IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells - Coscia, M; Pantaleoni, F; Riganti, C; Vitale, C; Rigoni, M; Peola, S; Castella, B; Foglietta, M; Griggio, V; Drandi, D; Ladetto, M; Bosia, A; et al. (Leukemia, 2011)
Keywords: 631/208/737; 631/80/82/23; 692/699/67/1990/283/1895; Adult; Aged; Aged, 80 and over; Apoptosis; B cells; B-cell receptor; B-Lymphocytes - metabolism; B-Lymphocytes - pathology; Bcl-2 protein; Biological and medical sciences; Blotting, Western; Bone marrow; Cancer Research; CD40 antigen; CD40 Ligand - metabolism; Chronic lymphocytic leukemia; Critical Care Medicine; Cytokines; Development and progression; Electrophoretic Mobility Shift Assay; Female; Genetic aspects; Health aspects; Hematologic and hematopoietic diseases; Hematology; Humans; Immunoglobulin Heavy Chains - genetics; Immunoglobulin Variable Region - genetics; Immunoglobulins; In vivo methods and tests; Intensive; Interleukin 4; Internal Medicine; Laboratories; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Leukemia, Lymphocytic, Chronic, B-Cell - immunology; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Leukocytes (mononuclear); Ligands; Lymphatic leukemia; Lymphocytes; Lymphocytes B; Lymphocytes T; Lymphoma; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Mutation - genetics; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB protein; Oncology; original-article; Peripheral blood mononuclear cells; Physiological aspects; Proto-Oncogene Proteins c-bcl-2 - metabolism; Receptors, Antigen, B-Cell - metabolism; Signal Transduction; Stromal cells; Therapeutic applications; Tumor cells; Tumor Cells, Cultured; Italy; chronic lymphocytic leukemia; immunoglobulin mutational status; tumor microenvironment; Human; Heavy peptide chain; Immunoglobulins; Hematology; Variable region; Spontaneous; Cell microenvironment; Malignant hemopathy; B-Lymphocyte; Signal transduction; Chronic lymphocytic leukemia; Cell death; Lymphoproliferative syndrome; Environment; Genetics; Mutation; Cancer; Apoptosis