表皮生长因子受体19外显子突变与初治肺腺癌脑转移的关系
目的探讨表皮生长因子受体（EGFR）突变与肺腺癌患者脑转移的关系。方法收集2010年8月至2015年5月山西省肿瘤医院收治的行EGFR基因突变检测的l063例肺腺癌患者，其中456例患者EGFR突变。采用Logistic多因素回归模型分析EGFR突变与肺腺癌患者脑转移的关系。结果初诊时发现脑转移的125例患者中，EGFR突变65例，其中EGFR19外显子突变36例。125例初诊脑转移患者中，EGFR19外显子的突变频率为28．8％（36／125）。456例EGFR突变患者中，脑转移65例（14．3％），其中EGFR19外显子突变36例（55．0％）。多因素分析显示，年龄、美国东部肿瘤协作组（E...
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| Published in | 中华肿瘤杂志 Vol. 39; no. 10; pp. 744 - 748 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
山西省肿瘤医院放疗科,太原,030013
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-3766 |
| DOI | 10.3760/cma.j.issn.0253-3766.2017.10.005 |
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| Abstract | 目的探讨表皮生长因子受体（EGFR）突变与肺腺癌患者脑转移的关系。方法收集2010年8月至2015年5月山西省肿瘤医院收治的行EGFR基因突变检测的l063例肺腺癌患者，其中456例患者EGFR突变。采用Logistic多因素回归模型分析EGFR突变与肺腺癌患者脑转移的关系。结果初诊时发现脑转移的125例患者中，EGFR突变65例，其中EGFR19外显子突变36例。125例初诊脑转移患者中，EGFR19外显子的突变频率为28．8％（36／125）。456例EGFR突变患者中，脑转移65例（14．3％），其中EGFR19外显子突变36例（55．0％）。多因素分析显示，年龄、美国东部肿瘤协作组（Ec0G）评分、EGFR突变状态和N分期与患者脑转移均有关（均P〈0．05）。亚组多因素分析显示，年龄、ECOG评分、EGFR19外显子状态和N分期与患者脑转移均有关（均尸〈O．05）。结论EGFR突变与脑转移有关，EGFR19外显子突变为脑转移的独立危险因素。 |
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| AbstractList | 目的 探讨表皮生长因子受体(EGFR)突变与肺腺癌患者脑转移的关系.方法 收集2010年8月至2015年5月山西省肿瘤医院收治的行EGFR基因突变检测的1 063例肺腺癌患者,其中456例患者EGFR突变.采用Logistic多因素回归模型分析EGFR突变与肺腺癌患者脑转移的关系.结果 初诊时发现脑转移的125例患者中,EGFR突变65例,其中EGFR 19外显子突变36例.125例初诊脑转移患者中,EGFR 19外显子的突变频率为28.8％ (36/125).456例EGFR突变患者中,脑转移65例(14.3％),其中EGFR 19外显子突变36例(55.0％).多因素分析显示,年龄、美国东部肿瘤协作组(ECOG)评分、EGFR突变状态和N分期与患者脑转移均有关(均P＜0.05).亚组多因素分析显示,年龄、ECOG评分、EGFR 19外显子状态和N分期与患者脑转移均有关(均P＜0.05).结论 EGFR突变与脑转移有关,EGFR 19外显子突变为脑转移的独立危险因素. 目的探讨表皮生长因子受体（EGFR）突变与肺腺癌患者脑转移的关系。方法收集2010年8月至2015年5月山西省肿瘤医院收治的行EGFR基因突变检测的l063例肺腺癌患者，其中456例患者EGFR突变。采用Logistic多因素回归模型分析EGFR突变与肺腺癌患者脑转移的关系。结果初诊时发现脑转移的125例患者中，EGFR突变65例，其中EGFR19外显子突变36例。125例初诊脑转移患者中，EGFR19外显子的突变频率为28．8％（36／125）。456例EGFR突变患者中，脑转移65例（14．3％），其中EGFR19外显子突变36例（55．0％）。多因素分析显示，年龄、美国东部肿瘤协作组（Ec0G）评分、EGFR突变状态和N分期与患者脑转移均有关（均P〈0．05）。亚组多因素分析显示，年龄、ECOG评分、EGFR19外显子状态和N分期与患者脑转移均有关（均尸〈O．05）。结论EGFR突变与脑转移有关，EGFR19外显子突变为脑转移的独立危险因素。 |
| Abstract_FL | Objective To investigate the relationship between the status of epidermal growth factor receptor (EGFR) mutations and brain metastases in patients with lung adenocarcinoma.Methods From August 2010 to May 2015,a total of 1 063 lung adenocarcinoma patients with identified status of EGFR mutations in Shanxi Cancer Hospital were enrolled,of which 456 patients had EGFR mutations.Multivariate Logistic regression model was used to analyze the correlation between EGFR mutation status and brain metastases in patients with lung adenocarcinoma.Results In 125 patients with brain metastases before initial treatment,65 patients had EGFR mutations,including 36 patients with deletion mutations in exon 19.The frequency of EGFR 19 exon mutation was 28.8％ (36/125).Among 456 patients with EGFR mutations,65(14.3％) patients were with brain metastases,in which 36 (55.0％) had deletion mutations in exon 19.The multivariate analysis showed that age,Eastern Cooperative Oncology Group (ECOG) score,EGFR mutations and N staging were associated with brain metastases (P ＜ 0.05).Further subgroup multivariate analyses showed that age,ECOG score,mutation status in exon 19 and N staging were associated with brain metastases (P＜0.05).Conclusions EGFR mutation status is related to brain metastases.Mutations in EGFR exon 19 is an independent risk factor for brain metastases. |
| Author | 王伟丽 李红卫 曹建忠 张霞琴 宋欣 贾素芳 贾海霞 |
| AuthorAffiliation | 山西省肿瘤医院放疗科,太原030013 |
| AuthorAffiliation_xml | – name: 山西省肿瘤医院放疗科,太原,030013 |
| Author_FL | Wang Weili Cao Jianzhong Zhang Xiaqin Jia Haixia Li Hongwei Song Xin Jia Sufang |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DocumentTitleAlternate | Impacts of EGFR 19 exon mutations on brain metastases in treatment-naive patients with lung adenocarcinoma |
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| Keywords | Adenocarcinoma 腺癌 受体,表皮生长因子 Receptor,epidermal growth factor 脑转移 突变 Brain metastases Mutation 肺肿瘤 Lung neoplasms |
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| Notes | Wang Weili, Li Hongnvei, Cao Jianzhong, Zhang Xiaqin, Song Xin, Jia Sufang, Jia Haixia Department of Radiation Oncology, Shanxi Cancer Hospital, Taiyuan 030013, China （ Wang WL, Li HW, Cao JZ, Zhang XQ, Song X, Jia SF, Jia HX） Objective To investigate the relationship between the status of epidermat growth factor receptor （EGFR） mutations and brain metastases in patients with lung adenoearcinoma. Methods From August 2010 to May 2015, a total of 1 063 lung adenoearcinoma patients with identified status of EGFR mutations in Shanxi Cancer Hospital were enrolled, of which 456 patients had EGFR mutations. Multivariate Logistic regression model was used to analyze the correlation between EGFR mutation status and brain metastases in patients with lung adenocareinoma. Results In 125 patients with brain metastases before initial treatment, 65 patients had EGFR mutations, including 36 patients with deletion mutations in exon 19. The frequency of EGFR 19 exon mutation was 28.8% （36/125）. Among 456 patients with EGFR muta |
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| PublicationTitle | 中华肿瘤杂志 |
| PublicationTitleAlternate | Chinese Journal of Oncology |
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| PublicationYear | 2017 |
| Publisher | 山西省肿瘤医院放疗科,太原,030013 |
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| Snippet | 目的探讨表皮生长因子受体（EGFR）突变与肺腺癌患者脑转移的关系。方法收集2010年8月至2015年5月山西省肿瘤医院收治的行EGFR基因突变检测的l063例肺腺癌患者，其中456例患... 目的 探讨表皮生长因子受体(EGFR)突变与肺腺癌患者脑转移的关系.方法 收集2010年8月至2015年5月山西省肿瘤医院收治的行EGFR基因突变检测的1 063例肺腺癌患者,其中456例患... |
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| SubjectTerms | 受体 突变 肺肿瘤 脑转移 腺癌 表皮生长因子 |
| Title | 表皮生长因子受体19外显子突变与初治肺腺癌脑转移的关系 |
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