Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully ge...

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Published inNature neuroscience Vol. 24; no. 8; pp. 1089 - 1099
Main Authors Maimon, Roy, Chillon-Marinas, Carlos, Snethlage, Cedric E., Singhal, Sarthak M., McAlonis-Downes, Melissa, Ling, Karen, Rigo, Frank, Bennett, C. Frank, Da Cruz, Sandrine, Hnasko, Thomas S., Muotri, Alysson R., Cleveland, Don W.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.08.2021
Nature Publishing Group
Subjects
631/378
631/378/368/2431
Aging
Amyotrophic lateral sclerosis
Animal Genetics and Genomics
Animals
Antisense oligonucleotides
Antisense therapy
Behavioral Sciences
Binding proteins
Biological response modifiers
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Brain research
Cellular Reprogramming - physiology
Cerebrospinal fluid
Circuits
Degeneration
Dentate gyrus
Dentate Gyrus - cytology
Dentate Gyrus - physiology
Disease
DNA biosynthesis
Ependymoglial Cells - cytology
Ependymoglial Cells - physiology
Gene expression
Genetic aspects
Glial cells
Glial fibrillary acidic protein
Injection
Maturation
Medical research
Mice
Mimicry
Nervous system
Neurobiology
Neurodegenerative diseases
Neurogenesis
Neurogenesis - physiology
Neuronal-glial interactions
Neurons
Neurons - cytology
Neurons - physiology
Neurosciences
Oligonucleotides
Oligonucleotides, Antisense
Physiological aspects
Polypyrimidine Tract-Binding Protein - antagonists & inhibitors
Proteins
Stem cells
Young adults
United States
Online AccessGet full text
ISSN1097-6256
1546-1726
1546-1726
DOI10.1038/s41593-021-00864-y

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Abstract Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully generate new neurons in the cortex and dentate gyrus of the aged adult mouse brain by transiently suppressing polypyrimidine tract binding protein 1 using an antisense oligonucleotide delivered by a single injection into cerebral spinal fluid. Radial glial-like cells and other GFAP-expressing cells convert into new neurons that, over a 2-month period, acquire mature neuronal character in a process mimicking normal neuronal maturation. The new neurons functionally integrate into endogenous circuits and modify mouse behavior. Thus, generation of new neurons in the dentate gyrus of the aging brain can be achieved with a therapeutically feasible approach, thereby opening prospects for production of neurons to replace those lost to neurodegenerative disease. Maimon et al. demonstrate a therapeutically viable approach, single-dose injection of a DNA drug to suppress synthesis of PTB, to generate new neurons in the aged mouse hippocampus and enhance memory after their integration into endogenous circuits.
AbstractList Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully generate new neurons in the cortex and dentate gyrus of the aged adult mouse brain by transiently suppressing polypyrimidine tract binding protein 1 using an antisense oligonucleotide delivered by a single injection into cerebral spinal fluid. Radial glial-like cells and other GFAP-expressing cells convert into new neurons that, over a 2-month period, acquire mature neuronal character in a process mimicking normal neuronal maturation. The new neurons functionally integrate into endogenous circuits and modify mouse behavior. Thus, generation of new neurons in the dentate gyrus of the aging brain can be achieved with a therapeutically feasible approach, thereby opening prospects for production of neurons to replace those lost to neurodegenerative disease.Maimon et al. demonstrate a therapeutically viable approach, single-dose injection of a DNA drug to suppress synthesis of PTB, to generate new neurons in the aged mouse hippocampus and enhance memory after their integration into endogenous circuits.
Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully generate new neurons in the cortex and dentate gyrus of the aged adult mouse brain by transiently suppressing polypyrimidine tract binding protein 1 using an antisense oligonucleotide delivered by a single injection into cerebral spinal fluid. Radial glial-like cells and other GFAP-expressing cells convert into new neurons that, over a 2-month period, acquire mature neuronal character in a process mimicking normal neuronal maturation. The new neurons functionally integrate into endogenous circuits and modify mouse behavior. Thus, generation of new neurons in the dentate gyrus of the aging brain can be achieved with a therapeutically feasible approach, thereby opening prospects for production of neurons to replace those lost to neurodegenerative disease. Maimon et al. demonstrate a therapeutically viable approach, single-dose injection of a DNA drug to suppress synthesis of PTB, to generate new neurons in the aged mouse hippocampus and enhance memory after their integration into endogenous circuits.
Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully generate new neurons in the cortex and dentate gyrus of the aged adult mouse brain by transiently suppressing polypyrimidine tract binding protein 1 using an antisense oligonucleotide delivered by a single injection into cerebral spinal fluid. Radial glial-like cells and other GFAP-expressing cells convert into new neurons that, over a 2-month period, acquire mature neuronal character in a process mimicking normal neuronal maturation. The new neurons functionally integrate into endogenous circuits and modify mouse behavior. Thus, generation of new neurons in the dentate gyrus of the aging brain can be achieved with a therapeutically feasible approach, thereby opening prospects for production of neurons to replace those lost to neurodegenerative disease.
Maimon et al. demonstrate a therapeutically viable approach, single-dose injection of a DNA drug to suppress synthesis of PTB, to generate new neurons in the aged mouse hippocampus and enhance memory after their integration into endogenous circuits.
Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully generate new neurons in the cortex and dentate gyrus of the aged adult mouse brain by transiently suppressing P olypyrimidine- T ract- B inding-Protein-1 (PTB) using an a nti s ense- o ligonucleotide (ASO) delivered by a single injection into cerebral spinal fluid. Radial glial-like cells and other GFAP-expressing cells convert into new neurons that over a two-month period acquire mature neuronal character in a process mimicking normal neuronal maturation. The new neurons functionally integrate into endogenous circuits and modify mouse behavior. Thus, generation of new neurons in the dentate gyrus of the aging brain can be achieved with a therapeutically feasible approach, thereby opening prospects for production of neurons to replace those lost to neurodegenerative disease.
Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully generate new neurons in the cortex and dentate gyrus of the aged adult mouse brain by transiently suppressing polypyrimidine tract binding protein 1 using an antisense oligonucleotide delivered by a single injection into cerebral spinal fluid. Radial glial-like cells and other GFAP-expressing cells convert into new neurons that, over a 2-month period, acquire mature neuronal character in a process mimicking normal neuronal maturation. The new neurons functionally integrate into endogenous circuits and modify mouse behavior. Thus, generation of new neurons in the dentate gyrus of the aging brain can be achieved with a therapeutically feasible approach, thereby opening prospects for production of neurons to replace those lost to neurodegenerative disease.Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept to clinical application. Here, we successfully generate new neurons in the cortex and dentate gyrus of the aged adult mouse brain by transiently suppressing polypyrimidine tract binding protein 1 using an antisense oligonucleotide delivered by a single injection into cerebral spinal fluid. Radial glial-like cells and other GFAP-expressing cells convert into new neurons that, over a 2-month period, acquire mature neuronal character in a process mimicking normal neuronal maturation. The new neurons functionally integrate into endogenous circuits and modify mouse behavior. Thus, generation of new neurons in the dentate gyrus of the aging brain can be achieved with a therapeutically feasible approach, thereby opening prospects for production of neurons to replace those lost to neurodegenerative disease.
Audience Academic
Author Bennett, C. Frank
Maimon, Roy
Snethlage, Cedric E.
Rigo, Frank
Da Cruz, Sandrine
Hnasko, Thomas S.
Ling, Karen
Cleveland, Don W.
Chillon-Marinas, Carlos
Muotri, Alysson R.
Singhal, Sarthak M.
McAlonis-Downes, Melissa
AuthorAffiliation 4 Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA
7 VIB-KU Leuven Center for Brain & Disease Research and Department of Neurosciences, KU Leuven, Leuven, Belgium
3 Department of Pediatrics, Rady Children’s Hospital San Diego, Stem Cell Program, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, CA, USA
2 Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA
6 Ionis Pharmaceuticals, Carlsbad, CA, USA
5 Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
1 Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34083786$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nn828
10.1016/S0006-8993(98)01258-X
10.1038/nature08797
10.1016/j.cell.2008.01.033
10.1186/s41232-020-00122-x
10.1016/j.stem.2019.08.002
10.1038/nrn.2017.107
10.1038/nrn.2016.46
10.1016/j.neuron.2012.05.009
10.1093/nar/gkl1071
10.1172/JCI25424
10.1038/6368
10.1038/nn.2156
10.1038/nature25975
10.1152/ajpheart.00503.2016
10.1038/s41586-018-0087-1
10.1523/JNEUROSCI.07-10-03142.1987
10.1523/JNEUROSCI.3648-05.2006
10.1038/4151030a
10.1002/cne.903010304
10.1371/journal.pone.0220125
10.1002/hipo.22380
10.1126/science.aba4624
10.1113/jphysiol.2008.154807
10.1038/ncomms14336
10.1007/s41048-018-0066-y
10.1038/nrn2822
10.1038/s41467-020-18046-y
10.1002/glia.22906
10.1056/NEJMoa1702752
10.1126/science.287.5457.1433
10.1186/s12935-020-01210-1
10.1097/CMR.0000000000000208
10.1016/j.neuron.2016.04.006
10.1038/417039a
10.12688/f1000research.12684.1
10.1016/j.cell.2020.03.024
10.1038/125230a0
10.1016/S0092-8674(00)80783-7
10.1016/j.gde.2013.06.005
10.1016/j.tranon.2018.10.008
10.1038/s41586-020-2388-4
10.1016/S1474-4422(13)70061-9
10.1146/annurev-neuro-070918-050501
10.1016/j.celrep.2015.07.051
10.1037/h0077579
10.1016/j.beproc.2011.12.004
10.1016/j.ymthe.2017.01.016
10.1074/jbc.M210326200
10.1016/j.cell.2016.09.027
10.1016/S0197-4580(03)00090-3
10.1093/nar/gkaa1235
10.1056/NEJMoa2003715
10.1038/s41593-018-0295-x
10.1016/j.neuron.2011.05.001
10.1074/jbc.274.34.23996
10.1016/j.stem.2015.09.003
10.1002/cne.901240303
10.18632/oncotarget.3851
10.1002/hipo.20122
10.1038/nn.2467
10.4049/jimmunol.133.4.1710
10.1101/2020.08.16.253195
10.3791/53825
ContentType Journal Article
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COPYRIGHT 2021 Nature Publishing Group
The Author(s), under exclusive licence to Springer Nature America, Inc. 2021.
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Author Contribution Statement
R.M., C.C.M., S.D.C., and D.W.C. conceived the study. R.M., C.C.M., C.E.S, S.M.S., K.L., F.R., C.F.B., S.D.C., T.H., A.R.M., and D.W.C. designed the study. R.M., C.C.M, C.E.S., S.M.S., M.M.D., and K.L. performed the experiments. R.M., C.C.M., S.M.S., analyzed the data. R.M., C.C.M, C.E.S, S.M.S, F.R., C.F.B., S.D.C., T.H., A.R.M., and D.W.C. wrote the manuscript; all authors discussed the results and commented on the manuscript.
ORCID 0000-0003-0867-2875
0000-0002-1934-3682
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/8338913
PMID 34083786
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References Heins (CR3) 2002; 5
Trujillo (CR21) 2019; 25
Miller (CR17) 2020; 383
Swayze (CR49) 2007; 35
Clemenson (CR52) 2015; 25
Zhao, van Praag (CR62) 2020; 11
Stafman (CR55) 2019; 12
Zhao, Teng, Summers, Ming, Gage (CR35) 2006; 26
Sorrells (CR30) 2018; 555
Deng, Aimone, Gage (CR36) 2010; 11
Zhou (CR9) 2020; 181
Jafar-Nejad (CR53) 2021; 49
Kase, Kase, Shimazaki, Okano (CR4) 2020; 40
Kosik, Finch (CR38) 1987; 7
Mertens, Marchetto, Bardy, Gage (CR5) 2016; 17
Gage (CR47) 2000; 287
Vickers (CR19) 2003; 278
Qian (CR8) 2020; 582
Bennett, Krainer, Cleveland (CR48) 2019; 42
Shimizu, Kaira, Yasuda, Asao, Ishikawa (CR57) 2016; 26
Ming, Song (CR24) 2011; 70
CR41
Zhao, Deng, Gage (CR25) 2008; 132
D. B. (CR1) 1930; 125
Song, Stevens, Gage (CR27) 2002; 417
Schreiner (CR32) 2015; 12
Altman, Bayer (CR39) 1990; 301
Barca-Mayo (CR51) 2017; 8
Di Lullo, Kriegstein (CR20) 2017; 18
Mumby, Tremblay, Lecluse, Lehmann (CR66) 2005; 15
James (CR58) 2016; 64
Krishnakumar, Blelloch (CR50) 2013; 23
Schafer (CR54) 2019; 22
Yousef (CR59) 2015; 6
Platzer, Zorn-Pauly (CR65) 2016; 311
Leavitt, Tabrizi (CR18) 2020; 367
Madisen (CR22) 2010; 13
Jiang (CR67) 2016; 90
Bond, Ming, Song (CR2) 2015; 17
Hu, Qian, Xue, Fu (CR12) 2018; 4
Doetsch, Caille, Lim, Garcia-Verdugo, Alvarez-Buylla (CR28) 1999; 97
Zhou (CR60) 2020; 20
Van Praag, Kempermann, Gage (CR43) 1999; 2
McAvoy (CR56) 2019; 14
Vierbuchen (CR6) 2010; 463
Eliasson (CR42) 1999; 274
La Manno (CR11) 2016; 167
Morgenstern, Lombardi, Schinder (CR29) 2008; 586
Heyser, Chemero (CR45) 2012; 89
Van Praag (CR37) 2002; 415
Kempermann, Song, Gage (CR40) 2015; 7
SHOLL (CR63) 1953; 87
Song, Berg, Bond, Ming (CR26) 2018; 7
Barker, Götz, Parmar (CR7) 2018; 557
Barnes (CR44) 1979; 93
Crawley (CR46) 1999; 835
Gerdes (CR61) 1984; 133
CR64
Smith (CR13) 2006; 116
Finkel (CR15) 2017; 377
Gerdes (CR33) 1984; 133
Toni (CR34) 2008; 11
Miller (CR16) 2013; 12
Kordasiewicz (CR14) 2012; 74
Altman, Das (CR23) 1965; 124
Weinberg, Criswell, Powell, Bhatt, McCown (CR10) 2017; 25
Heine, Maslam, Joëls, Lucassen (CR31) 2004; 25
RA Barker (864_CR7) 2018; 557
D Platzer (864_CR65) 2016; 311
J Hu (864_CR12) 2018; 4
E Di Lullo (864_CR20) 2017; 18
Y Kase (864_CR4) 2020; 40
J Altman (864_CR39) 1990; 301
H Van Praag (864_CR37) 2002; 415
H Van Praag (864_CR43) 1999; 2
CA Barnes (864_CR44) 1979; 93
C Zhao (864_CR25) 2008; 132
TM Miller (864_CR16) 2013; 12
VM Heine (864_CR31) 2004; 25
P Jafar-Nejad (864_CR53) 2021; 49
H Yousef (864_CR59) 2015; 6
KM McAvoy (864_CR56) 2019; 14
HB Kordasiewicz (864_CR14) 2012; 74
T Miller (864_CR17) 2020; 383
N Toni (864_CR34) 2008; 11
O Barca-Mayo (864_CR51) 2017; 8
JN Crawley (864_CR46) 1999; 835
H Song (864_CR27) 2002; 417
GD Clemenson (864_CR52) 2015; 25
N Heins (864_CR3) 2002; 5
G La Manno (864_CR11) 2016; 167
SF Sorrells (864_CR30) 2018; 555
R Krishnakumar (864_CR50) 2013; 23
BR Leavitt (864_CR18) 2020; 367
TA Vickers (864_CR19) 2003; 278
KS Kosik (864_CR38) 1987; 7
T Vierbuchen (864_CR6) 2010; 463
CA Trujillo (864_CR21) 2019; 25
F Doetsch (864_CR28) 1999; 97
B Schreiner (864_CR32) 2015; 12
864_CR41
NA Morgenstern (864_CR29) 2008; 586
C Eliasson (864_CR42) 1999; 274
H Qian (864_CR8) 2020; 582
CF Bennett (864_CR48) 2019; 42
J Zhou (864_CR60) 2020; 20
AM Bond (864_CR2) 2015; 17
J Altman (864_CR23) 1965; 124
DG Mumby (864_CR66) 2005; 15
D D. B. (864_CR1) 1930; 125
RE James (864_CR58) 2016; 64
CJ Heyser (864_CR45) 2012; 89
J Mertens (864_CR5) 2016; 17
RA Smith (864_CR13) 2006; 116
J Jiang (864_CR67) 2016; 90
RS Finkel (864_CR15) 2017; 377
L Madisen (864_CR22) 2010; 13
Gli Ming (864_CR24) 2011; 70
LL Stafman (864_CR55) 2019; 12
X Zhao (864_CR62) 2020; 11
W Deng (864_CR36) 2010; 11
G Kempermann (864_CR40) 2015; 7
C Zhao (864_CR35) 2006; 26
MS Weinberg (864_CR10) 2017; 25
H Zhou (864_CR9) 2020; 181
J Gerdes (864_CR33) 1984; 133
FH Gage (864_CR47) 2000; 287
DA SHOLL (864_CR63) 1953; 87
H Song (864_CR26) 2018; 7
ST Schafer (864_CR54) 2019; 22
J Gerdes (864_CR61) 1984; 133
EE Swayze (864_CR49) 2007; 35
A Shimizu (864_CR57) 2016; 26
864_CR64
References_xml – volume: 5
  start-page: 308
  year: 2002
  end-page: 315
  ident: CR3
  article-title: Glial cells generate neurons: the role of the transcription factor Pax6
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn828
– volume: 835
  start-page: 18
  year: 1999
  end-page: 26
  ident: CR46
  article-title: Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
  publication-title: Brain Res.
  doi: 10.1016/S0006-8993(98)01258-X
– volume: 463
  start-page: 1035
  year: 2010
  end-page: 1041
  ident: CR6
  article-title: Direct conversion of fibroblasts to functional neurons by defined factors
  publication-title: Nature
  doi: 10.1038/nature08797
– volume: 132
  start-page: 645
  year: 2008
  end-page: 660
  ident: CR25
  article-title: Mechanisms and functional implications of adult neurogenesis
  publication-title: Cell
  doi: 10.1016/j.cell.2008.01.033
– volume: 40
  year: 2020
  ident: CR4
  article-title: Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age?
  publication-title: Inflamm. Regen.
  doi: 10.1186/s41232-020-00122-x
– volume: 25
  start-page: 558
  year: 2019
  end-page: 569
  ident: CR21
  article-title: Complex oscillatory waves emerging from cortical organoids model early human brain network development
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2019.08.002
– volume: 18
  start-page: 573
  year: 2017
  end-page: 584
  ident: CR20
  article-title: The use of brain organoids to investigate neural development and disease
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2017.107
– volume: 17
  start-page: 424
  year: 2016
  end-page: 437
  ident: CR5
  article-title: Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2016.46
– volume: 133
  start-page: 1710
  year: 1984
  end-page: 1715
  ident: CR61
  article-title: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
  publication-title: J. Immunol.
– volume: 87
  start-page: 387
  year: 1953
  end-page: 406
  ident: CR63
  article-title: Dendritic organization in the neurons of the visual and motor cortices of the cat
  publication-title: J. Anat.
– volume: 74
  start-page: 1031
  year: 2012
  end-page: 1044
  ident: CR14
  article-title: Sustained therapeutic reversal of Huntington’s disease by transient repression of huntingtin synthesis
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.05.009
– volume: 35
  start-page: 687
  year: 2007
  end-page: 700
  ident: CR49
  article-title: Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkl1071
– volume: 116
  start-page: 2290
  year: 2006
  end-page: 2296
  ident: CR13
  article-title: Antisense oligonucleotide therapy for neurodegenerative disease
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI25424
– volume: 2
  start-page: 266
  year: 1999
  end-page: 270
  ident: CR43
  article-title: Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
  publication-title: Nat. Neurosci.
  doi: 10.1038/6368
– volume: 11
  start-page: 901
  year: 2008
  end-page: 907
  ident: CR34
  article-title: Neurons born in the adult dentate gyrus form functional synapses with target cells
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2156
– volume: 555
  start-page: 377
  year: 2018
  end-page: 381
  ident: CR30
  article-title: Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
  publication-title: Nature
  doi: 10.1038/nature25975
– volume: 311
  start-page: H1072
  year: 2016
  end-page: H1073
  ident: CR65
  article-title: Letter to the editor: Accurate cell capacitance determination from a single voltage step: a reminder to avoid unnecessary pitfalls
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00503.2016
– volume: 557
  start-page: 329
  year: 2018
  end-page: 334
  ident: CR7
  article-title: New approaches for brain repair—from rescue to reprogramming
  publication-title: Nature
  doi: 10.1038/s41586-018-0087-1
– volume: 7
  start-page: 3142
  year: 1987
  end-page: 3153
  ident: CR38
  article-title: MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.07-10-03142.1987
– volume: 26
  start-page: 3
  year: 2006
  end-page: 11
  ident: CR35
  article-title: Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3648-05.2006
– volume: 415
  start-page: 1030
  year: 2002
  end-page: 1034
  ident: CR37
  article-title: Functional neurogenesis in the adult hippocampus
  publication-title: Nature
  doi: 10.1038/4151030a
– volume: 301
  start-page: 365
  year: 1990
  end-page: 381
  ident: CR39
  article-title: Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.903010304
– volume: 14
  start-page: e0220125
  year: 2019
  ident: CR56
  article-title: Cell-autonomous and non-cell autonomous effects of neuronal loss in vivo
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0220125
– volume: 25
  start-page: 385
  year: 2015
  end-page: 392
  ident: CR52
  article-title: Enrichment rescues contextual discrimination deficit associated with immediate shock
  publication-title: Hippocampus
  doi: 10.1002/hipo.22380
– volume: 367
  start-page: 1428
  year: 2020
  end-page: 1429
  ident: CR18
  article-title: Antisense oligonucleotides for neurodegeneration
  publication-title: Science
  doi: 10.1126/science.aba4624
– ident: CR64
– volume: 586
  start-page: 3751
  year: 2008
  end-page: 3757
  ident: CR29
  article-title: Newborn granule cells in the ageing dentate gyrus
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2008.154807
– volume: 8
  start-page: 14336
  year: 2017
  ident: CR51
  article-title: Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14336
– volume: 4
  start-page: 204
  year: 2018
  end-page: 214
  ident: CR12
  article-title: PTB/nPTB: master regulators of neuronal fate in mammals
  publication-title: Biophys. Rep.
  doi: 10.1007/s41048-018-0066-y
– volume: 11
  start-page: 339
  year: 2010
  end-page: 350
  ident: CR36
  article-title: New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2822
– volume: 11
  start-page: 4275
  year: 2020
  ident: CR62
  article-title: Steps towards standardized quantification of adult neurogenesis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-18046-y
– volume: 64
  start-page: 105
  year: 2016
  end-page: 121
  ident: CR58
  article-title: Loss of galectin-3 decreases the number of immune cells in the subventricular zone and restores proliferation in a viral model of multiple sclerosis
  publication-title: Glia
  doi: 10.1002/glia.22906
– volume: 377
  start-page: 1723
  year: 2017
  end-page: 1732
  ident: CR15
  article-title: Nusinersen versus sham control in infantile-onset spinal muscular atrophy
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1702752
– volume: 287
  start-page: 1433
  year: 2000
  end-page: 1438
  ident: CR47
  article-title: Mammalian neural stem cells
  publication-title: Science
  doi: 10.1126/science.287.5457.1433
– volume: 20
  start-page: 134
  year: 2020
  ident: CR60
  article-title: Silencing of microRNA-135b inhibits invasion, migration, and stemness of CD24 CD44 pancreatic cancer stem cells through JADE-1-dependent AKT/mTOR pathway
  publication-title: Cancer Cell Int.
  doi: 10.1186/s12935-020-01210-1
– volume: 26
  start-page: 29
  year: 2016
  end-page: 34
  ident: CR57
  article-title: Decreased expression of class III β-tubulin is associated with unfavourable prognosis in patients with malignant melanoma
  publication-title: Melanoma Res.
  doi: 10.1097/CMR.0000000000000208
– volume: 7
  start-page: 9
  year: 2015
  ident: CR40
  article-title: Neurogenesis in the adult hippocampus
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 90
  start-page: 535
  year: 2016
  end-page: 550
  ident: CR67
  article-title: Gain of toxicity from ALS/FTD-linked repeat expansions in is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.04.006
– volume: 417
  start-page: 39
  year: 2002
  end-page: 44
  ident: CR27
  article-title: Astroglia induce neurogenesis from adult neural stem cells
  publication-title: Nature
  doi: 10.1038/417039a
– volume: 7
  start-page: 277
  year: 2018
  ident: CR26
  article-title: Radial glial cells in the adult dentate gyrus: what are they and where do they come from?
  publication-title: F1000Res.
  doi: 10.12688/f1000research.12684.1
– volume: 181
  start-page: 590
  year: 2020
  end-page: 693
  ident: CR9
  article-title: Glia-to-neuron conversion by CRISPR-CasRx alleviates symptoms of neurological disease in mice
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.024
– volume: 125
  start-page: 230
  year: 1930
  end-page: 231
  ident: CR1
  article-title: Degeneration and regeneration of the nervous system
  publication-title: Nature
  doi: 10.1038/125230a0
– volume: 97
  start-page: 703
  year: 1999
  end-page: 716
  ident: CR28
  article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80783-7
– volume: 23
  start-page: 548
  year: 2013
  end-page: 555
  ident: CR50
  article-title: Epigenetics of cellular reprogramming
  publication-title: Curr. Opin. Genet. Dev.
  doi: 10.1016/j.gde.2013.06.005
– volume: 12
  start-page: 200
  year: 2019
  end-page: 208
  ident: CR55
  article-title: Targeting PIM kinases affects maintenance of CD133 tumor cell population in hepatoblastoma
  publication-title: Transl. Oncol.
  doi: 10.1016/j.tranon.2018.10.008
– volume: 582
  start-page: 550
  year: 2020
  end-page: 556
  ident: CR8
  article-title: Reversing a model of Parkinson’ s disease with in situ converted nigral neurons
  publication-title: Nature
  doi: 10.1038/s41586-020-2388-4
– volume: 12
  start-page: 435
  year: 2013
  end-page: 442
  ident: CR16
  article-title: An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(13)70061-9
– volume: 42
  start-page: 385
  year: 2019
  end-page: 406
  ident: CR48
  article-title: Antisense oligonucleotide therapies for neurodegenerative diseases
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-070918-050501
– volume: 12
  start-page: 1377
  year: 2015
  end-page: 1384
  ident: CR32
  article-title: Astrocyte depletion impairs redox homeostasis and triggers neuronal loss in the adult CNS
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.07.051
– volume: 93
  start-page: 74
  year: 1979
  end-page: 104
  ident: CR44
  article-title: Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat
  publication-title: J. Comp. Physiol. Psychol.
  doi: 10.1037/h0077579
– volume: 89
  start-page: 232
  year: 2012
  end-page: 238
  ident: CR45
  article-title: Novel object exploration in mice: not all objects are created equal
  publication-title: Behav. Process.
  doi: 10.1016/j.beproc.2011.12.004
– volume: 25
  start-page: 928
  year: 2017
  end-page: 934
  ident: CR10
  article-title: Viral vector reprogramming of adult resident striatal oligodendrocytes into functional neurons
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2017.01.016
– volume: 278
  start-page: 7108
  year: 2003
  end-page: 7118
  ident: CR19
  article-title: Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M210326200
– volume: 133
  start-page: 1710
  year: 1984
  end-page: 1715
  ident: CR33
  article-title: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
  publication-title: J. Immunol.
– volume: 167
  start-page: 566
  year: 2016
  end-page: 580
  ident: CR11
  article-title: Molecular diversity of midbrain development in mouse, human, and stem cells
  publication-title: Cell
  doi: 10.1016/j.cell.2016.09.027
– volume: 25
  start-page: 361
  year: 2004
  end-page: 375
  ident: CR31
  article-title: Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation
  publication-title: Neurobiol. Aging
  doi: 10.1016/S0197-4580(03)00090-3
– volume: 49
  start-page: 657
  year: 2021
  end-page: 673
  ident: CR53
  article-title: The atlas of RNase H antisense oligonucleotide distribution and activity in the CNS of rodents and non-human primates following central administration
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1235
– volume: 383
  start-page: 109
  year: 2020
  end-page: 119
  ident: CR17
  article-title: Phase 1–2 trial of antisense oligonucleotide tofersen for SOD1 ALS
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2003715
– volume: 22
  start-page: 243
  year: 2019
  end-page: 255
  ident: CR54
  article-title: Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0295-x
– volume: 70
  start-page: 687
  year: 2011
  end-page: 702
  ident: CR24
  article-title: Adult neurogenesis in the mammalian brain: significant answers and significant questions
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.05.001
– volume: 274
  start-page: 23996
  year: 1999
  end-page: 24006
  ident: CR42
  article-title: Intermediate filament protein partnership in astrocytes
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.34.23996
– volume: 17
  start-page: 385
  year: 2015
  end-page: 395
  ident: CR2
  article-title: Adult mammalian neural stem cells and neurogenesis: five decades later
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.09.003
– ident: CR41
– volume: 124
  start-page: 319
  year: 1965
  end-page: 335
  ident: CR23
  article-title: Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.901240303
– volume: 6
  start-page: 11959
  year: 2015
  end-page: 11978
  ident: CR59
  article-title: Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3851
– volume: 15
  start-page: 1050
  year: 2005
  end-page: 1056
  ident: CR66
  article-title: Hippocampal damage and anterograde object-recognition in rats after long retention intervals
  publication-title: Hippocampus
  doi: 10.1002/hipo.20122
– volume: 13
  start-page: 133
  year: 2010
  end-page: 140
  ident: CR22
  article-title: A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2467
– volume: 133
  start-page: 1710
  year: 1984
  ident: 864_CR61
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.133.4.1710
– volume: 11
  start-page: 4275
  year: 2020
  ident: 864_CR62
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-18046-y
– volume: 20
  start-page: 134
  year: 2020
  ident: 864_CR60
  publication-title: Cancer Cell Int.
  doi: 10.1186/s12935-020-01210-1
– volume: 18
  start-page: 573
  year: 2017
  ident: 864_CR20
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2017.107
– volume: 7
  start-page: 9
  year: 2015
  ident: 864_CR40
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 167
  start-page: 566
  year: 2016
  ident: 864_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2016.09.027
– volume: 17
  start-page: 424
  year: 2016
  ident: 864_CR5
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2016.46
– volume: 132
  start-page: 645
  year: 2008
  ident: 864_CR25
  publication-title: Cell
  doi: 10.1016/j.cell.2008.01.033
– volume: 87
  start-page: 387
  year: 1953
  ident: 864_CR63
  publication-title: J. Anat.
– volume: 377
  start-page: 1723
  year: 2017
  ident: 864_CR15
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1702752
– volume: 25
  start-page: 558
  year: 2019
  ident: 864_CR21
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2019.08.002
– volume: 64
  start-page: 105
  year: 2016
  ident: 864_CR58
  publication-title: Glia
  doi: 10.1002/glia.22906
– ident: 864_CR41
  doi: 10.1101/2020.08.16.253195
– volume: 133
  start-page: 1710
  year: 1984
  ident: 864_CR33
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.133.4.1710
– volume: 835
  start-page: 18
  year: 1999
  ident: 864_CR46
  publication-title: Brain Res.
  doi: 10.1016/S0006-8993(98)01258-X
– volume: 415
  start-page: 1030
  year: 2002
  ident: 864_CR37
  publication-title: Nature
  doi: 10.1038/4151030a
– volume: 25
  start-page: 928
  year: 2017
  ident: 864_CR10
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2017.01.016
– volume: 278
  start-page: 7108
  year: 2003
  ident: 864_CR19
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M210326200
– volume: 367
  start-page: 1428
  year: 2020
  ident: 864_CR18
  publication-title: Science
  doi: 10.1126/science.aba4624
– volume: 11
  start-page: 339
  year: 2010
  ident: 864_CR36
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn2822
– volume: 14
  start-page: e0220125
  year: 2019
  ident: 864_CR56
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0220125
– volume: 17
  start-page: 385
  year: 2015
  ident: 864_CR2
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.09.003
– volume: 70
  start-page: 687
  year: 2011
  ident: 864_CR24
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.05.001
– volume: 274
  start-page: 23996
  year: 1999
  ident: 864_CR42
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.34.23996
– volume: 7
  start-page: 3142
  year: 1987
  ident: 864_CR38
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.07-10-03142.1987
– volume: 89
  start-page: 232
  year: 2012
  ident: 864_CR45
  publication-title: Behav. Process.
  doi: 10.1016/j.beproc.2011.12.004
– volume: 463
  start-page: 1035
  year: 2010
  ident: 864_CR6
  publication-title: Nature
  doi: 10.1038/nature08797
– volume: 555
  start-page: 377
  year: 2018
  ident: 864_CR30
  publication-title: Nature
  doi: 10.1038/nature25975
– volume: 586
  start-page: 3751
  year: 2008
  ident: 864_CR29
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2008.154807
– volume: 40
  year: 2020
  ident: 864_CR4
  publication-title: Inflamm. Regen.
  doi: 10.1186/s41232-020-00122-x
– volume: 25
  start-page: 361
  year: 2004
  ident: 864_CR31
  publication-title: Neurobiol. Aging
  doi: 10.1016/S0197-4580(03)00090-3
– volume: 93
  start-page: 74
  year: 1979
  ident: 864_CR44
  publication-title: J. Comp. Physiol. Psychol.
  doi: 10.1037/h0077579
– volume: 582
  start-page: 550
  year: 2020
  ident: 864_CR8
  publication-title: Nature
  doi: 10.1038/s41586-020-2388-4
– volume: 26
  start-page: 29
  year: 2016
  ident: 864_CR57
  publication-title: Melanoma Res.
  doi: 10.1097/CMR.0000000000000208
– volume: 49
  start-page: 657
  year: 2021
  ident: 864_CR53
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkaa1235
– volume: 2
  start-page: 266
  year: 1999
  ident: 864_CR43
  publication-title: Nat. Neurosci.
  doi: 10.1038/6368
– volume: 26
  start-page: 3
  year: 2006
  ident: 864_CR35
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.3648-05.2006
– volume: 35
  start-page: 687
  year: 2007
  ident: 864_CR49
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkl1071
– volume: 13
  start-page: 133
  year: 2010
  ident: 864_CR22
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2467
– volume: 90
  start-page: 535
  year: 2016
  ident: 864_CR67
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.04.006
– volume: 311
  start-page: H1072
  year: 2016
  ident: 864_CR65
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00503.2016
– volume: 15
  start-page: 1050
  year: 2005
  ident: 864_CR66
  publication-title: Hippocampus
  doi: 10.1002/hipo.20122
– volume: 12
  start-page: 1377
  year: 2015
  ident: 864_CR32
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2015.07.051
– volume: 417
  start-page: 39
  year: 2002
  ident: 864_CR27
  publication-title: Nature
  doi: 10.1038/417039a
– volume: 124
  start-page: 319
  year: 1965
  ident: 864_CR23
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.901240303
– volume: 181
  start-page: 590
  year: 2020
  ident: 864_CR9
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.024
– volume: 97
  start-page: 703
  year: 1999
  ident: 864_CR28
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80783-7
– volume: 5
  start-page: 308
  year: 2002
  ident: 864_CR3
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn828
– volume: 7
  start-page: 277
  year: 2018
  ident: 864_CR26
  publication-title: F1000Res.
  doi: 10.12688/f1000research.12684.1
– ident: 864_CR64
  doi: 10.3791/53825
– volume: 4
  start-page: 204
  year: 2018
  ident: 864_CR12
  publication-title: Biophys. Rep.
  doi: 10.1007/s41048-018-0066-y
– volume: 301
  start-page: 365
  year: 1990
  ident: 864_CR39
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.903010304
– volume: 23
  start-page: 548
  year: 2013
  ident: 864_CR50
  publication-title: Curr. Opin. Genet. Dev.
  doi: 10.1016/j.gde.2013.06.005
– volume: 22
  start-page: 243
  year: 2019
  ident: 864_CR54
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-018-0295-x
– volume: 116
  start-page: 2290
  year: 2006
  ident: 864_CR13
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI25424
– volume: 287
  start-page: 1433
  year: 2000
  ident: 864_CR47
  publication-title: Science
  doi: 10.1126/science.287.5457.1433
– volume: 25
  start-page: 385
  year: 2015
  ident: 864_CR52
  publication-title: Hippocampus
  doi: 10.1002/hipo.22380
– volume: 125
  start-page: 230
  year: 1930
  ident: 864_CR1
  publication-title: Nature
  doi: 10.1038/125230a0
– volume: 12
  start-page: 435
  year: 2013
  ident: 864_CR16
  publication-title: Lancet Neurol.
  doi: 10.1016/S1474-4422(13)70061-9
– volume: 42
  start-page: 385
  year: 2019
  ident: 864_CR48
  publication-title: Annu. Rev. Neurosci.
  doi: 10.1146/annurev-neuro-070918-050501
– volume: 557
  start-page: 329
  year: 2018
  ident: 864_CR7
  publication-title: Nature
  doi: 10.1038/s41586-018-0087-1
– volume: 383
  start-page: 109
  year: 2020
  ident: 864_CR17
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2003715
– volume: 74
  start-page: 1031
  year: 2012
  ident: 864_CR14
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.05.009
– volume: 12
  start-page: 200
  year: 2019
  ident: 864_CR55
  publication-title: Transl. Oncol.
  doi: 10.1016/j.tranon.2018.10.008
– volume: 6
  start-page: 11959
  year: 2015
  ident: 864_CR59
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3851
– volume: 8
  start-page: 14336
  year: 2017
  ident: 864_CR51
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14336
– volume: 11
  start-page: 901
  year: 2008
  ident: 864_CR34
  publication-title: Nat. Neurosci.
  doi: 10.1038/nn.2156
SSID ssj0007589
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Snippet Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of...
Maimon et al. demonstrate a therapeutically viable approach, single-dose injection of a DNA drug to suppress synthesis of PTB, to generate new neurons in the...
SourceID pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1089
SubjectTerms 631/378
631/378/368/2431
Aging
Amyotrophic lateral sclerosis
Animal Genetics and Genomics
Animals
Antisense oligonucleotides
Antisense therapy
Behavioral Sciences
Binding proteins
Biological response modifiers
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Brain research
Cellular Reprogramming - physiology
Cerebrospinal fluid
Circuits
Degeneration
Dentate gyrus
Dentate Gyrus - cytology
Dentate Gyrus - physiology
Disease
DNA biosynthesis
Ependymoglial Cells - cytology
Ependymoglial Cells - physiology
Gene expression
Genetic aspects
Glial cells
Glial fibrillary acidic protein
Injection
Maturation
Medical research
Mice
Mimicry
Nervous system
Neurobiology
Neurodegenerative diseases
Neurogenesis
Neurogenesis - physiology
Neuronal-glial interactions
Neurons
Neurons - cytology
Neurons - physiology
Neurosciences
Oligonucleotides
Oligonucleotides, Antisense
Physiological aspects
Polypyrimidine Tract-Binding Protein - antagonists & inhibitors
Proteins
Stem cells
Young adults
Title Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB
URI https://link.springer.com/article/10.1038/s41593-021-00864-y
https://www.ncbi.nlm.nih.gov/pubmed/34083786
https://www.proquest.com/docview/2557304587
https://www.proquest.com/docview/2537642440
https://pubmed.ncbi.nlm.nih.gov/PMC8338913
Volume 24
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