Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention,...

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Published inNature communications Vol. 7; no. 1; pp. 12601 - 17
Main Authors Chitsazzadeh, Vida, Coarfa, Cristian, Drummond, Jennifer A., Nguyen, Tri, Joseph, Aaron, Chilukuri, Suneel, Charpiot, Elizabeth, Adelmann, Charles H., Ching, Grace, Nguyen, Tran N., Nicholas, Courtney, Thomas, Valencia D., Migden, Michael, MacFarlane, Deborah, Thompson, Erika, Shen, Jianjun, Takata, Yoko, McNiece, Kayla, Polansky, Maxim A., Abbas, Hussein A., Rajapakshe, Kimal, Gower, Adam, Spira, Avrum, Covington, Kyle R., Xiao, Weimin, Gunaratne, Preethi, Pickering, Curtis, Frederick, Mitchell, Myers, Jeffrey N., Shen, Li, Yao, Hui, Su, Xiaoping, Rapini, Ronald P., Wheeler, David A., Hawk, Ernest T., Flores, Elsa R., Tsai, Kenneth Y.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 30.08.2016
Nature Publishing Group
Nature Portfolio
Subjects
38
38/39
631/67/1813/1352
631/67/69
64
64/60
Animals
Antineoplastic Agents - therapeutic use
Biochemistry
Biology
Cancer therapies
Carcinogenesis - genetics
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - prevention & control
Dermatology
Disease prevention
Disease Progression
DNA Mutational Analysis
Female
Gene Expression Profiling
Genomes
Genomics
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Keratosis, Actinic - pathology
Medicine
Mice
Mice, Hairless
Molecular Targeted Therapy - methods
multidisciplinary
Precancerous Conditions - genetics
Precancerous Conditions - pathology
Science
Science (multidisciplinary)
Sequence Analysis, RNA
Skin - pathology
Skin Neoplasms - etiology
Skin Neoplasms - genetics
Skin Neoplasms - prevention & control
Solar radiation
Surgery
Ultraviolet radiation
Ultraviolet Rays - adverse effects
Whole Exome Sequencing
United States > US
Texas
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/ncomms12601

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Abstract Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible. Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.
AbstractList Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible. Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible.
Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible.Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible.
ArticleNumber 12601
Author Chitsazzadeh, Vida
Migden, Michael
Nguyen, Tran N.
Nguyen, Tri
Takata, Yoko
Abbas, Hussein A.
Flores, Elsa R.
Spira, Avrum
Polansky, Maxim A.
Adelmann, Charles H.
Ching, Grace
Gunaratne, Preethi
Myers, Jeffrey N.
Gower, Adam
Hawk, Ernest T.
Charpiot, Elizabeth
Thomas, Valencia D.
Su, Xiaoping
Tsai, Kenneth Y.
Nicholas, Courtney
Rajapakshe, Kimal
Frederick, Mitchell
Covington, Kyle R.
Xiao, Weimin
Shen, Li
Yao, Hui
Drummond, Jennifer A.
Rapini, Ronald P.
Chilukuri, Suneel
Joseph, Aaron
Pickering, Curtis
Wheeler, David A.
Shen, Jianjun
Coarfa, Cristian
MacFarlane, Deborah
McNiece, Kayla
Thompson, Erika
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/27574101$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1002/mc.20636
10.1002/mc.20077
10.1002/gcc.20657
10.1038/jid.2011.91
10.1016/j.canlet.2008.01.042
10.1016/S1046-2023(02)00207-4
10.1158/1940-6207.CAPR-13-0372
10.1016/j.jaad.2012.09.052
10.1073/pnas.1114669108
10.1073/pnas.90.9.4216
10.2165/00019053-200927060-00002
10.1186/1476-4598-5-30
10.1016/S0006-291X(03)01099-4
10.1038/jid.2014.154
10.1073/pnas.0506580102
10.3109/10409238.2013.838202
10.1093/nar/gkt1181
10.1007/978-1-61779-427-8_19
10.7554/eLife.05005
10.1073/pnas.93.24.14025
10.1016/j.yexmp.2014.06.002
10.1155/2013/537028
10.1038/ncomms5088
10.1111/j.1365-2133.2009.09351.x
10.1038/modpathol.2011.39
10.1126/science.aaa6806
10.1371/journal.pone.0103206
10.1002/gcc.20814
10.1111/j.1365-2133.2009.09480.x
10.1158/1940-6207.CAPR-10-0058
10.1111/j.1600-0625.2009.01028.x
10.1038/sj.jid.5700157
10.7554/eLife.00969
10.1093/bioinformatics/bts665
10.1101/gr.092759.109
10.1158/1078-0432.CCR-14-1773
10.1056/NEJMoa1105358
10.1186/s13059-014-0550-8
10.1038/ng.3091
10.1016/j.devcel.2005.02.016
10.1093/nar/gni027
10.1038/nature11404
10.1126/science.1208130
10.1002/cncr.24284
10.1001/archdermatol.2009.378
10.1038/nm.3878
10.1038/ng.2935
10.1016/j.jdermsci.2008.08.012
10.1002/(SICI)1098-2744(199602)15:2<96::AID-MC2>3.0.CO;2-P
10.1126/science.1206923
10.1186/1471-2407-13-58
10.1111/php.12377
10.1001/archderm.139.7.876
10.1002/mc.20064
10.1093/carcin/16.5.1141
10.1038/ng.465
10.1038/jid.2010.169
10.1016/j.jaad.2012.11.037
10.1186/s13058-015-0531-1
10.1371/journal.pone.0090581
10.1038/ng1861
10.1111/exd.12153
10.1158/1940-6207.CAPR-11-0427
10.1111/j.1365-2133.2007.08360.x
10.1093/bioinformatics/btl483
10.1046/j.1523-1747.2000.00173.x
10.1038/nature12477
10.1172/JCI46458
10.1101/gad.192955.112
10.1038/ng.3357
10.1158/1078-0432.CCR-14-1768
10.1111/j.1346-8138.2006.00075.x
10.1038/ng.3343
10.1002/mc.20004
10.1016/S0304-3835(98)00351-6
10.1093/biostatistics/kxj037
10.1038/nature14129
10.1101/036541
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References Nindl (CR15) 2006; 5
Soufir (CR27) 2004; 39
Haider (CR18) 2006; 126
Eckert (CR50) 2013; 2013
Ooi (CR52) 2014; 7
Wang, Kong, Li, Yang, Feng (CR51) 2015; 17
Dworkin (CR30) 2009; 48
Neidecker, Davis-Ajami, Balkrishnan, Feldman (CR5) 2009; 27
Gunaratne, Coarfa, Soibam, Tandon (CR54) 2012; 822
Toll (CR11) 2009; 161
CR39
Akilesh (CR58) 2011; 121
Harbig, Sprinkle, Enkemann (CR22) 2005; 33
Kasem (CR60) 2014; 97
Miao (CR47) 2014; 5
Brash (CR38) 2015; 91
Wang (CR33) 2011; 108
Subramanian (CR79) 2005; 102
Hudson (CR21) 2010; 49
Bruegger (CR55) 2013; 22
Warino (CR2) 2006; 32
Rundhaug (CR31) 2005; 42
Nassar, Latil, Boeckx, Lambrechts, Blanpain (CR70) 2015; 21
Hameetman (CR16) 2013; 13
Alexandrov (CR72) 2013; 500
Stachler (CR69) 2015; 47
Lin (CR65) 2014; 46
Pacifico (CR8) 2008; 158
Jonason (CR37) 1996; 93
Nghiem, Walterscheid, Kazimi, Ullrich (CR71) 2002; 28
Ashton, Weinstein, Maguire, Griffiths (CR28) 2003; 139
Chen (CR75) 2013; 29
Agarwal, Bell, Nam, Bartel (CR78) 2015; 4
Carter, Eklund, Kohane, Harris, Szallasi (CR42) 2006; 38
Criscione (CR3) 2009; 115
Dooley, Reddy, Wilborn, Davis (CR17) 2003; 306
Toll (CR10) 2010; 19
Martincorena (CR36) 2015; 348
Wang (CR59) 2012; 26
Sekulic (CR13) 2010; 3
Kumar, Butler (CR46) 1999; 137
Pickering (CR34) 2014; 20
Ross-Innes (CR68) 2015; 47
Lee (CR73) 2014; 9
Khan (CR26) 1996; 15
Zaravinos, Kanellou, Spandidos (CR6) 2010; 162
Krzywinski (CR80) 2009; 19
Dziunycz (CR56) 2010; 130
Hammerman (CR64) 2012; 489
Chang, Nevins (CR53) 2006; 22
Stransky (CR61) 2011; 333
Rosen, Lebwohl (CR1) 2013; 68
Ziegler (CR41) 1993; 90
Salgado (CR12) 2010; 49
Einspahr (CR44) 2012; 5
Wang (CR57) 2014; 9
Li (CR35) 2015; 21
Kozomara, Griffiths-Jones (CR76) 2014; 42
Kar, Gutierrez-Hartmann (CR43) 2013; 48
Bass (CR66) 2009; 41
Johnson, Li, Rabinovic (CR77) 2007; 8
Kathpalia (CR19) 2006; 33
Lee (CR40) 2014; 46
Karia, Han, Schmults (CR4) 2013; 68
Bhatia, Spiegelman (CR48) 2005; 42
CR63
Benavides, Oberyszyn, VanBuskirk, Reeve, Kusewitt (CR23) 2009; 53
Rehman, Takata, Wu, Rees (CR9) 1996; 12
South (CR32) 2014; 134
Kanellou (CR7) 2008; 264
van Kranen (CR25) 1995; 16
Mammucari (CR49) 2005; 8
Padilla, Sebastian, Jiang, Nindl, Larson (CR14) 2010; 146
Love, Huber, Anders (CR74) 2014; 15
Su (CR45) 2012; 366
Popp (CR29) 2000; 115
Agrawal (CR62) 2011; 333
Ra, Li, Binder (CR20) 2011; 24
Vin (CR24) 2013; 2
Arron, Ruby, Dybbro, Ganem, Derisi (CR67) 2011; 131
AP South (BFncomms12601_CR32) 2014; 134
D Nassar (BFncomms12601_CR70) 2015; 21
BFncomms12601_CR39
N Stransky (BFncomms12601_CR61) 2011; 333
S Popp (BFncomms12601_CR29) 2000; 115
CS Lee (BFncomms12601_CR40) 2014; 46
A Zaravinos (BFncomms12601_CR6) 2010; 162
WE Johnson (BFncomms12601_CR77) 2007; 8
JE Rundhaug (BFncomms12601_CR31) 2005; 42
YY Li (BFncomms12601_CR35) 2015; 21
A Toll (BFncomms12601_CR10) 2010; 19
LG Hudson (BFncomms12601_CR21) 2010; 49
P Dziunycz (BFncomms12601_CR56) 2010; 130
DX Nghiem (BFncomms12601_CR71) 2002; 28
J Harbig (BFncomms12601_CR22) 2005; 33
AP Kumar (BFncomms12601_CR46) 1999; 137
JG Einspahr (BFncomms12601_CR44) 2012; 5
Q Miao (BFncomms12601_CR47) 2014; 5
W Wang (BFncomms12601_CR59) 2012; 26
PS Karia (BFncomms12601_CR4) 2013; 68
LB Alexandrov (BFncomms12601_CR72) 2013; 500
L Warino (BFncomms12601_CR2) 2006; 32
AS Jonason (BFncomms12601_CR37) 1996; 93
SL Carter (BFncomms12601_CR42) 2006; 38
P Kanellou (BFncomms12601_CR7) 2008; 264
T Rosen (BFncomms12601_CR1) 2013; 68
RS Padilla (BFncomms12601_CR14) 2010; 146
QS Wang (BFncomms12601_CR51) 2015; 17
F Su (BFncomms12601_CR45) 2012; 366
A Kar (BFncomms12601_CR43) 2013; 48
S Akilesh (BFncomms12601_CR58) 2011; 121
MI Love (BFncomms12601_CR74) 2014; 15
A Pacifico (BFncomms12601_CR8) 2008; 158
I Rehman (BFncomms12601_CR9) 1996; 12
N Agrawal (BFncomms12601_CR62) 2011; 333
A Kozomara (BFncomms12601_CR76) 2014; 42
C Mammucari (BFncomms12601_CR49) 2005; 8
N Bhatia (BFncomms12601_CR48) 2005; 42
ST Arron (BFncomms12601_CR67) 2011; 131
CR Pickering (BFncomms12601_CR34) 2014; 20
AM Dworkin (BFncomms12601_CR30) 2009; 48
NJ Wang (BFncomms12601_CR33) 2011; 108
PH Gunaratne (BFncomms12601_CR54) 2012; 822
C Bruegger (BFncomms12601_CR55) 2013; 22
BFncomms12601_CR63
K Kasem (BFncomms12601_CR60) 2014; 97
F Benavides (BFncomms12601_CR23) 2009; 53
A Ziegler (BFncomms12601_CR41) 1993; 90
DEUV Brash (BFncomms12601_CR38) 2015; 91
KJ Ashton (BFncomms12601_CR28) 2003; 139
CS Ross-Innes (BFncomms12601_CR68) 2015; 47
N Soufir (BFncomms12601_CR27) 2004; 39
A Wang (BFncomms12601_CR57) 2014; 9
RL Eckert (BFncomms12601_CR50) 2013; 2013
DC Lin (BFncomms12601_CR65) 2014; 46
SG Khan (BFncomms12601_CR26) 1996; 15
AJ Bass (BFncomms12601_CR66) 2009; 41
MD Stachler (BFncomms12601_CR69) 2015; 47
R Salgado (BFncomms12601_CR12) 2010; 49
AT Ooi (BFncomms12601_CR52) 2014; 7
A Sekulic (BFncomms12601_CR13) 2010; 3
TP Dooley (BFncomms12601_CR17) 2003; 306
M Krzywinski (BFncomms12601_CR80) 2009; 19
VP Kathpalia (BFncomms12601_CR19) 2006; 33
MV Neidecker (BFncomms12601_CR5) 2009; 27
Y Chen (BFncomms12601_CR75) 2013; 29
L Hameetman (BFncomms12601_CR16) 2013; 13
AS Haider (BFncomms12601_CR18) 2006; 126
PS Hammerman (BFncomms12601_CR64) 2012; 489
A Subramanian (BFncomms12601_CR79) 2005; 102
I Nindl (BFncomms12601_CR15) 2006; 5
H Vin (BFncomms12601_CR24) 2013; 2
HJ van Kranen (BFncomms12601_CR25) 1995; 16
I Martincorena (BFncomms12601_CR36) 2015; 348
A Toll (BFncomms12601_CR11) 2009; 161
SH Ra (BFncomms12601_CR20) 2011; 24
V Agarwal (BFncomms12601_CR78) 2015; 4
WP Lee (BFncomms12601_CR73) 2014; 9
VD Criscione (BFncomms12601_CR3) 2009; 115
JT Chang (BFncomms12601_CR53) 2006; 22
24927874 - Exp Mol Pathol. 2014 Aug;97(1):99-104
10374837 - Cancer Lett. 1999 Apr 1;137(2):159-65
25589618 - Clin Cancer Res. 2015 Mar 15;21(6):1447-56
24662767 - J Invest Dermatol. 2014 Oct;134(10 ):2630-8
23945592 - Nature. 2013 Aug 22;500(7463):415-21
24275495 - Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73
23162058 - Bioinformatics. 2013 Jan 15;29(2):266-7
21743436 - Mod Pathol. 2011 Jul;24(7):963-73
24618292 - Cancer Prev Res (Phila). 2014 May;7(5):487-95
25194279 - Nat Genet. 2014 Oct;46(10):1060-2
20737481 - Genes Chromosomes Cancer. 2010 Nov;49(11):1054-61
22006338 - Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17761-6
18938063 - J Dermatol Sci. 2009 Jan;53(1):10-8
22256804 - N Engl J Med. 2012 Jan 19;366(3):207-15
15866158 - Dev Cell. 2005 May;8(5):665-76
19541911 - Genome Res. 2009 Sep;19(9):1639-45
16700662 - J Dermatol. 2006 May;33(5):309-18
23762562 - J Skin Cancer. 2013;2013:537028
7767977 - Carcinogenesis. 1995 May;16(5):1141-7
8599584 - Mol Carcinog. 1996 Feb;15(2):96-103
26168291 - Nat Med. 2015 Aug;21(8):946-54
25354245 - Photochem Photobiol. 2015 Jan-Feb;91(1):15-26
22960745 - Nature. 2012 Sep 27;489(7417):519-25
24686850 - Nat Genet. 2014 May;46(5):467-73
15547921 - Mol Carcinog. 2005 Jan;42(1):40-52
24599324 - PLoS One. 2014 Mar 05;9(3):e90581
23228302 - J Am Acad Dermatol. 2013 Jan;68(1 Suppl 1):S2-9
20564339 - Mol Carcinog. 2010 Jul;49(7):619-29
20231500 - Arch Dermatol. 2010 Mar;146(3):288-93
22389437 - Cancer Prev Res (Phila). 2012 Mar;5(3):403-13
8943054 - Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14025-9
12821146 - Biochem Biophys Res Commun. 2003 Jul 11;306(4):1026-36
25303977 - Clin Cancer Res. 2014 Dec 15;20(24):6582-92
15722477 - Nucleic Acids Res. 2005 Feb 18;33(3):e31
22948661 - Genes Dev. 2012 Sep 1;26(17 ):1959-71
21911940 - J Clin Invest. 2011 Oct;121(10):4127-37
25068518 - PLoS One. 2014 Jul 28;9(7):e103206
21490616 - J Invest Dermatol. 2011 Aug;131(8):1745-53
25999502 - Science. 2015 May 22;348(6237):880-6
20876729 - Cancer Prev Res (Phila). 2010 Oct;3(10 ):1277-83
19640009 - Pharmacoeconomics. 2009;27(6):451-64
16199517 - Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
25631445 - Nature. 2015 Jan 29;517(7536):576-82
15057871 - Mol Carcinog. 2004 Apr;39(4):195-8
23711067 - Exp Dermatol. 2013 Jun;22(6):426-8
24066765 - Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):522-43
20574436 - J Invest Dermatol. 2010 Nov;130(11):2686-9
22144206 - Methods Mol Biol. 2012;822:273-88
19382202 - Cancer. 2009 Jun 1;115(11):2523-30
8700506 - Oncogene. 1996 Jun 20;12(12):2483-90
16921376 - Nat Genet. 2006 Sep;38(9):1043-8
25516281 - Genome Biol. 2014;15(12):550
26267216 - Elife. 2015 Aug 12;4:null
16918567 - Dermatol Surg. 2006 Aug;32(8):1045-9
25848863 - Breast Cancer Res. 2015 Feb 26;17 :30
18331779 - Cancer Lett. 2008 Jun 8;264(1):145-61
18070208 - Br J Dermatol. 2008 Feb;158(2):291-7
23379751 - BMC Cancer. 2013 Feb 05;13:58
16632515 - Biostatistics. 2007 Jan;8(1):118-27
12873882 - Arch Dermatol. 2003 Jul;139(7):876-82
19673870 - Br J Dermatol. 2009 Nov;161(5):1112-8
20156290 - Exp Dermatol. 2010 Feb;19(2):151-3
24909826 - Nat Commun. 2014 Jun 09;5:4088
21798893 - Science. 2011 Aug 26;333(6046):1157-60
16893473 - Mol Cancer. 2006 Aug 08;5:30
26192915 - Nat Genet. 2015 Sep;47(9):1038-46
19849697 - Br J Dermatol. 2010 Feb 1;162(2):325-31
26192918 - Nat Genet. 2015 Sep;47(9):1047-55
19296524 - Genes Chromosomes Cancer. 2009 Jun;48(6):490-501
15765534 - Mol Carcinog. 2005 Apr;42(4):213-21
24192036 - Elife. 2013 Nov 05;2:e00969
17000751 - Bioinformatics. 2006 Dec 1;22(23):2926-33
12231185 - Methods. 2002 Sep;28(1):25-33
16470182 - J Invest Dermatol. 2006 Apr;126(4):869-81
23375456 - J Am Acad Dermatol. 2013 Jun;68(6):957-66
8483937 - Proc Natl Acad Sci U S A. 1993 May 1;90(9):4216-20
11121147 - J Invest Dermatol. 2000 Dec;115(6):1095-103
19801978 - Nat Genet. 2009 Nov;41(11):1238-42
21798897 - Science. 2011 Aug 26;333(6046):1154-7
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  start-page: 619
  year: 2010
  end-page: 629
  ident: CR21
  article-title: Microarray analysis of cutaneous squamous cell carcinomas reveals enhanced expression of epidermal differentiation complex genes
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20636
– volume: 42
  start-page: 213
  year: 2005
  end-page: 221
  ident: CR48
  article-title: Activation of Wnt/beta-catenin/Tcf signaling in mouse skin carcinogenesis
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20077
– volume: 48
  start-page: 490
  year: 2009
  end-page: 501
  ident: CR30
  article-title: Chromosomal aberrations in UVB-induced tumors of immunosuppressed mice
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.20657
– volume: 131
  start-page: 1745
  year: 2011
  end-page: 1753
  ident: CR67
  article-title: Transcriptome sequencing demonstrates that human papillomavirus is not active in cutaneous squamous cell carcinoma
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2011.91
– volume: 264
  start-page: 145
  year: 2008
  end-page: 161
  ident: CR7
  article-title: Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis
  publication-title: Cancer. Lett.
  doi: 10.1016/j.canlet.2008.01.042
– ident: CR39
– volume: 28
  start-page: 25
  year: 2002
  end-page: 33
  ident: CR71
  article-title: Ultraviolet radiation-induced immunosuppression of delayed-type hypersensitivity in mice
  publication-title: Methods
  doi: 10.1016/S1046-2023(02)00207-4
– volume: 7
  start-page: 487
  year: 2014
  end-page: 495
  ident: CR52
  article-title: Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis
  publication-title: Cancer Prev. Res. (Phila)
  doi: 10.1158/1940-6207.CAPR-13-0372
– volume: 68
  start-page: S2
  year: 2013
  end-page: S9
  ident: CR1
  article-title: Prevalence and awareness of actinic keratosis: barriers and opportunities
  publication-title: J. Am. Acad. Dermatol.
  doi: 10.1016/j.jaad.2012.09.052
– volume: 108
  start-page: 17761
  year: 2011
  end-page: 17766
  ident: CR33
  article-title: Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1114669108
– volume: 90
  start-page: 4216
  year: 1993
  end-page: 4220
  ident: CR41
  article-title: Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.90.9.4216
– volume: 27
  start-page: 451
  year: 2009
  end-page: 464
  ident: CR5
  article-title: Pharmacoeconomic considerations in treating actinic keratosis
  publication-title: Pharmacoeconomics
  doi: 10.2165/00019053-200927060-00002
– volume: 5
  start-page: 30
  year: 2006
  ident: CR15
  article-title: Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-5-30
– volume: 306
  start-page: 1026
  year: 2003
  end-page: 1036
  ident: CR17
  article-title: Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/S0006-291X(03)01099-4
– volume: 134
  start-page: 2630
  year: 2014
  end-page: 2638
  ident: CR32
  article-title: NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2014.154
– volume: 102
  start-page: 15545
  year: 2005
  end-page: 15550
  ident: CR79
  article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 48
  start-page: 522
  year: 2013
  end-page: 543
  ident: CR43
  article-title: Molecular mechanisms of ETS transcription factor-mediated tumorigenesis
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.3109/10409238.2013.838202
– volume: 42
  start-page: D68
  year: 2014
  end-page: D73
  ident: CR76
  article-title: miRBase: annotating high confidence microRNAs using deep sequencing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt1181
– volume: 822
  start-page: 273
  year: 2012
  end-page: 288
  ident: CR54
  article-title: miRNA data analysis: next-gen sequencing
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-61779-427-8_19
– volume: 4
  start-page: 1
  year: 2015
  end-page: 38
  ident: CR78
  article-title: Predicting effective microRNA target sites in mammalian mRNAs
  publication-title: Elife
  doi: 10.7554/eLife.05005
– volume: 93
  start-page: 14025
  year: 1996
  end-page: 14029
  ident: CR37
  article-title: Frequent clones of p53-mutated keratinocytes in normal human skin
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.24.14025
– volume: 97
  start-page: 99
  year: 2014
  end-page: 104
  ident: CR60
  article-title: JK1 (FAM134B) represses cell migration in colon cancer: a functional study of a novel gene
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2014.06.002
– volume: 2013
  start-page: 537028
  year: 2013
  ident: CR50
  article-title: AP1 transcription factors in epidermal differentiation and skin cancer
  publication-title: J. Skin Cancer
  doi: 10.1155/2013/537028
– volume: 5
  start-page: 4088
  year: 2014
  ident: CR47
  article-title: Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5088
– volume: 161
  start-page: 1112
  year: 2009
  end-page: 1118
  ident: CR11
  article-title: MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma
  publication-title: Br. J. Dermatol.
  doi: 10.1111/j.1365-2133.2009.09351.x
– volume: 24
  start-page: 963
  year: 2011
  end-page: 973
  ident: CR20
  article-title: Molecular discrimination of cutaneous squamous cell carcinoma from actinic keratosis and normal skin
  publication-title: Mod. Pathol.
  doi: 10.1038/modpathol.2011.39
– volume: 348
  start-page: 880
  year: 2015
  end-page: 886
  ident: CR36
  article-title: Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin
  publication-title: Science
  doi: 10.1126/science.aaa6806
– volume: 9
  start-page: e103206
  year: 2014
  ident: CR57
  article-title: MicroRNA-31 is overexpressed in cutaneous squamous cell carcinoma and regulates cell motility and colony formation ability of tumor cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0103206
– volume: 49
  start-page: 1054
  year: 2010
  end-page: 1061
  ident: CR12
  article-title: CKS1B amplification is a frequent event in cutaneous squamous cell carcinoma with aggressive clinical behaviour
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.20814
– volume: 162
  start-page: 325
  year: 2010
  end-page: 331
  ident: CR6
  article-title: Viral DNA detection and RAS mutations in actinic keratosis and nonmelanoma skin cancers
  publication-title: Br. J. Dermatol.
  doi: 10.1111/j.1365-2133.2009.09480.x
– volume: 3
  start-page: 1277
  year: 2010
  end-page: 1283
  ident: CR13
  article-title: Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma
  publication-title: Cancer Prev. Res. (Phila.)
  doi: 10.1158/1940-6207.CAPR-10-0058
– volume: 19
  start-page: 151
  year: 2010
  end-page: 153
  ident: CR10
  article-title: Epidermal growth factor receptor gene numerical aberrations are frequent events in actinic keratoses and invasive cutaneous squamous cell carcinomas
  publication-title: Exp. Dermatol.
  doi: 10.1111/j.1600-0625.2009.01028.x
– volume: 126
  start-page: 869
  year: 2006
  end-page: 881
  ident: CR18
  article-title: Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/sj.jid.5700157
– volume: 2
  start-page: e00969
  year: 2013
  ident: CR24
  article-title: BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling
  publication-title: Elife
  doi: 10.7554/eLife.00969
– volume: 29
  start-page: 266
  year: 2013
  end-page: 267
  ident: CR75
  article-title: VirusSeq: software to identify viruses and their integration sites using next-generation sequencing of human cancer tissue
  publication-title: Bioinformatics.
  doi: 10.1093/bioinformatics/bts665
– volume: 19
  start-page: 1639
  year: 2009
  end-page: 1645
  ident: CR80
  article-title: Circos: an information aesthetic for comparative genomics
  publication-title: Genome Res.
  doi: 10.1101/gr.092759.109
– volume: 21
  start-page: 1447
  year: 2015
  end-page: 1456
  ident: CR35
  article-title: Genomic analysis of metastatic cutaneous squamous cell carcinoma
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-14-1773
– volume: 366
  start-page: 207
  year: 2012
  end-page: 215
  ident: CR45
  article-title: RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1105358
– volume: 15
  start-page: 550
  year: 2014
  ident: CR74
  article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 46
  start-page: 1060
  year: 2014
  end-page: 1062
  ident: CR40
  article-title: Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3091
– volume: 8
  start-page: 665
  year: 2005
  end-page: 676
  ident: CR49
  article-title: Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control
  publication-title: Dev. Cell.
  doi: 10.1016/j.devcel.2005.02.016
– volume: 33
  start-page: e31
  year: 2005
  ident: CR22
  article-title: A sequence-based identification of the genes detected by probesets on the Affymetrix U133 plus 2.0 array
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gni027
– volume: 489
  start-page: 519
  year: 2012
  end-page: 525
  ident: CR64
  article-title: Comprehensive genomic characterization of squamous cell lung cancers
  publication-title: Nature
  doi: 10.1038/nature11404
– volume: 333
  start-page: 1157
  year: 2011
  end-page: 1160
  ident: CR61
  article-title: The mutational landscape of head and neck squamous cell carcinoma
  publication-title: Science
  doi: 10.1126/science.1208130
– volume: 115
  start-page: 2523
  year: 2009
  end-page: 2530
  ident: CR3
  article-title: Actinic keratoses: natural history and risk of malignant transformation in the Veterans Affairs Topical Tretinoin Chemoprevention Trial
  publication-title: Cancer
  doi: 10.1002/cncr.24284
– volume: 146
  start-page: 288
  year: 2010
  end-page: 293
  ident: CR14
  article-title: Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma: a spectrum of disease progression
  publication-title: Arch. Dermatol.
  doi: 10.1001/archdermatol.2009.378
– volume: 21
  start-page: 946
  year: 2015
  end-page: 954
  ident: CR70
  article-title: Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma
  publication-title: Nat. Med.
  doi: 10.1038/nm.3878
– volume: 46
  start-page: 467
  year: 2014
  end-page: 473
  ident: CR65
  article-title: Genomic and molecular characterization of esophageal squamous cell carcinoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2935
– volume: 53
  start-page: 10
  year: 2009
  end-page: 18
  ident: CR23
  article-title: The hairless mouse in skin research
  publication-title: J. Dermatol. Sci.
  doi: 10.1016/j.jdermsci.2008.08.012
– volume: 15
  start-page: 96
  year: 1996
  end-page: 103
  ident: CR26
  article-title: Mutations in ras oncogenes: rare events in ultraviolet B radiation-induced mouse skin tumorigenesis
  publication-title: Mol. Carcinog.
  doi: 10.1002/(SICI)1098-2744(199602)15:2<96::AID-MC2>3.0.CO;2-P
– volume: 12
  start-page: 2483
  year: 1996
  end-page: 2490
  ident: CR9
  article-title: Genetic change in actinic keratoses
  publication-title: Oncogene
– volume: 333
  start-page: 1154
  year: 2011
  end-page: 1157
  ident: CR62
  article-title: Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
  publication-title: Science
  doi: 10.1126/science.1206923
– volume: 13
  start-page: 58
  year: 2013
  ident: CR16
  article-title: Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-13-58
– volume: 91
  start-page: 15
  year: 2015
  end-page: 26
  ident: CR38
  article-title: signature mutations
  publication-title: Photochem. Photobiol.
  doi: 10.1111/php.12377
– volume: 139
  start-page: 876
  year: 2003
  end-page: 882
  ident: CR28
  article-title: Chromosomal aberrations in squamous cell carcinoma and solar keratoses revealed by comparative genomic hybridization
  publication-title: Arch. Dermatol.
  doi: 10.1001/archderm.139.7.876
– volume: 42
  start-page: 40
  year: 2005
  end-page: 52
  ident: CR31
  article-title: SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20064
– volume: 16
  start-page: 1141
  year: 1995
  end-page: 1147
  ident: CR25
  article-title: Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/16.5.1141
– volume: 41
  start-page: 1238
  year: 2009
  end-page: 1242
  ident: CR66
  article-title: SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
  publication-title: Nat. Genet.
  doi: 10.1038/ng.465
– volume: 130
  start-page: 2686
  year: 2010
  end-page: 2689
  ident: CR56
  article-title: Squamous cell carcinoma of the skin shows a distinct microRNA profile modulated by UV radiation
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2010.169
– volume: 68
  start-page: 957
  year: 2013
  end-page: 966
  ident: CR4
  article-title: Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012
  publication-title: J. Am. Acad. Dermatol.
  doi: 10.1016/j.jaad.2012.11.037
– volume: 17
  start-page: 30
  year: 2015
  ident: CR51
  article-title: FOXF2 deficiency promotes epithelial-mesenchymal transition and metastasis of basal-like breast cancer
  publication-title: Breast Cancer Res.
  doi: 10.1186/s13058-015-0531-1
– volume: 9
  start-page: e90581
  year: 2014
  ident: CR73
  article-title: MOSAIK: a hash-based algorithm for accurate next-generation sequencing short-read mapping
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0090581
– ident: CR63
– volume: 38
  start-page: 1043
  year: 2006
  end-page: 1048
  ident: CR42
  article-title: A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
  publication-title: Nat. Genet.
  doi: 10.1038/ng1861
– volume: 32
  start-page: 1045
  year: 2006
  end-page: 1049
  ident: CR2
  article-title: Frequency and cost of actinic keratosis treatment
  publication-title: Dermatol. Surg.
– volume: 22
  start-page: 426
  year: 2013
  end-page: 428
  ident: CR55
  article-title: MicroRNA expression differs in cutaneous squamous cell carcinomas and healthy skin of immunocompetent individuals
  publication-title: Exp. Dermatol.
  doi: 10.1111/exd.12153
– volume: 5
  start-page: 403
  year: 2012
  end-page: 413
  ident: CR44
  article-title: Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma
  publication-title: Cancer Prev. Res. (Phila.)
  doi: 10.1158/1940-6207.CAPR-11-0427
– volume: 158
  start-page: 291
  year: 2008
  end-page: 297
  ident: CR8
  article-title: Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers
  publication-title: Br. J. Dermatol.
  doi: 10.1111/j.1365-2133.2007.08360.x
– volume: 22
  start-page: 2926
  year: 2006
  end-page: 2933
  ident: CR53
  article-title: GATHER: a systems approach to interpreting genomic signatures
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btl483
– volume: 115
  start-page: 1095
  year: 2000
  end-page: 1103
  ident: CR29
  article-title: Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis
  publication-title: J. Invest. Dermatol.
  doi: 10.1046/j.1523-1747.2000.00173.x
– volume: 500
  start-page: 415
  year: 2013
  end-page: 421
  ident: CR72
  article-title: Signatures of mutational processes in human cancer
  publication-title: Nature
  doi: 10.1038/nature12477
– volume: 121
  start-page: 4127
  year: 2011
  end-page: 4137
  ident: CR58
  article-title: Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI46458
– volume: 26
  start-page: 1959
  year: 2012
  end-page: 1971
  ident: CR59
  article-title: PTPN14 is required for the density-dependent control of YAP1
  publication-title: Genes Dev.
  doi: 10.1101/gad.192955.112
– volume: 47
  start-page: 1038
  year: 2015
  end-page: 1046
  ident: CR68
  article-title: Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3357
– volume: 20
  start-page: 6582
  year: 2014
  end-page: 6592
  ident: CR34
  article-title: Mutational landscape of aggressive cutaneous squamous cell carcinoma
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-14-1768
– volume: 33
  start-page: 309
  year: 2006
  end-page: 318
  ident: CR19
  article-title: Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures
  publication-title: J. Dermatol.
  doi: 10.1111/j.1346-8138.2006.00075.x
– volume: 47
  start-page: 1047
  year: 2015
  end-page: 1055
  ident: CR69
  article-title: Paired exome analysis of Barrett's esophagus and adenocarcinoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3343
– volume: 39
  start-page: 195
  year: 2004
  end-page: 198
  ident: CR27
  article-title: INK4a-ARF mutations in skin carcinomas from UV irradiated hairless mice
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20004
– volume: 137
  start-page: 159
  year: 1999
  end-page: 165
  ident: CR46
  article-title: Enhanced Sp1 DNA-binding activity in murine keratinocyte cell lines and epidermal tumors
  publication-title: Cancer Lett.
  doi: 10.1016/S0304-3835(98)00351-6
– volume: 8
  start-page: 118
  year: 2007
  end-page: 127
  ident: CR77
  article-title: Adjusting batch effects in microarray expression data using empirical Bayes methods
  publication-title: Biostatistics
  doi: 10.1093/biostatistics/kxj037
– volume: 3
  start-page: 1277
  year: 2010
  ident: BFncomms12601_CR13
  publication-title: Cancer Prev. Res. (Phila.)
  doi: 10.1158/1940-6207.CAPR-10-0058
– volume: 24
  start-page: 963
  year: 2011
  ident: BFncomms12601_CR20
  publication-title: Mod. Pathol.
  doi: 10.1038/modpathol.2011.39
– volume: 22
  start-page: 2926
  year: 2006
  ident: BFncomms12601_CR53
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btl483
– volume: 9
  start-page: e90581
  year: 2014
  ident: BFncomms12601_CR73
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0090581
– volume: 7
  start-page: 487
  year: 2014
  ident: BFncomms12601_CR52
  publication-title: Cancer Prev. Res. (Phila)
  doi: 10.1158/1940-6207.CAPR-13-0372
– volume: 108
  start-page: 17761
  year: 2011
  ident: BFncomms12601_CR33
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1114669108
– volume: 115
  start-page: 1095
  year: 2000
  ident: BFncomms12601_CR29
  publication-title: J. Invest. Dermatol.
  doi: 10.1046/j.1523-1747.2000.00173.x
– volume: 19
  start-page: 1639
  year: 2009
  ident: BFncomms12601_CR80
  publication-title: Genome Res.
  doi: 10.1101/gr.092759.109
– volume: 139
  start-page: 876
  year: 2003
  ident: BFncomms12601_CR28
  publication-title: Arch. Dermatol.
  doi: 10.1001/archderm.139.7.876
– volume: 822
  start-page: 273
  year: 2012
  ident: BFncomms12601_CR54
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-61779-427-8_19
– volume: 161
  start-page: 1112
  year: 2009
  ident: BFncomms12601_CR11
  publication-title: Br. J. Dermatol.
  doi: 10.1111/j.1365-2133.2009.09351.x
– volume: 33
  start-page: 309
  year: 2006
  ident: BFncomms12601_CR19
  publication-title: J. Dermatol.
  doi: 10.1111/j.1346-8138.2006.00075.x
– volume: 5
  start-page: 403
  year: 2012
  ident: BFncomms12601_CR44
  publication-title: Cancer Prev. Res. (Phila.)
  doi: 10.1158/1940-6207.CAPR-11-0427
– volume: 9
  start-page: e103206
  year: 2014
  ident: BFncomms12601_CR57
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0103206
– volume: 20
  start-page: 6582
  year: 2014
  ident: BFncomms12601_CR34
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-14-1768
– volume: 17
  start-page: 30
  year: 2015
  ident: BFncomms12601_CR51
  publication-title: Breast Cancer Res.
  doi: 10.1186/s13058-015-0531-1
– volume: 42
  start-page: D68
  year: 2014
  ident: BFncomms12601_CR76
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt1181
– volume: 21
  start-page: 1447
  year: 2015
  ident: BFncomms12601_CR35
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-14-1773
– volume: 134
  start-page: 2630
  year: 2014
  ident: BFncomms12601_CR32
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2014.154
– volume: 38
  start-page: 1043
  year: 2006
  ident: BFncomms12601_CR42
  publication-title: Nat. Genet.
  doi: 10.1038/ng1861
– ident: BFncomms12601_CR63
  doi: 10.1038/nature14129
– volume: 121
  start-page: 4127
  year: 2011
  ident: BFncomms12601_CR58
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI46458
– volume: 12
  start-page: 2483
  year: 1996
  ident: BFncomms12601_CR9
  publication-title: Oncogene
– volume: 42
  start-page: 40
  year: 2005
  ident: BFncomms12601_CR31
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20064
– volume: 48
  start-page: 522
  year: 2013
  ident: BFncomms12601_CR43
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.3109/10409238.2013.838202
– volume: 500
  start-page: 415
  year: 2013
  ident: BFncomms12601_CR72
  publication-title: Nature
  doi: 10.1038/nature12477
– volume: 130
  start-page: 2686
  year: 2010
  ident: BFncomms12601_CR56
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2010.169
– volume: 22
  start-page: 426
  year: 2013
  ident: BFncomms12601_CR55
  publication-title: Exp. Dermatol.
  doi: 10.1111/exd.12153
– volume: 68
  start-page: S2
  year: 2013
  ident: BFncomms12601_CR1
  publication-title: J. Am. Acad. Dermatol.
  doi: 10.1016/j.jaad.2012.09.052
– volume: 21
  start-page: 946
  year: 2015
  ident: BFncomms12601_CR70
  publication-title: Nat. Med.
  doi: 10.1038/nm.3878
– volume: 2013
  start-page: 537028
  year: 2013
  ident: BFncomms12601_CR50
  publication-title: J. Skin Cancer
  doi: 10.1155/2013/537028
– volume: 489
  start-page: 519
  year: 2012
  ident: BFncomms12601_CR64
  publication-title: Nature
  doi: 10.1038/nature11404
– volume: 41
  start-page: 1238
  year: 2009
  ident: BFncomms12601_CR66
  publication-title: Nat. Genet.
  doi: 10.1038/ng.465
– volume: 158
  start-page: 291
  year: 2008
  ident: BFncomms12601_CR8
  publication-title: Br. J. Dermatol.
  doi: 10.1111/j.1365-2133.2007.08360.x
– volume: 131
  start-page: 1745
  year: 2011
  ident: BFncomms12601_CR67
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/jid.2011.91
– volume: 46
  start-page: 1060
  year: 2014
  ident: BFncomms12601_CR40
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3091
– volume: 90
  start-page: 4216
  year: 1993
  ident: BFncomms12601_CR41
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.90.9.4216
– volume: 16
  start-page: 1141
  year: 1995
  ident: BFncomms12601_CR25
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/16.5.1141
– volume: 2
  start-page: e00969
  year: 2013
  ident: BFncomms12601_CR24
  publication-title: Elife
  doi: 10.7554/eLife.00969
– volume: 102
  start-page: 15545
  year: 2005
  ident: BFncomms12601_CR79
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506580102
– volume: 68
  start-page: 957
  year: 2013
  ident: BFncomms12601_CR4
  publication-title: J. Am. Acad. Dermatol.
  doi: 10.1016/j.jaad.2012.11.037
– volume: 49
  start-page: 1054
  year: 2010
  ident: BFncomms12601_CR12
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.20814
– volume: 146
  start-page: 288
  year: 2010
  ident: BFncomms12601_CR14
  publication-title: Arch. Dermatol.
  doi: 10.1001/archdermatol.2009.378
– volume: 97
  start-page: 99
  year: 2014
  ident: BFncomms12601_CR60
  publication-title: Exp. Mol. Pathol.
  doi: 10.1016/j.yexmp.2014.06.002
– volume: 162
  start-page: 325
  year: 2010
  ident: BFncomms12601_CR6
  publication-title: Br. J. Dermatol.
  doi: 10.1111/j.1365-2133.2009.09480.x
– volume: 27
  start-page: 451
  year: 2009
  ident: BFncomms12601_CR5
  publication-title: Pharmacoeconomics
  doi: 10.2165/00019053-200927060-00002
– volume: 4
  start-page: 1
  year: 2015
  ident: BFncomms12601_CR78
  publication-title: Elife
  doi: 10.7554/eLife.05005
– volume: 42
  start-page: 213
  year: 2005
  ident: BFncomms12601_CR48
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20077
– volume: 115
  start-page: 2523
  year: 2009
  ident: BFncomms12601_CR3
  publication-title: Cancer
  doi: 10.1002/cncr.24284
– volume: 91
  start-page: 15
  year: 2015
  ident: BFncomms12601_CR38
  publication-title: Photochem. Photobiol.
  doi: 10.1111/php.12377
– volume: 46
  start-page: 467
  year: 2014
  ident: BFncomms12601_CR65
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2935
– volume: 93
  start-page: 14025
  year: 1996
  ident: BFncomms12601_CR37
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.93.24.14025
– volume: 333
  start-page: 1157
  year: 2011
  ident: BFncomms12601_CR61
  publication-title: Science
  doi: 10.1126/science.1208130
– volume: 137
  start-page: 159
  year: 1999
  ident: BFncomms12601_CR46
  publication-title: Cancer Lett.
  doi: 10.1016/S0304-3835(98)00351-6
– volume: 39
  start-page: 195
  year: 2004
  ident: BFncomms12601_CR27
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20004
– volume: 5
  start-page: 4088
  year: 2014
  ident: BFncomms12601_CR47
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms5088
– volume: 8
  start-page: 118
  year: 2007
  ident: BFncomms12601_CR77
  publication-title: Biostatistics
  doi: 10.1093/biostatistics/kxj037
– volume: 264
  start-page: 145
  year: 2008
  ident: BFncomms12601_CR7
  publication-title: Cancer. Lett.
  doi: 10.1016/j.canlet.2008.01.042
– volume: 32
  start-page: 1045
  year: 2006
  ident: BFncomms12601_CR2
  publication-title: Dermatol. Surg.
– volume: 48
  start-page: 490
  year: 2009
  ident: BFncomms12601_CR30
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.20657
– volume: 13
  start-page: 58
  year: 2013
  ident: BFncomms12601_CR16
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-13-58
– volume: 49
  start-page: 619
  year: 2010
  ident: BFncomms12601_CR21
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20636
– volume: 47
  start-page: 1047
  year: 2015
  ident: BFncomms12601_CR69
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3343
– volume: 15
  start-page: 96
  year: 1996
  ident: BFncomms12601_CR26
  publication-title: Mol. Carcinog.
  doi: 10.1002/(SICI)1098-2744(199602)15:2<96::AID-MC2>3.0.CO;2-P
– volume: 33
  start-page: e31
  year: 2005
  ident: BFncomms12601_CR22
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gni027
– ident: BFncomms12601_CR39
  doi: 10.1101/036541
– volume: 47
  start-page: 1038
  year: 2015
  ident: BFncomms12601_CR68
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3357
– volume: 29
  start-page: 266
  year: 2013
  ident: BFncomms12601_CR75
  publication-title: Bioinformatics.
  doi: 10.1093/bioinformatics/bts665
– volume: 366
  start-page: 207
  year: 2012
  ident: BFncomms12601_CR45
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1105358
– volume: 126
  start-page: 869
  year: 2006
  ident: BFncomms12601_CR18
  publication-title: J. Invest. Dermatol.
  doi: 10.1038/sj.jid.5700157
– volume: 333
  start-page: 1154
  year: 2011
  ident: BFncomms12601_CR62
  publication-title: Science
  doi: 10.1126/science.1206923
– volume: 19
  start-page: 151
  year: 2010
  ident: BFncomms12601_CR10
  publication-title: Exp. Dermatol.
  doi: 10.1111/j.1600-0625.2009.01028.x
– volume: 306
  start-page: 1026
  year: 2003
  ident: BFncomms12601_CR17
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/S0006-291X(03)01099-4
– volume: 5
  start-page: 30
  year: 2006
  ident: BFncomms12601_CR15
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-5-30
– volume: 26
  start-page: 1959
  year: 2012
  ident: BFncomms12601_CR59
  publication-title: Genes Dev.
  doi: 10.1101/gad.192955.112
– volume: 8
  start-page: 665
  year: 2005
  ident: BFncomms12601_CR49
  publication-title: Dev. Cell.
  doi: 10.1016/j.devcel.2005.02.016
– volume: 348
  start-page: 880
  year: 2015
  ident: BFncomms12601_CR36
  publication-title: Science
  doi: 10.1126/science.aaa6806
– volume: 53
  start-page: 10
  year: 2009
  ident: BFncomms12601_CR23
  publication-title: J. Dermatol. Sci.
  doi: 10.1016/j.jdermsci.2008.08.012
– volume: 15
  start-page: 550
  year: 2014
  ident: BFncomms12601_CR74
  publication-title: Genome Biol.
  doi: 10.1186/s13059-014-0550-8
– volume: 28
  start-page: 25
  year: 2002
  ident: BFncomms12601_CR71
  publication-title: Methods
  doi: 10.1016/S1046-2023(02)00207-4
– reference: 15866158 - Dev Cell. 2005 May;8(5):665-76
– reference: 21798897 - Science. 2011 Aug 26;333(6046):1154-7
– reference: 15765534 - Mol Carcinog. 2005 Apr;42(4):213-21
– reference: 23228302 - J Am Acad Dermatol. 2013 Jan;68(1 Suppl 1):S2-9
– reference: 22389437 - Cancer Prev Res (Phila). 2012 Mar;5(3):403-13
– reference: 12873882 - Arch Dermatol. 2003 Jul;139(7):876-82
– reference: 24927874 - Exp Mol Pathol. 2014 Aug;97(1):99-104
– reference: 11121147 - J Invest Dermatol. 2000 Dec;115(6):1095-103
– reference: 18331779 - Cancer Lett. 2008 Jun 8;264(1):145-61
– reference: 25354245 - Photochem Photobiol. 2015 Jan-Feb;91(1):15-26
– reference: 21798893 - Science. 2011 Aug 26;333(6046):1157-60
– reference: 19640009 - Pharmacoeconomics. 2009;27(6):451-64
– reference: 8599584 - Mol Carcinog. 1996 Feb;15(2):96-103
– reference: 15547921 - Mol Carcinog. 2005 Jan;42(1):40-52
– reference: 24618292 - Cancer Prev Res (Phila). 2014 May;7(5):487-95
– reference: 24066765 - Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):522-43
– reference: 8943054 - Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14025-9
– reference: 20564339 - Mol Carcinog. 2010 Jul;49(7):619-29
– reference: 26192918 - Nat Genet. 2015 Sep;47(9):1047-55
– reference: 25589618 - Clin Cancer Res. 2015 Mar 15;21(6):1447-56
– reference: 20876729 - Cancer Prev Res (Phila). 2010 Oct;3(10 ):1277-83
– reference: 26267216 - Elife. 2015 Aug 12;4:null
– reference: 20737481 - Genes Chromosomes Cancer. 2010 Nov;49(11):1054-61
– reference: 16700662 - J Dermatol. 2006 May;33(5):309-18
– reference: 19541911 - Genome Res. 2009 Sep;19(9):1639-45
– reference: 19673870 - Br J Dermatol. 2009 Nov;161(5):1112-8
– reference: 24662767 - J Invest Dermatol. 2014 Oct;134(10 ):2630-8
– reference: 19296524 - Genes Chromosomes Cancer. 2009 Jun;48(6):490-501
– reference: 15057871 - Mol Carcinog. 2004 Apr;39(4):195-8
– reference: 26192915 - Nat Genet. 2015 Sep;47(9):1038-46
– reference: 16921376 - Nat Genet. 2006 Sep;38(9):1043-8
– reference: 16632515 - Biostatistics. 2007 Jan;8(1):118-27
– reference: 10374837 - Cancer Lett. 1999 Apr 1;137(2):159-65
– reference: 25303977 - Clin Cancer Res. 2014 Dec 15;20(24):6582-92
– reference: 23379751 - BMC Cancer. 2013 Feb 05;13:58
– reference: 26168291 - Nat Med. 2015 Aug;21(8):946-54
– reference: 23762562 - J Skin Cancer. 2013;2013:537028
– reference: 19801978 - Nat Genet. 2009 Nov;41(11):1238-42
– reference: 8700506 - Oncogene. 1996 Jun 20;12(12):2483-90
– reference: 25999502 - Science. 2015 May 22;348(6237):880-6
– reference: 24275495 - Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73
– reference: 15722477 - Nucleic Acids Res. 2005 Feb 18;33(3):e31
– reference: 21490616 - J Invest Dermatol. 2011 Aug;131(8):1745-53
– reference: 17000751 - Bioinformatics. 2006 Dec 1;22(23):2926-33
– reference: 23945592 - Nature. 2013 Aug 22;500(7463):415-21
– reference: 22256804 - N Engl J Med. 2012 Jan 19;366(3):207-15
– reference: 12231185 - Methods. 2002 Sep;28(1):25-33
– reference: 21911940 - J Clin Invest. 2011 Oct;121(10):4127-37
– reference: 22960745 - Nature. 2012 Sep 27;489(7417):519-25
– reference: 23162058 - Bioinformatics. 2013 Jan 15;29(2):266-7
– reference: 19849697 - Br J Dermatol. 2010 Feb 1;162(2):325-31
– reference: 19382202 - Cancer. 2009 Jun 1;115(11):2523-30
– reference: 16918567 - Dermatol Surg. 2006 Aug;32(8):1045-9
– reference: 24686850 - Nat Genet. 2014 May;46(5):467-73
– reference: 22006338 - Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17761-6
– reference: 22144206 - Methods Mol Biol. 2012;822:273-88
– reference: 12821146 - Biochem Biophys Res Commun. 2003 Jul 11;306(4):1026-36
– reference: 22948661 - Genes Dev. 2012 Sep 1;26(17 ):1959-71
– reference: 24192036 - Elife. 2013 Nov 05;2:e00969
– reference: 23375456 - J Am Acad Dermatol. 2013 Jun;68(6):957-66
– reference: 25848863 - Breast Cancer Res. 2015 Feb 26;17 :30
– reference: 16893473 - Mol Cancer. 2006 Aug 08;5:30
– reference: 25516281 - Genome Biol. 2014;15(12):550
– reference: 24909826 - Nat Commun. 2014 Jun 09;5:4088
– reference: 16470182 - J Invest Dermatol. 2006 Apr;126(4):869-81
– reference: 18070208 - Br J Dermatol. 2008 Feb;158(2):291-7
– reference: 25631445 - Nature. 2015 Jan 29;517(7536):576-82
– reference: 23711067 - Exp Dermatol. 2013 Jun;22(6):426-8
– reference: 24599324 - PLoS One. 2014 Mar 05;9(3):e90581
– reference: 20156290 - Exp Dermatol. 2010 Feb;19(2):151-3
– reference: 21743436 - Mod Pathol. 2011 Jul;24(7):963-73
– reference: 25068518 - PLoS One. 2014 Jul 28;9(7):e103206
– reference: 7767977 - Carcinogenesis. 1995 May;16(5):1141-7
– reference: 25194279 - Nat Genet. 2014 Oct;46(10):1060-2
– reference: 8483937 - Proc Natl Acad Sci U S A. 1993 May 1;90(9):4216-20
– reference: 20231500 - Arch Dermatol. 2010 Mar;146(3):288-93
– reference: 16199517 - Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
– reference: 20574436 - J Invest Dermatol. 2010 Nov;130(11):2686-9
– reference: 18938063 - J Dermatol Sci. 2009 Jan;53(1):10-8
SSID ssj0000391844
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Snippet Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in...
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in...
Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic...
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SubjectTerms 38
38/39
631/67/1813/1352
631/67/69
64
64/60
Animals
Antineoplastic Agents - therapeutic use
Biochemistry
Biology
Cancer therapies
Carcinogenesis - genetics
Carcinoma, Squamous Cell - etiology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - prevention & control
Dermatology
Disease prevention
Disease Progression
DNA Mutational Analysis
Female
Gene Expression Profiling
Genomes
Genomics
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Keratosis, Actinic - pathology
Medicine
Mice
Mice, Hairless
Molecular Targeted Therapy - methods
multidisciplinary
Precancerous Conditions - genetics
Precancerous Conditions - pathology
Science
Science (multidisciplinary)
Sequence Analysis, RNA
Skin - pathology
Skin Neoplasms - etiology
Skin Neoplasms - genetics
Skin Neoplasms - prevention & control
Solar radiation
Surgery
Ultraviolet radiation
Ultraviolet Rays - adverse effects
Whole Exome Sequencing
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Title Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates
URI https://link.springer.com/article/10.1038/ncomms12601
https://www.ncbi.nlm.nih.gov/pubmed/27574101
https://www.proquest.com/docview/1814929113
https://www.proquest.com/docview/1815681648
https://pubmed.ncbi.nlm.nih.gov/PMC5013636
https://doaj.org/article/2337471e297249159e9e90238c07490c
Volume 7
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