Melatonin improves quality and longevity of chronic neural recording
The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) in...
Saved in:
| Published in | Biomaterials Vol. 180; pp. 225 - 239 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Ltd
01.10.2018
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0142-9612 1878-5905 1878-5905 |
| DOI | 10.1016/j.biomaterials.2018.07.026 |
Cover
| Abstract | The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration by inhibiting caspase-1, -3, and -9 activation and mitochondrial cytochrome c release, as well as reducing oxidative stress and neuroinflammation. This study examined the effect of MT administration on the quality and longevity of neural recording from an implanted microelectrode in the visual cortex of mice for 16 weeks. MT (30 mg/kg) was administered via daily intraperitoneal injection for acute (3 days before and 14 days post-implantation) and chronic (3 days before and 16 weeks post-implantation) exposures. During the first 4 weeks, both MT groups showed significantly higher single-unit (SU) yield, signal-to-noise ratio (SNR), and amplitude compared to the vehicle control group. However, after 4 weeks of implantation, the SU yield of the acute treatment group dropped to the same level as the control group, while the chronic treatment group maintained significantly higher SU yield compared to both acute (week 5–16) and control (week 0–16) mice. Histological studies revealed a significant increase in neuronal viability and decrease in neuronal apoptosis around the implanted electrode at week 16 in the chronic group in comparison to control and acute subjects, which is correlated with reduced oxidative stress and increased number of pro-regeneration arginase-1 positive microglia cells. These results demonstrate the potent effect of MT treatment in maintaining a high-quality electrode-tissue interface and suggest that MT promotes neuroprotection possibly through its anti-apoptotic, anti-inflammatory, and anti-oxidative properties. |
|---|---|
| AbstractList | The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration by inhibiting caspase−1, −3 and −9 activation and mitochondrial cytochrome c release, as well as reducing oxidative stress and neuroinflammation. This study examined the effect of MT administration on the quality and longevity of neural recording from implanted microelectrode in the visual cortex of mice for 16 weeks. MT (30 mg/kg) was administered via daily intraperitoneal injection for acute (3 days before and 14 days post implantation) and chronic (3 days before and 16 weeks post implantation) exposures. During the first 4 weeks, both MT groups showed significantly higher single-unit (SU) yield, signal-to-noise ratio (SNR), and amplitude compared to the vehicle control group. However, after 4 weeks of implantation, the SU yield of the acute treatment group dropped to the same level as control group, while the chronic treatment group maintained significantly higher SU yield compared to both acute (week 5–16) and control (week 0–16) mice. Histological studies revealed a significant increase in neuronal viability and decrease in neuronal apoptosis around implanted electrode at week 16 in the chronic group in comparison to control and acute subjects, which is correlated with reduced oxidative stress and increased number of pro-regeneration arginase-1 positive microglia cells. These results demonstrate the potent effect of MT treatment in maintaining a high quality electrode-tissue interface and suggest that MT promotes neuroprotection possibly through its anti-apoptotic, anti-inflammatory and anti-oxidative properties. This study demonstrated the potent effect of melatonin treatment in inhibiting persistent inflammation and neuronal loss, as well as maintaining high quality neural recording in chronic microelectrode brain implantation. The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration by inhibiting caspase-1, -3, and -9 activation and mitochondrial cytochrome c release, as well as reducing oxidative stress and neuroinflammation. This study examined the effect of MT administration on the quality and longevity of neural recording from an implanted microelectrode in the visual cortex of mice for 16 weeks. MT (30 mg/kg) was administered via daily intraperitoneal injection for acute (3 days before and 14 days post-implantation) and chronic (3 days before and 16 weeks post-implantation) exposures. During the first 4 weeks, both MT groups showed significantly higher single-unit (SU) yield, signal-to-noise ratio (SNR), and amplitude compared to the vehicle control group. However, after 4 weeks of implantation, the SU yield of the acute treatment group dropped to the same level as the control group, while the chronic treatment group maintained significantly higher SU yield compared to both acute (week 5–16) and control (week 0–16) mice. Histological studies revealed a significant increase in neuronal viability and decrease in neuronal apoptosis around the implanted electrode at week 16 in the chronic group in comparison to control and acute subjects, which is correlated with reduced oxidative stress and increased number of pro-regeneration arginase-1 positive microglia cells. These results demonstrate the potent effect of MT treatment in maintaining a high-quality electrode-tissue interface and suggest that MT promotes neuroprotection possibly through its anti-apoptotic, anti-inflammatory, and anti-oxidative properties. The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration by inhibiting caspase-1, -3, and -9 activation and mitochondrial cytochrome c release, as well as reducing oxidative stress and neuroinflammation. This study examined the effect of MT administration on the quality and longevity of neural recording from an implanted microelectrode in the visual cortex of mice for 16 weeks. MT (30 mg/kg) was administered via daily intraperitoneal injection for acute (3 days before and 14 days post-implantation) and chronic (3 days before and 16 weeks post-implantation) exposures. During the first 4 weeks, both MT groups showed significantly higher single-unit (SU) yield, signal-to-noise ratio (SNR), and amplitude compared to the vehicle control group. However, after 4 weeks of implantation, the SU yield of the acute treatment group dropped to the same level as the control group, while the chronic treatment group maintained significantly higher SU yield compared to both acute (week 5-16) and control (week 0-16) mice. Histological studies revealed a significant increase in neuronal viability and decrease in neuronal apoptosis around the implanted electrode at week 16 in the chronic group in comparison to control and acute subjects, which is correlated with reduced oxidative stress and increased number of pro-regeneration arginase-1 positive microglia cells. These results demonstrate the potent effect of MT treatment in maintaining a high-quality electrode-tissue interface and suggest that MT promotes neuroprotection possibly through its anti-apoptotic, anti-inflammatory, and anti-oxidative properties.The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring, and neuronal loss. Melatonin (MT) has shown remarkable neuroprotective and neurorestorative effects in treating central nervous system (CNS) injuries and degeneration by inhibiting caspase-1, -3, and -9 activation and mitochondrial cytochrome c release, as well as reducing oxidative stress and neuroinflammation. This study examined the effect of MT administration on the quality and longevity of neural recording from an implanted microelectrode in the visual cortex of mice for 16 weeks. MT (30 mg/kg) was administered via daily intraperitoneal injection for acute (3 days before and 14 days post-implantation) and chronic (3 days before and 16 weeks post-implantation) exposures. During the first 4 weeks, both MT groups showed significantly higher single-unit (SU) yield, signal-to-noise ratio (SNR), and amplitude compared to the vehicle control group. However, after 4 weeks of implantation, the SU yield of the acute treatment group dropped to the same level as the control group, while the chronic treatment group maintained significantly higher SU yield compared to both acute (week 5-16) and control (week 0-16) mice. Histological studies revealed a significant increase in neuronal viability and decrease in neuronal apoptosis around the implanted electrode at week 16 in the chronic group in comparison to control and acute subjects, which is correlated with reduced oxidative stress and increased number of pro-regeneration arginase-1 positive microglia cells. These results demonstrate the potent effect of MT treatment in maintaining a high-quality electrode-tissue interface and suggest that MT promotes neuroprotection possibly through its anti-apoptotic, anti-inflammatory, and anti-oxidative properties. |
| Author | Carlisle, Diane L. Kozai, Takashi D.Y. Friedlander, Robert M. Golabchi, Asiyeh Wu, Bingchen Li, Xia Cui, Xinyan Tracy |
| AuthorAffiliation | 2 Center for Neural Basis of Cognition 4 Neuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine 5 Neurotechnology Division of the University of Pittsburgh Brain Institute 3 McGowan Institute for Regenerative Medicine, University of Pittsburgh 1 Department of Bioengineering, University of Pittsburgh |
| AuthorAffiliation_xml | – name: 5 Neurotechnology Division of the University of Pittsburgh Brain Institute – name: 3 McGowan Institute for Regenerative Medicine, University of Pittsburgh – name: 2 Center for Neural Basis of Cognition – name: 4 Neuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine – name: 1 Department of Bioengineering, University of Pittsburgh |
| Author_xml | – sequence: 1 givenname: Asiyeh surname: Golabchi fullname: Golabchi, Asiyeh organization: Department of Bioengineering, University of Pittsburgh, USA – sequence: 2 givenname: Bingchen surname: Wu fullname: Wu, Bingchen organization: Department of Bioengineering, University of Pittsburgh, USA – sequence: 3 givenname: Xia surname: Li fullname: Li, Xia organization: Department of Bioengineering, University of Pittsburgh, USA – sequence: 4 givenname: Diane L. surname: Carlisle fullname: Carlisle, Diane L. organization: Neuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, USA – sequence: 5 givenname: Takashi D.Y. surname: Kozai fullname: Kozai, Takashi D.Y. organization: Department of Bioengineering, University of Pittsburgh, USA – sequence: 6 givenname: Robert M. surname: Friedlander fullname: Friedlander, Robert M. organization: Neuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh School of Medicine, USA – sequence: 7 givenname: Xinyan Tracy surname: Cui fullname: Cui, Xinyan Tracy email: xic11@pitt.edu organization: Department of Bioengineering, University of Pittsburgh, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30053658$$D View this record in MEDLINE/PubMed |
| BookMark | eNqVkstu1DAUhi1URKeFV0ARKzYJviS-gISAlptUxAbWlsc-mXpw7KmTDJq3x6MpVelqWFlH5z-f_3M5QycxRUDoBcENwYS_WjdLnwYzQfYmjA3FRDZYNJjyR2hBpJB1p3B3ghaYtLRWnNBTdDaOa1xi3NIn6JRh3DHeyQW6_AbBTCn6WPlhk9MWxupmNsFPu8pEV4UUV7DdR6mv7HUuSltFmLMJVQabsvNx9RQ97osTeHb7nqOfnz7-uPhSX33__PXi_VVtO6GmWrCOK7KUxdCyNbZ1yjnWyb5XylFGBGtb3DsusaWUUdqWRE-NtEZwjqUy7By9OXDnuDG73yYEvcl-MHmnCdb72ei1vj8bvZ-NxkKX2ZTqt4fqzbwcwFmIU-nijpCM1_9mor_Wq7TVnAjFuCqAl7eAnG5mGCc9-NFCCCZCmstnhBHJOWNHSLGQZUmYiyJ9ft_WnZ-_OyqC1weBzWkcM_T_1_S7B8XWT2byad-iD8chLg8IKKvdesh6tB6iBefLBUzaJX8c5sMDjA2-XJMJv2B3LOQPrNzymA |
| CitedBy_id | crossref_primary_10_1016_j_ijbiomac_2021_12_074 crossref_primary_10_1016_j_molliq_2020_114082 crossref_primary_10_3390_mi9090445 crossref_primary_10_1039_D0AN00051E crossref_primary_10_1016_j_biomaterials_2023_122210 crossref_primary_10_3390_mi13030480 crossref_primary_10_1016_j_actbio_2019_08_032 crossref_primary_10_1088_1741_2552_aceca5 crossref_primary_10_3390_mi11090838 crossref_primary_10_1039_D2TB00584K crossref_primary_10_1002_adbi_201900287 crossref_primary_10_3390_mi12121446 crossref_primary_10_1016_j_biomaterials_2023_122326 crossref_primary_10_1016_j_biopha_2021_111593 crossref_primary_10_1016_j_biomaterials_2020_119842 crossref_primary_10_1210_endocr_bqaa119 crossref_primary_10_3390_mi9100494 crossref_primary_10_1002_admi_202201066 crossref_primary_10_1016_j_biomaterials_2018_08_046 crossref_primary_10_3390_mi12080972 crossref_primary_10_1002_adhm_202100107 crossref_primary_10_1016_j_bios_2023_115242 crossref_primary_10_3390_antiox11081628 crossref_primary_10_1002_adhm_201900622 crossref_primary_10_1002_anbr_202400114 crossref_primary_10_1039_D0TB00471E crossref_primary_10_3389_fbioe_2020_602216 crossref_primary_10_1016_j_actbio_2023_07_038 crossref_primary_10_1016_j_biomaterials_2019_119519 crossref_primary_10_1016_j_biomaterials_2022_121784 crossref_primary_10_1089_rej_2023_0047 crossref_primary_10_1111_jpi_70037 crossref_primary_10_3389_fbioe_2023_1284927 crossref_primary_10_3390_ijms22158296 crossref_primary_10_1088_1741_2552_ad36e1 crossref_primary_10_1016_j_actbio_2023_01_002 crossref_primary_10_1016_j_bbi_2024_03_004 crossref_primary_10_1016_j_bioactmat_2024_08_034 crossref_primary_10_1016_j_intimp_2023_109976 crossref_primary_10_1557_s43577_023_00530_7 crossref_primary_10_1016_j_biomaterials_2021_121060 crossref_primary_10_3390_mi12020208 crossref_primary_10_1002_adhm_202002150 crossref_primary_10_1021_acs_accounts_4c00057 crossref_primary_10_1088_1741_2552_ad5049 crossref_primary_10_1016_j_copbio_2021_10_003 crossref_primary_10_1152_jn_00299_2018 crossref_primary_10_1088_1741_2552_abe8f1 crossref_primary_10_3390_mi9100476 crossref_primary_10_2139_ssrn_4097603 crossref_primary_10_1016_j_bios_2020_112096 crossref_primary_10_3390_mi14051015 crossref_primary_10_1016_j_actbio_2022_06_038 crossref_primary_10_3389_fnins_2019_00493 crossref_primary_10_1016_j_biomaterials_2020_119767 crossref_primary_10_1088_1741_2552_ab1ef9 crossref_primary_10_1631_jzus_B1800280 crossref_primary_10_1088_2516_1091_ad0b19 crossref_primary_10_1002_jbt_70194 crossref_primary_10_3389_fimmu_2022_1014013 |
| Cites_doi | 10.1146/annurev.neuro.27.070203.144233 10.1016/j.lfs.2014.08.024 10.1111/j.1600-079X.2009.00721.x 10.1111/j.1600-079X.2009.00699.x 10.1111/j.1600-079X.2012.00978.x 10.1016/j.biomaterials.2016.02.013 10.1038/s41551-017-0154-1 10.1088/1741-2552/aaa03e 10.1111/j.1600-079X.2008.00570.x 10.1124/dmd.104.000885 10.1111/jpi.12162 10.1016/j.cobme.2017.09.003 10.1034/j.1600-079X.2000.290105.x 10.1152/jn.00162.2017 10.1016/j.neuron.2006.09.019 10.1523/JNEUROSCI.17-05-01683.1997 10.1088/1741-2552/aa9dae 10.1016/j.bcp.2010.07.041 10.2174/157015909787602823 10.1016/j.biomaterials.2014.07.039 10.1111/j.1600-079X.2011.00885.x 10.1038/srep40144 10.1073/pnas.1934665100 10.1016/j.nbd.2013.03.008 10.1016/j.jneumeth.2005.08.015 10.1517/14728222.2013.834890 10.1163/156856897X00357 10.1038/nature04970 10.1126/scitranslmed.aaf8083 10.3758/BF03195489 10.1088/1741-2560/9/6/066001 10.1016/j.brainres.2007.02.024 10.1016/j.jneumeth.2009.06.026 10.1111/j.1600-079X.2009.00739.x 10.1038/nn.3469 10.1517/13543784.9.4.747 10.1016/j.biomaterials.2018.02.037 10.1016/j.biomaterials.2010.05.050 10.3389/fneng.2014.00002 10.1016/j.biomaterials.2014.10.040 10.1111/j.1600-079X.2011.00863.x 10.1523/JNEUROSCI.2488-08.2008 10.1136/bmj.38731.532766.F6 10.1021/acschemneuro.7b00403 10.1007/s00418-014-1301-3 10.1111/j.1600-079X.2009.00729.x 10.1016/S0168-8278(03)00504-X 10.1111/j.1600-079X.1999.tb00578.x 10.1007/s00018-003-2319-1 10.1016/j.jneumeth.2015.10.007 10.1088/1741-2560/12/1/011001 10.1111/j.1600-079X.2011.00916.x 10.1016/j.expneurol.2005.04.020 10.1088/1741-2560/12/4/046002 10.2174/157015910792246155 10.1016/j.neuint.2014.06.015 10.1089/neu.2010.1646 10.1016/j.tox.2010.04.008 10.1038/hr.2016.103 10.1016/j.biomaterials.2016.10.054 10.1021/cn500256e 10.1111/jpi.12012 10.1111/j.1600-079X.2011.00858.x 10.1016/S0013-4686(99)00094-8 10.1155/2017/1835195 10.1002/hipo.10090 10.2119/molmed.2008.00117 10.1016/j.neuron.2015.01.028 10.1016/S0891-5849(03)00408-8 10.1523/JNEUROSCI.3879-08.2008 10.1002/adfm.201701269 10.1088/1741-2560/6/5/056003 10.1016/j.biomaterials.2013.03.007 10.1016/j.biomaterials.2014.08.006 10.1182/blood-2005-09-3691 10.4068/cmj.2012.48.2.116 10.1186/s12951-018-0340-7 10.1111/jpi.12337 10.4081/916 10.1016/S0140-6736(12)61816-9 10.18388/abp.2012_2116 10.18632/oncotarget.15780 10.1111/jpi.12267 10.1152/jn.00785.2013 10.3389/fnagi.2017.00208 10.1088/1741-2560/7/4/046011 10.1111/j.1600-079X.2012.01014.x 10.1146/annurev.neuro.051508.135241 10.3389/fneng.2014.00010 10.1163/156856897X00366 10.1111/j.1600-079X.2010.00821.x 10.1111/jpi.12087 10.1111/jpi.12045 10.1034/j.1600-079X.2002.02899.x 10.1186/s12916-017-1000-8 10.1111/jpi.12360 10.1177/0271678X18755225 10.1016/S0165-0270(96)00050-7 10.1038/nn1233 10.1088/1741-2560/9/4/046020 10.1152/jn.90989.2008 10.1016/j.jneumeth.2014.12.010 10.1016/j.biomaterials.2013.05.035 10.3390/ijms14048638 10.1016/S0006-8993(03)03023-3 10.1016/j.biomaterials.2018.04.043 10.1111/jpi.12292 10.1016/S0165-0270(98)00031-4 10.1016/S0165-0270(02)00149-8 10.1016/S0531-5565(00)00121-2 10.1111/j.1600-079X.2010.00759.x 10.1088/1741-2560/4/2/L01 10.1007/BF01795308 10.1111/j.1600-079X.1995.tb00187.x 10.1088/1741-2560/2/4/006 10.1088/1741-2560/8/4/045005 10.1007/s12640-012-9350-7 10.1073/pnas.1705768114 10.1155/2012/670294 10.1088/1741-2560/10/6/066014 10.3390/molecules201018886 10.1038/nmat3468 10.1111/j.1525-1497.2005.0243.x |
| ContentType | Journal Article |
| Copyright | 2018 Elsevier Ltd Copyright © 2018 Elsevier Ltd. All rights reserved. |
| Copyright_xml | – notice: 2018 Elsevier Ltd – notice: Copyright © 2018 Elsevier Ltd. All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 5PM ADTOC UNPAY |
| DOI | 10.1016/j.biomaterials.2018.07.026 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Engineering |
| EISSN | 1878-5905 |
| EndPage | 239 |
| ExternalDocumentID | oai:pubmedcentral.nih.gov:6179369 PMC6179369 30053658 10_1016_j_biomaterials_2018_07_026 S0142961218305106 |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: R01 NS094396 – fundername: NINDS NIH HHS grantid: R01 NS062019 – fundername: NIDA NIH HHS grantid: R21 DA043817 – fundername: NINDS NIH HHS grantid: R01 NS089688 – fundername: NINDS NIH HHS grantid: R01 NS100743 |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM 9JN AABNK AABXZ AAEDT AAEDW AAEPC AAHBH AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXUO AAYWO ABFNM ABGSF ABJNI ABMAC ABNUV ABUDA ABWVN ABXDB ABXRA ACDAQ ACGFS ACIUM ACLOT ACNNM ACRLP ACRPL ACVFH ADBBV ADCNI ADEWK ADEZE ADMUD ADNMO ADTZH ADUVX AEBSH AECPX AEHWI AEIPS AEKER AENEX AEUPX AEVXI AEZYN AFFNX AFJKZ AFPUW AFRHN AFRZQ AFTJW AFXIZ AGHFR AGQPQ AGRDE AGUBO AGYEJ AHHHB AHJVU AHPOS AI. AIEXJ AIGII AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKURH AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP ASPBG AVWKF AXJTR AZFZN BJAXD BKOJK BLXMC CS3 DU5 EBS EFJIC EFKBS EFLBG EJD ENUVR EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMK HMO HVGLF HZ~ IHE J1W JJJVA KOM M24 M41 MAGPM MO0 N9A O-L O9- OAUVE OB- OM. OZT P-8 P-9 P2P PC. Q38 R2- RNS ROL RPZ SAE SCC SDF SDG SDP SES SEW SMS SPC SPCBC SSG SSM SST SSU SSZ T5K TN5 VH1 WH7 WUQ XPP XUV Z5R ZMT ~G- ~HD AACTN AAIAV AAYOK ABYKQ AFCTW AFKWA AJBFU AJOXV AMFUW DOVZS RIG AAYXX CITATION AGCQF AGRNS BNPGV CGR CUY CVF ECM EIF NPM SSH 7X8 7S9 L.6 5PM ADTOC UNPAY |
| ID | FETCH-LOGICAL-c579t-735691b8612b4ac4d9dd358ff99d23173440fd680c223224ff9f2a8ca766089a3 |
| IEDL.DBID | UNPAY |
| ISSN | 0142-9612 1878-5905 |
| IngestDate | Sun Oct 26 03:49:09 EDT 2025 Tue Sep 30 16:55:46 EDT 2025 Thu Oct 02 05:24:28 EDT 2025 Thu Oct 02 06:45:02 EDT 2025 Mon Jul 21 06:07:21 EDT 2025 Thu Oct 02 04:27:16 EDT 2025 Thu Apr 24 23:04:28 EDT 2025 Fri Feb 23 02:49:13 EST 2024 Tue Oct 14 19:30:04 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Inflammatory gliosis Oxidative stress Melatonin Antioxidant Single-unit recording Microelectrode arrays |
| Language | English |
| License | Copyright © 2018 Elsevier Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c579t-735691b8612b4ac4d9dd358ff99d23173440fd680c223224ff9f2a8ca766089a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: A.G. carried out the experiments and analyzed the data. B.W. helped with daily MT injection. X.L. worked on histological tissue preparation. A.G. wrote the manuscript with input from all authors. T.K. and X.T.C. supervised data collection and analysis. D.C. and R.F. provided expertise on MT’s biological mechanisms. X.T.C. and R.F. conceived the original idea. X.T.C. supervised the project. |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://www.ncbi.nlm.nih.gov/pmc/articles/6179369 |
| PMID | 30053658 |
| PQID | 2078590067 |
| PQPubID | 23479 |
| PageCount | 15 |
| ParticipantIDs | unpaywall_primary_10_1016_j_biomaterials_2018_07_026 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6179369 proquest_miscellaneous_2131866339 proquest_miscellaneous_2078590067 pubmed_primary_30053658 crossref_primary_10_1016_j_biomaterials_2018_07_026 crossref_citationtrail_10_1016_j_biomaterials_2018_07_026 elsevier_sciencedirect_doi_10_1016_j_biomaterials_2018_07_026 elsevier_clinicalkey_doi_10_1016_j_biomaterials_2018_07_026 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-10-01 |
| PublicationDateYYYYMMDD | 2018-10-01 |
| PublicationDate_xml | – month: 10 year: 2018 text: 2018-10-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Biomaterials |
| PublicationTitleAlternate | Biomaterials |
| PublicationYear | 2018 |
| Publisher | Elsevier Ltd |
| Publisher_xml | – name: Elsevier Ltd |
| References | Deigner, Haberkorn, Kinscherf (bib50) 2000; 9 Horn, Busch, Hawthorne, van Rooijen, Silver (bib118) 2008; 28 Fee, Mitra, Kleinfeld (bib71) 1996; 69 Barrese, Rao, Paroo, Triebwasser, Vargas-Irwin, Franquemont (bib81) 2013; 10 Walle, Hsieh, DeLegge, Oatis (bib127) 2004; 32 Wellman, Kozai (bib23) 2018; 164 Favero, Franceschetti, Bonomini, Rodella, Rezzani (bib33) 2017; 2017 Prasad, Sankar, Dyer, Knott, Xue, Nishida (bib14) 2011; 2011 Lin, Chao, Li, Xu, Liu, Hou (bib34) 2016; 61 Manchester, Coto-Montes, Boga, Andersen, Zhou, Galano (bib36) 2015; 59 Jou, Peng, Hsu, Jou, Reiter, Yang (bib45) 2010; 48 Esposito, Cuzzocrea (bib42) 2010; 8 Kozai, Jaquins-Gerstl, Vazquez, Michael, Cui (bib15) 2015; 6 Agabiti-Rosei, Favero, De Ciuceis, Rossini, Porteri, Rodella (bib104) 2017; 40 Jan, Hamilton, Seward, Fast, Freeman, Laudon (bib124) 2000; 29 Lin, Mei, Liu, Li, Zuo, Liu (bib54) 2011; 50 Radogna, Diederich, Ghibelli (bib40) 2010; 80 Kozai, Langhals, Patel, Deng, Zhang, Smith (bib65) 2012; 11 Buscemi, Vandermeer, Hooton, Pandya, Tjosvold, Hartling (bib130) 2006; 332 Veneroso, Tunon, Gonzalez-Gallego, Collado (bib55) 2009; 47 Sainz, Mayo, Rodriguez, Tan, Lopez-Burillo, Reiter (bib47) 2003; 60 Robertson, Levine, Haynes, Gutierrez, Baratta, Tan (bib75) 2015; 143 McConnell, Rees, Levey, Gutekunst, Gross, Bellamkonda (bib30) 2009; 6 Brewer (bib51) 2000; 35 Flesher, Collinger, Foldes, Weiss, Downey, Tyler-Kabara (bib9) 2016; 8 Salatino, Winter, Drazin, Purcell (bib17) 2017; 118 Zhang, Zhang (bib35) 2014; 57 Buzsaki, Stark, Berenyi, Khodagholy, Kipke, Yoon (bib4) 2015; 86 Buzsaki (bib102) 2004; 7 Kozai, Vazquez, Weaver, Kim, Cui (bib85) 2012; 9 Agil, Reiter, Jimenez-Aranda, Iban-Arias, Navarro-Alarcon, Marchal (bib52) 2013; 54 Wang, Ma, Meng, Zhu, Sun, Huo (bib84) 2012; 53 Eles, Vazquez, Snyder, Lagenaur, Murphy, Kozai, Cui (bib88) 2017; 113 Kang, Koh, Lee (bib90) 2011; 50 Collinger, Wodlinger, Downey, Wang, Tyler-Kabara, Weber (bib8) 2013; 381 Wagenaar, Potter (bib70) 2002; 120 Szarowski, Andersen, Retterer, Spence, Isaacson, Craighead (bib27) 2003; 983 Hermann, Ravikumar, Shoffstall, Ereifej, Kovach, Chang (bib31) 2017; 15 Streit, Kreutzberg (bib115) 1987; 16 Subbaroyan, Martin, Kipke (bib92) 2005; 2 Kaur, Ling (bib96) 1999; 26 Posadzki, Bajpai, Kyaw, Roberts, Brzezinski, Christopoulos (bib132) 2018; 16 Siomek (bib108) 2012; 59 Iordanova, Vazquez, Kozai, Fukuda, Kim (bib6) 2018; 38 Wellman, Eles, Ludwig, Seymour, Michelson, McFadden (bib16) 2018; 28 Ludwig, Miriani, Langhals, Joseph, Anderson, Kipke (bib69) 2009; 101 Reiter, Mayo, Tan, Sainz, Alatorre-Jimenez, Qin (bib103) 2016; 61 Negi, Kumar, Sharma (bib91) 2011; 50 Kozai, Gugel, Li, Gilgunn, Khilwani, Ozdoganlar (bib72) 2014; 35 Gensel, Kopper, Zhang, Orr, Bailey (bib76) 2017; 7 Zhang, Cook, Kim, Baranov, Jiang, Smith (bib67) 2013; 55 Baydas, Reiter, Yasar, Tuzcu, Akdemir, Nedzvetskii (bib121) 2003; 35 Mauriz, Collado, Veneroso, Reiter, Gonzalez-Gallego (bib32) 2013; 54 Liu, Gong, Xiong, Ye, Xiong, Zhuang (bib94) 2013; 55 Bruck, Aeed, Avni, Shirin, Matas, Shahmurov (bib59) 2004; 40 Jung-Hynes, Reiter, Ahmad (bib133) 2010; 48 Miron, Boyd, Zhao, Yuen, Ruckh, Shadrach (bib119) 2013; 16 Jorfi, Skousen, Weder, Capadona (bib79) 2015; 12 Hu, Wang, Pan, Zhang, Fang, Jiang (bib112) 2017; 8 Ananth, Gopalakrishnakone, Kaur (bib123) 2003; 13 Hatsopoulos, Donoghue (bib1) 2009; 32 Cornelissen, Peters, Palmer (bib64) 2002; 34 Zhong, Bellamkonda (bib126) 2007; 1148 Donat, Scott, Gentleman, Sastre (bib116) 2017; 9 Schwartz (bib11) 2004; 27 Kozai, Li, Bodily, Caparosa, Zenonos, Carlisle (bib29) 2014; 35 Biran, Martin, Tresco (bib26) 2005; 195 Suofu, Li, Jean-Alphonse, Jia, Khattar, Li (bib44) 2017; 114 Wellman, Kozai (bib24) 2017; 8 Pappolla, Sos, Omar, Bick, Hickson-Bick, Reiter (bib48) 1997; 17 Yu, Kubota, Okita, Maeda (bib120) 2017; 12 Rennaker, Miller, Tang, Wilson (bib25) 2007; 4 Woeppel, Yang, Cui (bib106) 2017; 4 Sullivan, Sebastian, Hall (bib117) 2011; 28 Rousche, Normann (bib13) 1998; 82 Chestek, Gilja, Nuyujukian, Foster, Fan, Kaufman (bib10) 2011; 8 Dijkstra, Dopp, Joling, Kraal (bib78) 1985; 54 Brainard (bib63) 1997; 10 Bizzarri, Proietti, Cucina, Reiter (bib38) 2013; 17 Berényi, Somogyvári, Nagy, Roux, Long, Fujisawa (bib5) 2014; 111 Saxena, Karumbaiah, Gaupp, Patkar, Patil, Betancur (bib111) 2013; 34 Nicolelis, Dimitrov, Carmena, Crist, Lehew, Kralik (bib12) 2003; 100 Kozai, Jaquins-Gerstl, Vazquez, Michael, Cui (bib86) 2016; 87 Potter-Baker, Stewart, Tomaszewski, Wong, Meador, Ziats (bib21) 2015; 12 Wang, Wu, You, Ji, Chen (bib83) 2013; 55 Paradies, Petrosillo, Paradies, Reiter, Ruggiero (bib46) 2010; 48 Kozai, Eles, Vazquez, Cui (bib87) 2016; 258 Purcell, Thompson, Ludwig, Kipke (bib89) 2009; 183 Kozai, Marzullo, Hooi, Langhals, Majewska, Brown (bib109) 2010; 7 Permpoonputtana, Govitrapong (bib58) 2013; 23 Das, McDowell, Pava, Smith, Reiter, Woodward (bib100) 2010; 48 Michelson, Vazquez, Eles, Salatino, Purcell, Williams (bib18) 2018; 15 Schmitt, Schultze, Faßbender, Buß, Lüth, Schöning (bib105) 1999; 44 Tsai, Chen, Tsai, Ching, Chuang (bib53) 2011; 51 Martinez, Gordon (bib77) 2014; 6 Kleiner, Brainard, Pelli, Ingling, Murray, Broussard (bib62) 2007; 36 Zhang, Cook, Kim, Baranov, Jiang, Smith (bib43) 2013; 55 Deng, Tang, Tseng, Wu (bib56) 2006; 108 Eghbal, Ahmadian, Azarmi, Parvizpur (bib41) 2016; 1 Galano, Tan, Reiter (bib97) 2011; 51 Nina, Ben, Nicola, Rena, Lisa, Lisa (bib131) 2005; 20 Prasad, Xue, Dieme, Sankar, Mayrand, Nishida (bib82) 2014; 7 Uttara, Singh, Zamboni, Mahajan (bib107) 2009; 7 Park, Lee, Sung, Kim (bib122) 2012; 48 Potter, Buck, Self, Callanan, Sunil, Capadona (bib125) 2013; 34 Mazzetti, Frigerio, Gelati, Salmaggi, Vitellaro-Zuccarello (bib113) 2004; 48 Villacampa, Almolda, González, Castellano (bib74) 2013 Hochberg, Serruya, Friehs, Mukand, Saleh, Caplan (bib7) 2006; 442 Tan, Manchester, Esteban-Zubero, Zhou, Reiter (bib37) 2015; 20 Ding, Wang, Xu, Lu, Zhang, Zhu (bib95) 2014; 76 Pelli (bib68) 1997; 10 Winslow, Christensen, Yang, Solzbacher, Tresco (bib110) 2010; 31 Bonnefont-Rousselot, Collin (bib129) 2010; 278 Sohal, Jackson, Jackson, Clowry, Vassilevski, O'Neill (bib28) 2014; 7 Robertson, Levine, Haynes, Gutierrez, Baratta, Tan (bib114) 2015; 143 Yoo, Yim, Kim, Jang, Lea, Hwang (bib60) 2002; 33 Kozai, Du, Gugel, Smith, Chase, Bodily (bib66) 2015; 242 Vriend, Reiter (bib61) 2014; 115 Eles, Vazquez, Kozai, XT Cui (bib20) 2018; 174 Espino, Pariente, Rodriguez (bib98) 2012; 2012 Salatino, Ludwig, Kozai, Purcell (bib19) 2017; 1 Shen, Cao, Snyder, Woeppel, Eles, Cui (bib128) 2018; 16 Sainz, Mayo, Uria, Kotler, Antolin, Rodriguez (bib49) 1995; 19 Pazar, Kolgazi, Memisoglu, Bahadir, Sirvanci, Yaman (bib93) 2016; 60 Korkmaz, Reiter, Topal, Manchester, Oter, Tan (bib57) 2009; 15 Kozai, Catt, Li, Gugel, Olafsson, Vazquez (bib80) 2015; 37 Zhou, Zhang, Zhao, Wei (bib99) 2008; 45 Douglas, Stuart, Sheryl, Victor (bib101) 2016; 13 Potter, Buck, Self, Capadona (bib73) 2012; 9 Kipke, Shain, Buzsaki, Fetz, Henderson, Hetke (bib3) 2008; 28 Polikov, Tresco, Reichert (bib22) 2005; 148 Carrillo-Vico, Lardone, Alvarez-Sanchez, Rodriguez-Rodriguez, Guerrero (bib39) 2013; 14 Schwartz, Cui, Weber, Moran (bib2) 2006; 52 Hatsopoulos (10.1016/j.biomaterials.2018.07.026_bib1) 2009; 32 Potter-Baker (10.1016/j.biomaterials.2018.07.026_bib21) 2015; 12 Martinez (10.1016/j.biomaterials.2018.07.026_bib77) 2014; 6 Brainard (10.1016/j.biomaterials.2018.07.026_bib63) 1997; 10 Miron (10.1016/j.biomaterials.2018.07.026_bib119) 2013; 16 Chestek (10.1016/j.biomaterials.2018.07.026_bib10) 2011; 8 Potter (10.1016/j.biomaterials.2018.07.026_bib73) 2012; 9 Siomek (10.1016/j.biomaterials.2018.07.026_bib108) 2012; 59 Sohal (10.1016/j.biomaterials.2018.07.026_bib28) 2014; 7 Schmitt (10.1016/j.biomaterials.2018.07.026_bib105) 1999; 44 Favero (10.1016/j.biomaterials.2018.07.026_bib33) 2017; 2017 Zhou (10.1016/j.biomaterials.2018.07.026_bib99) 2008; 45 Pappolla (10.1016/j.biomaterials.2018.07.026_bib48) 1997; 17 Agil (10.1016/j.biomaterials.2018.07.026_bib52) 2013; 54 Winslow (10.1016/j.biomaterials.2018.07.026_bib110) 2010; 31 Eles (10.1016/j.biomaterials.2018.07.026_bib88) 2017; 113 Kaur (10.1016/j.biomaterials.2018.07.026_bib96) 1999; 26 Streit (10.1016/j.biomaterials.2018.07.026_bib115) 1987; 16 Hermann (10.1016/j.biomaterials.2018.07.026_bib31) 2017; 15 Bonnefont-Rousselot (10.1016/j.biomaterials.2018.07.026_bib129) 2010; 278 Polikov (10.1016/j.biomaterials.2018.07.026_bib22) 2005; 148 Wellman (10.1016/j.biomaterials.2018.07.026_bib24) 2017; 8 Kleiner (10.1016/j.biomaterials.2018.07.026_bib62) 2007; 36 Kozai (10.1016/j.biomaterials.2018.07.026_bib86) 2016; 87 Ludwig (10.1016/j.biomaterials.2018.07.026_bib69) 2009; 101 Kozai (10.1016/j.biomaterials.2018.07.026_bib80) 2015; 37 Liu (10.1016/j.biomaterials.2018.07.026_bib94) 2013; 55 Walle (10.1016/j.biomaterials.2018.07.026_bib127) 2004; 32 Brewer (10.1016/j.biomaterials.2018.07.026_bib51) 2000; 35 Ding (10.1016/j.biomaterials.2018.07.026_bib95) 2014; 76 Pelli (10.1016/j.biomaterials.2018.07.026_bib68) 1997; 10 Prasad (10.1016/j.biomaterials.2018.07.026_bib82) 2014; 7 Collinger (10.1016/j.biomaterials.2018.07.026_bib8) 2013; 381 McConnell (10.1016/j.biomaterials.2018.07.026_bib30) 2009; 6 Sainz (10.1016/j.biomaterials.2018.07.026_bib49) 1995; 19 Purcell (10.1016/j.biomaterials.2018.07.026_bib89) 2009; 183 Rennaker (10.1016/j.biomaterials.2018.07.026_bib25) 2007; 4 Suofu (10.1016/j.biomaterials.2018.07.026_bib44) 2017; 114 Cornelissen (10.1016/j.biomaterials.2018.07.026_bib64) 2002; 34 Kozai (10.1016/j.biomaterials.2018.07.026_bib66) 2015; 242 Park (10.1016/j.biomaterials.2018.07.026_bib122) 2012; 48 Carrillo-Vico (10.1016/j.biomaterials.2018.07.026_bib39) 2013; 14 Manchester (10.1016/j.biomaterials.2018.07.026_bib36) 2015; 59 Subbaroyan (10.1016/j.biomaterials.2018.07.026_bib92) 2005; 2 Uttara (10.1016/j.biomaterials.2018.07.026_bib107) 2009; 7 Hochberg (10.1016/j.biomaterials.2018.07.026_bib7) 2006; 442 Mauriz (10.1016/j.biomaterials.2018.07.026_bib32) 2013; 54 Kipke (10.1016/j.biomaterials.2018.07.026_bib3) 2008; 28 Donat (10.1016/j.biomaterials.2018.07.026_bib116) 2017; 9 Tsai (10.1016/j.biomaterials.2018.07.026_bib53) 2011; 51 Schwartz (10.1016/j.biomaterials.2018.07.026_bib2) 2006; 52 Buzsaki (10.1016/j.biomaterials.2018.07.026_bib4) 2015; 86 Berényi (10.1016/j.biomaterials.2018.07.026_bib5) 2014; 111 Kozai (10.1016/j.biomaterials.2018.07.026_bib109) 2010; 7 Potter (10.1016/j.biomaterials.2018.07.026_bib125) 2013; 34 Kozai (10.1016/j.biomaterials.2018.07.026_bib29) 2014; 35 Salatino (10.1016/j.biomaterials.2018.07.026_bib19) 2017; 1 Kang (10.1016/j.biomaterials.2018.07.026_bib90) 2011; 50 Lin (10.1016/j.biomaterials.2018.07.026_bib34) 2016; 61 Esposito (10.1016/j.biomaterials.2018.07.026_bib42) 2010; 8 Espino (10.1016/j.biomaterials.2018.07.026_bib98) 2012; 2012 Flesher (10.1016/j.biomaterials.2018.07.026_bib9) 2016; 8 Iordanova (10.1016/j.biomaterials.2018.07.026_bib6) 2018; 38 Permpoonputtana (10.1016/j.biomaterials.2018.07.026_bib58) 2013; 23 Saxena (10.1016/j.biomaterials.2018.07.026_bib111) 2013; 34 Baydas (10.1016/j.biomaterials.2018.07.026_bib121) 2003; 35 Ananth (10.1016/j.biomaterials.2018.07.026_bib123) 2003; 13 Veneroso (10.1016/j.biomaterials.2018.07.026_bib55) 2009; 47 Bruck (10.1016/j.biomaterials.2018.07.026_bib59) 2004; 40 Shen (10.1016/j.biomaterials.2018.07.026_bib128) 2018; 16 Szarowski (10.1016/j.biomaterials.2018.07.026_bib27) 2003; 983 Wang (10.1016/j.biomaterials.2018.07.026_bib83) 2013; 55 Robertson (10.1016/j.biomaterials.2018.07.026_bib114) 2015; 143 Agabiti-Rosei (10.1016/j.biomaterials.2018.07.026_bib104) 2017; 40 Rousche (10.1016/j.biomaterials.2018.07.026_bib13) 1998; 82 Wang (10.1016/j.biomaterials.2018.07.026_bib84) 2012; 53 Kozai (10.1016/j.biomaterials.2018.07.026_bib72) 2014; 35 Hu (10.1016/j.biomaterials.2018.07.026_bib112) 2017; 8 Salatino (10.1016/j.biomaterials.2018.07.026_bib17) 2017; 118 Yoo (10.1016/j.biomaterials.2018.07.026_bib60) 2002; 33 Galano (10.1016/j.biomaterials.2018.07.026_bib97) 2011; 51 Douglas (10.1016/j.biomaterials.2018.07.026_bib101) 2016; 13 Reiter (10.1016/j.biomaterials.2018.07.026_bib103) 2016; 61 Jorfi (10.1016/j.biomaterials.2018.07.026_bib79) 2015; 12 Kozai (10.1016/j.biomaterials.2018.07.026_bib87) 2016; 258 Tan (10.1016/j.biomaterials.2018.07.026_bib37) 2015; 20 Kozai (10.1016/j.biomaterials.2018.07.026_bib15) 2015; 6 Posadzki (10.1016/j.biomaterials.2018.07.026_bib132) 2018; 16 Radogna (10.1016/j.biomaterials.2018.07.026_bib40) 2010; 80 Sainz (10.1016/j.biomaterials.2018.07.026_bib47) 2003; 60 Wellman (10.1016/j.biomaterials.2018.07.026_bib16) 2018; 28 Paradies (10.1016/j.biomaterials.2018.07.026_bib46) 2010; 48 Mazzetti (10.1016/j.biomaterials.2018.07.026_bib113) 2004; 48 Nina (10.1016/j.biomaterials.2018.07.026_bib131) 2005; 20 Lin (10.1016/j.biomaterials.2018.07.026_bib54) 2011; 50 Nicolelis (10.1016/j.biomaterials.2018.07.026_bib12) 2003; 100 Zhang (10.1016/j.biomaterials.2018.07.026_bib35) 2014; 57 Kozai (10.1016/j.biomaterials.2018.07.026_bib85) 2012; 9 Wellman (10.1016/j.biomaterials.2018.07.026_bib23) 2018; 164 Villacampa (10.1016/j.biomaterials.2018.07.026_bib74) 2013 Buscemi (10.1016/j.biomaterials.2018.07.026_bib130) 2006; 332 Zhang (10.1016/j.biomaterials.2018.07.026_bib67) 2013; 55 Gensel (10.1016/j.biomaterials.2018.07.026_bib76) 2017; 7 Zhong (10.1016/j.biomaterials.2018.07.026_bib126) 2007; 1148 Schwartz (10.1016/j.biomaterials.2018.07.026_bib11) 2004; 27 Michelson (10.1016/j.biomaterials.2018.07.026_bib18) 2018; 15 Fee (10.1016/j.biomaterials.2018.07.026_bib71) 1996; 69 Eles (10.1016/j.biomaterials.2018.07.026_bib20) 2018; 174 Bizzarri (10.1016/j.biomaterials.2018.07.026_bib38) 2013; 17 Kozai (10.1016/j.biomaterials.2018.07.026_bib65) 2012; 11 Prasad (10.1016/j.biomaterials.2018.07.026_bib14) 2011; 2011 Vriend (10.1016/j.biomaterials.2018.07.026_bib61) 2014; 115 Pazar (10.1016/j.biomaterials.2018.07.026_bib93) 2016; 60 Das (10.1016/j.biomaterials.2018.07.026_bib100) 2010; 48 Wagenaar (10.1016/j.biomaterials.2018.07.026_bib70) 2002; 120 Dijkstra (10.1016/j.biomaterials.2018.07.026_bib78) 1985; 54 Woeppel (10.1016/j.biomaterials.2018.07.026_bib106) 2017; 4 Jan (10.1016/j.biomaterials.2018.07.026_bib124) 2000; 29 Deng (10.1016/j.biomaterials.2018.07.026_bib56) 2006; 108 Yu (10.1016/j.biomaterials.2018.07.026_bib120) 2017; 12 Eghbal (10.1016/j.biomaterials.2018.07.026_bib41) 2016; 1 Zhang (10.1016/j.biomaterials.2018.07.026_bib43) 2013; 55 Negi (10.1016/j.biomaterials.2018.07.026_bib91) 2011; 50 Jou (10.1016/j.biomaterials.2018.07.026_bib45) 2010; 48 Sullivan (10.1016/j.biomaterials.2018.07.026_bib117) 2011; 28 Biran (10.1016/j.biomaterials.2018.07.026_bib26) 2005; 195 Robertson (10.1016/j.biomaterials.2018.07.026_bib75) 2015; 143 Horn (10.1016/j.biomaterials.2018.07.026_bib118) 2008; 28 Jung-Hynes (10.1016/j.biomaterials.2018.07.026_bib133) 2010; 48 Korkmaz (10.1016/j.biomaterials.2018.07.026_bib57) 2009; 15 Barrese (10.1016/j.biomaterials.2018.07.026_bib81) 2013; 10 Deigner (10.1016/j.biomaterials.2018.07.026_bib50) 2000; 9 Buzsaki (10.1016/j.biomaterials.2018.07.026_bib102) 2004; 7 |
| References_xml | – volume: 37 start-page: 25 year: 2015 end-page: 39 ident: bib80 article-title: Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording publication-title: Biomaterials – volume: 983 start-page: 23 year: 2003 end-page: 35 ident: bib27 article-title: Brain responses to micro-machined silicon devices publication-title: Brain Res. – volume: 148 start-page: 1 year: 2005 end-page: 18 ident: bib22 article-title: Response of brain tissue to chronically implanted neural electrodes publication-title: J. Neurosci. Meth. – volume: 48 start-page: 423 year: 2004 end-page: 428 ident: bib113 article-title: Lycopersicon esculentum lectin: an effective and versatile endothelial marker of normal and tumoral blood vessels in the central nervous system publication-title: Eur. J. Histochem. – volume: 20 start-page: 1151 year: 2005 end-page: 1158 ident: bib131 article-title: The efficacy and safety of exogenous melatonin for primary sleep disorders publication-title: J. Gen. Intern. Med. – volume: 48 start-page: 9 year: 2010 end-page: 19 ident: bib133 article-title: Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer publication-title: J. Pineal Res. – volume: 51 start-page: 1 year: 2011 end-page: 16 ident: bib97 article-title: Melatonin as a natural ally against oxidative stress: a physicochemical examination publication-title: J. Pineal Res. – volume: 9 year: 2012 ident: bib85 article-title: In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes publication-title: J. Neural. Eng. – volume: 332 start-page: 385 year: 2006 ident: bib130 article-title: Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis publication-title: Bmj – volume: 7 start-page: 2 year: 2014 ident: bib82 article-title: Abiotic-biotic characterization of Pt/Ir microelectrode arrays in chronic implants publication-title: Front. Neuroeng. – volume: 8 start-page: 361ra141 year: 2016 ident: bib9 article-title: Intracortical microstimulation of human somatosensory cortex publication-title: Sci. Transl. Med. – volume: 183 start-page: 149 year: 2009 end-page: 157 ident: bib89 article-title: Flavopiridol reduces the impedance of neural prostheses in vivo without affecting recording quality publication-title: J. Neurosci. Meth. – volume: 48 start-page: 297 year: 2010 end-page: 310 ident: bib46 article-title: Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease publication-title: J. Pineal Res. – volume: 7 start-page: 40144 year: 2017 ident: bib76 article-title: Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment publication-title: Sci. Rep. – volume: 50 start-page: 436 year: 2011 end-page: 444 ident: bib54 article-title: Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats publication-title: J. Pineal Res. – volume: 35 start-page: 9620 year: 2014 end-page: 9634 ident: bib29 article-title: Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response publication-title: Biomaterials – volume: 15 year: 2018 ident: bib18 article-title: Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new Emphasis on the Biological Interface publication-title: J. Neural. Eng. – volume: 32 start-page: 1377 year: 2004 end-page: 1382 ident: bib127 article-title: Walle UK. High absorption but very low bioavailability of oral resveratrol in humans publication-title: Drug Metabol. Dispos. – volume: 8 year: 2011 ident: bib10 article-title: Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex publication-title: J. Neural. Eng. – volume: 2 start-page: 103 year: 2005 end-page: 113 ident: bib92 article-title: A finite-element model of the mechanical effects of implantable microelectrodes in the cerebral cortex publication-title: J. Neural. Eng. – volume: 16 start-page: 18 year: 2018 ident: bib132 article-title: Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action publication-title: BMC Med. – volume: 120 start-page: 113 year: 2002 end-page: 120 ident: bib70 article-title: Real-time multi-channel stimulus artifact suppression by local curve fitting publication-title: J. Neurosci. Meth. – volume: 12 year: 2015 ident: bib79 article-title: Progress towards biocompatible intracortical microelectrodes for neural interfacing applications publication-title: J. Neural. Eng. – volume: 50 start-page: 124 year: 2011 end-page: 131 ident: bib91 article-title: Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-kappaB and Nrf2 cascades publication-title: J. Pineal Res. – volume: 80 start-page: 1844 year: 2010 end-page: 1852 ident: bib40 article-title: Melatonin: a pleiotropic molecule regulating inflammation publication-title: Biochem. Pharmacol. – volume: 164 start-page: 121 year: 2018 end-page: 133 ident: bib23 article-title: In vivo spatiotemporal dynamics of NG2 glia activity caused by neural electrode implantation publication-title: Biomaterials – volume: 61 start-page: 253 year: 2016 end-page: 278 ident: bib103 article-title: Melatonin as an antioxidant: under promises but over delivers publication-title: J. Pineal Res. – volume: 44 start-page: 3865 year: 1999 end-page: 3883 ident: bib105 article-title: Passivation and corrosion of microelectrode arrays publication-title: Electrochim. Acta – volume: 52 start-page: 205 year: 2006 end-page: 220 ident: bib2 article-title: Brain-controlled interfaces: movement restoration with neural prosthetics publication-title: Neuron – volume: 31 start-page: 9163 year: 2010 end-page: 9172 ident: bib110 article-title: A comparison of the tissue response to chronically implanted Parylene-C-coated and uncoated planar silicon microelectrode arrays in rat cortex publication-title: Biomaterials – volume: 87 start-page: 157 year: 2016 end-page: 169 ident: bib86 article-title: Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo publication-title: Biomaterials – volume: 16 start-page: 13 year: 2018 ident: bib128 article-title: ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood–brain barrier publication-title: J. Nanobiotechnol. – volume: 57 start-page: 131 year: 2014 end-page: 146 ident: bib35 article-title: Melatonin: a well-documented antioxidant with conditional pro-oxidant actions publication-title: J. Pineal Res. – volume: 2012 year: 2012 ident: bib98 article-title: Oxidative stress and immunosenescence: therapeutic effects of melatonin publication-title: Oxid. Med. Cell Longev. – volume: 82 start-page: 1 year: 1998 end-page: 15 ident: bib13 article-title: Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex publication-title: J. Neurosci. Meth. – volume: 9 start-page: 208 year: 2017 ident: bib116 article-title: Microglial activation in traumatic brain injury publication-title: Front. Aging Neurosci. – volume: 55 start-page: 26 year: 2013 end-page: 35 ident: bib43 article-title: Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis publication-title: Neurobiol. Dis. – volume: 35 start-page: 9255 year: 2014 end-page: 9268 ident: bib72 article-title: Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes publication-title: Biomaterials – volume: 59 start-page: 403 year: 2015 end-page: 419 ident: bib36 article-title: Melatonin: an ancient molecule that makes oxygen metabolically tolerable publication-title: J. Pineal Res. – volume: 20 start-page: 18886 year: 2015 end-page: 18906 ident: bib37 article-title: Melatonin as a potent and inducible endogenous antioxidant: synthesis and metabolism publication-title: Molecules – volume: 381 start-page: 557 year: 2013 end-page: 564 ident: bib8 article-title: High-performance neuroprosthetic control by an individual with tetraplegia publication-title: Lancet – volume: 9 start-page: 747 year: 2000 end-page: 764 ident: bib50 article-title: Apoptosis modulators in the therapy of neurodegenerative diseases publication-title: Expet Opin. Invest. Drugs – volume: 15 year: 2017 ident: bib31 article-title: Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance publication-title: J. Neural. Eng. – volume: 8 start-page: 2578 year: 2017 end-page: 2582 ident: bib24 article-title: Understanding the inflammatory tissue reaction to brain implants to improve neurochemical sensing performance publication-title: ACS Chem. Neurosci. – volume: 1 start-page: 862 year: 2017 end-page: 877 ident: bib19 article-title: Glial responses to implanted electrodes in the brain publication-title: Nature Biomed. Eng. – volume: 7 start-page: 10 year: 2014 ident: bib28 article-title: The sinusoidal probe: a new approach to improve electrode longevity publication-title: Front. Neuroeng. – volume: 28 start-page: 9330 year: 2008 end-page: 9341 ident: bib118 article-title: Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions publication-title: J. Neurosci.: Official J. Soc. Neurosci. – volume: 26 start-page: 158 year: 1999 end-page: 168 ident: bib96 article-title: Effects of melatonin on macrophages/microglia in postnatal rat brain publication-title: J. Pineal Res. – volume: 6 start-page: 48 year: 2015 end-page: 67 ident: bib15 article-title: Brain tissue responses to neural implants impact signal sensitivity and intervention strategies publication-title: ACS Chem. Neurosci. – volume: 53 start-page: 129 year: 2012 end-page: 137 ident: bib84 article-title: Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model publication-title: J. Pineal Res. – volume: 4 start-page: L1 year: 2007 end-page: L5 ident: bib25 article-title: Minocycline increases quality and longevity of chronic neural recordings publication-title: J. Neural. Eng. – volume: 55 start-page: 14 year: 2013 end-page: 25 ident: bib94 article-title: Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells publication-title: J. Pineal Res. – volume: 48 start-page: 20 year: 2010 end-page: 38 ident: bib45 article-title: Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes publication-title: J. Pineal Res. – volume: 17 start-page: 1483 year: 2013 end-page: 1496 ident: bib38 article-title: Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review publication-title: Expert Opin. Ther. Targets – volume: 40 start-page: 86 year: 2004 end-page: 93 ident: bib59 article-title: Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats publication-title: J. Hepatol. – volume: 115 start-page: 8 year: 2014 end-page: 14 ident: bib61 article-title: Melatonin as a proteasome inhibitor. Is there any clinical evidence? publication-title: Life Sci. – volume: 50 start-page: 403 year: 2011 end-page: 411 ident: bib90 article-title: Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway publication-title: J. Pineal Res. – volume: 2011 start-page: 3020 year: 2011 end-page: 3023 ident: bib14 article-title: Coupling biotic and abiotic metrics to create a testbed for predicting neural electrode performance publication-title: Conf Proc. IEEE Eng. Med. Biol. Soc. – start-page: 261 year: 2013 end-page: 279 ident: bib74 article-title: Tomato lectin histochemistry for microglial visualization publication-title: Microglia: Methods and Protocols – volume: 12 year: 2015 ident: bib21 article-title: Implications of chronic daily anti-oxidant administration on the inflammatory response to intracortical microelectrodes publication-title: J. Neural. Eng. – volume: 54 start-page: 381 year: 2013 end-page: 388 ident: bib52 article-title: Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats publication-title: J. Pineal Res. – volume: 15 start-page: 43 year: 2009 end-page: 50 ident: bib57 article-title: Melatonin: an established antioxidant worthy of use in clinical trials publication-title: Mol. Med. – volume: 12 year: 2017 ident: bib120 article-title: The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells publication-title: PLoS One – volume: 2017 start-page: 13 year: 2017 ident: bib33 article-title: Melatonin as an anti-inflammatory agent modulating inflammasome activation publication-title: Int. J. Endocrinol. – volume: 118 start-page: 194 year: 2017 end-page: 202 ident: bib17 article-title: Functional remodeling of subtype-specific markers surrounding implanted neuroprostheses publication-title: J. Neurophysiol. – volume: 35 start-page: 1165 year: 2000 end-page: 1183 ident: bib51 article-title: Neuronal plasticity and stressor toxicity during aging publication-title: Exp. Gerontol. – volume: 10 year: 2013 ident: bib81 article-title: Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates publication-title: J. Neural. Eng. – volume: 100 start-page: 11041 year: 2003 end-page: 11046 ident: bib12 article-title: Chronic, multisite, multielectrode recordings in macaque monkeys publication-title: Proc. Natl. Acad. Sci. Unit. States Am. – volume: 45 start-page: 157 year: 2008 end-page: 165 ident: bib99 article-title: Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta1-42 publication-title: J. Pineal Res. – volume: 28 year: 2018 ident: bib16 article-title: A materials roadmap to functional neural interface design publication-title: Adv. Funct. Mater. – volume: 48 start-page: 157 year: 2010 end-page: 169 ident: bib100 article-title: The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors publication-title: J. Pineal Res. – volume: 60 start-page: 1407 year: 2003 end-page: 1426 ident: bib47 article-title: Melatonin and cell death: differential actions on apoptosis in normal and cancer cells publication-title: Cell. Mol. Life Sci. CMLS – volume: 19 start-page: 178 year: 1995 end-page: 188 ident: bib49 article-title: The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes publication-title: J. Pineal Res. – volume: 278 start-page: 55 year: 2010 end-page: 67 ident: bib129 article-title: Melatonin: action as antioxidant and potential applications in human disease and aging publication-title: Toxicology – volume: 28 start-page: 311 year: 2011 end-page: 318 ident: bib117 article-title: Therapeutic window analysis of the neuroprotective effects of cyclosporine A after traumatic brain injury publication-title: J. Neurotrauma – volume: 195 start-page: 115 year: 2005 end-page: 126 ident: bib26 article-title: Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays publication-title: Exp. Neurol. – volume: 59 start-page: 323 year: 2012 end-page: 331 ident: bib108 article-title: NF-kappaB signaling pathway and free radical impact publication-title: Acta Biochim. Pol. – volume: 8 start-page: 31638 year: 2017 end-page: 31654 ident: bib112 article-title: Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/NF-κB signaling pathway after LPS treatment in neonatal rats publication-title: Oncotarget – volume: 108 start-page: 518 year: 2006 end-page: 524 ident: bib56 article-title: Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding publication-title: Blood – volume: 13 year: 2016 ident: bib101 article-title: Correlations between histology and neuronal activity recorded by microelectrodes implanted chronically in the cerebral cortex publication-title: J. Neural. Eng. – volume: 113 start-page: 279 year: 2017 end-page: 292 ident: bib88 article-title: Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy publication-title: Biomaterials – volume: 242 start-page: 15 year: 2015 end-page: 40 ident: bib66 article-title: Comprehensive chronic laminar single-unit, multi-unit, and local field potential recording performance with planar single shank electrode arrays publication-title: J. Neurosci. Meth. – volume: 29 start-page: 34 year: 2000 end-page: 39 ident: bib124 article-title: Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders publication-title: J. Pineal Res. – volume: 10 start-page: 433 year: 1997 end-page: 436 ident: bib63 article-title: The psychophysics toolbox publication-title: Spatial Vis. – volume: 258 start-page: 46 year: 2016 end-page: 55 ident: bib87 article-title: Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights publication-title: J. Neurosci. Meth. – volume: 10 start-page: 437 year: 1997 end-page: 442 ident: bib68 article-title: The VideoToolbox software for visual psychophysics: transforming numbers into movies publication-title: Spatial Vis. – volume: 60 start-page: 74 year: 2016 end-page: 83 ident: bib93 article-title: The neuroprotective and anti-apoptotic effects of melatonin on hemolytic hyperbilirubinemia-induced oxidative brain damage publication-title: J. Pineal Res. – volume: 38 start-page: 627 year: 2018 end-page: 640 ident: bib6 article-title: Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits publication-title: J. Cerebr. Blood Flow Metabol. – volume: 28 start-page: 11830 year: 2008 end-page: 11838 ident: bib3 article-title: Advanced neurotechnologies for chronic neural interfaces: new horizons and clinical opportunities publication-title: J. Neurosci. – volume: 9 year: 2012 ident: bib73 article-title: Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses publication-title: J. Neural. Eng. – volume: 51 start-page: 233 year: 2011 end-page: 245 ident: bib53 article-title: Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats publication-title: J. Pineal Res. – volume: 34 start-page: 613 year: 2002 end-page: 617 ident: bib64 article-title: The eyelink toolbox: eye tracking with MATLAB and the psychophysics toolbox publication-title: Behav. Res. Meth. – volume: 16 start-page: 249 year: 1987 end-page: 260 ident: bib115 article-title: Lectin binding by resting and reactive microglia publication-title: J. Neurocytol. – volume: 16 start-page: 1211 year: 2013 end-page: 1218 ident: bib119 article-title: M2 microglia/macrophages drive oligodendrocyte differentiation during CNS remyelination publication-title: Nat. Neurosci. – volume: 76 start-page: 23 year: 2014 end-page: 31 ident: bib95 article-title: Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: possible involvement of mTOR pathway publication-title: Neurochem. Int. – volume: 32 start-page: 249 year: 2009 end-page: 266 ident: bib1 article-title: The science of neural interface systems publication-title: Annu. Rev. Neurosci. – volume: 1148 start-page: 15 year: 2007 end-page: 27 ident: bib126 article-title: Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes publication-title: Brain Res. – volume: 11 start-page: 1065 year: 2012 end-page: 1073 ident: bib65 article-title: Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces publication-title: Nat. Mater. – volume: 1 start-page: 9 year: 2016 ident: bib41 article-title: A review of biological and pharmacological actions of melatonin: oxidant and prooxidant properties publication-title: Pharmacol. Rep. – volume: 36 start-page: 1 year: 2007 ident: bib62 article-title: What's new in Psychtoolbox-3 publication-title: Perception – volume: 143 start-page: 225 year: 2015 end-page: 234 ident: bib114 article-title: Use of labeled tomato lectin for imaging vasculature structures publication-title: Histochem. Cell Biol. – volume: 47 start-page: 184 year: 2009 end-page: 191 ident: bib55 article-title: Melatonin reduces cardiac inflammatory injury induced by acute exercise publication-title: J. Pineal Res. – volume: 34 start-page: 4703 year: 2013 end-page: 4713 ident: bib111 article-title: The impact of chronic blood-brain barrier breach on intracortical electrode function publication-title: Biomaterials – volume: 27 start-page: 487 year: 2004 end-page: 507 ident: bib11 article-title: Cortical neural prosthetics publication-title: Annu. Rev. Neurosci. – volume: 101 start-page: 1679 year: 2009 end-page: 1689 ident: bib69 article-title: Using a common average reference to improve cortical neuron recordings from microelectrode arrays publication-title: J. Neurophysiol. – volume: 55 start-page: 399 year: 2013 end-page: 408 ident: bib83 article-title: Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway publication-title: J. Pineal Res. – volume: 111 start-page: 1132 year: 2014 end-page: 1149 ident: bib5 article-title: Large-scale, high-density (up to 512 channels) recording of local circuits in behaving animals publication-title: J. Neurophysiol. – volume: 23 start-page: 189 year: 2013 end-page: 199 ident: bib58 article-title: The anti-inflammatory effect of melatonin on methamphetamine-induced proinflammatory mediators in human neuroblastoma dopamine SH-SY5Y cell lines publication-title: Neurotox. Res. – volume: 7 start-page: 65 year: 2009 end-page: 74 ident: bib107 article-title: Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options publication-title: Curr. Neuropharmacol. – volume: 54 start-page: 1 year: 2013 end-page: 14 ident: bib32 article-title: A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives publication-title: J. Pineal Res. – volume: 143 start-page: 225 year: 2015 end-page: 234 ident: bib75 article-title: Use of labeled tomato lectin for imaging vasculature structures publication-title: Histochem. Cell Biol. – volume: 54 start-page: 589 year: 1985 end-page: 599 ident: bib78 article-title: The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3 publication-title: Immunology – volume: 35 start-page: 797 year: 2003 end-page: 804 ident: bib121 article-title: Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats publication-title: Free Radical Biol. Med. – volume: 8 start-page: 228 year: 2010 end-page: 242 ident: bib42 article-title: Antiinflammatory activity of melatonin in central nervous system publication-title: Curr. Neuropharmacol. – volume: 34 start-page: 7001 year: 2013 end-page: 7015 ident: bib125 article-title: The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes publication-title: Biomaterials – volume: 6 year: 2009 ident: bib30 article-title: Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration publication-title: J. Neural. Eng. – volume: 86 start-page: 92 year: 2015 end-page: 105 ident: bib4 article-title: Tools for probing local circuits: high-density silicon probes combined with optogenetics publication-title: Neuron – volume: 69 start-page: 175 year: 1996 end-page: 188 ident: bib71 article-title: Automatic sorting of multiple unit neuronal signals in the presence of anisotropic and non-Gaussian variability publication-title: J. Neurosci. Meth. – volume: 61 start-page: 177 year: 2016 end-page: 186 ident: bib34 article-title: Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy publication-title: J. Pineal Res. – volume: 55 start-page: 26 year: 2013 end-page: 35 ident: bib67 article-title: Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis publication-title: Neurobiol. Dis. – volume: 442 start-page: 164 year: 2006 end-page: 171 ident: bib7 article-title: Neuronal ensemble control of prosthetic devices by a human with tetraplegia publication-title: Nature – volume: 14 start-page: 8638 year: 2013 end-page: 8683 ident: bib39 article-title: Melatonin: buffering the immune system publication-title: Int. J. Mol. Sci. – volume: 4 start-page: 21 year: 2017 end-page: 31 ident: bib106 article-title: Recent advances in neural electrode–tissue interfaces publication-title: Curr. Opin. Biomed. Eng. – volume: 114 start-page: E7997 year: 2017 end-page: E8006 ident: bib44 article-title: Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 174 start-page: 79 year: 2018 end-page: 94 ident: bib20 article-title: In vivo imaging of neuronal calcium during electrode implantation: Spatial and temporal mapping of damage and recovery publication-title: Biomaterials – volume: 17 start-page: 1683 year: 1997 end-page: 1690 ident: bib48 article-title: Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide publication-title: J. Neurosci.: Official J. Soc. Neurosci. – volume: 6 start-page: 13 year: 2014 ident: bib77 publication-title: The M1 and M2 Paradigm of Macrophage Activation: Time for Reassessment – volume: 7 start-page: 446 year: 2004 end-page: 451 ident: bib102 article-title: Large-scale recording of neuronal ensembles publication-title: Nat. Neurosci. – volume: 7 year: 2010 ident: bib109 article-title: Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping publication-title: J. Neural. Eng. – volume: 40 start-page: 41 year: 2017 end-page: 50 ident: bib104 article-title: Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice publication-title: Hypertens. Res. – volume: 48 start-page: 116 year: 2012 end-page: 122 ident: bib122 article-title: The effect of melatonin on retinal ganglion cell survival in ischemic retina publication-title: Chonnam Med. J. – volume: 13 start-page: 375 year: 2003 end-page: 387 ident: bib123 article-title: Protective role of melatonin in domoic acid-induced neuronal damage in the hippocampus of adult rats publication-title: Hippocampus – volume: 33 start-page: 146 year: 2002 end-page: 150 ident: bib60 article-title: Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-β immortalized pineal cells publication-title: J. Pineal Res. – volume: 27 start-page: 487 year: 2004 ident: 10.1016/j.biomaterials.2018.07.026_bib11 article-title: Cortical neural prosthetics publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.27.070203.144233 – volume: 115 start-page: 8 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib61 article-title: Melatonin as a proteasome inhibitor. Is there any clinical evidence? publication-title: Life Sci. doi: 10.1016/j.lfs.2014.08.024 – volume: 48 start-page: 20 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib45 article-title: Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2009.00721.x – volume: 47 start-page: 184 year: 2009 ident: 10.1016/j.biomaterials.2018.07.026_bib55 article-title: Melatonin reduces cardiac inflammatory injury induced by acute exercise publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2009.00699.x – volume: 53 start-page: 129 year: 2012 ident: 10.1016/j.biomaterials.2018.07.026_bib84 article-title: Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2012.00978.x – volume: 87 start-page: 157 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib86 article-title: Dexamethasone retrodialysis attenuates microglial response to implanted probes in vivo publication-title: Biomaterials doi: 10.1016/j.biomaterials.2016.02.013 – volume: 1 start-page: 862 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib19 article-title: Glial responses to implanted electrodes in the brain publication-title: Nature Biomed. Eng. doi: 10.1038/s41551-017-0154-1 – volume: 15 issue: 2 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib31 article-title: Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance publication-title: J. Neural. Eng. doi: 10.1088/1741-2552/aaa03e – volume: 45 start-page: 157 year: 2008 ident: 10.1016/j.biomaterials.2018.07.026_bib99 article-title: Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-beta1-42 publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2008.00570.x – volume: 32 start-page: 1377 year: 2004 ident: 10.1016/j.biomaterials.2018.07.026_bib127 article-title: Walle UK. High absorption but very low bioavailability of oral resveratrol in humans publication-title: Drug Metabol. Dispos. doi: 10.1124/dmd.104.000885 – volume: 57 start-page: 131 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib35 article-title: Melatonin: a well-documented antioxidant with conditional pro-oxidant actions publication-title: J. Pineal Res. doi: 10.1111/jpi.12162 – volume: 4 start-page: 21 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib106 article-title: Recent advances in neural electrode–tissue interfaces publication-title: Curr. Opin. Biomed. Eng. doi: 10.1016/j.cobme.2017.09.003 – volume: 29 start-page: 34 year: 2000 ident: 10.1016/j.biomaterials.2018.07.026_bib124 article-title: Clinical trials of controlled-release melatonin in children with sleep-wake cycle disorders publication-title: J. Pineal Res. doi: 10.1034/j.1600-079X.2000.290105.x – volume: 118 start-page: 194 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib17 article-title: Functional remodeling of subtype-specific markers surrounding implanted neuroprostheses publication-title: J. Neurophysiol. doi: 10.1152/jn.00162.2017 – volume: 52 start-page: 205 year: 2006 ident: 10.1016/j.biomaterials.2018.07.026_bib2 article-title: Brain-controlled interfaces: movement restoration with neural prosthetics publication-title: Neuron doi: 10.1016/j.neuron.2006.09.019 – volume: 54 start-page: 589 year: 1985 ident: 10.1016/j.biomaterials.2018.07.026_bib78 article-title: The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3 publication-title: Immunology – volume: 17 start-page: 1683 year: 1997 ident: 10.1016/j.biomaterials.2018.07.026_bib48 article-title: Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide publication-title: J. Neurosci.: Official J. Soc. Neurosci. doi: 10.1523/JNEUROSCI.17-05-01683.1997 – volume: 15 issue: 3 year: 2018 ident: 10.1016/j.biomaterials.2018.07.026_bib18 article-title: Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new Emphasis on the Biological Interface publication-title: J. Neural. Eng. doi: 10.1088/1741-2552/aa9dae – volume: 80 start-page: 1844 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib40 article-title: Melatonin: a pleiotropic molecule regulating inflammation publication-title: Biochem. Pharmacol. doi: 10.1016/j.bcp.2010.07.041 – volume: 7 start-page: 65 year: 2009 ident: 10.1016/j.biomaterials.2018.07.026_bib107 article-title: Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options publication-title: Curr. Neuropharmacol. doi: 10.2174/157015909787602823 – volume: 35 start-page: 9255 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib72 article-title: Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.07.039 – volume: 51 start-page: 233 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib53 article-title: Melatonin attenuates brain contusion-induced oxidative insult, inactivation of signal transducers and activators of transcription 1, and upregulation of suppressor of cytokine signaling-3 in rats publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2011.00885.x – volume: 7 start-page: 40144 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib76 article-title: Predictive screening of M1 and M2 macrophages reveals the immunomodulatory effectiveness of post spinal cord injury azithromycin treatment publication-title: Sci. Rep. doi: 10.1038/srep40144 – volume: 100 start-page: 11041 year: 2003 ident: 10.1016/j.biomaterials.2018.07.026_bib12 article-title: Chronic, multisite, multielectrode recordings in macaque monkeys publication-title: Proc. Natl. Acad. Sci. Unit. States Am. doi: 10.1073/pnas.1934665100 – volume: 55 start-page: 26 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib67 article-title: Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2013.03.008 – volume: 148 start-page: 1 year: 2005 ident: 10.1016/j.biomaterials.2018.07.026_bib22 article-title: Response of brain tissue to chronically implanted neural electrodes publication-title: J. Neurosci. Meth. doi: 10.1016/j.jneumeth.2005.08.015 – volume: 17 start-page: 1483 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib38 article-title: Molecular mechanisms of the pro-apoptotic actions of melatonin in cancer: a review publication-title: Expert Opin. Ther. Targets doi: 10.1517/14728222.2013.834890 – volume: 10 start-page: 433 year: 1997 ident: 10.1016/j.biomaterials.2018.07.026_bib63 article-title: The psychophysics toolbox publication-title: Spatial Vis. doi: 10.1163/156856897X00357 – volume: 442 start-page: 164 year: 2006 ident: 10.1016/j.biomaterials.2018.07.026_bib7 article-title: Neuronal ensemble control of prosthetic devices by a human with tetraplegia publication-title: Nature doi: 10.1038/nature04970 – volume: 8 start-page: 361ra141 issue: 361 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib9 article-title: Intracortical microstimulation of human somatosensory cortex publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aaf8083 – volume: 34 start-page: 613 year: 2002 ident: 10.1016/j.biomaterials.2018.07.026_bib64 article-title: The eyelink toolbox: eye tracking with MATLAB and the psychophysics toolbox publication-title: Behav. Res. Meth. doi: 10.3758/BF03195489 – volume: 9 year: 2012 ident: 10.1016/j.biomaterials.2018.07.026_bib85 article-title: In vivo two-photon microscopy reveals immediate microglial reaction to implantation of microelectrode through extension of processes publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/9/6/066001 – volume: 1148 start-page: 15 year: 2007 ident: 10.1016/j.biomaterials.2018.07.026_bib126 article-title: Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes publication-title: Brain Res. doi: 10.1016/j.brainres.2007.02.024 – volume: 183 start-page: 149 year: 2009 ident: 10.1016/j.biomaterials.2018.07.026_bib89 article-title: Flavopiridol reduces the impedance of neural prostheses in vivo without affecting recording quality publication-title: J. Neurosci. Meth. doi: 10.1016/j.jneumeth.2009.06.026 – volume: 48 start-page: 157 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib100 article-title: The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2009.00739.x – volume: 16 start-page: 1211 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib119 article-title: M2 microglia/macrophages drive oligodendrocyte differentiation during CNS remyelination publication-title: Nat. Neurosci. doi: 10.1038/nn.3469 – volume: 9 start-page: 747 year: 2000 ident: 10.1016/j.biomaterials.2018.07.026_bib50 article-title: Apoptosis modulators in the therapy of neurodegenerative diseases publication-title: Expet Opin. Invest. Drugs doi: 10.1517/13543784.9.4.747 – volume: 164 start-page: 121 year: 2018 ident: 10.1016/j.biomaterials.2018.07.026_bib23 article-title: In vivo spatiotemporal dynamics of NG2 glia activity caused by neural electrode implantation publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.02.037 – volume: 31 start-page: 9163 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib110 article-title: A comparison of the tissue response to chronically implanted Parylene-C-coated and uncoated planar silicon microelectrode arrays in rat cortex publication-title: Biomaterials doi: 10.1016/j.biomaterials.2010.05.050 – volume: 7 start-page: 2 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib82 article-title: Abiotic-biotic characterization of Pt/Ir microelectrode arrays in chronic implants publication-title: Front. Neuroeng. doi: 10.3389/fneng.2014.00002 – volume: 37 start-page: 25 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib80 article-title: Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.10.040 – volume: 50 start-page: 436 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib54 article-title: Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2011.00863.x – volume: 13 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib101 article-title: Correlations between histology and neuronal activity recorded by microelectrodes implanted chronically in the cerebral cortex publication-title: J. Neural. Eng. – volume: 28 start-page: 9330 year: 2008 ident: 10.1016/j.biomaterials.2018.07.026_bib118 article-title: Another barrier to regeneration in the CNS: activated macrophages induce extensive retraction of dystrophic axons through direct physical interactions publication-title: J. Neurosci.: Official J. Soc. Neurosci. doi: 10.1523/JNEUROSCI.2488-08.2008 – volume: 332 start-page: 385 year: 2006 ident: 10.1016/j.biomaterials.2018.07.026_bib130 article-title: Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis publication-title: Bmj doi: 10.1136/bmj.38731.532766.F6 – volume: 8 start-page: 2578 issue: 12 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib24 article-title: Understanding the inflammatory tissue reaction to brain implants to improve neurochemical sensing performance publication-title: ACS Chem. Neurosci. doi: 10.1021/acschemneuro.7b00403 – volume: 143 start-page: 225 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib114 article-title: Use of labeled tomato lectin for imaging vasculature structures publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-014-1301-3 – volume: 48 start-page: 9 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib133 article-title: Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2009.00729.x – volume: 40 start-page: 86 year: 2004 ident: 10.1016/j.biomaterials.2018.07.026_bib59 article-title: Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats publication-title: J. Hepatol. doi: 10.1016/S0168-8278(03)00504-X – volume: 26 start-page: 158 year: 1999 ident: 10.1016/j.biomaterials.2018.07.026_bib96 article-title: Effects of melatonin on macrophages/microglia in postnatal rat brain publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.1999.tb00578.x – volume: 60 start-page: 1407 year: 2003 ident: 10.1016/j.biomaterials.2018.07.026_bib47 article-title: Melatonin and cell death: differential actions on apoptosis in normal and cancer cells publication-title: Cell. Mol. Life Sci. CMLS doi: 10.1007/s00018-003-2319-1 – volume: 258 start-page: 46 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib87 article-title: Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights publication-title: J. Neurosci. Meth. doi: 10.1016/j.jneumeth.2015.10.007 – volume: 12 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib79 article-title: Progress towards biocompatible intracortical microelectrodes for neural interfacing applications publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/12/1/011001 – volume: 51 start-page: 1 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib97 article-title: Melatonin as a natural ally against oxidative stress: a physicochemical examination publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2011.00916.x – volume: 36 start-page: 1 year: 2007 ident: 10.1016/j.biomaterials.2018.07.026_bib62 article-title: What's new in Psychtoolbox-3 publication-title: Perception – volume: 195 start-page: 115 year: 2005 ident: 10.1016/j.biomaterials.2018.07.026_bib26 article-title: Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2005.04.020 – volume: 12 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib21 article-title: Implications of chronic daily anti-oxidant administration on the inflammatory response to intracortical microelectrodes publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/12/4/046002 – volume: 8 start-page: 228 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib42 article-title: Antiinflammatory activity of melatonin in central nervous system publication-title: Curr. Neuropharmacol. doi: 10.2174/157015910792246155 – volume: 76 start-page: 23 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib95 article-title: Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: possible involvement of mTOR pathway publication-title: Neurochem. Int. doi: 10.1016/j.neuint.2014.06.015 – volume: 28 start-page: 311 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib117 article-title: Therapeutic window analysis of the neuroprotective effects of cyclosporine A after traumatic brain injury publication-title: J. Neurotrauma doi: 10.1089/neu.2010.1646 – volume: 278 start-page: 55 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib129 article-title: Melatonin: action as antioxidant and potential applications in human disease and aging publication-title: Toxicology doi: 10.1016/j.tox.2010.04.008 – volume: 40 start-page: 41 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib104 article-title: Effect of long-term treatment with melatonin on vascular markers of oxidative stress/inflammation and on the anticontractile activity of perivascular fat in aging mice publication-title: Hypertens. Res. doi: 10.1038/hr.2016.103 – volume: 113 start-page: 279 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib88 article-title: Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy publication-title: Biomaterials doi: 10.1016/j.biomaterials.2016.10.054 – volume: 6 start-page: 48 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib15 article-title: Brain tissue responses to neural implants impact signal sensitivity and intervention strategies publication-title: ACS Chem. Neurosci. doi: 10.1021/cn500256e – volume: 54 start-page: 381 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib52 article-title: Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats publication-title: J. Pineal Res. doi: 10.1111/jpi.12012 – volume: 6 start-page: 13 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib77 – volume: 50 start-page: 403 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib90 article-title: Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2011.00858.x – volume: 44 start-page: 3865 year: 1999 ident: 10.1016/j.biomaterials.2018.07.026_bib105 article-title: Passivation and corrosion of microelectrode arrays publication-title: Electrochim. Acta doi: 10.1016/S0013-4686(99)00094-8 – volume: 2017 start-page: 13 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib33 article-title: Melatonin as an anti-inflammatory agent modulating inflammasome activation publication-title: Int. J. Endocrinol. doi: 10.1155/2017/1835195 – volume: 55 start-page: 26 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib43 article-title: Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2013.03.008 – volume: 13 start-page: 375 year: 2003 ident: 10.1016/j.biomaterials.2018.07.026_bib123 article-title: Protective role of melatonin in domoic acid-induced neuronal damage in the hippocampus of adult rats publication-title: Hippocampus doi: 10.1002/hipo.10090 – volume: 15 start-page: 43 year: 2009 ident: 10.1016/j.biomaterials.2018.07.026_bib57 article-title: Melatonin: an established antioxidant worthy of use in clinical trials publication-title: Mol. Med. doi: 10.2119/molmed.2008.00117 – volume: 86 start-page: 92 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib4 article-title: Tools for probing local circuits: high-density silicon probes combined with optogenetics publication-title: Neuron doi: 10.1016/j.neuron.2015.01.028 – volume: 35 start-page: 797 year: 2003 ident: 10.1016/j.biomaterials.2018.07.026_bib121 article-title: Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats publication-title: Free Radical Biol. Med. doi: 10.1016/S0891-5849(03)00408-8 – volume: 28 start-page: 11830 year: 2008 ident: 10.1016/j.biomaterials.2018.07.026_bib3 article-title: Advanced neurotechnologies for chronic neural interfaces: new horizons and clinical opportunities publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3879-08.2008 – volume: 28 issue: 12 year: 2018 ident: 10.1016/j.biomaterials.2018.07.026_bib16 article-title: A materials roadmap to functional neural interface design publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201701269 – volume: 2011 start-page: 3020 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib14 article-title: Coupling biotic and abiotic metrics to create a testbed for predicting neural electrode performance publication-title: Conf Proc. IEEE Eng. Med. Biol. Soc. – volume: 6 year: 2009 ident: 10.1016/j.biomaterials.2018.07.026_bib30 article-title: Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/6/5/056003 – start-page: 261 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib74 article-title: Tomato lectin histochemistry for microglial visualization – volume: 34 start-page: 4703 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib111 article-title: The impact of chronic blood-brain barrier breach on intracortical electrode function publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.03.007 – volume: 35 start-page: 9620 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib29 article-title: Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response publication-title: Biomaterials doi: 10.1016/j.biomaterials.2014.08.006 – volume: 108 start-page: 518 year: 2006 ident: 10.1016/j.biomaterials.2018.07.026_bib56 article-title: Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding publication-title: Blood doi: 10.1182/blood-2005-09-3691 – volume: 48 start-page: 116 year: 2012 ident: 10.1016/j.biomaterials.2018.07.026_bib122 article-title: The effect of melatonin on retinal ganglion cell survival in ischemic retina publication-title: Chonnam Med. J. doi: 10.4068/cmj.2012.48.2.116 – volume: 12 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib120 article-title: The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells publication-title: PLoS One – volume: 16 start-page: 13 year: 2018 ident: 10.1016/j.biomaterials.2018.07.026_bib128 article-title: ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood–brain barrier publication-title: J. Nanobiotechnol. doi: 10.1186/s12951-018-0340-7 – volume: 61 start-page: 177 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib34 article-title: Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy publication-title: J. Pineal Res. doi: 10.1111/jpi.12337 – volume: 48 start-page: 423 year: 2004 ident: 10.1016/j.biomaterials.2018.07.026_bib113 article-title: Lycopersicon esculentum lectin: an effective and versatile endothelial marker of normal and tumoral blood vessels in the central nervous system publication-title: Eur. J. Histochem. doi: 10.4081/916 – volume: 381 start-page: 557 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib8 article-title: High-performance neuroprosthetic control by an individual with tetraplegia publication-title: Lancet doi: 10.1016/S0140-6736(12)61816-9 – volume: 59 start-page: 323 year: 2012 ident: 10.1016/j.biomaterials.2018.07.026_bib108 article-title: NF-kappaB signaling pathway and free radical impact publication-title: Acta Biochim. Pol. doi: 10.18388/abp.2012_2116 – volume: 8 start-page: 31638 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib112 article-title: Melatonin protects against blood-brain barrier damage by inhibiting the TLR4/NF-κB signaling pathway after LPS treatment in neonatal rats publication-title: Oncotarget doi: 10.18632/oncotarget.15780 – volume: 59 start-page: 403 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib36 article-title: Melatonin: an ancient molecule that makes oxygen metabolically tolerable publication-title: J. Pineal Res. doi: 10.1111/jpi.12267 – volume: 1 start-page: 9 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib41 article-title: A review of biological and pharmacological actions of melatonin: oxidant and prooxidant properties publication-title: Pharmacol. Rep. – volume: 111 start-page: 1132 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib5 article-title: Large-scale, high-density (up to 512 channels) recording of local circuits in behaving animals publication-title: J. Neurophysiol. doi: 10.1152/jn.00785.2013 – volume: 9 start-page: 208 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib116 article-title: Microglial activation in traumatic brain injury publication-title: Front. Aging Neurosci. doi: 10.3389/fnagi.2017.00208 – volume: 7 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib109 article-title: Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/7/4/046011 – volume: 54 start-page: 1 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib32 article-title: A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2012.01014.x – volume: 32 start-page: 249 year: 2009 ident: 10.1016/j.biomaterials.2018.07.026_bib1 article-title: The science of neural interface systems publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.neuro.051508.135241 – volume: 7 start-page: 10 year: 2014 ident: 10.1016/j.biomaterials.2018.07.026_bib28 article-title: The sinusoidal probe: a new approach to improve electrode longevity publication-title: Front. Neuroeng. doi: 10.3389/fneng.2014.00010 – volume: 10 start-page: 437 year: 1997 ident: 10.1016/j.biomaterials.2018.07.026_bib68 article-title: The VideoToolbox software for visual psychophysics: transforming numbers into movies publication-title: Spatial Vis. doi: 10.1163/156856897X00366 – volume: 50 start-page: 124 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib91 article-title: Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-kappaB and Nrf2 cascades publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2010.00821.x – volume: 55 start-page: 399 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib83 article-title: Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway publication-title: J. Pineal Res. doi: 10.1111/jpi.12087 – volume: 55 start-page: 14 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib94 article-title: Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells publication-title: J. Pineal Res. doi: 10.1111/jpi.12045 – volume: 33 start-page: 146 year: 2002 ident: 10.1016/j.biomaterials.2018.07.026_bib60 article-title: Melatonin suppresses NO-induced apoptosis via induction of Bcl-2 expression in PGT-β immortalized pineal cells publication-title: J. Pineal Res. doi: 10.1034/j.1600-079X.2002.02899.x – volume: 16 start-page: 18 year: 2018 ident: 10.1016/j.biomaterials.2018.07.026_bib132 article-title: Melatonin and health: an umbrella review of health outcomes and biological mechanisms of action publication-title: BMC Med. doi: 10.1186/s12916-017-1000-8 – volume: 61 start-page: 253 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib103 article-title: Melatonin as an antioxidant: under promises but over delivers publication-title: J. Pineal Res. doi: 10.1111/jpi.12360 – volume: 38 start-page: 627 issue: 4 year: 2018 ident: 10.1016/j.biomaterials.2018.07.026_bib6 article-title: Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits publication-title: J. Cerebr. Blood Flow Metabol. doi: 10.1177/0271678X18755225 – volume: 69 start-page: 175 year: 1996 ident: 10.1016/j.biomaterials.2018.07.026_bib71 article-title: Automatic sorting of multiple unit neuronal signals in the presence of anisotropic and non-Gaussian variability publication-title: J. Neurosci. Meth. doi: 10.1016/S0165-0270(96)00050-7 – volume: 7 start-page: 446 year: 2004 ident: 10.1016/j.biomaterials.2018.07.026_bib102 article-title: Large-scale recording of neuronal ensembles publication-title: Nat. Neurosci. doi: 10.1038/nn1233 – volume: 9 year: 2012 ident: 10.1016/j.biomaterials.2018.07.026_bib73 article-title: Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/9/4/046020 – volume: 101 start-page: 1679 year: 2009 ident: 10.1016/j.biomaterials.2018.07.026_bib69 article-title: Using a common average reference to improve cortical neuron recordings from microelectrode arrays publication-title: J. Neurophysiol. doi: 10.1152/jn.90989.2008 – volume: 242 start-page: 15 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib66 article-title: Comprehensive chronic laminar single-unit, multi-unit, and local field potential recording performance with planar single shank electrode arrays publication-title: J. Neurosci. Meth. doi: 10.1016/j.jneumeth.2014.12.010 – volume: 34 start-page: 7001 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib125 article-title: The effect of resveratrol on neurodegeneration and blood brain barrier stability surrounding intracortical microelectrodes publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.05.035 – volume: 14 start-page: 8638 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib39 article-title: Melatonin: buffering the immune system publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms14048638 – volume: 983 start-page: 23 year: 2003 ident: 10.1016/j.biomaterials.2018.07.026_bib27 article-title: Brain responses to micro-machined silicon devices publication-title: Brain Res. doi: 10.1016/S0006-8993(03)03023-3 – volume: 174 start-page: 79 year: 2018 ident: 10.1016/j.biomaterials.2018.07.026_bib20 article-title: In vivo imaging of neuronal calcium during electrode implantation: Spatial and temporal mapping of damage and recovery publication-title: Biomaterials doi: 10.1016/j.biomaterials.2018.04.043 – volume: 60 start-page: 74 year: 2016 ident: 10.1016/j.biomaterials.2018.07.026_bib93 article-title: The neuroprotective and anti-apoptotic effects of melatonin on hemolytic hyperbilirubinemia-induced oxidative brain damage publication-title: J. Pineal Res. doi: 10.1111/jpi.12292 – volume: 82 start-page: 1 year: 1998 ident: 10.1016/j.biomaterials.2018.07.026_bib13 article-title: Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex publication-title: J. Neurosci. Meth. doi: 10.1016/S0165-0270(98)00031-4 – volume: 120 start-page: 113 year: 2002 ident: 10.1016/j.biomaterials.2018.07.026_bib70 article-title: Real-time multi-channel stimulus artifact suppression by local curve fitting publication-title: J. Neurosci. Meth. doi: 10.1016/S0165-0270(02)00149-8 – volume: 35 start-page: 1165 year: 2000 ident: 10.1016/j.biomaterials.2018.07.026_bib51 article-title: Neuronal plasticity and stressor toxicity during aging publication-title: Exp. Gerontol. doi: 10.1016/S0531-5565(00)00121-2 – volume: 48 start-page: 297 year: 2010 ident: 10.1016/j.biomaterials.2018.07.026_bib46 article-title: Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.2010.00759.x – volume: 4 start-page: L1 year: 2007 ident: 10.1016/j.biomaterials.2018.07.026_bib25 article-title: Minocycline increases quality and longevity of chronic neural recordings publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/4/2/L01 – volume: 16 start-page: 249 year: 1987 ident: 10.1016/j.biomaterials.2018.07.026_bib115 article-title: Lectin binding by resting and reactive microglia publication-title: J. Neurocytol. doi: 10.1007/BF01795308 – volume: 19 start-page: 178 year: 1995 ident: 10.1016/j.biomaterials.2018.07.026_bib49 article-title: The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes publication-title: J. Pineal Res. doi: 10.1111/j.1600-079X.1995.tb00187.x – volume: 2 start-page: 103 year: 2005 ident: 10.1016/j.biomaterials.2018.07.026_bib92 article-title: A finite-element model of the mechanical effects of implantable microelectrodes in the cerebral cortex publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/2/4/006 – volume: 8 year: 2011 ident: 10.1016/j.biomaterials.2018.07.026_bib10 article-title: Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/8/4/045005 – volume: 23 start-page: 189 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib58 article-title: The anti-inflammatory effect of melatonin on methamphetamine-induced proinflammatory mediators in human neuroblastoma dopamine SH-SY5Y cell lines publication-title: Neurotox. Res. doi: 10.1007/s12640-012-9350-7 – volume: 114 start-page: E7997 year: 2017 ident: 10.1016/j.biomaterials.2018.07.026_bib44 article-title: Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1705768114 – volume: 2012 year: 2012 ident: 10.1016/j.biomaterials.2018.07.026_bib98 article-title: Oxidative stress and immunosenescence: therapeutic effects of melatonin publication-title: Oxid. Med. Cell Longev. doi: 10.1155/2012/670294 – volume: 10 year: 2013 ident: 10.1016/j.biomaterials.2018.07.026_bib81 article-title: Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates publication-title: J. Neural. Eng. doi: 10.1088/1741-2560/10/6/066014 – volume: 143 start-page: 225 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib75 article-title: Use of labeled tomato lectin for imaging vasculature structures publication-title: Histochem. Cell Biol. doi: 10.1007/s00418-014-1301-3 – volume: 20 start-page: 18886 year: 2015 ident: 10.1016/j.biomaterials.2018.07.026_bib37 article-title: Melatonin as a potent and inducible endogenous antioxidant: synthesis and metabolism publication-title: Molecules doi: 10.3390/molecules201018886 – volume: 11 start-page: 1065 year: 2012 ident: 10.1016/j.biomaterials.2018.07.026_bib65 article-title: Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces publication-title: Nat. Mater. doi: 10.1038/nmat3468 – volume: 20 start-page: 1151 year: 2005 ident: 10.1016/j.biomaterials.2018.07.026_bib131 article-title: The efficacy and safety of exogenous melatonin for primary sleep disorders publication-title: J. Gen. Intern. Med. doi: 10.1111/j.1525-1497.2005.0243.x |
| SSID | ssj0014042 |
| Score | 2.5174043 |
| Snippet | The chronic performance of implantable neural electrodes is hindered by inflammatory brain tissue responses, including microglia activation, glial scarring,... |
| SourceID | unpaywall pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 225 |
| SubjectTerms | Animals Antioxidant Antioxidants - metabolism apoptosis Apoptosis - drug effects caspase-1 cytochrome c electrodes Gliosis - drug therapy Gliosis - metabolism histology Inflammation - drug therapy Inflammation - metabolism Inflammatory gliosis intraperitoneal injection longevity Male Melatonin Melatonin - pharmacology Melatonin - therapeutic use Mice Mice, Inbred C57BL Microelectrode arrays Microelectrodes mitochondria neuroglia neurons neuroprotective effect Oxidative stress Oxidative Stress - drug effects Single-unit recording viability visual cortex |
| SummonAdditionalLinks | – databaseName: Elsevier ScienceDirect dbid: .~1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fa9swED5KH7ruoXTtfqTdhgZ99eJIsmRR-lC6lTLInlbom5Ata8sITlgTSl_6t_fOsk1Cy8jYo22dje_Od4f83XcAJxJLVh6kTLgZFYnElJc4zkdJ6VJvHPdeNe1j4-_q6lp-u8lutuCi64UhWGUb-2NMb6J1e2bYanM4n0yGBEvihgiwckGeRbTbUmqaYvD5oYd5EHsMjzBGntDqjni0wXhRi7tbRFMTzCtviDyJaOH5JPW0CH2KpXyxrOfu_s5NpyuJ6nIf9toKk53Hl3gFW1V9AC9XeAcPYGfc_lE_hC9jQsPRniybNPsL1S2LjZb3zNWeTWf1z4rmS7BZYGVk0mVEgomPiBs8eMfXcH359cfFVdJOVkjKTJtFokWm0DY56qOQrpTeeC-yPARjPBZ8WkiZBq_ytMTqAZM8Xgjc5aXTSqW5ceINbNezunoHDMunyvFR0KlyWIyFQmifBR9CwaVWTg3AdKq0ZUs7TtMvprbDl_22q2awZAabaotmGIDoZeeRfGMjqdPOYrZrL8WAaDFHbCR91kuvOeLG8p86J7H4pdLvF1dXsyUt0jnNaFX6L2tGghgIhTADeBsdq39zGiwgsGAcgF5zuX4BMYWvX6knvxrGcEVhWOE9Ze-c_6DQo_9UyTHs0lGEQL6H7cWfZfUBS7lF8bH5Vh8BSXpKtw priority: 102 providerName: Elsevier |
| Title | Melatonin improves quality and longevity of chronic neural recording |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0142961218305106 https://dx.doi.org/10.1016/j.biomaterials.2018.07.026 https://www.ncbi.nlm.nih.gov/pubmed/30053658 https://www.proquest.com/docview/2078590067 https://www.proquest.com/docview/2131866339 https://pubmed.ncbi.nlm.nih.gov/PMC6179369 https://www.ncbi.nlm.nih.gov/pmc/articles/6179369 |
| UnpaywallVersion | submittedVersion |
| Volume | 180 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1878-5905 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014042 issn: 1878-5905 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1878-5905 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014042 issn: 1878-5905 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect (Elsevier) customDbUrl: eissn: 1878-5905 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014042 issn: 1878-5905 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: ScienceDirect Freedom Collection Journals customDbUrl: eissn: 1878-5905 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014042 issn: 1878-5905 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1878-5905 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0014042 issn: 1878-5905 databaseCode: AKRWK dateStart: 19800101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwEB7tthKPA49lgfCogsQ13SR27FiIQwWsCqgVQlRaTpFjx1DIphWkQsuB3844TqIui1CXY2RPInsm8Rf7m28AnlKErLGhNIhFlAcUl7xAxnEUKBlqIWOtWZM-Npuz6YK-OUlO9iDqcmEa0r7Kl-OqPB1Xy88Nt3J9qo46ntgRsyHFxD4MWYLwewDDxfzd5KOjKsaBYO6EM8W_o0SESSc02nC6bEq7rJ1rLa0rbYQ7rbDC3xeli6DzInfy6qZay7Mfsiy3Fqbjm_C-G5Ljo3wdb-p8rH7-ofZ4qTHfghstTPUnruk27BXVAVzfEi88gCuz9lj-DrycWUqd3dj1l80mRfHdd9maZ76stF-uqk-FLVLhr4yvnByvb5U08RFulwjveAiL41cfXkyDtjxDoBIu6oCThKGDU5zwnEpFtdCaJKkxQmhEjZxQGhrN0lAhBEGkgA0mlqmSnLEwFZLchUG1qor74CMGK2QcGR4yiYjO5ITrxGhj8phyJpkHovNPplrtcltCo8w6ktqXbNu3mfVtFvIMfesB6W3XTsFjJ6tnXRhkXY4qflUzXGh2sn7eW7dIxiGUne2fdJGX4etuz3BkVaw2thNPbaFXxv_RJyJWxpAQ4cE9F639yG11AoKo0wN-Lo77DlZu_HwLRmQjO94GoQe0j_hLTOiD_zN7CNfslaNPPoJB_W1TPEYYWOcj2B__ikYwnLx-O52P2s_Abx1oYq4 |
| linkProvider | Unpaywall |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fb9MwED6NITH2gGAwKD-NxGtoajt2LMQDGkwF1j1t0t4sJ46hU5VW0ArtZX87d3EStRpCRbzWvkS5u9xdne--A3gjsWTlQcqEm1GRSEx5ieN8lJQu9cZx71XTPjY5VeNz-eUiu9iBo64XhmCVbeyPMb2J1u0vw1abw8V0OiRYEjdEgJUL8ix1C27LjGv6B_b2usd5EH0MjzhGntD2jnm0AXlRj7tbRlsTzitvmDyJaeHPWepmFXoTTLm3qhfu6pebzdYy1fF9uNeWmOxDfIoHsFPVB7C_Rjx4AHcm7Sf1h_BxQnA4OpRl0-aAofrJYqflFXO1Z7N5_a2iARNsHlgZqXQZsWDiLeIJD17xEZwffzo7GiftaIWkzLRZJlpkCo2Toz4K6Urpjfciy0MwxmPFp4WUafAqT0ssHzDL40LgLi-dVirNjROHsFvP6-oJMKyfKsdHQafKYTUWCqF9FnwIBZdaOTUA06nSli3vOI2_mNkOYHZp181gyQw21RbNMADRyy4i-8ZWUu86i9muvxQjosUksZX0-156wxO3ln_dOYnFV5W-v7i6mq9ok85pSKvSf9kzEkRBKIQZwOPoWP2T02QBgRXjAPSGy_UbiCp8c6Wefm8owxXFYYXXlL1z_oNCn_6nSl7B3vhscmJPPp9-fQZ3aSXiIZ_D7vLHqnqBdd2yeNm8t78B5BVN2g |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bi9QwFD6ss-Dlwct6qzci-NrZtkmTBvFhUZdFmEXEgfWppEmjo93OoB1k_fWeNE2ZdUVmfSzJaUnOafM1-c53AF4whKyZZSzOZFrFDJe8WGVZGmuVGKkyY3ifPjY75kdz9u4kP9mBNOTC9KR9XS2mbXM6bRdfem7l6lTvB57YPnchxeUV2OU5wu8J7M6P3x988lTFLJbcn3AW-HeUyyQPQqM9p8ultKvOu9bRuopeuNMJK_x9UboIOi9yJ6-t25U6-6maZmNhOrwFH8KQPB_l23TdVVP96w-1x0uN-TbcHGAqOfBNd2CnbvfgxoZ44R5cnQ3H8nfhzcxR6tzGLln0mxT1D-KzNc-Iag1plu3n2hWpIEtLtJfjJU5JEx_hd4nwjvdgfvj24-ujeCjPEOtcyC4WNOfo4AInvGJKMyONoXlhrZQGUaOgjCXW8CLRCEEQKWCDzVShleA8KaSi92HSLtv6IRDEYLXKUisSrhDR2YoKk1tjbZUxwRWPQAb_lHrQLnclNJoykNS-lpu-LZ1vy0SU6NsI6Gi78goeW1m9DGFQhhxV_KqWuNBsZf1qtB6QjEcoW9s_D5FX4uvuznBUWy_XrpMoXKFXLv7RJ6VOxpBSGcEDH63jyF11AoqoMwJxLo7HDk5u_HwLRmQvOz4EYQRsjPhLTOij_zN7DNfdladPPoFJ931dP0UY2FXPhhf_N87VYCI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Melatonin+improves+quality+and+longevity+of+chronic+neural+recording&rft.jtitle=Biomaterials&rft.au=Golabchi%2C+Asiyeh&rft.au=Wu%2C+Bingchen&rft.au=Li%2C+Xia&rft.au=Carlisle%2C+Diane+L&rft.date=2018-10-01&rft.eissn=1878-5905&rft.volume=180&rft.spage=225&rft_id=info:doi/10.1016%2Fj.biomaterials.2018.07.026&rft_id=info%3Apmid%2F30053658&rft.externalDocID=30053658 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0142-9612&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0142-9612&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0142-9612&client=summon |