Physical and neurobehavioral determinants of reproductive onset and success

John Perry, Ken Ong and colleagues perform a genome-wide association study for reproductive ability, behavior and success to determine underlying genetic factors. They find 38 variants associated with age of first sexual intercourse and show that both physical and neurobehavioral traits influence th...

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Published inNature genetics Vol. 48; no. 6; pp. 617 - 623
Main Authors Day, Felix R, Helgason, Hannes, Chasman, Daniel I, Rose, Lynda M, Loh, Po-Ru, Scott, Robert A, Helgason, Agnar, Kong, Augustine, Masson, Gisli, Magnusson, Olafur Th, Gudbjartsson, Daniel, Thorsteinsdottir, Unnur, Buring, Julie E, Ridker, Paul M, Sulem, Patrick, Stefansson, Kari, Ong, Ken K, Perry, John R B
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.06.2016
Nature Publishing Group
Subjects
45/43
631/208/205/2138
692/308/2056
Adolescent
Adult
Age
Age Factors
Agriculture
Animal Genetics and Genomics
Behavior
Biomedicine
Cancer Research
Cell Adhesion Molecules - genetics
Coitus
Datasets
Estrogen Receptor alpha - genetics
Female
Gene Function
Genetic aspects
Genetic research
Genome-wide association studies
Genome-Wide Association Study
Genomes
Human Genetics
Human reproduction
Humans
Identification and classification
Male
Membrane Proteins - genetics
Mens health
Methionine Sulfoxide Reductases - genetics
Methods
Nerve Tissue Proteins - genetics
Puberty
Quantitative trait loci
Risk taking
RNA-Binding Proteins - genetics
Sex
Sexual Behavior
Studies
Success
Womens health
Young Adult
Online AccessGet full text
ISSN1061-4036
1546-1718
DOI10.1038/ng.3551

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Abstract John Perry, Ken Ong and colleagues perform a genome-wide association study for reproductive ability, behavior and success to determine underlying genetic factors. They find 38 variants associated with age of first sexual intercourse and show that both physical and neurobehavioral traits influence the onset of reproductive activity. The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated ( P < 5 × 10 −8 ) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations ( P < 5 × 10 −8 ) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6 – SEMA3F ), number of children ( CADM2 and ESR1 ), irritable temperament ( MSRA ) and risk-taking propensity ( CADM2 ). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.
AbstractList The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 x [10.sup.-8]) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 x [10.sup.-8]) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk- taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.
The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 × 10(-8)) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 × 10(-8)) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk-taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.
The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated (P < 5 × 10^sup -8^) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations (P < 5 × 10^sup -8^) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6-SEMA3F), number of children (CADM2 and ESR1), irritable temperament (MSRA) and risk-taking propensity (CADM2). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.
John Perry, Ken Ong and colleagues perform a genome-wide association study for reproductive ability, behavior and success to determine underlying genetic factors. They find 38 variants associated with age of first sexual intercourse and show that both physical and neurobehavioral traits influence the onset of reproductive activity. The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide association study of 125,667 UK Biobank participants, we identify 38 loci associated ( P < 5 × 10 −8 ) with age at first sexual intercourse. These findings were taken forward in 241,910 men and women from Iceland and 20,187 women from the Women's Genome Health Study. Several of the identified loci also exhibit associations ( P < 5 × 10 −8 ) with other reproductive and behavioral traits, including age at first birth (variants in or near ESR1 and RBM6 – SEMA3F ), number of children ( CADM2 and ESR1 ), irritable temperament ( MSRA ) and risk-taking propensity ( CADM2 ). Mendelian randomization analyses infer causal influences of earlier puberty timing on earlier first sexual intercourse, earlier first birth and lower educational attainment. In turn, likely causal consequences of earlier first sexual intercourse include reproductive, educational, psychiatric and cardiometabolic outcomes.
Audience Academic
Author Masson, Gisli
Loh, Po-Ru
Rose, Lynda M
Helgason, Agnar
Stefansson, Kari
Sulem, Patrick
Helgason, Hannes
Ong, Ken K
Thorsteinsdottir, Unnur
Scott, Robert A
Ridker, Paul M
Day, Felix R
Perry, John R B
Buring, Julie E
Chasman, Daniel I
Kong, Augustine
Magnusson, Olafur Th
Gudbjartsson, Daniel
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Snippet John Perry, Ken Ong and colleagues perform a genome-wide association study for reproductive ability, behavior and success to determine underlying genetic...
The ages of puberty, first sexual intercourse and first birth signify the onset of reproductive ability, behavior and success, respectively. In a genome-wide...
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SubjectTerms 45/43
631/208/205/2138
692/308/2056
Adolescent
Adult
Age
Age Factors
Agriculture
Animal Genetics and Genomics
Behavior
Biomedicine
Cancer Research
Cell Adhesion Molecules - genetics
Coitus
Datasets
Estrogen Receptor alpha - genetics
Female
Gene Function
Genetic aspects
Genetic research
Genome-wide association studies
Genome-Wide Association Study
Genomes
Human Genetics
Human reproduction
Humans
Identification and classification
Male
Membrane Proteins - genetics
Mens health
Methionine Sulfoxide Reductases - genetics
Methods
Nerve Tissue Proteins - genetics
Puberty
Quantitative trait loci
Risk taking
RNA-Binding Proteins - genetics
Sex
Sexual Behavior
Studies
Success
Womens health
Young Adult
Title Physical and neurobehavioral determinants of reproductive onset and success
URI https://link.springer.com/article/10.1038/ng.3551
https://www.ncbi.nlm.nih.gov/pubmed/27089180
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Volume 48
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