Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction - Yeh, Yu-Te; Sona, Chandan; Yan, Xin; Li, Yunxiao; Pathak, Adrija; McDermott, Mark I.; Xie, Zhigang; Liu, Liangwen; Arunagiri, Anoop; Wang, Yuting; Cazenave-Gassiot, Amaury; Ghosh, Adhideb; et al. (Nature communications, 2023)
Keywords: 14/19; 14/28; 38/39; 631/443/319/1642/137/773; 631/45/287/1194; 64/110; 692/163/2743/137/773; 82/29; 82/51; 82/58; Animals; Beta cells; Clonal deletion; Defects; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Exocytosis; Failure; Flox; Glucose - metabolism; Golgi apparatus; Granular materials; Human subjects; Humanities and Social Sciences; Humans; Hyperglycemia; Insulin; Insulin - metabolism; Insulin secretion; Insulin-Secreting Cells - metabolism; Islets of Langerhans - metabolism; Kinases; Maturation; Mice; multidisciplinary; Pancreas; Phosphatidylinositol transfer protein; Proinsulin - metabolism; Proteins; Restoration; Science; Science (multidisciplinary); Synthesis