The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin - Krastev, Dragomir B.; Li, Shudong; Sun, Yilun; Wicks, Andrew J.; Hoslett, Gwendoline; Weekes, Daniel; Badder, Luned M.; Knight, Eleanor G.; Marlow, Rebecca; Pardo, Mercedes Calvo; Yu, Lu; Talele, Tanaji T.; et al. (Nature cell biology, 2022)
Keywords: 13/106; 13/109; 13/31; 14/19; 14/35; 631/337/1427/2566; 631/80/458/538; 631/80/458/582; 692/699/67/1059/602; 82/1; 82/58; 82/80; Adenosine diphosphate; Adenosine triphosphatase; Anticancer properties; Biomedical and Life Sciences; Cancer Research; Cell Biology; Cell Line, Tumor; Chromatin; Chromatin - metabolism; Cytotoxicity; Developmental Biology; Disulfiram; Disulfiram - analogs & derivatives; Disulfiram - pharmacology; HCT116 Cells; HeLa Cells; Homologous recombination; Homology; Humans; Immunoprecipitation; Inhibitors; Labeling; Life Sciences; Mass spectrometry; Mass spectroscopy; MCF-7 Cells; Metabolites; Neoplasms - drug therapy; Nuclear Proteins - metabolism; Organoids; Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors; Poly (ADP-Ribose) Polymerase-1 - metabolism; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Poly-ADP-Ribose Binding Proteins - metabolism; Protein Inhibitors of Activated STAT - metabolism; Recruitment; Ribose; Scientific imaging; Spectroscopy; Stem Cells; SUMO protein; Sumoylation; Toxicity; Transcription Factors - metabolism; Trapping; Tumors; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; Valosin Containing Protein - metabolism