A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian c...
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| Published in | Cell Vol. 152; no. 4; pp. 909 - 922 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
14.02.2013
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0092-8674 1097-4172 1097-4172 |
| DOI | 10.1016/j.cell.2013.01.030 |
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| Abstract | Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian cells. First, we use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs. We then construct double-shRNA libraries from these to systematically measure GIs between hits. A GI map focused on ricin susceptibility broadly recapitulates known pathways and provides many unexpected insights. These include a noncanonical role for COPI, a previously uncharacterized protein complex affecting toxin clearance, a specialized role for the ribosomal protein RPS25, and functionally distinct mammalian TRAPP complexes. The ability to rapidly generate mammalian GI maps provides a potentially transformative tool for defining gene function and designing combination therapies based on synergistic pairs.
[Display omitted]
► Ultracomplex shRNA library minimizes false positives/negatives in genome-wide screens ► Pooled double-shRNA strategy systematically maps genetic interactions between hits ► Application of two-step strategy identifies pathways controlling ricin susceptibility ► The resulting map uncovers functionally distinct mammalian TRAPP complexes
A high-throughput method that relies on the use of ultracomplex shRNA libraries makes it possible to create genetic interaction maps in mammalian cells. This approach will be applicable to many cellular processes and conditions, as illustrated by the discovery of distinct TRAPP complexes involved in endocytosis. |
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| AbstractList | Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian cells. First, we use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs. We then construct double-shRNA libraries from these to systematically measure GIs between hits. A GI map focused on ricin susceptibility broadly recapitulates known pathways and provides many unexpected insights. These include a noncanonical role for COPI, a previously uncharacterized protein complex affecting toxin clearance, a specialized role for the ribosomal protein RPS25, and functionally distinct mammalian TRAPP complexes. The ability to rapidly generate mammalian GI maps provides a potentially transformative tool for defining gene function and designing combination therapies based on synergistic pairs. Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian cells. First, we use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs. We then construct double-shRNA libraries from these to systematically measure GIs between hits. A GI map focused on ricin susceptibility broadly recapitulates known pathways and provides many unexpected insights. These include a noncanonical role for COPI, a previously uncharacterized protein complex affecting toxin clearance, a specialized role for the ribosomal protein RPS25, and functionally distinct mammalian TRAPP complexes. The ability to rapidly generate mammalian GI maps provides a potentially transformative tool for defining gene function and designing combination therapies based on synergistic pairs.Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian cells. First, we use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs. We then construct double-shRNA libraries from these to systematically measure GIs between hits. A GI map focused on ricin susceptibility broadly recapitulates known pathways and provides many unexpected insights. These include a noncanonical role for COPI, a previously uncharacterized protein complex affecting toxin clearance, a specialized role for the ribosomal protein RPS25, and functionally distinct mammalian TRAPP complexes. The ability to rapidly generate mammalian GI maps provides a potentially transformative tool for defining gene function and designing combination therapies based on synergistic pairs. Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian cells. First, we use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs. We then construct double-shRNA libraries from these to systematically measure GIs between hits. A GI map focused on ricin susceptibility broadly recapitulates known pathways and provides many unexpected insights. These include a noncanonical role for COPI, a previously uncharacterized protein complex affecting toxin clearance, a specialized role for the ribosomal protein RPS25, and functionally distinct mammalian TRAPP complexes. The ability to rapidly generate mammalian GI maps provides a potentially transformative tool for defining gene function and designing combination therapies based on synergistic pairs. [Display omitted] ► Ultracomplex shRNA library minimizes false positives/negatives in genome-wide screens ► Pooled double-shRNA strategy systematically maps genetic interactions between hits ► Application of two-step strategy identifies pathways controlling ricin susceptibility ► The resulting map uncovers functionally distinct mammalian TRAPP complexes A high-throughput method that relies on the use of ultracomplex shRNA libraries makes it possible to create genetic interaction maps in mammalian cells. This approach will be applicable to many cellular processes and conditions, as illustrated by the discovery of distinct TRAPP complexes involved in endocytosis. Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the systematic exploration of gene function in microorganisms. Here, we present a two-stage strategy to construct high-density GI maps in mammalian cells. First, we use ultra-complex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs. We then construct double-shRNA libraries from these to systematically measure GIs between hits. A GI map focused on ricin susceptibility broadly recapitulates known pathways and provides many unexpected insights. These include a non-canonical role for COPI, a novel protein complex (SRIC) affecting toxin clearance, a specialized role for the ribosomal protein RPS25, and functionally distinct mammalian TRAPP complexes. The ability to rapidly generate mammalian GI maps provides a potentially transformative tool for defining gene function and designing combination therapies based on synergistic pairs. |
| Author | Bassik, Michael C. Weibezahn, Jimena Lebbink, Robert Jan Wang, Shuyi Chen, Siyuan Poser, Ina Horlbeck, Max A. Hein, Marco Y. Mann, Matthias Kampmann, Martin Weissman, Jonathan S. Hyman, Anthony A. McManus, Michael T. LeProust, Emily M. |
| AuthorAffiliation | 5 Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany 6 Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany 3 Department of Microbiology and Immunology, and University of California San Francisco Diabetes Center, University of California, San Francisco, San Francisco, California, USA 7 Genomics Solution Unit, Agilent Technologies Inc., Santa Clara, California, USA 1 Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA |
| AuthorAffiliation_xml | – name: 7 Genomics Solution Unit, Agilent Technologies Inc., Santa Clara, California, USA – name: 3 Department of Microbiology and Immunology, and University of California San Francisco Diabetes Center, University of California, San Francisco, San Francisco, California, USA – name: 5 Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany – name: 6 Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany – name: 1 Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, USA |
| Author_xml | – sequence: 1 givenname: Michael C. surname: Bassik fullname: Bassik, Michael C. email: bassik@cmp.ucsf.edu organization: Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94122, USA – sequence: 2 givenname: Martin surname: Kampmann fullname: Kampmann, Martin email: martin.kampmann@ucsf.edu organization: Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94122, USA – sequence: 3 givenname: Robert Jan surname: Lebbink fullname: Lebbink, Robert Jan organization: Department of Microbiology and Immunology and University of California San Francisco Diabetes Center, University of California, San Francisco, San Francisco, CA 94122, USA – sequence: 4 givenname: Shuyi surname: Wang fullname: Wang, Shuyi organization: Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94122, USA – sequence: 5 givenname: Marco Y. surname: Hein fullname: Hein, Marco Y. organization: Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany – sequence: 6 givenname: Ina surname: Poser fullname: Poser, Ina organization: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany – sequence: 7 givenname: Jimena surname: Weibezahn fullname: Weibezahn, Jimena organization: Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94122, USA – sequence: 8 givenname: Max A. surname: Horlbeck fullname: Horlbeck, Max A. organization: Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94122, USA – sequence: 9 givenname: Siyuan surname: Chen fullname: Chen, Siyuan organization: Genomics Solution Unit, Agilent Technologies Inc., Santa Clara, CA 95051, USA – sequence: 10 givenname: Matthias surname: Mann fullname: Mann, Matthias organization: Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried 82152, Germany – sequence: 11 givenname: Anthony A. surname: Hyman fullname: Hyman, Anthony A. organization: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany – sequence: 12 givenname: Emily M. surname: LeProust fullname: LeProust, Emily M. organization: Genomics Solution Unit, Agilent Technologies Inc., Santa Clara, CA 95051, USA – sequence: 13 givenname: Michael T. surname: McManus fullname: McManus, Michael T. organization: Department of Microbiology and Immunology and University of California San Francisco Diabetes Center, University of California, San Francisco, San Francisco, CA 94122, USA – sequence: 14 givenname: Jonathan S. surname: Weissman fullname: Weissman, Jonathan S. organization: Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94122, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23394947$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nrm2999 10.1038/nbt.1857 10.1038/nmeth.1239 10.1038/nature09204 10.1038/nprot.2007.427 10.1091/mbc.E09-05-0387 10.1038/nmeth724 10.1126/science.1195618 10.1038/nprot.2008.211 10.1371/journal.pone.0023350 10.1111/j.1600-0854.2011.01181.x 10.1126/science.1225787 10.1073/pnas.95.25.14863 10.1038/15658 10.1074/jbc.M303425200 10.1038/nature08460 10.1158/2159-8290.CD-11-0224 10.1093/nar/gkn923 10.1038/nmeth.1581 10.1126/science.1178955 10.1038/ncb2339 10.1016/j.ajhg.2010.08.018 10.1038/nmeth.1330 10.1101/gad.1832209 10.1016/j.cell.2009.05.006 10.1073/pnas.1119675109 10.1186/gb-2009-10-3-r25 10.1038/nmeth.1199 10.1371/journal.pone.0010180 10.1016/j.cell.2006.01.040 10.1073/pnas.1530509100 10.1016/j.tcb.2008.04.006 10.1091/mbc.E10-11-0873 10.1038/nature05527 10.1083/jcb.201108103 10.1016/j.devcel.2012.04.010 10.1016/j.cell.2011.03.020 10.1126/science.1149185 10.1177/1087057110397890 10.1038/415141a 10.1038/embor.2009.236 10.1073/pnas.1109363108 10.1016/j.molcel.2012.05.028 10.1038/ng1650 10.1091/mbc.11.12.4205 10.1038/nmeth1009-721 10.1073/pnas.0810485105 10.1016/j.cell.2008.12.009 10.1016/S0167-4889(02)00163-5 10.1038/nmeth1104-163 10.1128/JVI.00243-06 10.1016/j.molcel.2011.02.008 10.1038/ng.405 10.1083/jcb.201003006 10.1038/nmeth.1240 10.1101/cshperspect.a005231 10.1016/j.tcb.2010.11.003 10.1016/j.devcel.2011.06.014 10.1016/S1097-2765(01)00190-3 10.1016/j.febslet.2010.04.008 10.1146/annurev.genet.39.073003.114751 10.1016/j.cell.2012.04.028 10.4161/rna.6.1.7565 10.1242/jcs.004200 10.1242/jcs.03436 |
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| Notes | http://dx.doi.org/10.1016/j.cell.2013.01.030 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work Current Address: Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands |
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| References | Amessou, Fradagrada, Falguières, Lord, Smith, Roberts, Lamaze, Johannes (bib1) 2007; 120 Sandvig, Torgersen, Engedal, Skotland, Iversen (bib46) 2010; 584 Merrill, Gromeier (bib37) 2006; 80 Gavin, Bösche, Krause, Grandi, Marzioch, Bauer, Schultz, Rick, Michon, Cruciat (bib23) 2002; 415 Llorente, Lauvrak, van Deurs, Sandvig (bib33) 2003; 278 Barbie, Tamayo, Boehm, Kim, Moody, Dunn, Schinzel, Sandy, Meylan, Scholl (bib5) 2009; 462 Horn, Sandmann, Fischer, Axelsson, Huber, Boutros (bib28) 2011; 8 Paddison, Cleary, Silva, Chang, Sheth, Sachidanandam, Hannon (bib40) 2004; 1 Barber (bib4) 2009; 6 Kaelin (bib30) 2012; 337 Behrends, Sowa, Gygi, Harper (bib8) 2010; 466 Cai, Yu, Menon, Cai, Lazarova, Fu, Reinisch, Hay, Ferro-Novick (bib11) 2007; 445 Barrowman, Bhandari, Reinisch, Ferro-Novick (bib6) 2010; 11 Carette, Guimaraes, Wuethrich, Blomen, Varadarajan, Sun, Bell, Yuan, Muellner, Nijman (bib13) 2011; 29 Johannes, Popoff (bib29) 2008; 135 Bandyopadhyay, Mehta, Kuo, Sung, Chuang, Jaehnig, Bodenmiller, Licon, Copeland, Shales (bib3) 2010; 330 Yamasaki, Menon, Yu, Barrowman, Meerloo, Oorschot, Klumperman, Satoh, Ferro-Novick (bib54) 2009; 20 Fromme, Orci, Schekman (bib21) 2008; 18 Luo, Emanuele, Li, Creighton, Schlabach, Westbrook, Wong, Elledge (bib35) 2009; 137 Ashworth, Lord, Reis-Filho (bib2) 2011; 145 Girod, Storrie, Simpson, Johannes, Goud, Roberts, Lord, Nilsson, Pepperkok (bib25) 1999; 1 Popoff, Adolf, Brügger, Wieland (bib43) 2011; 3 Collins, Weissman, Krogan (bib18) 2009; 6 Cheung, Cowley, Weir, Boehm, Rusin, Scott, East, Ali, Lizotte, Wong (bib15) 2011; 108 Geiger, Andritschke, Friebe, Herzog, Luisoni, Heger, Helenius (bib24) 2011; 13 Silva, Li, Chang, Ge, Golding, Rickles, Siolas, Hu, Paddison, Schlabach (bib49) 2005; 37 Bassik, Lebbink, Churchman, Ingolia, Patena, LeProust, Schuldiner, Weissman, McManus (bib7) 2009; 6 Zong, Wu, Chan, Choi, Chan, Tanner, Yu (bib55) 2011; 6 Kim, Ahn, Kurth, Ullmann, Kim, Kulharya, Ha, Itokawa, Meliciani, Wenzel (bib31) 2010; 87 Fellmann, Zuber, McJunkin, Chang, Malone, Dickins, Xu, Hengartner, Elledge, Hannon, Lowe (bib20) 2011; 41 Ryan, Roguev, Patrick, Xu, Jahari, Tong, Beltrao, Shales, Qu, Collins (bib44) 2012; 46 Marcotte, Brown, Suarez, Sayad, Karamboulas, Krzyzanowski, Sircoulomb, Medrano, Fedyshyn, Koh (bib36) 2012; 2 Choi, Davey, Schluter, Pandher, Fang, Foster, Conibear (bib16) 2011; 12 Grimmer, Iversen, van Deurs, Sandvig (bib26) 2000; 11 Chen, Hu, Mikoryak, Draper (bib14) 2002; 1589 Dixon, Costanzo, Baryshnikova, Andrews, Boone (bib19) 2009; 43 Typas, Nichols, Siegele, Shales, Collins, Lim, Braberg, Yamamoto, Takeuchi, Wanner (bib53) 2008; 5 Cleary, Kilian, Wang, Bradshaw, Cavet, Ge, Kulkarni, Paddison, Chang, Sheth (bib17) 2004; 1 Frost, Elgort, Brandman, Ives, Collins, Miller-Vedam, Weibezahn, Hein, Poser, Mann (bib22) 2012; 149 Silva, Marran, Parker, Silva, Golding, Schlabach, Elledge, Hannon, Chang (bib50) 2008; 319 Spooner, Lord (bib51) 2012; 357 Moreau, Kumar, Wang, Chaumet, Chew, Chevalley, Bard (bib39) 2011; 21 Zuk, Hechter, Sunyaev, Lander (bib56) 2012; 109 Moffat, Grueneberg, Yang, Kim, Kloepfer, Hinkle, Piqani, Eisenhaure, Luo, Grenier (bib38) 2006; 124 Carette, Guimaraes, Varadarajan, Park, Wuethrich, Godarova, Kotecki, Cochran, Spooner, Ploegh, Brummelkamp (bib12) 2009; 326 Sacher, Barrowman, Wang, Horecka, Zhang, Pypaert, Ferro-Novick (bib45) 2001; 7 Pawar, De, Briggs, Omar, Sweeney, Lord, Roberts, Spooner, Moffat (bib41) 2011; 16 Landry, Hertz, Thompson (bib32) 2009; 23 Bonifacino, Hierro (bib9) 2011; 21 Pierce, Davis, Nislow, Giaever (bib42) 2007; 2 Storey, Tibshirani (bib52) 2003; 100 Guimaraes, Carette, Varadarajan, Antos, Popp, Spooner, Brummelkamp, Ploegh (bib27) 2011; 195 Schwarz, Iolascon, Verissimo, Trede, Horsley, Chen, Paw, Hopfner, Holzmann, Russo (bib47) 2009; 41 Butland, Babu, Díaz-Mejía, Bohdana, Phanse, Gold, Yang, Li, Gagarinova, Pogoutse (bib10) 2008; 5 Scrivens, Noueihed, Shahrzad, Hul, Brunet, Sacher (bib48) 2011; 22 Lord, Roberts, Lencer (bib34) 2005; 300 Horn (10.1016/j.cell.2013.01.030_bib28) 2011; 8 Luo (10.1016/j.cell.2013.01.030_bib64) 2008; 105 Sacher (10.1016/j.cell.2013.01.030_bib45) 2001; 7 Collins (10.1016/j.cell.2013.01.030_bib18) 2009; 6 Spooner (10.1016/j.cell.2013.01.030_bib51) 2012; 357 Linford (10.1016/j.cell.2013.01.030_bib62) 2012; 22 Lord (10.1016/j.cell.2013.01.030_bib34) 2005; 300 Butland (10.1016/j.cell.2013.01.030_bib10) 2008; 5 Girod (10.1016/j.cell.2013.01.030_bib25) 1999; 1 Merrill (10.1016/j.cell.2013.01.030_bib37) 2006; 80 Luo (10.1016/j.cell.2013.01.030_bib35) 2009; 137 Kaelin (10.1016/j.cell.2013.01.030_bib30) 2012; 337 Ryan (10.1016/j.cell.2013.01.030_bib44) 2012; 46 Geiger (10.1016/j.cell.2013.01.030_bib24) 2011; 13 Cleary (10.1016/j.cell.2013.01.030_bib17) 2004; 1 Llorente (10.1016/j.cell.2013.01.030_bib33) 2003; 278 Pawar (10.1016/j.cell.2013.01.030_bib41) 2011; 16 Schwarz (10.1016/j.cell.2013.01.030_bib47) 2009; 41 Zong (10.1016/j.cell.2013.01.030_bib55) 2011; 6 Kim (10.1016/j.cell.2013.01.030_bib31) 2010; 87 Pierce (10.1016/j.cell.2013.01.030_bib42) 2007; 2 Scrivens (10.1016/j.cell.2013.01.030_bib48) 2011; 22 Dixon (10.1016/j.cell.2013.01.030_bib19) 2009; 43 Chen (10.1016/j.cell.2013.01.030_bib14) 2002; 1589 Marcotte (10.1016/j.cell.2013.01.030_bib36) 2012; 2 Eisen (10.1016/j.cell.2013.01.030_bib58) 1998; 95 Bonifacino (10.1016/j.cell.2013.01.030_bib9) 2011; 21 Fellmann (10.1016/j.cell.2013.01.030_bib20) 2011; 41 Yamasaki (10.1016/j.cell.2013.01.030_bib54) 2009; 20 Silva (10.1016/j.cell.2013.01.030_bib50) 2008; 319 Amessou (10.1016/j.cell.2013.01.030_bib1) 2007; 120 Matveeva (10.1016/j.cell.2013.01.030_bib65) 2010; 5 Behrends (10.1016/j.cell.2013.01.030_bib8) 2010; 466 Cheung (10.1016/j.cell.2013.01.030_bib15) 2011; 108 Moffat (10.1016/j.cell.2013.01.030_bib38) 2006; 124 Huang (10.1016/j.cell.2013.01.030_bib59) 2009; 37 Paddison (10.1016/j.cell.2013.01.030_bib40) 2004; 1 Gavin (10.1016/j.cell.2013.01.030_bib23) 2002; 415 Popoff (10.1016/j.cell.2013.01.030_bib43) 2011; 3 Zuk (10.1016/j.cell.2013.01.030_bib56) 2012; 109 Langmead (10.1016/j.cell.2013.01.030_bib61) 2009; 10 Sandvig (10.1016/j.cell.2013.01.030_bib46) 2010; 584 Grimmer (10.1016/j.cell.2013.01.030_bib26) 2000; 11 Barber (10.1016/j.cell.2013.01.030_bib4) 2009; 6 Guimaraes (10.1016/j.cell.2013.01.030_bib27) 2011; 195 Choi (10.1016/j.cell.2013.01.030_bib16) 2011; 12 Ashworth (10.1016/j.cell.2013.01.030_bib2) 2011; 145 Fromme (10.1016/j.cell.2013.01.030_bib21) 2008; 18 Barbie (10.1016/j.cell.2013.01.030_bib5) 2009; 462 Landry (10.1016/j.cell.2013.01.030_bib32) 2009; 23 Carette (10.1016/j.cell.2013.01.030_bib13) 2011; 29 Frost (10.1016/j.cell.2013.01.030_bib22) 2012; 149 Typas (10.1016/j.cell.2013.01.030_bib53) 2008; 5 Cai (10.1016/j.cell.2013.01.030_bib11) 2007; 445 Huang (10.1016/j.cell.2013.01.030_bib60) 2009; 4 Lozupone (10.1016/j.cell.2013.01.030_bib63) 2009; 10 Moreau (10.1016/j.cell.2013.01.030_bib39) 2011; 21 Storey (10.1016/j.cell.2013.01.030_bib52) 2003; 100 Silva (10.1016/j.cell.2013.01.030_bib49) 2005; 37 Castro (10.1016/j.cell.2013.01.030_bib57) 2007; 120 Bandyopadhyay (10.1016/j.cell.2013.01.030_bib3) 2010; 330 Bassik (10.1016/j.cell.2013.01.030_bib7) 2009; 6 Sohaskey (10.1016/j.cell.2013.01.030_bib67) 2010; 189 Johannes (10.1016/j.cell.2013.01.030_bib29) 2008; 135 Carette (10.1016/j.cell.2013.01.030_bib12) 2009; 326 Poser (10.1016/j.cell.2013.01.030_bib66) 2008; 5 Barrowman (10.1016/j.cell.2013.01.030_bib6) 2010; 11 19965467 - Science. 2009 Nov 27;326(5957):1231-5 12007788 - Biochim Biophys Acta. 2002 Apr 3;1589(2):124-39 21183348 - Trends Cell Biol. 2011 Mar;21(3):159-67 21364088 - J Biomol Screen. 2011 Apr;16(4):436-42 21453443 - Traffic. 2011 Jun;12(6):715-25 21525244 - Mol Biol Cell. 2011 Jun 15;22(12):2083-93 21782526 - Dev Cell. 2011 Aug 16;21(2):231-44 21458666 - Cell. 2011 Apr 1;145(1):30-8 20966969 - Nat Rev Mol Cell Biol. 2010 Nov;11(11):759-63 19953683 - Nat Methods. 2009 Oct;6(10):721-23 21353615 - Mol Cell. 2011 Mar 18;41(6):733-46 21378980 - Nat Methods. 2011 Apr;8(4):341-6 19160513 - Nat Methods. 2008 Sep;5(9):781-7 19712041 - Annu Rev Genet. 2009;43:601-25 17287728 - Nature. 2007 Feb 22;445(7130):941-4 19106622 - RNA Biol. 2009 Jan-Mar;6(1):35-9 16200065 - Nat Genet. 2005 Nov;37(11):1281-8 20887964 - Am J Hum Genet. 2010 Oct 8;87(4):465-79 19561605 - Nat Genet. 2009 Aug;41(8):936-40 19448642 - Nat Methods. 2009 Jun;6(6):443-5 16564017 - Cell. 2006 Mar 24;124(6):1283-98 12847103 - J Biol Chem. 2003 Sep 12;278(37):35850-5 17389686 - J Cell Sci. 2007 Apr 15;120(Pt 8):1457-68 20562859 - Nature. 2010 Jul 1;466(7302):68-76 21746896 - Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12372-7 19656848 - Mol Biol Cell. 2009 Oct;20(19):4205-15 22223662 - Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8 19490893 - Cell. 2009 May 29;137(5):835-48 21844168 - Cold Spring Harb Perspect Biol. 2011 Nov;3(11):a005231 15782200 - Nat Methods. 2004 Dec;1(3):241-8 16144086 - Nat Methods. 2004 Nov;1(2):163-7 23419280 - Nat Rev Genet. 2013 Apr;14(4):240 21761287 - Curr Top Microbiol Immunol. 2012;357:19-40 18239125 - Science. 2008 Feb 1;319(5863):617-20 16573240 - Curr Top Microbiol Immunol. 2005;300:149-68 22585861 - Cancer Discov. 2012 Feb;2(2):172-89 19952110 - Genes Dev. 2009 Dec 1;23(23):2753-64 21623355 - Nat Biotechnol. 2011 Jun;29(6):542-6 10559986 - Nat Cell Biol. 1999 Nov;1(7):423-30 20385131 - FEBS Lett. 2010 Jun 18;584(12):2626-34 11239471 - Mol Cell. 2001 Feb;7(2):433-42 12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 11102518 - Mol Biol Cell. 2000 Dec;11(12):4205-16 16809299 - J Virol. 2006 Jul;80(14):6936-42 11805826 - Nature. 2002 Jan 10;415(6868):141-7 22682253 - Cell. 2012 Jun 8;149(6):1339-52 19109890 - Cell. 2008 Dec 26;135(7):1175-87 21858081 - PLoS One. 2011;6(8):e23350 21947079 - Nat Cell Biol. 2011 Nov;13(11):1305-14 23653921 - Nat Methods. 2013 Apr;10(4):281 21127252 - Science. 2010 Dec 3;330(6009):1385-9 18677321 - Nat Methods. 2008 Sep;5(9):789-95 19847166 - Nature. 2009 Nov 5;462(7269):108-12 18534853 - Trends Cell Biol. 2008 Jul;18(7):330-6 22837515 - Science. 2012 Jul 27;337(6093):421-2 18007632 - Nat Protoc. 2007;2(11):2958-74 22681890 - Mol Cell. 2012 Jun 8;46(5):691-704 22123862 - J Cell Biol. 2011 Nov 28;195(5):751-64 |
| References_xml | – volume: 8 start-page: 341 year: 2011 end-page: 346 ident: bib28 article-title: Mapping of signaling networks through synthetic genetic interaction analysis by RNAi publication-title: Nat. Methods – volume: 149 start-page: 1339 year: 2012 end-page: 1352 ident: bib22 article-title: Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions publication-title: Cell – volume: 18 start-page: 330 year: 2008 end-page: 336 ident: bib21 article-title: Coordination of COPII vesicle trafficking by Sec23 publication-title: Trends Cell Biol. – volume: 6 start-page: 35 year: 2009 end-page: 39 ident: bib4 article-title: The NFAR’s (nuclear factors associated with dsRNA): evolutionarily conserved members of the dsRNA binding protein family publication-title: RNA Biol. – volume: 23 start-page: 2753 year: 2009 end-page: 2764 ident: bib32 article-title: RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs publication-title: Genes Dev. – volume: 462 start-page: 108 year: 2009 end-page: 112 ident: bib5 article-title: Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 publication-title: Nature – volume: 109 start-page: 1193 year: 2012 end-page: 1198 ident: bib56 article-title: The mystery of missing heritability: Genetic interactions create phantom heritability publication-title: Proc. Natl. Acad. Sci. USA – volume: 100 start-page: 9440 year: 2003 end-page: 9445 ident: bib52 article-title: Statistical significance for genomewide studies publication-title: Proc. Natl. Acad. Sci. USA – volume: 11 start-page: 4205 year: 2000 end-page: 4216 ident: bib26 article-title: Endosome to Golgi transport of ricin is regulated by cholesterol publication-title: Mol. Biol. Cell – volume: 445 start-page: 941 year: 2007 end-page: 944 ident: bib11 article-title: TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 publication-title: Nature – volume: 16 start-page: 436 year: 2011 end-page: 442 ident: bib41 article-title: RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance publication-title: J. Biomol. Screen. – volume: 2 start-page: 2958 year: 2007 end-page: 2974 ident: bib42 article-title: Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures publication-title: Nat. Protoc. – volume: 120 start-page: 1457 year: 2007 end-page: 1468 ident: bib1 article-title: Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins publication-title: J. Cell Sci. – volume: 300 start-page: 149 year: 2005 end-page: 168 ident: bib34 article-title: Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation publication-title: Curr. Top. Microbiol. Immunol. – volume: 2 start-page: 172 year: 2012 end-page: 189 ident: bib36 article-title: Essential gene profiles in breast, pancreatic, and ovarian cancer cells publication-title: Cancer Discov. – volume: 330 start-page: 1385 year: 2010 end-page: 1389 ident: bib3 article-title: Rewiring of genetic networks in response to DNA damage publication-title: Science – volume: 1 start-page: 423 year: 1999 end-page: 430 ident: bib25 article-title: Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum publication-title: Nat. Cell Biol. – volume: 6 start-page: 443 year: 2009 end-page: 445 ident: bib7 article-title: Rapid creation and quantitative monitoring of high coverage shRNA libraries publication-title: Nat. Methods – volume: 108 start-page: 12372 year: 2011 end-page: 12377 ident: bib15 article-title: Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer publication-title: Proc. Natl. Acad. Sci. USA – volume: 87 start-page: 465 year: 2010 end-page: 479 ident: bib31 article-title: WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome publication-title: Am. J. Hum. Genet. – volume: 80 start-page: 6936 year: 2006 end-page: 6942 ident: bib37 article-title: The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site publication-title: J. Virol. – volume: 41 start-page: 936 year: 2009 end-page: 940 ident: bib47 article-title: Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II publication-title: Nat. Genet. – volume: 37 start-page: 1281 year: 2005 end-page: 1288 ident: bib49 article-title: Second-generation shRNA libraries covering the mouse and human genomes publication-title: Nat. Genet. – volume: 12 start-page: 715 year: 2011 end-page: 725 ident: bib16 article-title: Organization and assembly of the TRAPPII complex publication-title: Traffic – volume: 415 start-page: 141 year: 2002 end-page: 147 ident: bib23 article-title: Functional organization of the yeast proteome by systematic analysis of protein complexes publication-title: Nature – volume: 278 start-page: 35850 year: 2003 end-page: 35855 ident: bib33 article-title: Induction of direct endosome to endoplasmic reticulum transport in Chinese hamster ovary (CHO) cells (LdlF) with a temperature-sensitive defect in epsilon-coatomer protein (epsilon-COP) publication-title: J. Biol. Chem. – volume: 29 start-page: 542 year: 2011 end-page: 546 ident: bib13 article-title: Global gene disruption in human cells to assign genes to phenotypes by deep sequencing publication-title: Nat. Biotechnol. – volume: 20 start-page: 4205 year: 2009 end-page: 4215 ident: bib54 article-title: mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles publication-title: Mol. Biol. Cell – volume: 145 start-page: 30 year: 2011 end-page: 38 ident: bib2 article-title: Genetic interactions in cancer progression and treatment publication-title: Cell – volume: 11 start-page: 759 year: 2010 end-page: 763 ident: bib6 article-title: TRAPP complexes in membrane traffic: convergence through a common Rab publication-title: Nat. Rev. Mol. Cell Biol. – volume: 1 start-page: 241 year: 2004 end-page: 248 ident: bib17 article-title: Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis publication-title: Nat. Methods – volume: 137 start-page: 835 year: 2009 end-page: 848 ident: bib35 article-title: A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene publication-title: Cell – volume: 326 start-page: 1231 year: 2009 end-page: 1235 ident: bib12 article-title: Haploid genetic screens in human cells identify host factors used by pathogens publication-title: Science – volume: 357 start-page: 19 year: 2012 end-page: 40 ident: bib51 article-title: How ricin and Shiga toxin reach the cytosol of target cells: retrotranslocation from the endoplasmic reticulum publication-title: Curr. Top. Microbiol. Immunol. – volume: 7 start-page: 433 year: 2001 end-page: 442 ident: bib45 article-title: TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport publication-title: Mol. Cell – volume: 584 start-page: 2626 year: 2010 end-page: 2634 ident: bib46 article-title: Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine publication-title: FEBS Lett. – volume: 135 start-page: 1175 year: 2008 end-page: 1187 ident: bib29 article-title: Tracing the retrograde route in protein trafficking publication-title: Cell – volume: 21 start-page: 159 year: 2011 end-page: 167 ident: bib9 article-title: Transport according to GARP: receiving retrograde cargo at the trans-Golgi network publication-title: Trends Cell Biol. – volume: 5 start-page: 781 year: 2008 end-page: 787 ident: bib53 article-title: High-throughput, quantitative analyses of genetic interactions in E. coli publication-title: Nat. Methods – volume: 5 start-page: 789 year: 2008 end-page: 795 ident: bib10 article-title: eSGA: E. coli synthetic genetic array analysis publication-title: Nat. Methods – volume: 21 start-page: 231 year: 2011 end-page: 244 ident: bib39 article-title: Genome-wide RNAi screens identify genes required for Ricin and PE intoxications publication-title: Dev. Cell – volume: 319 start-page: 617 year: 2008 end-page: 620 ident: bib50 article-title: Profiling essential genes in human mammary cells by multiplex RNAi screening publication-title: Science – volume: 3 start-page: a005231 year: 2011 ident: bib43 article-title: COPI budding within the Golgi stack publication-title: Cold Spring Harb. Perspect. Biol. – volume: 1589 start-page: 124 year: 2002 end-page: 139 ident: bib14 article-title: Retrograde transport of protein toxins under conditions of COPI dysfunction publication-title: Biochim. Biophys. Acta – volume: 466 start-page: 68 year: 2010 end-page: 76 ident: bib8 article-title: Network organization of the human autophagy system publication-title: Nature – volume: 6 start-page: e23350 year: 2011 ident: bib55 article-title: The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability publication-title: PLoS ONE – volume: 337 start-page: 421 year: 2012 end-page: 422 ident: bib30 article-title: Molecular biology. Use and abuse of RNAi to study mammalian gene function publication-title: Science – volume: 124 start-page: 1283 year: 2006 end-page: 1298 ident: bib38 article-title: A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen publication-title: Cell – volume: 43 start-page: 601 year: 2009 end-page: 625 ident: bib19 article-title: Systematic mapping of genetic interaction networks publication-title: Annu. Rev. Genet. – volume: 41 start-page: 733 year: 2011 end-page: 746 ident: bib20 article-title: Functional identification of optimized RNAi triggers using a massively parallel sensor assay publication-title: Mol. Cell – volume: 195 start-page: 751 year: 2011 end-page: 764 ident: bib27 article-title: Identification of host cell factors required for intoxication through use of modified cholera toxin publication-title: J. Cell Biol. – volume: 13 start-page: 1305 year: 2011 end-page: 1314 ident: bib24 article-title: BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol publication-title: Nat. Cell Biol. – volume: 46 start-page: 691 year: 2012 end-page: 704 ident: bib44 article-title: Hierarchical modularity and the evolution of genetic interactomes across species publication-title: Mol. Cell – volume: 6 start-page: 721 year: 2009 end-page: 723 ident: bib18 article-title: From information to knowledge: new technologies for defining gene function publication-title: Nat. Methods – volume: 22 start-page: 2083 year: 2011 end-page: 2093 ident: bib48 article-title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking publication-title: Mol. Biol. Cell – volume: 1 start-page: 163 year: 2004 end-page: 167 ident: bib40 article-title: Cloning of short hairpin RNAs for gene knockdown in mammalian cells publication-title: Nat. Methods – volume: 11 start-page: 759 year: 2010 ident: 10.1016/j.cell.2013.01.030_bib6 article-title: TRAPP complexes in membrane traffic: convergence through a common Rab publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2999 – volume: 29 start-page: 542 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib13 article-title: Global gene disruption in human cells to assign genes to phenotypes by deep sequencing publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1857 – volume: 5 start-page: 789 year: 2008 ident: 10.1016/j.cell.2013.01.030_bib10 article-title: eSGA: E. coli synthetic genetic array analysis publication-title: Nat. Methods doi: 10.1038/nmeth.1239 – volume: 357 start-page: 19 year: 2012 ident: 10.1016/j.cell.2013.01.030_bib51 article-title: How ricin and Shiga toxin reach the cytosol of target cells: retrotranslocation from the endoplasmic reticulum publication-title: Curr. Top. Microbiol. Immunol. – volume: 466 start-page: 68 year: 2010 ident: 10.1016/j.cell.2013.01.030_bib8 article-title: Network organization of the human autophagy system publication-title: Nature doi: 10.1038/nature09204 – volume: 2 start-page: 2958 year: 2007 ident: 10.1016/j.cell.2013.01.030_bib42 article-title: Genome-wide analysis of barcoded Saccharomyces cerevisiae gene-deletion mutants in pooled cultures publication-title: Nat. Protoc. doi: 10.1038/nprot.2007.427 – volume: 20 start-page: 4205 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib54 article-title: mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E09-05-0387 – volume: 1 start-page: 241 year: 2004 ident: 10.1016/j.cell.2013.01.030_bib17 article-title: Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis publication-title: Nat. Methods doi: 10.1038/nmeth724 – volume: 330 start-page: 1385 year: 2010 ident: 10.1016/j.cell.2013.01.030_bib3 article-title: Rewiring of genetic networks in response to DNA damage publication-title: Science doi: 10.1126/science.1195618 – volume: 4 start-page: 44 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib60 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nat. Protoc. doi: 10.1038/nprot.2008.211 – volume: 6 start-page: e23350 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib55 article-title: The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability publication-title: PLoS ONE doi: 10.1371/journal.pone.0023350 – volume: 12 start-page: 715 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib16 article-title: Organization and assembly of the TRAPPII complex publication-title: Traffic doi: 10.1111/j.1600-0854.2011.01181.x – volume: 337 start-page: 421 year: 2012 ident: 10.1016/j.cell.2013.01.030_bib30 article-title: Molecular biology. Use and abuse of RNAi to study mammalian gene function publication-title: Science doi: 10.1126/science.1225787 – volume: 95 start-page: 14863 year: 1998 ident: 10.1016/j.cell.2013.01.030_bib58 article-title: Cluster analysis and display of genome-wide expression patterns publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.95.25.14863 – volume: 1 start-page: 423 year: 1999 ident: 10.1016/j.cell.2013.01.030_bib25 article-title: Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum publication-title: Nat. Cell Biol. doi: 10.1038/15658 – volume: 278 start-page: 35850 year: 2003 ident: 10.1016/j.cell.2013.01.030_bib33 article-title: Induction of direct endosome to endoplasmic reticulum transport in Chinese hamster ovary (CHO) cells (LdlF) with a temperature-sensitive defect in epsilon-coatomer protein (epsilon-COP) publication-title: J. Biol. Chem. doi: 10.1074/jbc.M303425200 – volume: 462 start-page: 108 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib5 article-title: Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 publication-title: Nature doi: 10.1038/nature08460 – volume: 2 start-page: 172 year: 2012 ident: 10.1016/j.cell.2013.01.030_bib36 article-title: Essential gene profiles in breast, pancreatic, and ovarian cancer cells publication-title: Cancer Discov. doi: 10.1158/2159-8290.CD-11-0224 – volume: 37 start-page: 1 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib59 article-title: Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn923 – volume: 8 start-page: 341 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib28 article-title: Mapping of signaling networks through synthetic genetic interaction analysis by RNAi publication-title: Nat. Methods doi: 10.1038/nmeth.1581 – volume: 326 start-page: 1231 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib12 article-title: Haploid genetic screens in human cells identify host factors used by pathogens publication-title: Science doi: 10.1126/science.1178955 – volume: 13 start-page: 1305 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib24 article-title: BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol publication-title: Nat. Cell Biol. doi: 10.1038/ncb2339 – volume: 87 start-page: 465 year: 2010 ident: 10.1016/j.cell.2013.01.030_bib31 article-title: WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2010.08.018 – volume: 6 start-page: 443 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib7 article-title: Rapid creation and quantitative monitoring of high coverage shRNA libraries publication-title: Nat. Methods doi: 10.1038/nmeth.1330 – volume: 23 start-page: 2753 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib32 article-title: RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs publication-title: Genes Dev. doi: 10.1101/gad.1832209 – volume: 137 start-page: 835 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib35 article-title: A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene publication-title: Cell doi: 10.1016/j.cell.2009.05.006 – volume: 109 start-page: 1193 year: 2012 ident: 10.1016/j.cell.2013.01.030_bib56 article-title: The mystery of missing heritability: Genetic interactions create phantom heritability publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1119675109 – volume: 10 start-page: R25 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib61 article-title: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome publication-title: Genome Biol. doi: 10.1186/gb-2009-10-3-r25 – volume: 5 start-page: 409 year: 2008 ident: 10.1016/j.cell.2013.01.030_bib66 article-title: BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals publication-title: Nat. Methods doi: 10.1038/nmeth.1199 – volume: 5 start-page: e10180 year: 2010 ident: 10.1016/j.cell.2013.01.030_bib65 article-title: Optimization of duplex stability and terminal asymmetry for shRNA design publication-title: PLoS ONE doi: 10.1371/journal.pone.0010180 – volume: 124 start-page: 1283 year: 2006 ident: 10.1016/j.cell.2013.01.030_bib38 article-title: A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen publication-title: Cell doi: 10.1016/j.cell.2006.01.040 – volume: 100 start-page: 9440 year: 2003 ident: 10.1016/j.cell.2013.01.030_bib52 article-title: Statistical significance for genomewide studies publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1530509100 – volume: 18 start-page: 330 year: 2008 ident: 10.1016/j.cell.2013.01.030_bib21 article-title: Coordination of COPII vesicle trafficking by Sec23 publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2008.04.006 – volume: 22 start-page: 2083 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib48 article-title: C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E10-11-0873 – volume: 445 start-page: 941 year: 2007 ident: 10.1016/j.cell.2013.01.030_bib11 article-title: TRAPPI tethers COPII vesicles by binding the coat subunit Sec23 publication-title: Nature doi: 10.1038/nature05527 – volume: 195 start-page: 751 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib27 article-title: Identification of host cell factors required for intoxication through use of modified cholera toxin publication-title: J. Cell Biol. doi: 10.1083/jcb.201108103 – volume: 22 start-page: 952 year: 2012 ident: 10.1016/j.cell.2013.01.030_bib62 article-title: Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells publication-title: Dev. Cell doi: 10.1016/j.devcel.2012.04.010 – volume: 145 start-page: 30 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib2 article-title: Genetic interactions in cancer progression and treatment publication-title: Cell doi: 10.1016/j.cell.2011.03.020 – volume: 319 start-page: 617 year: 2008 ident: 10.1016/j.cell.2013.01.030_bib50 article-title: Profiling essential genes in human mammary cells by multiplex RNAi screening publication-title: Science doi: 10.1126/science.1149185 – volume: 16 start-page: 436 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib41 article-title: RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance publication-title: J. Biomol. Screen. doi: 10.1177/1087057110397890 – volume: 415 start-page: 141 year: 2002 ident: 10.1016/j.cell.2013.01.030_bib23 article-title: Functional organization of the yeast proteome by systematic analysis of protein complexes publication-title: Nature doi: 10.1038/415141a – volume: 10 start-page: 1348 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib63 article-title: The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells publication-title: EMBO Rep. doi: 10.1038/embor.2009.236 – volume: 108 start-page: 12372 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib15 article-title: Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.1109363108 – volume: 46 start-page: 691 year: 2012 ident: 10.1016/j.cell.2013.01.030_bib44 article-title: Hierarchical modularity and the evolution of genetic interactomes across species publication-title: Mol. Cell doi: 10.1016/j.molcel.2012.05.028 – volume: 37 start-page: 1281 year: 2005 ident: 10.1016/j.cell.2013.01.030_bib49 article-title: Second-generation shRNA libraries covering the mouse and human genomes publication-title: Nat. Genet. doi: 10.1038/ng1650 – volume: 11 start-page: 4205 year: 2000 ident: 10.1016/j.cell.2013.01.030_bib26 article-title: Endosome to Golgi transport of ricin is regulated by cholesterol publication-title: Mol. Biol. Cell doi: 10.1091/mbc.11.12.4205 – volume: 6 start-page: 721 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib18 article-title: From information to knowledge: new technologies for defining gene function publication-title: Nat. Methods doi: 10.1038/nmeth1009-721 – volume: 105 start-page: 20380 year: 2008 ident: 10.1016/j.cell.2013.01.030_bib64 article-title: Highly parallel identification of essential genes in cancer cells publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0810485105 – volume: 135 start-page: 1175 year: 2008 ident: 10.1016/j.cell.2013.01.030_bib29 article-title: Tracing the retrograde route in protein trafficking publication-title: Cell doi: 10.1016/j.cell.2008.12.009 – volume: 1589 start-page: 124 year: 2002 ident: 10.1016/j.cell.2013.01.030_bib14 article-title: Retrograde transport of protein toxins under conditions of COPI dysfunction publication-title: Biochim. Biophys. Acta doi: 10.1016/S0167-4889(02)00163-5 – volume: 1 start-page: 163 year: 2004 ident: 10.1016/j.cell.2013.01.030_bib40 article-title: Cloning of short hairpin RNAs for gene knockdown in mammalian cells publication-title: Nat. Methods doi: 10.1038/nmeth1104-163 – volume: 80 start-page: 6936 year: 2006 ident: 10.1016/j.cell.2013.01.030_bib37 article-title: The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site publication-title: J. Virol. doi: 10.1128/JVI.00243-06 – volume: 41 start-page: 733 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib20 article-title: Functional identification of optimized RNAi triggers using a massively parallel sensor assay publication-title: Mol. Cell doi: 10.1016/j.molcel.2011.02.008 – volume: 41 start-page: 936 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib47 article-title: Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II publication-title: Nat. Genet. doi: 10.1038/ng.405 – volume: 189 start-page: 511 year: 2010 ident: 10.1016/j.cell.2013.01.030_bib67 article-title: Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice publication-title: J. Cell Biol. doi: 10.1083/jcb.201003006 – volume: 5 start-page: 781 year: 2008 ident: 10.1016/j.cell.2013.01.030_bib53 article-title: High-throughput, quantitative analyses of genetic interactions in E. coli publication-title: Nat. Methods doi: 10.1038/nmeth.1240 – volume: 3 start-page: a005231 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib43 article-title: COPI budding within the Golgi stack publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a005231 – volume: 300 start-page: 149 year: 2005 ident: 10.1016/j.cell.2013.01.030_bib34 article-title: Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation publication-title: Curr. Top. Microbiol. Immunol. – volume: 21 start-page: 159 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib9 article-title: Transport according to GARP: receiving retrograde cargo at the trans-Golgi network publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2010.11.003 – volume: 21 start-page: 231 year: 2011 ident: 10.1016/j.cell.2013.01.030_bib39 article-title: Genome-wide RNAi screens identify genes required for Ricin and PE intoxications publication-title: Dev. Cell doi: 10.1016/j.devcel.2011.06.014 – volume: 7 start-page: 433 year: 2001 ident: 10.1016/j.cell.2013.01.030_bib45 article-title: TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport publication-title: Mol. Cell doi: 10.1016/S1097-2765(01)00190-3 – volume: 584 start-page: 2626 year: 2010 ident: 10.1016/j.cell.2013.01.030_bib46 article-title: Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine publication-title: FEBS Lett. doi: 10.1016/j.febslet.2010.04.008 – volume: 43 start-page: 601 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib19 article-title: Systematic mapping of genetic interaction networks publication-title: Annu. Rev. Genet. doi: 10.1146/annurev.genet.39.073003.114751 – volume: 149 start-page: 1339 year: 2012 ident: 10.1016/j.cell.2013.01.030_bib22 article-title: Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions publication-title: Cell doi: 10.1016/j.cell.2012.04.028 – volume: 6 start-page: 35 year: 2009 ident: 10.1016/j.cell.2013.01.030_bib4 article-title: The NFAR’s (nuclear factors associated with dsRNA): evolutionarily conserved members of the dsRNA binding protein family publication-title: RNA Biol. doi: 10.4161/rna.6.1.7565 – volume: 120 start-page: 2454 year: 2007 ident: 10.1016/j.cell.2013.01.030_bib57 article-title: Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells publication-title: J. Cell Sci. doi: 10.1242/jcs.004200 – volume: 120 start-page: 1457 year: 2007 ident: 10.1016/j.cell.2013.01.030_bib1 article-title: Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins publication-title: J. Cell Sci. doi: 10.1242/jcs.03436 – reference: 22682253 - Cell. 2012 Jun 8;149(6):1339-52 – reference: 21623355 - Nat Biotechnol. 2011 Jun;29(6):542-6 – reference: 17287728 - Nature. 2007 Feb 22;445(7130):941-4 – reference: 22585861 - Cancer Discov. 2012 Feb;2(2):172-89 – reference: 21453443 - Traffic. 2011 Jun;12(6):715-25 – reference: 21364088 - J Biomol Screen. 2011 Apr;16(4):436-42 – reference: 22223662 - Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8 – reference: 21844168 - Cold Spring Harb Perspect Biol. 2011 Nov;3(11):a005231 – reference: 21761287 - Curr Top Microbiol Immunol. 2012;357:19-40 – reference: 20562859 - Nature. 2010 Jul 1;466(7302):68-76 – reference: 19656848 - Mol Biol Cell. 2009 Oct;20(19):4205-15 – reference: 11102518 - Mol Biol Cell. 2000 Dec;11(12):4205-16 – reference: 18239125 - Science. 2008 Feb 1;319(5863):617-20 – reference: 19712041 - Annu Rev Genet. 2009;43:601-25 – reference: 17389686 - J Cell Sci. 2007 Apr 15;120(Pt 8):1457-68 – reference: 21458666 - Cell. 2011 Apr 1;145(1):30-8 – reference: 19160513 - Nat Methods. 2008 Sep;5(9):781-7 – reference: 22123862 - J Cell Biol. 2011 Nov 28;195(5):751-64 – reference: 20887964 - Am J Hum Genet. 2010 Oct 8;87(4):465-79 – reference: 10559986 - Nat Cell Biol. 1999 Nov;1(7):423-30 – reference: 16200065 - Nat Genet. 2005 Nov;37(11):1281-8 – reference: 19106622 - RNA Biol. 2009 Jan-Mar;6(1):35-9 – reference: 19561605 - Nat Genet. 2009 Aug;41(8):936-40 – reference: 21183348 - Trends Cell Biol. 2011 Mar;21(3):159-67 – reference: 19952110 - Genes Dev. 2009 Dec 1;23(23):2753-64 – reference: 12847103 - J Biol Chem. 2003 Sep 12;278(37):35850-5 – reference: 19847166 - Nature. 2009 Nov 5;462(7269):108-12 – reference: 12007788 - Biochim Biophys Acta. 2002 Apr 3;1589(2):124-39 – reference: 20385131 - FEBS Lett. 2010 Jun 18;584(12):2626-34 – reference: 21378980 - Nat Methods. 2011 Apr;8(4):341-6 – reference: 18007632 - Nat Protoc. 2007;2(11):2958-74 – reference: 18534853 - Trends Cell Biol. 2008 Jul;18(7):330-6 – reference: 19448642 - Nat Methods. 2009 Jun;6(6):443-5 – reference: 21858081 - PLoS One. 2011;6(8):e23350 – reference: 21525244 - Mol Biol Cell. 2011 Jun 15;22(12):2083-93 – reference: 23653921 - Nat Methods. 2013 Apr;10(4):281 – reference: 20966969 - Nat Rev Mol Cell Biol. 2010 Nov;11(11):759-63 – reference: 19109890 - Cell. 2008 Dec 26;135(7):1175-87 – reference: 19490893 - Cell. 2009 May 29;137(5):835-48 – reference: 11239471 - Mol Cell. 2001 Feb;7(2):433-42 – reference: 16573240 - Curr Top Microbiol Immunol. 2005;300:149-68 – reference: 16809299 - J Virol. 2006 Jul;80(14):6936-42 – reference: 19965467 - Science. 2009 Nov 27;326(5957):1231-5 – reference: 12883005 - Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 – reference: 21782526 - Dev Cell. 2011 Aug 16;21(2):231-44 – reference: 23419280 - Nat Rev Genet. 2013 Apr;14(4):240 – reference: 16564017 - Cell. 2006 Mar 24;124(6):1283-98 – reference: 21127252 - Science. 2010 Dec 3;330(6009):1385-9 – reference: 22681890 - Mol Cell. 2012 Jun 8;46(5):691-704 – reference: 18677321 - Nat Methods. 2008 Sep;5(9):789-95 – reference: 21746896 - Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12372-7 – reference: 19953683 - Nat Methods. 2009 Oct;6(10):721-23 – reference: 15782200 - Nat Methods. 2004 Dec;1(3):241-8 – reference: 21353615 - Mol Cell. 2011 Mar 18;41(6):733-46 – reference: 11805826 - Nature. 2002 Jan 10;415(6868):141-7 – reference: 21947079 - Nat Cell Biol. 2011 Nov;13(11):1305-14 – reference: 22837515 - Science. 2012 Jul 27;337(6093):421-2 – reference: 16144086 - Nat Methods. 2004 Nov;1(2):163-7 |
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| Snippet | Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of one gene depends on the presence of a second, have enabled the... |
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| SubjectTerms | Atorvastatin Calcium Biological Transport Carrier Proteins - metabolism Cell Line, Tumor Coat Protein Complex I - metabolism Endoplasmic Reticulum - metabolism Epistasis, Genetic genes Heptanoic Acids - pharmacology Humans mammals Membrane Proteins - metabolism microorganisms phenotype Proto-Oncogene Proteins - metabolism Pyrroles - pharmacology Ribosomal Proteins - metabolism ricin Ricin - toxicity RNA, Small Interfering Vesicular Transport Proteins - metabolism |
| Title | A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility |
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