Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy - Meshnick, S.R. (University of Michigan School of Public Health, Ann Arbor, MI.); Taylor, T.E; Kamchonwongpaisan, S (Microbiological Reviews, 1996)
Keywords: ADVERSE EFFECTS; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; antimalarial properties; Antimalarials; Antimalarials - metabolism; Antimalarials - pharmacology; Antimalarials - therapeutic use; Antiparasitic agents; ANTIPROTOZOAIRE; ANTIPROTOZOAL AGENTS; artemisinin; Artemisinins; Biological and medical sciences; Clinical Trials as Topic; DERIVATIVES; drug effects; Drug Resistance; DRUG THERAPY; DRUG TOXICITY; DRUGS; EFECTOS SECUNDARIOS; EFFET SECONDAIRE; FARMACOLOGIA; GENERO HUMANO; GENRE HUMAIN; Humans; LITERATURE REVIEWS; MALARIA; Malaria - drug therapy; Malaria, Falciparum; Malaria, Falciparum - drug therapy; MANKIND; Medical sciences; MEDICAMENT; MEDICAMENTOS; MEDICAMENTOS CONTRA PROTOZOARIOS; MEDICINAL PROPERTIES; METABOLISM; METABOLISME; METABOLISMO; Peroxides; Peroxides - metabolism; Peroxides - pharmacology; Peroxides - therapeutic use; Peroxides - toxicity; pharmacokinetics; PHARMACOLOGIE; PHARMACOLOGY; Pharmacology. Drug treatments; Plasmodium; Plasmodium falciparum; Plasmodium falciparum - drug effects; PROPERTIES; PROPIEDADES MEDICINALES; PROPRIETE PHARMACOLOGIQUE; QINGHAOSU; RESISTANCE AUX PRODUITS CHIMIQUES; RESISTANCE TO CHEMICALS; RESISTENCIA A PRODUCTOS QUIMICOS; Sesquiterpenes; Sesquiterpenes - metabolism; Sesquiterpenes - pharmacology; Sesquiterpenes - therapeutic use; Sesquiterpenes - toxicity; SIDE EFFECTS; TERAPEUTICA MEDICAMENTOSA; therapeutic use; THERAPEUTIQUE MEDICAMENTEUSE; TOXICIDAD; TOXICITE; TOXICITY; Endoperoxide; Protozoa; Antimalarial; Protozoal disease; Malaria; Toxicity; Parasitosis; Review; Compositae; Metabolism; Medicinal plant; Infection; Plasmodium falciparum; Chemotherapy; Treatment; Structure activity relation; Dicotyledones; Angiospermae; Parasiticid; Plant origin; Spermatophyta; Mechanism of action; Pharmacokinetics; Sporozoa