.30702 – volume: 62 start-page: 170 year: 2007 ident: 38196_CR70 publication-title: Pediatr. Res. doi: 10.1203/PDR.0b013e3180a03232 – volume: 32 start-page: 1493 year: 2016 ident: 38196_CR32 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw018 – volume: 6 start-page: e1001051 year: 2010 ident: 38196_CR12 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1001051 – volume: 96 start-page: 4240 year: 1999 ident: 38196_CR46 publication-title: Proc. Natl Acad. Sci. U. S. A doi: 10.1073/pnas.96.8.4240 – volume: 3 start-page: 636 year: 2017 ident: 38196_CR57 publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.5945 – volume: 39 start-page: 336 year: 2018 ident: 38196_CR62 publication-title: Carcinogenesis doi: 10.1093/carcin/bgx113 – volume: 14 start-page: 1212 year: 2012 ident: 38196_CR68 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2607 – volume: 14 start-page: 1360 year: 2019 ident: 38196_CR21 publication-title: J. Thorac. Oncol. doi: 10.1016/j.jtho.2019.04.008 – volume: 27 start-page: S2 year: 2017 ident: 38196_CR30 publication-title: J. Epidemiol. doi: 10.1016/j.je.2016.12.005 – volume: 147 start-page: 105975 year: 2021 ident: 38196_CR71 publication-title: Environ. Int doi: 10.1016/j.envint.2020.105975 – volume: 329 start-page: 227 year: 2009 ident: 38196_CR67 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2009.02.032 – volume: 141 start-page: 447 year: 2017 ident: 38196_CR28 publication-title: Int J. Cancer doi: 10.1002/ijc.30702 – volume: 44 start-page: 900 year: 2012 ident: 38196_CR15 publication-title: Nat. Genet. doi: 10.1038/ng.2353 – volume: 25 start-page: 620 year: 2016 ident: 38196_CR11 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddv494 – volume: 50 start-page: 693 year: 2018 ident: 38196_CR86 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0099-7 – volume: 137 start-page: 311 year: 2015 ident: 38196_CR56 publication-title: Int J. Cancer doi: 10.1002/ijc.29393 – volume: 11 year: 2020 ident: 38196_CR63 publication-title: Nat. Commun. doi: 10.1038/s41467-020-16483-3 – volume: 26 start-page: 454 year: 2017 ident: 38196_CR13 publication-title: Hum. Mol. Genet. – volume: 2 start-page: 100084 year: 2022 ident: 38196_CR54 publication-title: Cell Genom. doi: 10.1016/j.xgen.2021.100084 – volume: 99 start-page: 76 year: 2016 ident: 38196_CR60 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2016.05.001 – volume: 131 start-page: 265 year: 2012 ident: 38196_CR7 publication-title: Int J. Cancer doi: 10.1002/ijc.27477 – volume: 99 start-page: 1245 year: 2016 ident: 38196_CR37 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2016.10.003 – volume: 47 start-page: 1482 year: 2015 ident: 38196_CR49 publication-title: Nat. Genet. doi: 10.1038/ng.3423 – volume: 44 start-page: 369 year: 2012 ident: 38196_CR79 publication-title: Nat. Genet. doi: 10.1038/ng.2213 – volume: 4 start-page: 803 year: 2011 ident: 38196_CR83 publication-title: Cancer Prev. Res. (Philos.) doi: 10.1158/1940-6207.CAPR-11-0212 – volume: 44 start-page: D877 year: 2016 ident: 38196_CR34 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1340 – volume: 177 start-page: 2622 year: 2010 ident: 38196_CR45 publication-title: Am. J. Pathol. doi: 10.2353/ajpath.2010.091075 – volume: 195 start-page: 663 year: 2017 ident: 38196_CR84 publication-title: Am. J. Respir. Crit. Care Med. doi: 10.1164/rccm.201602-0300OC – volume: 85 start-page: 679 year: 2009 ident: 38196_CR18 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2009.09.012 – volume: 40 start-page: 1407 year: 2008 ident: 38196_CR20 publication-title: Nat. Genet. doi: 10.1038/ng.273 – volume: 11 start-page: 1653 year: 2016 ident: 38196_CR2 publication-title: J. Thorac. Oncol. doi: 10.1016/j.jtho.2016.05.021 – volume: 46 start-page: 736 year: 2014 ident: 38196_CR17 publication-title: Nat. Genet. doi: 10.1038/ng.3002 – volume: 452 start-page: 633 year: 2008 ident: 38196_CR22 publication-title: Nature doi: 10.1038/nature06885 – volume: 3 start-page: 67 year: 2014 ident: 38196_CR44 publication-title: Lung Cancer Manag. doi: 10.2217/lmt.13.72 – volume: 21 start-page: 4980 year: 2012 ident: 38196_CR31 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds334 – volume: 45 start-page: 2408 year: 2017 ident: 38196_CR39 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw1186 – volume: 22 start-page: 581 year: 2008 ident: 38196_CR42 publication-title: Genes Dev. doi: 10.1101/gad.1614608 – volume: 40 start-page: 616 year: 2008 ident: 38196_CR19 publication-title: Nat. Genet. doi: 10.1038/ng.109 – volume: 49 start-page: 1126 year: 2017 ident: 38196_CR16 publication-title: Nat. Genet. doi: 10.1038/ng.3892 – volume: 69 start-page: 5065 year: 2009 ident: 38196_CR23 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-0081 – volume: 11 year: 2020 ident: 38196_CR41 publication-title: Cell Death Dis. doi: 10.1038/s41419-020-2457-5 – volume: 68 start-page: 394 year: 2018 ident: 38196_CR1 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21492 – volume: 26 start-page: 1627 year: 2016 ident: 38196_CR81 publication-title: Genome Res. doi: 10.1101/gr.209759.116 – volume: 36 start-page: 193 year: 2009 ident: 38196_CR53 publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.08.009 – volume: 315 start-page: 2300 year: 2016 ident: 38196_CR74 publication-title: JAMA doi: 10.1001/jama.2016.6255 – volume: 59 start-page: 993 year: 2010 ident: 38196_CR40 publication-title: Metabolism doi: 10.1016/j.metabol.2009.10.022 – volume: 21 start-page: 5385 year: 2012 ident: 38196_CR87 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/dds382 – volume: 85 start-page: 8 year: 2019 ident: 38196_CR3 publication-title: Ann. Glob. Health doi: 10.5334/aogh.2419 – volume: 57 start-page: 622 year: 2015 ident: 38196_CR52 publication-title: Mol. Cell doi: 10.1016/j.molcel.2014.12.024 – volume: 11 start-page: 591 year: 2021 ident: 38196_CR73 publication-title: Cancer Disco. doi: 10.1158/2159-8290.CD-20-1165 – volume: 10 year: 2019 ident: 38196_CR65 publication-title: Nat. Commun. doi: 10.1038/s41467-019-08831-9 – ident: 38196_CR8 doi: 10.1093/acprof:oso/9780195149616.001.0001 – volume: 31 start-page: 4536 year: 2013 ident: 38196_CR47 publication-title: J. Clin. Oncol. doi: 10.1200/JCO.2013.50.6105 – volume: 44 start-page: 895 year: 2012 ident: 38196_CR77 publication-title: Nat. Genet. doi: 10.1038/ng.2351 – volume: 2 start-page: 1295 year: 2016 ident: 38196_CR64 publication-title: JAMA Oncol. doi: 10.1001/jamaoncol.2016.1025 – volume: 149 start-page: 795 year: 2012 ident: 38196_CR51 publication-title: Cell doi: 10.1016/j.cell.2012.03.030 – volume: 190 start-page: 962 year: 2021 ident: 38196_CR6 publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwaa234 – volume: 11 start-page: 511 year: 2020 ident: 38196_CR43 publication-title: Thorac. Cancer doi: 10.1111/1759-7714.13328 – volume: 47 start-page: 1228 year: 2015 ident: 38196_CR80 publication-title: Nat. Genet. doi: 10.1038/ng.3404 – volume: 24 start-page: 5356 year: 2015 ident: 38196_CR58 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddv252 – volume: 23 year: 2022 ident: 38196_CR35 publication-title: Genome Biol. doi: 10.1186/s13059-021-02560-3 – volume: 52 start-page: 177 year: 2020 ident: 38196_CR72 publication-title: Nat. Genet. doi: 10.1038/s41588-019-0569-6 – volume: 10 start-page: 3 year: 2019 ident: 38196_CR4 publication-title: Thorac. Cancer doi: 10.1111/1759-7714.12916 – volume: 8 start-page: 351ra107 year: 2016 ident: 38196_CR50 publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaf7837 – volume: 7 year: 2016 ident: 38196_CR76 publication-title: Nat. Commun. doi: 10.1038/ncomms12451 – volume: 50 start-page: 621 year: 2018 ident: 38196_CR36 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0081-4 – volume: 74 start-page: 4090 year: 2014 ident: 38196_CR59 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-0459 – volume: 42 start-page: 893 year: 2010 ident: 38196_CR14 publication-title: Nat. Genet. doi: 10.1038/ng.667 – volume: 50 start-page: 1318 year: 2018 ident: 38196_CR26 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0193-x – volume: 361 start-page: 769 year: 2018 ident: 38196_CR69 publication-title: Science doi: 10.1126/science.aaq1327 – volume: 29 start-page: 452 year: 2020 ident: 38196_CR75 publication-title: Cancer Epidemiol. Biomark. Prev. doi: 10.1158/1055-9965.EPI-19-1221 – volume: 47 start-page: 1236 year: 2015 ident: 38196_CR27 publication-title: Nat. Genet. doi: 10.1038/ng.3406 – volume: 50 start-page: 1196 year: 2018 ident: 38196_CR55 publication-title: Nat. Genet. doi: 10.1038/s41588-018-0164-2 – volume: 35 start-page: 1528 year: 2014 ident: 38196_CR61 publication-title: Carcinogenesis doi: 10.1093/carcin/bgu076 – volume: 14 start-page: 1315 year: 2004 ident: 38196_CR48 publication-title: Genome Res. doi: 10.1101/gr.2122004 – ident: 38196_CR78 doi: 10.1002/cam4.1557 – volume: 48 start-page: 245 year: 2016 ident: 38196_CR85 publication-title: Nat. Genet. doi: 10.1038/ng.3506 – volume: 44 start-page: 1330 year: 2012 ident: 38196_CR9 publication-title: Nat. Genet. doi: 10.1038/ng.2456 – volume: 22 start-page: 1790 year: 2012 ident: 38196_CR33 publication-title: Genome Res. doi: 10.1101/gr.137323.112 – volume: 287 start-page: 10099 year: 2012 ident: 38196_CR66 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.303669 – volume: 43 start-page: 792 year: 2011 ident: 38196_CR10 publication-title: Nat. Genet. doi: 10.1038/ng.875 – volume: 26 start-page: 579 year: 2016 ident: 38196_CR5 publication-title: J. Epidemiol. doi: 10.2188/jea.JE20150257 – volume: 93 start-page: 825 year: 2005 ident: 38196_CR29 publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6602769 – volume: 12 year: 2021 ident: 38196_CR38 publication-title: Nat. Commun. doi: 10.1038/s41467-020-20885-8 – volume: 7 start-page: 881 year: 2019 ident: 38196_CR24 publication-title: Lancet Respir. Med. doi: 10.1016/S2213-2600(19)30144-4 – volume: 72 start-page: 3753 year: 2012 ident: 38196_CR82 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-1160 – ident: 38196_CR25 |
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| Snippet | Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we... Abstract Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability.... |
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| SubjectTerms | 38/43 631/208/205/2138 631/67/2324 Adenocarcinoma Adenocarcinoma of Lung - genetics Asia, Eastern - epidemiology Cancer Chromosome 11 Chromosome 2 Gene loci Gene mapping Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Heritability Humanities and Social Sciences Humans Lung cancer Lung Neoplasms - epidemiology Lung Neoplasms - genetics multidisciplinary Polygenic inheritance Polymorphism, Single Nucleotide Population studies Populations Quantitative trait loci Risk Science Science (multidisciplinary) Smoking Transcriptomes |
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| Title | Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population |
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