吲哚丙酮酸的酮-烯醇互变异构化的NMR研究

吲哚丙酮酸是色氨酸代谢途径中的一种重要α-酮酸,但其酮-烯醇互变异构化现象及互变异构体的NMR数据尚未见报道.该文采用多维NMR技术研究了吲哚丙酮酸在不同溶剂中主要存在形式.使用2D NMR谱对吲哚丙酮酸的烯醇式和酮式结构进行了NMR研究.结果表明吲哚丙酮酸在乙腈溶液中主要以烯醇式结构存在,而在水溶液中主要以酮式结构存在....

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Bibliographic Details
Published in波谱学杂志 Vol. 31; no. 1; pp. 81 - 90
Main Author 杨晓艳 吴香玉 安艳捧 唐惠儒
Format Journal Article
LanguageChinese
Published 中国科学院大学,北京100049%中国科学院生物磁共振分析重点实验室,波谱与原子分子物理国家重点实验室,武汉磁共振中心(中国科学院武汉物理与数学研究所),湖北武汉430071 2014
中国科学院生物磁共振分析重点实验室,波谱与原子分子物理国家重点实验室,武汉磁共振中心(中国科学院武汉物理与数学研究所),湖北武汉430071
Subjects
2D
NMR
吲哚丙酮酸
归属
液体磁共振（NMR）
NMR
2D NMR
assignment
归属
液体磁共振(NMR)
吲哚丙酮酸
indole-3-pyruvic acid
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ISSN1000-4556

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Summary:吲哚丙酮酸是色氨酸代谢途径中的一种重要α-酮酸,但其酮-烯醇互变异构化现象及互变异构体的NMR数据尚未见报道.该文采用多维NMR技术研究了吲哚丙酮酸在不同溶剂中主要存在形式.使用2D NMR谱对吲哚丙酮酸的烯醇式和酮式结构进行了NMR研究.结果表明吲哚丙酮酸在乙腈溶液中主要以烯醇式结构存在,而在水溶液中主要以酮式结构存在.
Bibliography:NMR, assignment, 2D NMR, indole-3-pyruvic acid
Indole-3-pyruvic acid is an important a-keto acid in the tryptophan pathway. In this work, two main forms of indole-3-pyruvic acid in acetonitrile and water solutions were studied using multi-dimensional NMR techniques. The results showed that both forms were present, and the enol-form of indole-3-pyruvic acid was the dominant form in acetontrile whereas the keto-form was the main form in water. This work provided detailed assignments for the 1H and 13C NMR signals from both the enol- and keto-forms of indole-3-pyruvic acid, offering essential spectroscopic information for this metabolite.
42-1180/04
YANG Xiao-yan, WUXiang-yu, AN Yan-peng, TANG Hui-ru [ 1. Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance （Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences）, Wuhan 430071, China; 2. University of Chinese Academy of Sciences,
ISSN:1000-4556