IRGM1 links mitochondrial quality control to autoimmunity - Rai, Prashant; Janardhan, Kyathanahalli S.; Meacham, Julie; Madenspacher, Jennifer H.; Lin, Wan-Chi; Karmaus, Peer W. F.; Martinez, Jennifer; Li, Quan-Zhen; Yan, Mei; Zeng, Jialiu; Grinstaff, Mark W.; Shirihai, Orian S.; et al. (Nature immunology, 2021)
Keywords: 631/250/127; 631/250/262; 631/250/38; 631/80/39; 692/420/2780; AMP; Animals; Autoimmune diseases; Autoimmune Diseases - genetics; Autoimmune Diseases - immunology; Autoimmune Diseases - metabolism; Autoimmune Diseases - pathology; Autoimmunity; Autophagy; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cells, Cultured; Cyclic GMP; Cytosol; Deoxyribonucleic acid; Development and progression; DNA; Enzymes; Fibroblasts; Fibroblasts - immunology; Fibroblasts - metabolism; Fibroblasts - pathology; Gene Expression Regulation; Genetic aspects; GTP-Binding Proteins - deficiency; GTP-Binding Proteins - genetics; GTP-Binding Proteins - metabolism; Health aspects; Hydrolases; Immunology; Infectious Diseases; Inflammation; Inflammatory diseases; Lacrimal gland and Nasolacrimal duct; Macrophages; Macrophages - immunology; Macrophages - metabolism; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Mitochondria - genetics; Mitochondria - immunology; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial DNA; Mitophagy; Nucleic acids; Nucleotidyltransferases - genetics; Nucleotidyltransferases - metabolism; Pancreas; Pathology; Phagocytosis; Quality control; Signal Transduction; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - metabolism; Toll-like receptors; γ-Interferon; United States