Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB - Maimon, Roy; Chillon-Marinas, Carlos; Snethlage, Cedric E.; Singhal, Sarthak M.; McAlonis-Downes, Melissa; Ling, Karen; Rigo, Frank; Bennett, C. Frank; Da Cruz, Sandrine; Hnasko, Thomas S.; Muotri, Alysson R.; Cleveland, Don W. (Nature neuroscience, 2021)
Keywords: 631/378; 631/378/368/2431; Aging; Amyotrophic lateral sclerosis; Animal Genetics and Genomics; Animals; Antisense oligonucleotides; Antisense therapy; Behavioral Sciences; Binding proteins; Biological response modifiers; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Brain; Brain research; Cellular Reprogramming - physiology; Cerebrospinal fluid; Circuits; Degeneration; Dentate gyrus; Dentate Gyrus - cytology; Dentate Gyrus - physiology; Disease; DNA biosynthesis; Ependymoglial Cells - cytology; Ependymoglial Cells - physiology; Gene expression; Genetic aspects; Glial cells; Glial fibrillary acidic protein; Injection; Maturation; Medical research; Mice; Mimicry; Nervous system; Neurobiology; Neurodegenerative diseases; Neurogenesis; Neurogenesis - physiology; Neuronal-glial interactions; Neurons; Neurons - cytology; Neurons - physiology; Neurosciences; Oligonucleotides; Oligonucleotides, Antisense; Physiological aspects; Polypyrimidine Tract-Binding Protein - antagonists & inhibitors; Proteins; Stem cells; Young adults; United States