Can flow proneness be protective against mental and cardiovascular health problems? A genetically informed prospective cohort study

• Published in: Translational psychiatry Vol. 14; no. 1; pp. 144 - 8
• Main Authors: Gaston, Emma, Ullén, Fredrik, Wesseldijk, Laura W., Mosing, Miriam A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.03.2024; Nature Publishing Group
• Subjects: 631/477/2811; 692/53/2421; 692/699/476/1333; 692/699/476/1414; 692/699/476/1799; Anxiety; Anxiety Disorders - genetics; Behavioral Sciences; Biological Psychology; Bipolar disorder; Cross-Sectional Studies; Humans; Medicine; Medicine & Public Health; Mental depression; Neurosciences; Pharmacotherapy; Prospective Studies; Psychiatry; Schizophrenia; Twins, Dizygotic - genetics; Twins, Monozygotic - genetics
• ISSN: 2158-3188; 2158-3188
• DOI: 10.1038/s41398-024-02855-6

Flow is a phenomenon where one experiences optimal challenge, marked by an intense, effortless, and rewarding concentration on a task. Past research shows that flow proneness is associated with good mental and cardiovascular health. However, this research has been primarily cross-sectional, based on self-report data, and has not controlled for potential confounding effects of neuroticism. In a large, longitudinal twin sample ( N  = 9361), we used nationwide patient registry data to test whether flow proneness predicted registry-based diagnoses of depression, anxiety, schizophrenia, bipolar disorder, stress-related disorders, or cardiovascular diseases. We used survival analyses taking time to diagnosis into account to test if (a) there is a relationship between flow proneness and health diagnoses over time, (b) neuroticism confounds this relationship, and (c) the relationship remains present within discordant monozygotic twin pairs ( N  = 952), thereby controlling for genetic and shared environmental confounding. Individuals with higher flow proneness had a decreased risk of receiving diagnoses for depression (16%; CI [14%, 18%]), anxiety (16%; CI [13%, 18%]), schizophrenia (15%; CI [4%, 25%]), bipolar (12%; CI [6%, 18%]), stress-related (9%; CI [9%, 12%]), and cardiovascular disorders (4%; CI [1%, 8%]). When controlling for neuroticism, higher flow proneness still decreased the risk of depression (6%; CI [3%, 9%]) and anxiety diagnoses (5%; CI [1%, 8%]). Monozygotic twins who experienced more flow than their co-twin had a lower risk for depression (16%; CI [5%, 26%]) and anxiety (13%; CI [1%, 24%]), though only the association with depression remained significant when also controlling for neuroticism (13%; CI [1%, 24%]). Findings are in line with a causal protective role of flow experiences on depression and potentially anxiety and highlight that neuroticism and familial factors are notable confounding factors in observed associations between flow proneness and health outcomes.