慢性心力衰竭患者红细胞分布宽度与微量白蛋白尿的相关性研究
目的 观察慢性心力衰竭（CHF）患者红细胞分布宽度（RDW）与微量白蛋白尿（MAU）的变化,并探讨它们和心功能分级的关系。方法 190例CHF患者按照NYHA心功能分级标准分为NYHAⅡ级（轻度组）、NYHAⅢ级（中度组）及NYHAⅣ级（重度组）。同期正常体检者共100例为对照组。比较4组MAU与尿肌酐（Scr）比值（UACR）、RDW、Scr、血红蛋白（Hb）、B型尿钠钛（BNP）、左室射血分数（LVEF）水平差异,分析UACR、RDW、Scr、Hb、BNP、LVEF之间的相关性。结果 慢性心衰各亚组RDW、Scr、BNP、超敏C反应蛋白（hs CRP）、左室舒张末期内径（LVEDd）、左室...
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| Published in | 天津医药 Vol. 43; no. 9; pp. 1018 - 1021 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
天津医科大学基础医学院 邮编300070
2015
天津中医药大学第一附属医院检验科 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-9896 |
| DOI | 10.11958/j.issn.0253-9896.2015.09.017 |
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| Abstract | 目的 观察慢性心力衰竭（CHF）患者红细胞分布宽度（RDW）与微量白蛋白尿（MAU）的变化,并探讨它们和心功能分级的关系。方法 190例CHF患者按照NYHA心功能分级标准分为NYHAⅡ级（轻度组）、NYHAⅢ级（中度组）及NYHAⅣ级（重度组）。同期正常体检者共100例为对照组。比较4组MAU与尿肌酐（Scr）比值（UACR）、RDW、Scr、血红蛋白（Hb）、B型尿钠钛（BNP）、左室射血分数（LVEF）水平差异,分析UACR、RDW、Scr、Hb、BNP、LVEF之间的相关性。结果 慢性心衰各亚组RDW、Scr、BNP、超敏C反应蛋白（hs CRP）、左室舒张末期内径（LVEDd）、左室质量（LVM）、左室质量指数（LVMI）、UACR均高于对照组,且随着轻、中、重度组心功能分级增高依次增高,Hb、LVEF随心功能分级增高依次降低（均P〈0.05）。UACR、RDW随着心功能分级增高呈逐渐增高的趋势（P〈0.05）。两者与BNP均呈正相关,与LVEF、Hb呈负相关,两者之间呈正相关（均P〈0.05）。结论 UACR、RDW与心功能分级有关,RDW、MAU评估可以用于CHF患者的预后评价。 |
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| AbstractList | 目的 观察慢性心力衰竭（CHF）患者红细胞分布宽度（RDW）与微量白蛋白尿（MAU）的变化,并探讨它们和心功能分级的关系。方法 190例CHF患者按照NYHA心功能分级标准分为NYHAⅡ级（轻度组）、NYHAⅢ级（中度组）及NYHAⅣ级（重度组）。同期正常体检者共100例为对照组。比较4组MAU与尿肌酐（Scr）比值（UACR）、RDW、Scr、血红蛋白（Hb）、B型尿钠钛（BNP）、左室射血分数（LVEF）水平差异,分析UACR、RDW、Scr、Hb、BNP、LVEF之间的相关性。结果 慢性心衰各亚组RDW、Scr、BNP、超敏C反应蛋白（hs CRP）、左室舒张末期内径（LVEDd）、左室质量（LVM）、左室质量指数（LVMI）、UACR均高于对照组,且随着轻、中、重度组心功能分级增高依次增高,Hb、LVEF随心功能分级增高依次降低（均P〈0.05）。UACR、RDW随着心功能分级增高呈逐渐增高的趋势（P〈0.05）。两者与BNP均呈正相关,与LVEF、Hb呈负相关,两者之间呈正相关（均P〈0.05）。结论 UACR、RDW与心功能分级有关,RDW、MAU评估可以用于CHF患者的预后评价。 R541.6%R540.4; 目的：观察慢性心力衰竭（CHF）患者红细胞分布宽度（RDW）与微量白蛋白尿（MAU）的变化，并探讨它们和心功能分级的关系。方法190例CHF患者按照NYHA心功能分级标准分为NYHAⅡ级(轻度组)、NYHAⅢ级(中度组)及NYHAⅣ级(重度组)。同期正常体检者共100例为对照组。比较4组MAU与尿肌酐（Scr）比值（UACR）、RDW、Scr、血红蛋白（Hb）、B型尿钠钛（BNP）、左室射血分数（LVEF）水平差异,分析UACR、RDW、Scr、Hb、BNP、LVEF之间的相关性。结果慢性心衰各亚组RDW、Scr、BNP、超敏C反应蛋白（hsCRP）、左室舒张末期内径（LVEDd）、左室质量（LVM）、左室质量指数（LVMI）、UACR均高于对照组，且随着轻、中、重度组心功能分级增高依次增高，Hb、LVEF随心功能分级增高依次降低（均P<0.05）。UACR、RDW随着心功能分级增高呈逐渐增高的趋势(P<0.05)。两者与BNP均呈正相关,与LVEF、Hb呈负相关,两者之间呈正相关(均P<0.05)。结论 UACR、RDW与心功能分级有关，RDW、MAU评估可以用于CHF患者的预后评价。 |
| Abstract_FL | Objective To observe changes of red blood cell distribution width (RDW) and trace albumin urine (MAU) in patients with chronic heart failure (CHF) and to explore the relationship between them and cardiac function classification. Methods A total of 190 patients with CHF were divided into mild group (NYHA grade II), moderate group (NYHA gradeⅢ) and severe group (NYHA gradeⅣ), according to the grade of cardiac function. A total of 100 subjects with normal physi?cal examination during the same period were selected as the control group. The changes of MAU, urinary creatinine (Scr) ra?tio (UACR), RDW, Scr, hemoglobin (Hb), type B urine sodium titanium (BNP) and left ventricular ejection fraction (LVEF)were compared between four groups. The correlation between UACR, RDW, Scr, Hb, BNP and LVEF were analyzed. Re?sults The levels of RDW, Scr, BNP, hypersensitive C-reactive protein (hsCRP), LVEDd, LVM, LVMI and UACR were sig?nificantly higher in chronic heart failure group than those of control, showing a trend of increase gradually with the rising of heart function classification (P<0.05). The values of Hb and LVEF showed a gradually decreasing trend with the increased heart function classification (P < 0.05). The values of UACR and RDW showed a gradually increasing trend with the in?creased heart function classification (P<0.05). There was a positive correlation between UACR and RDW, and both had a positive correlation with BNP, and a negative correlation with LVEF and Hb(P<0.05). Conclusion RDW and MAU are re?lated to the cardiac function classification, and both can be used for the evaluation of the prognosis in patients with CHF. |
| Author | 王超 |
| AuthorAffiliation | 天津医科大学基础医学院,300070 天津中医药大学第一附属医院检验科 |
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| Author_FL | WANG Chao |
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| Author_xml | – sequence: 1 fullname: 王超 |
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| DocumentTitleAlternate | Study on the correlation between red cell distribution width and microalbuminuria in patients with chronic heart failure |
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| Keywords | trace albumin urine heart failure chronic disease red blood cell distribu-tion width 红细胞分布宽度 预后 诊断技术,心血管 慢性病 微量白蛋白尿 心力衰竭 diagnostic techniques,cardiovascular prognosis |
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| Notes | heart failure;chronic disease;prognosis;diagnostic techniques,cardiovascular;red blood cell distribu-tion width;trace albumin urine Objective To observe changes of red blood cell distribution width （RDW） and trace albumin urine （MAU） in patients with chronic heart failure （CHF） and to explore the relationship between them and cardiac function classification. Methods A total of 190 patients with CHF were divided into mild group （NYHA grade II）, moderate group （NYHA gradeⅢ） and severe group （NYHA gradeⅣ）, according to the grade of cardiac function. A total of 100 subjects with normal physical examination during the same period were selected as the control group. The changes of MAU, urinary creatinine （Scr） ratio （UACR）, RDW, Scr, hemoglobin （Hb）, type B urine sodium titanium （BNP） and left ventricular ejection fraction （LVEF）were compared between four groups. The correlation between UACR, RDW, Scr, Hb, BNP and LVEF were analyzed. Results The levels of RDW, Scr, BNP, hypersensitive C-reactive protein （hsCRP）, LVE |
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| PublicationYear | 2015 |
| Publisher | 天津医科大学基础医学院 邮编300070 天津中医药大学第一附属医院检验科 |
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| Snippet | 目的 观察慢性心力衰竭（CHF）患者红细胞分布宽度（RDW）与微量白蛋白尿（MAU）的变化,并探讨它们和心功能分级的关系。方法 190例CHF患者按照NYHA心功能分级标准分为NYHAⅡ... R541.6%R540.4; 目的：观察慢性心力衰竭（CHF）患者红细胞分布宽度（RDW）与微量白蛋白尿（MAU）的变化，并探讨它们和心功能分级的关系。方法190例CHF患者按照NYHA心功能分... |
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| SubjectTerms | 微量白蛋白尿 心力衰竭 慢性病 红细胞分布宽度 诊断技术,心血管 预后 |
| Title | 慢性心力衰竭患者红细胞分布宽度与微量白蛋白尿的相关性研究 |
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