Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy
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| Published in | Microbiological Reviews Vol. 60; no. 2; pp. 301 - 315 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Society for Microbiology
01.06.1996
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 0146-0749 1092-2172 1098-5557 |
| DOI | 10.1128/mmbr.60.2.301-315.1996 |
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| AbstractList | Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease. Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue MMBR About MMBR Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy MMBR RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 1092-2172 Online ISSN: 1098-5557 Copyright © 2014 by the American Society for Microbiology. For an alternate route to MMBR .asm.org, visit: MMBR |
| Author | Meshnick, S.R. (University of Michigan School of Public Health, Ann Arbor, MI.) Taylor, T.E Kamchonwongpaisan, S |
| AuthorAffiliation | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA. meshnick@umich.edu |
| AuthorAffiliation_xml | – name: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor 48109-2029, USA. meshnick@umich.edu |
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| Keywords | Endoperoxide Protozoa Antimalarial Protozoal disease Malaria Toxicity Parasitosis Review Compositae Metabolism Medicinal plant Infection Plasmodium falciparum Chemotherapy Treatment Structure activity relation Dicotyledones Angiospermae Parasiticid Plant origin Spermatophyta Mechanism of action Pharmacokinetics Sporozoa |
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Mendeley... Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of... |
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| StartPage | 301 |
| SubjectTerms | ADVERSE EFFECTS Animals Antibiotics. Antiinfectious agents. Antiparasitic agents antimalarial properties Antimalarials Antimalarials - metabolism Antimalarials - pharmacology Antimalarials - therapeutic use Antiparasitic agents ANTIPROTOZOAIRE ANTIPROTOZOAL AGENTS artemisinin Artemisinins Biological and medical sciences Clinical Trials as Topic DERIVATIVES drug effects Drug Resistance DRUG THERAPY DRUG TOXICITY DRUGS EFECTOS SECUNDARIOS EFFET SECONDAIRE FARMACOLOGIA GENERO HUMANO GENRE HUMAIN Humans LITERATURE REVIEWS MALARIA Malaria - drug therapy Malaria, Falciparum Malaria, Falciparum - drug therapy MANKIND Medical sciences MEDICAMENT MEDICAMENTOS MEDICAMENTOS CONTRA PROTOZOARIOS MEDICINAL PROPERTIES METABOLISM METABOLISME METABOLISMO Peroxides Peroxides - metabolism Peroxides - pharmacology Peroxides - therapeutic use Peroxides - toxicity pharmacokinetics PHARMACOLOGIE PHARMACOLOGY Pharmacology. Drug treatments Plasmodium Plasmodium falciparum Plasmodium falciparum - drug effects PROPERTIES PROPIEDADES MEDICINALES PROPRIETE PHARMACOLOGIQUE QINGHAOSU RESISTANCE AUX PRODUITS CHIMIQUES RESISTANCE TO CHEMICALS RESISTENCIA A PRODUCTOS QUIMICOS Sesquiterpenes Sesquiterpenes - metabolism Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Sesquiterpenes - toxicity SIDE EFFECTS TERAPEUTICA MEDICAMENTOSA therapeutic use THERAPEUTIQUE MEDICAMENTEUSE TOXICIDAD TOXICITE TOXICITY |
| Title | Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy |
| URI | http://mmbr.asm.org/content/60/2/301.abstract https://www.ncbi.nlm.nih.gov/pubmed/8801435 https://www.proquest.com/docview/15595115 https://www.proquest.com/docview/48817948 https://pubmed.ncbi.nlm.nih.gov/PMC239445 |
| Volume | 60 |
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