IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections
Polymorphisms in the interferon lambda gene locus ( ) such as the genetic variants and are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of variation for...
Saved in:
| Published in | Frontiers in cellular and infection microbiology Vol. 9; p. 340 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
04.10.2019
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2235-2988 2235-2988 |
| DOI | 10.3389/fcimb.2019.00340 |
Cover
| Abstract | Polymorphisms in the interferon lambda gene locus (
) such as the
genetic variants
and
are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of
variation for the clearance of respiratory tract pathogens in Rwandan children (≤5 years old,
= 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell
genotype at
and
. Approximately 1/3 of the children were homozygous for the
T allele and the
ΔG allele, which are overrepresented in subjects of African descent. These
variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that
genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract. |
|---|---|
| AbstractList | Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (<= 5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 Delta G allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract. Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (<= 5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 Delta G allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract. Polymorphisms in the interferon lambda gene locus ( IFNL ) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (≤5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815 . Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 ΔG allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract. Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (≤5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 ΔG allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract. Polymorphisms in the interferon lambda gene locus ( ) such as the genetic variants and are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of variation for the clearance of respiratory tract pathogens in Rwandan children (≤5 years old, = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell genotype at and . Approximately 1/3 of the children were homozygous for the T allele and the ΔG allele, which are overrepresented in subjects of African descent. These variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract. Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (≤5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 ΔG allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract.Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (≤5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 ΔG allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract. |
| Author | Nilsson, Staffan Andersson, Maria E. Rugwizangoga, Belson Ármannsdóttir, Brynja Hellstrand, Kristoffer Aurelius, Johan Kabayiza, Jean-Claude Martner, Anna Nilsson, Malin S. Lindh, Magnus |
| AuthorAffiliation | 6 Department of Laboratory Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden 3 Department of Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden 4 Department of Pediatrics, School of Medicine and Pharmacy, University of Rwanda , Kigali , Rwanda 5 Department of Mathematical Sciences, Chalmers University of Technology , Gothenburg , Sweden 1 TIMM Laboratory, Department of Infectious Diseases, Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden 2 Pathology Unit, Department of Clinical Biology, School of Medicine and Pharmacy, University of Rwanda , Kigali , Rwanda |
| AuthorAffiliation_xml | – name: 1 TIMM Laboratory, Department of Infectious Diseases, Sahlgrenska Cancer Center, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden – name: 2 Pathology Unit, Department of Clinical Biology, School of Medicine and Pharmacy, University of Rwanda , Kigali , Rwanda – name: 3 Department of Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden – name: 4 Department of Pediatrics, School of Medicine and Pharmacy, University of Rwanda , Kigali , Rwanda – name: 5 Department of Mathematical Sciences, Chalmers University of Technology , Gothenburg , Sweden – name: 6 Department of Laboratory Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden |
| Author_xml | – sequence: 1 givenname: Belson surname: Rugwizangoga fullname: Rugwizangoga, Belson – sequence: 2 givenname: Maria E. surname: Andersson fullname: Andersson, Maria E. – sequence: 3 givenname: Jean-Claude surname: Kabayiza fullname: Kabayiza, Jean-Claude – sequence: 4 givenname: Malin S. surname: Nilsson fullname: Nilsson, Malin S. – sequence: 5 givenname: Brynja surname: Ármannsdóttir fullname: Ármannsdóttir, Brynja – sequence: 6 givenname: Johan surname: Aurelius fullname: Aurelius, Johan – sequence: 7 givenname: Staffan surname: Nilsson fullname: Nilsson, Staffan – sequence: 8 givenname: Kristoffer surname: Hellstrand fullname: Hellstrand, Kristoffer – sequence: 9 givenname: Magnus surname: Lindh fullname: Lindh, Magnus – sequence: 10 givenname: Anna surname: Martner fullname: Martner, Anna |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31637221$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/286409$$DView record from Swedish Publication Index https://research.chalmers.se/publication/516067$$DView record from Swedish Publication Index |
| BookMark | eNp1ks1vEzEQxVeoiJbSOye0Ry4J_ty1L0hVREukqKDQwtGa9c4mrjbexd6lyn-Pk5SqQaovtsZvfm80em-zE995zLL3lEw5V_pTY92mmjJC9ZQQLsir7IwxLidMK3Xy7H2aXcR4T9IpCVOav8lOOS14yRg9y9r51c1C5Nfou2HbY8y_B6ydHfJZixDAW8y7Jl_eXOY_XRhjEjifLx_A1-Dz2dq1dUCf_3LDOr_rewz5EmPvAgxd2Oa3ARJp7hu0g-t8fJe9bqCNePF4n2d3V19uZ18ni2_X89nlYmJlWQyTglRYUyW0FoqIAoEJRVX6IxVADVxyC4pSSSwAFY22qkLSSGkbwSqmG36ezQ_cuoN70we3gbA1HTizL3RhZSAMzrZoypJZXRSqrKQUSKCqUHJZCo2sqZWkifXjwIoP2I_VES1gTEuya2PX0G4wRBPRoEZBQVrD03RGWKsNkCY50aJsuK51WZJEnbxIXY29SaXVuKMxVQiik_7zQZ_EG6wt-iFAe9R2_OPd2qy6P6YoVSmLneHHR0Dofo8YB7Nx0WLbgsdujIZxklahpeRJ-uG515PJv9AkATkIbOhiDNg8SSgxu2iafTTNLppmH83UUvzXYt0Au1CkaV37cuNfz_PqSw |
| CitedBy_id | crossref_primary_10_1016_j_cyto_2021_155491 crossref_primary_10_1038_s41598_021_00747_z crossref_primary_10_1093_cid_ciac447 crossref_primary_10_1134_S0026893323020152 crossref_primary_10_1186_s12879_021_05777_6 crossref_primary_10_1186_s12985_021_01692_z crossref_primary_10_3389_fcell_2021_627914 crossref_primary_10_3390_genes14112075 crossref_primary_10_12688_wellcomeopenres_16559_1 crossref_primary_10_3389_fcimb_2021_656393 crossref_primary_10_4103_aihb_aihb_113_22 crossref_primary_10_1186_s12936_021_03689_z crossref_primary_10_3389_fimmu_2021_772588 crossref_primary_10_4049_immunohorizons_2200010 crossref_primary_10_1016_j_lfs_2023_121907 crossref_primary_10_1038_s41435_021_00127_7 crossref_primary_10_1089_jir_2023_0014 crossref_primary_10_1007_s00705_021_05070_6 crossref_primary_10_3390_microorganisms10020363 crossref_primary_10_1038_s41467_025_56119_y crossref_primary_10_3390_jcm9103315 crossref_primary_10_3103_S0095452723060038 crossref_primary_10_31857_S0026898423020179 crossref_primary_10_1002_JLB_3A0120_001RRR |
| Cites_doi | 10.1111/jgh.12424 10.1159/000369902 10.1002/hep.24683 10.1038/ni875 10.1089/jir.2019.0043 10.3389/fimmu.2017.01707 10.1038/ng.2521 10.1371/journal.pone.0146054 10.2217/pgs.15.65 10.1111/j.1365-2893.2010.01425.x 10.1038/ni873 10.1111/j.1398-9995.2008.01826.x 10.1371/journal.ppat.1000017 10.3109/00365548.2014.951681 10.1189/jlb.1208761 10.1038/nature15393 10.1371/journal.pone.0085899 10.1128/JVI.00272-10 10.15252/emmm.201606413 10.1089/jir.2019.0044 10.1038/nature08463 10.1038/nature08309 10.3389/fimmu.2017.00119 10.3389/fimmu.2017.01661 |
| ContentType | Journal Article |
| Copyright | Copyright © 2019 Rugwizangoga, Andersson, Kabayiza, Nilsson, Ármannsdóttir, Aurelius, Nilsson, Hellstrand, Lindh and Martner. Copyright © 2019 Rugwizangoga, Andersson, Kabayiza, Nilsson, Ármannsdóttir, Aurelius, Nilsson, Hellstrand, Lindh and Martner. 2019 Rugwizangoga, Andersson, Kabayiza, Nilsson, Ármannsdóttir, Aurelius, Nilsson, Hellstrand, Lindh and Martner |
| Copyright_xml | – notice: Copyright © 2019 Rugwizangoga, Andersson, Kabayiza, Nilsson, Ármannsdóttir, Aurelius, Nilsson, Hellstrand, Lindh and Martner. – notice: Copyright © 2019 Rugwizangoga, Andersson, Kabayiza, Nilsson, Ármannsdóttir, Aurelius, Nilsson, Hellstrand, Lindh and Martner. 2019 Rugwizangoga, Andersson, Kabayiza, Nilsson, Ármannsdóttir, Aurelius, Nilsson, Hellstrand, Lindh and Martner |
| DBID | AAYXX CITATION NPM 7X8 5PM ADTPV AOWAS F1U ABBSD D8T F1S ZZAVC DOA |
| DOI | 10.3389/fcimb.2019.00340 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) SwePub SwePub Articles SWEPUB Göteborgs universitet SWEPUB Chalmers tekniska högskola full text SWEPUB Freely available online SWEPUB Chalmers tekniska högskola SwePub Articles full text DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2235-2988 |
| ExternalDocumentID | oai_doaj_org_article_772c96687b554e0abbe535749e2fd851 oai_research_chalmers_se_e9e41a5c_3aa1_4cc9_a0fe_7167f39d9770 oai_gup_ub_gu_se_286409 PMC6787560 31637221 10_3389_fcimb_2019_00340 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE INR KQ8 M48 M~E OK1 PGMZT RPM IAO IEA IHR IHW INH IPNFZ ISR NPM RIG 7X8 5PM ADTPV AOWAS F1U ABBSD D8T F1S ZZAVC |
| ID | FETCH-LOGICAL-c576t-60bed1849948046ea24818c570baada353ca81150caa14f9c8be0f55cf42b29f3 |
| IEDL.DBID | M48 |
| ISSN | 2235-2988 |
| IngestDate | Wed Aug 27 01:14:23 EDT 2025 Thu Aug 21 06:11:06 EDT 2025 Thu Aug 21 06:25:57 EDT 2025 Thu Aug 21 14:05:46 EDT 2025 Thu Sep 04 16:16:04 EDT 2025 Thu Jan 02 22:59:37 EST 2025 Tue Jul 01 04:32:21 EDT 2025 Thu Apr 24 22:53:11 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | rs12979860 rs368234815 infection RNA virus upper respiratory tract single nucleotide polymorphisms dinucleotide polymorphisms interferon lambda |
| Language | English |
| License | Copyright © 2019 Rugwizangoga, Andersson, Kabayiza, Nilsson, Ármannsdóttir, Aurelius, Nilsson, Hellstrand, Lindh and Martner. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c576t-60bed1849948046ea24818c570baada353ca81150caa14f9c8be0f55cf42b29f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Clinical Microbiology, a section of the journal Frontiers in Cellular and Infection Microbiology Edited by: Yi-Wei Tang, Memorial Sloan Kettering Cancer Center, United States These authors have contributed equally to this work Reviewed by: Ludmila Prokunina-Olsson, National Institutes of Health (NIH), United States; Robert Cody Sharp, University of Florida Health, United States |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fcimb.2019.00340 |
| PMID | 31637221 |
| PQID | 2307729553 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_772c96687b554e0abbe535749e2fd851 swepub_primary_oai_research_chalmers_se_e9e41a5c_3aa1_4cc9_a0fe_7167f39d9770 swepub_primary_oai_gup_ub_gu_se_286409 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6787560 proquest_miscellaneous_2307729553 pubmed_primary_31637221 crossref_primary_10_3389_fcimb_2019_00340 crossref_citationtrail_10_3389_fcimb_2019_00340 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-10-04 |
| PublicationDateYYYYMMDD | 2019-10-04 |
| PublicationDate_xml | – month: 10 year: 2019 text: 2019-10-04 day: 04 |
| PublicationDecade | 2010 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in cellular and infection microbiology |
| PublicationTitleAlternate | Front Cell Infect Microbiol |
| PublicationYear | 2019 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Khaitov (B9) 2009; 64 Indolfi (B8) 2014; 9 Hemann (B7) 2017; 8 Kotenko (B10) 2002; 4 Lindh (B12) 2011; 18 Syedbasha (B21) 2017; 8 Mordstein (B13) 2010; 84 Zanoni (B24) 2017; 8 Prokunina-Olsson (B16) 2013; 45 Sheppard (B19) 2002; 4 Onabajo (B14) 2019 Andersson (B1) 2014; 46 Roberts (B18) 2014; 29 Sommereyns (B20) 2008; 4 Prokunina-Olsson (B15) 2019 De Nicola (B3) 2012; 55 (B22) 2015; 526 Griffiths (B6) 2015; 7 Thomas (B23) 2009; 461 Davidson (B2) 2016; 8 Elfving (B4) 2016; 11 Ge (B5) 2009; 461 Li (B11) 2009; 86 Rembeck (B17) 2015; 16 |
| References_xml | – volume: 29 start-page: 179 year: 2014 ident: B18 article-title: Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: analysis from the PREDICT and CHARIOT studies publication-title: J. Gastroenterol. Hepatol. doi: 10.1111/jgh.12424 – volume: 7 start-page: 231 year: 2015 ident: B6 article-title: The role of interferon-λ locus polymorphisms in hepatitis C and other infectious diseases publication-title: J. Innate Immun. doi: 10.1159/000369902 – volume: 55 start-page: 336 year: 2012 ident: B3 article-title: Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4 publication-title: Hepatology doi: 10.1002/hep.24683 – volume: 4 start-page: 69 year: 2002 ident: B10 article-title: IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex publication-title: Nat. Immunol. doi: 10.1038/ni875 – year: 2019 ident: B15 article-title: Genetics of the human interferon lambda region publication-title: J. Interferon Cytokine Res doi: 10.1089/jir.2019.0043 – volume: 8 start-page: 1707 year: 2017 ident: B7 article-title: Interferon lambda genetics and biology in regulation of viral control publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.01707 – volume: 45 start-page: 164 year: 2013 ident: B16 article-title: A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus publication-title: Nat. Genet. doi: 10.1038/ng.2521 – volume: 11 start-page: e0146054 year: 2016 ident: B4 article-title: Acute uncomplicated febrile illness in children aged 2-59 months in Zanzibar – aetiologies, antibiotic treatment and outcome publication-title: PLoS ONE doi: 10.1371/journal.pone.0146054 – volume: 16 start-page: 1179 year: 2015 ident: B17 article-title: Impact of IL28B, ITPA and PNPLA3 genetic variants on therapeutic outcome and progression of hepatitis C virus infection publication-title: Pharmacogenomics doi: 10.2217/pgs.15.65 – volume: 18 start-page: e325 year: 2011 ident: B12 article-title: IL28B polymorphisms determine early viral kinetics and treatment outcome in patients receiving peginterferon/ribavirin for chronic hepatitis C genotype 1 publication-title: J. Viral Hepat. doi: 10.1111/j.1365-2893.2010.01425.x – volume: 4 start-page: 63 year: 2002 ident: B19 article-title: IL-28, IL-29 and their class II cytokine receptor IL-28R publication-title: Nat. Immunol. doi: 10.1038/ni873 – volume: 64 start-page: 375 year: 2009 ident: B9 article-title: Respiratory virus induction of alpha-, beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells publication-title: Allergy doi: 10.1111/j.1398-9995.2008.01826.x – volume: 4 start-page: e1000017 year: 2008 ident: B20 article-title: IFN-lambda (IFN-λ) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1000017 – volume: 46 start-page: 897 year: 2014 ident: B1 article-title: Comparison of the FilmArray assay and in-house real-time PCR for detection of respiratory infection publication-title: Scand. J. Infect. Dis. doi: 10.3109/00365548.2014.951681 – volume: 86 start-page: 23 year: 2009 ident: B11 article-title: Interferon-λs: the modulators of antivirus, antitumor, and immune responses publication-title: J. Leukoc. Biol. doi: 10.1189/jlb.1208761 – volume: 526 start-page: 68 year: 2015 ident: B22 article-title: A global reference for human genetic variation publication-title: Nature doi: 10.1038/nature15393 – volume: 9 start-page: e85899 year: 2014 ident: B8 article-title: Comparative analysis of rs12979860 SNP of the IFNL3 gene in children with hepatitis C and ethnic matched controls using 1000 genomes project data publication-title: PLoS ONE doi: 10.1371/journal.pone.0085899 – volume: 84 start-page: 5670 year: 2010 ident: B13 article-title: Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections publication-title: J. Virol. doi: 10.1128/JVI.00272-10 – volume: 8 start-page: 1099 year: 2016 ident: B2 article-title: IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201606413 – year: 2019 ident: B14 article-title: The IFN-λ4 conundrum: when a good interferon goes bad publication-title: J. Interferon Cytokine Res doi: 10.1089/jir.2019.0044 – volume: 461 start-page: 798 year: 2009 ident: B23 article-title: Genetic variation in IL28B and spontaneous clearance of hepatitis C virus publication-title: Nature doi: 10.1038/nature08463 – volume: 461 start-page: 399 year: 2009 ident: B5 article-title: Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance publication-title: Nature doi: 10.1038/nature08309 – volume: 8 start-page: 119 year: 2017 ident: B21 article-title: Interferon lambda: modulating immunity in infectious diseases publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.00119 – volume: 8 start-page: 1661 year: 2017 ident: B24 article-title: Interferon (IFN)-λ takes the helm: immunomodulatory roles of type III IFNs publication-title: Front. Immunol. doi: 10.3389/fimmu.2017.01661 |
| SSID | ssj0000702893 |
| Score | 2.3091831 |
| Snippet | Polymorphisms in the interferon lambda gene locus (
) such as the
genetic variants
and
are predictive of resolution of hepatitis C virus infection, but... Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of... Polymorphisms in the interferon lambda gene locus ( IFNL ) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of... |
| SourceID | doaj swepub pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 340 |
| SubjectTerms | Cellular and Infection Microbiology dinucleotide polymorphisms genetic-variation hepatitis-c il28b Immunologi inom det medicinska området Immunology Immunology in the Medical Area infection interferon lambda lambda-s Microbiology Microbiology in the Medical Area Mikrobiologi inom det medicinska området polymorphisms RNA virus rs12979860 rs368234815 single nucleotide polymorphisms tract upper respiratory upper respiratory tract |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1bi9QwFA6yIPgi3q03IojgQ5m2SdrmcR0cd2UdZNjRfQtJmuwU1s4wnSL-e89Ju-MUF33xtU3acr6T5js5N0LeWFMIn2kfO1-yGFZiHhvOdQx7j0ldZYDPoaH4eZ6fLPmnC3Fx0OoLY8L68sC94CbA_ixQ8rIwsPG5RBvjBBMFly7zVRmSp7NEJgfGVPgHF-hBY71fEqwwOfG2_m4wlAvrUzI86zjYh0K5_ps45p-hkqOComETmt0jdwf2SI_7r75PbrnmAbnd95P8-ZBcnc7mZ5x-dM0aj1Zb-mWLfpgdnWJzCMSXrj1dzI_p13rbtTCgbujiBx4mNHQ6pHXTb_VuRZebjdvSxW9HPD3HfCp6OgRvNe0jspx9OJ-exEM7hdiCUbGL88S4Cgw6KXkJVrHTGYfdGu4lRutKM8GsLpEgWq1T7qUtjUu8ENbzzGTSs8fkqFk37imh0rEKc1p1WsLDstw4TLD1FTMa-JhPIzK5Fq6yQ61xbHlxpcDmQDhUgEMhHCrAEZF3-xmbvs7GX8a-R7z247BCdrgAeqMGvVH_0puIvL5GW8GKQjeJbty6axWGxoOKCsEi8qRHf_8qBvS1yDKYXYz0YvQt4ztNvQpVu4EVFEAvI_K216DRlMtuo-DSZadap0CwYHVH5OyGgUMJqJWyq9Bfp8UJTjqeamEVA-QUt1YqnXiQQZoXnskKOH7y7H8I7Tm5gzCEYEb-ghzttp17CaRsZ16F9fcLbKg2jg priority: 102 providerName: Directory of Open Access Journals |
| Title | IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31637221 https://www.proquest.com/docview/2307729553 https://pubmed.ncbi.nlm.nih.gov/PMC6787560 https://gup.ub.gu.se/publication/286409 https://research.chalmers.se/publication/516067 https://doaj.org/article/772c96687b554e0abbe535749e2fd851 |
| Volume | 9 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bi9QwFA6yIvgi3q2XJYIIPtRtm2TaPoisg-OurIMMO7pvIUmTmYGxHdsOuv_ec9LuLMVB8HHapFPOSXq-L-dGyCujU-ES5ULrMhbCThyFmnMVgu3RsS004Dkkil-mo5M5_3whLq7To3sBNnupHfaTmtfrt79_Xr6HDf8OGSfY2yNnVj80Rmlh6UnGgcDf9N4iDOTrwb7_LqfoVUOXM5hEESZ5lnV-y70PGdgpX85_Hwb9O5RyUHDUG6nJXXKnR5f0uFsO98gNW94nt7p-k5cPyPp0Mj3j9JMtKzx6bejXGv00LR1j8wjUP60cnU2P6bdVvW1gwKqks1942FDScZ_2Tb-v2iWdbza2prNrRz09x3wretoHd5XNQzKffDwfn4R9u4XQAOlow1GkbQGEL895BqzZqoSDNYd7kVaqUEwwozIEkEapmLvcZNpGTgjjeKKT3LFH5KCsSvuE0NyyAnNeVZzBw5KRtpiA6wqmFeA1Fwfk6Eq40vS1yLElxloCJ0F1SK8OieqQXh0BebObsenqcPxj7AfU124cVtD2F6p6IfsNKYFVGKB6WaoBUNlIaW0FEynPbeIKgKEBeXmlbQk7Dt0oqrTVtpEYOg9LWAgWkMed9nd_xQDepkkCs9PBuhi8y_BOuVr6qt6AGlKAnwF53a2gwZTFdiPh0mIrGytBsMDKA3K2Z2BfImopzdL332lwgs0tj5UwkoHmJDcmlypyIIN4lDqWF8ABoqf_IeBn5Db-8DGN_Dk5aOutfQHYrNWH_kzj0G-8P7c1ON8 |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IFNL4+Genotypes+Predict+Clearance+of+RNA+Viruses+in+Rwandan+Children+With+Upper+Respiratory+Tract+Infections&rft.jtitle=Frontiers+in+cellular+and+infection+microbiology&rft.au=Rugwizangoga%2C+Belson&rft.au=Andersson%2C+Maria+E.&rft.au=Kabayiza%2C+Jean-Claude&rft.au=Nilsson%2C+Malin+S.&rft.date=2019-10-04&rft.issn=2235-2988&rft.eissn=2235-2988&rft.volume=9&rft_id=info:doi/10.3389%2Ffcimb.2019.00340&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fcimb_2019_00340 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2235-2988&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2235-2988&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2235-2988&client=summon |