7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase - Brenner, Marian; Zink, Christoph; Witzinger, Linda; Keller, Angelika; Hadamek, Kerstin; Bothe, Sebastian; Neuenschwander, Martin; Villmann, Carmen; von Kries, Jens Peter; Schindelin, Hermann; Jeanclos, Elisabeth; Gohla, Antje (eLife, 2024)
Keywords: 7,8-dihydroxyflavone; Amino acids; Animals; Biochemistry and Chemical Biology; Biosynthesis; cognition; Cognition & reasoning; Crystallography; Dietary supplements; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Flavones - chemistry; Flavones - metabolism; Flavones - pharmacology; Health aspects; Hippocampus; Hippocampus - drug effects; Hippocampus - metabolism; Homeostasis; Humans; Kinases; Medical research; Medicine, Experimental; Memory; Metabolism; Mice; Mice, Inbred C57BL; Middle age; Molecular modelling; Neurons - drug effects; Neurons - metabolism; Phosphatase; Phosphatases; Phosphates; Phosphoric Monoester Hydrolases - antagonists & inhibitors; Phosphoric Monoester Hydrolases - metabolism; Proteins; pyridoxal phosphatase; pyridoxal phosphatase inhibitor; Pyridoxal Phosphate - metabolism; Scientific equipment and supplies industry; Statistical analysis; Structural Biology and Molecular Biophysics; Vitamin B6; Vitamin deficiency; Vitamins; X-ray crystal structure; Canada; United States; Germany; mouse; pyridoxal phosphatase inhibitor; chemical biology; cognition; biochemistry; vitamin B6; 7,8-dihydroxyflavone; X-ray crystal structure; pyridoxal phosphatase; structural biology; molecular biophysics